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Special Collections
Featured Collections
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This collection includes recent studies investigating the adaptive and innate immune response induced by M. tuberculosis and HIV-1 infection. The collection includes studies i... -
This collection highlights the latest discoveries in the field of innate immunity in viral infection, barrier defense, liver health, inflammation, and cancer. We hope you enjo...
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This collection highlights the latest discoveries in lymphatic biology, including studies on lymphatic vessels in the skin, skull, intestine, and lung, novel imaging technique... -
This collection highlights recent findings in the fields of hematopoiesis and myeloid lineages, including the role of neutrophils in myocardial and vascular injury, the charac... -
This collection covers a wide range of topics including antitumor T cell responses, central and peripheral tolerance establishment and maintenance, intestinal mucosal immunolo... -
Our annual Best of JEM series highlights research in basic immunology, immunotherapy and tumor immunology, inborn errors of immunity, neurodegeneration, and inflammation.... -
This year’s Nobel Prize in Physiology or Medicine was awarded to Mary E. Brunkow, Frederick J. Ramsdell and Shimon Sakaguchi for their discoveries concerning peripheral ... -
This collection highlights the latest discoveries in cancer immunology and immunotherapy, covering a broad range of topics including T cell biology, immune checkpoint inhibito... -
This collection highlights recent findings in the field of immune communication. The selected articles cover a range of topics including early antiviral defense programs in hu... -
This collection highlights the most recent findings in the innate immunity field published in JEM. It spotlights cutting-edge research on the mechanistic aspects of innate imm... -
This collection highlights the latest discoveries in neuroscience, including original research articles and reviews published at JEM that cover meningeal lymphatics, pain, neu... -
This collection highlights recent advances in our understanding of macrophages and dendritic cells, and their roles in infection, allergy, cancer, neuroinflammation, and neuro... -
This collection of neuroimmunology and neurodegeneration articles covers a broad range of topics including macular degeneration, the role of microglia, β-amyloid transpor... -
This special collection, timed to coincide with the Federation of Clinical Immunology Societies annual meeting, FOCIS 2025, features recent and exciting advances in the field ... -
This special collection on immunometabolism spotlights two reviews, one on age- and diet-dependent metabolic remodeling of the tumor immune microenvironment and the other on r... -
This collection highlights recent immunology findings in the field of B cells, CD8+ T cell stemness, priming and differentiation, CD4+ T cell heterogeneity, autoimmunity, lymp... -
This collection highlights recent advances in the field of human inborn errors of immunity. You will find research on immune dysregulations with genetic bases leading to ... -
This collection highlights advances in cancer biology, tumor immunology, and emerging therapeutic strategies, with a particular focus on the dynamic interplay between cancer c... -
This collection emphasizes the pivotal role of tumor metabolism in cancer progression, immune modulation, and therapy resistance. It highlights cutting-edge research on metabo... -
This collection highlights recent advances in B lymphocyte biology from homeostasis to inflammation, and dysfunction leading to lymphoma development. You will find research on... -
This collection highlights recent publications in JEM on host-microbe interactions. It includes a study on the colitogenicity and perturbations of gut microbiota in immunother... -
This collection explores lymphocyte cell differentiation in specific microenvironments and innate immune memory, including studies investigating innate responses in the nasal ... -
This special collection highlights recent immunology studies published in JEM. These studies cover a range of topics, including barrier immunity, microbiota, molecular immunol... -
Our annual Best of JEM series highlights research in basic immunology, immunotherapy and tumor immunology, inborn errors of immunity, neurodegeneration, and inflammation. We r... -
This collection highlights recent authoritative texts on different aspects of the immune system. We bring you scholarly overviews of the latest research on topics such as thym... -
This collection, timed to coincide with the the Cytokines 2024 meeting, highlights the roles of cytokines in allergic inflammation, autoimmunity, viral and bacterial infection... -
This collection includes a series of reviews on thymus and T cell development, a review on B cell tolerance and autoimmunity, and several studies on T and B cells and related ... -
This collection highlights the latest discoveries in neuroscience, including meningeal lymphatics, anti-amyloid immunotherapy, tauopathy, and the role of microglia in the path... -
This special collection highlights studies on cancer biology, tumor immunology and therapeutic development published in JEM in the past 12 months. These studies provide insigh... -
This collection highlights the latest discoveries on innate lymphoid cells (ILCs) published in JEM. The included articles span the origin and development of ILCs and their rol... -
This collection focuses on the interface between the immune system and the environment at mucosal surfaces. The selected articles cover a range of topics including mucosal bar... -
This collection explores the metabolic programing of immune cells, including T cells, neutrophils, microglia, macrophages, monocytes and hematopoietic progenitors, in cancer a... -
This special collection, timed to coincide with the Federation of Clinical Immunology Societies annual meeting, FOCIS 2024, features recent and exciting advances in the field ... -
This collection covers retinal degeneration, meningeal lymphatics, anti-amyloid immunotherapy, tauopathy, and the role of microglia in the pathogenesis of neuroinflammation. W... -
This collection highlights recently published studies on myelopoiesis, novel leukemia therapies, hematopoiesis and acute myelogenous leukemia. We hope you enjoy reading this c... -
This collection highlights the latest discoveries about TLR signaling, inflammasomes, innate immune signaling in host-pathogen interaction and inflammation. We hope you enjoy ... -
This collection highlights recent pulications on thymic epithelial cells, T cell development, T cell tolerance and autoimmunity, inborn errors of T cell development and functi... -
This collection features recent and exciting advances in immunology, celebrating JEM’s long commitment to publishing outstanding basic as well as translational studies. ... -
This collection showcases pioneering studies on cancer biology, tumor microenvironment, anti-tumor immunity, and cutting-edge anti-cancer therapies that have been published in... -
This collection highlights the latest discoveries in lymphatic vessels in both health and disease, including glymphatics, lymphoid tissues, lymph node metastasis, mechanisms o... -
This collection discusses the successes and challenges of immune checkpoint blockade therapy, explores tumor immunity based on T cell biology and beyond, and proposes new tech... -
Barriers sites are characterized by complex immunological crosstalk between pathogens, commensals, and the immune system. We present a collection of recent JEM papers dissecti... -
This special collection highlights recent immunology research published in JEM covering immuno-enginneering, adaptive immunity, innate immune function, molecular regulation of... -
The year 2023 has witnessed the Journal of Experimental Medicine (JEM)'s unwavering commitment to publishing groundbreaking studies that advance our understanding of all aspec... -
This collection features the latest discoveries in neuroscience, including articles on brain lymphatics, analysis of tau response genes, aging, molecular mechanisms in neuroin... -
This collection of JEM articles and reviews highlights the roles of cytokines in inflammation, homeostasis of mucosal barriers, infection, autoimmunity, and metabolic disorder... -
This special collection explores how microbiota, diet and metabolites shape the immune system. It includes a viewpoint on gut microbiota biofilms, a review and a research arti... -
This collection features original research articles and reviews published at JEM in 2023 that cover a broad range of topics related to cancer cell plasticity, metastasis, micr... -
A collection on the immunological determinants of autoimmunity and their relevence to the identification of novel treatments. This collection spans articles published in JEM i... -
This special collection, timed to coincide with the Federation of Clinical Immunology Societies annual meeting, FOCiS 2023, highlights recent discoveries in the field of trans... -
This collection includes articles on ILC subsets in airway and intestinal mucosa, the role of metabolism in shaping ILC functions, human polyclonal unconventional T cell linea... -
This collection covers the interface between B cell biology, infectious diseases and autoimmunity. Topics include type 1 diabetes, the intracellular trafficking of HLA molecul... -
This collection highlights recently published studies on hematopoietic stem cell regulation, leukemia, the role of stem cells following injury and in disease progression, and ... -
A collection covering a broad range of topics including meningeal lymphatics and meningeal immunity, the role of microglia in mediating tau pathology and synaptic pruning, tra... -
Topics covered in this collection include oxidative metabolism in tumor-associated macrophages (TAMs), nutrition uptake and communication network changes under different diets... -
This collection highlights recent immunology research on lymphocyte trafficking, activation and residency at mucosal sites, food allergy treatment and homeostatic networks res... -
A collection including recent publications on innate immune signaling, such as the NLRP1 and the cGAS/STING pathway, and innate immune cells (macrophages and NK cells) modulat... -
A collection on the molecular pathways affecting plasma cell maintenance and function, B cell regulation during infection and malignancies, and the role of aged B cells in dri... -
In recognition of the importance of cancer research and its potential to improve human health, the Journal of Experimental Medicine (JEM) has established a dedicated annual Ca... -
A collection on lung, liver and cardiac fibrosis, fibroblast-immune cell interactions, and the genetic basis of nonalcoholic fatty liver disease (NASH). We hope you will enjoy... -
This collection highlights recent immunology research articles covering a range of topics including immunometabolism, mucosal immunology, lymphocyte activation, immune cell di... -
Many aspects of our life and research have changed drastically over the last three years. Nevertheless, the goal of publishing groundbreaking studies at the Journal of Experim... -
A collection of recent JEM preclinical and clinical studies that develop novel immunotherapies for cancer. Read and learn how we could harness innate immune cells, adaptive im... -
This collection highlights the latest discoveries in neuroscience, including articles on neuro-immune crosstalk, gut-brain axis, neural circuitry in appetite suppression, meni... -
This collection highlights the latest discoveries in lymphatic vessels in both health and disease. This includes glymphatics, lymphoid tissues, fluid transport, vessel biology... -
A collection covering the pathogenesis of immune disorders such as multiple sclerosis and autoimmune vasculitis and the mechanisms for maintaining tolerance. We hope you enjoy... -
This collection highlights recently published studies on experimental hematopoietic stem cell regulation, bone marrow failure and bone marrow microvasculature, as well as B-ce... -
A collection covering the roles of cytokine signaling, including interferon and interleukin functions in innate and adaptive immunity, all relevant to the Cytokines 2022 meeti... -
Cancer proliferation and survival signaling, tumor immunology, tumor microenvironment, metastasis and anti-cancer therapeutic approaches are all featured in this special colle... -
This collection includes studies investigating the contribution of innate and adaptive immunity to tuberculosis pathogenesis and Mycobacterium tuberculosis factors affecting p... -
A collection on the interface between the immune system and the environment at mucosal surfaces. Papers cover a wide range of topics, including mucosal barrier humoral immunit... -
A collection of latest breakthroughs in translational immunology to coincide with FOCIS 2022. Papers highlight recent discoveries in the field of human immunology, including t... -
A collection highlighting the latest discoveries related to neuroimmunology and neurodegeneration: from neuro-immune crosstalk to molecular mechanisms underlying Alzheimer's D... -
This collection explores stem cell biology across organ systems—from their involvement in muscle and bone regeneration to lung immune defense and their central role in hematop... -
This collection covers a range of topics including cancer immunology, innate immune responses linked to COVID-19, host-parasite interactions, lymphocyte activation, signaling ... -
A collection highlighting the latest discoveries related to innate immunity, from basic biology to human pathologies. Research includes a wide range of topics, from neurotoxic... -
This collection includes investigations of the immune determinants of HIV-1 latency, analyses of neutralizing antibodies and novel systems to investigate antiviral immunothera... -
This collection reflects the advent of new lines of cancer research, including studies on the tumor microenvironment, tumor metabolism, anti-tumor immunity, and innovative ant... -
A collection on the intersection of vascular biology and immunology covering a range of topics including neuroinflammation, innate immune subsets contribution to AAA and COVID... -
A collection of clinical studies that focus on patients with solid tumors or hematologic malignancies which revolutionize our understanding of the origins and development of c... -
A collection covering a wide range of topics including neuroinflammation, T and B lymphocyte activation, immune cell residency and differentiation, inflammation, host-parasite... -
A collection highlighting our continuing interest in original findings in disease pathogenesis and therapeutic opportunities. Ten research articles published in 2021 that were... -
A collection on the roles and implications of innate immunity, adaptive immunity, and cytokines in cancer immunology and immunotherapy research. Articles featured in the colle... -
A collection on neurodegeneration in Alzheimer's disease, neuroinvasion of SARS-CoV-2, peripheral neuropathy, stroke, and acute spinal cord injury, as well as the role of inna... -
A Continuing Medical Education (CME) initiative, in collaboration with Memorial Sloan Kettering Cancer Center. Each Journal-Based CME activity consists of a full-text article ... -
A collection relevant to the Cytokines 2021 virtual meeting. Research covers the roles of cytokine signaling, including the interferon and interleukin pathways, in innate immu... -
A collection addressing different aspects of cardiovascular biology and disease. The articles featured cover subjects from endothelial cell function to cardiac injury and aort... -
A collection of novel mechanisms of inflammasome regulation and the role of inflammasomes in inflammation, cancer and immune defense. Articles featured in the collection were ... -
A collection on hematologic malignancies, including heterogenous disease-propagating stem cells, regulation of translation, metabolism, cell cycle, cell death, and development... -
A collection uncovering the roles of lysophospholipids and other signaling lipids in immunity, from modulating B cell and T cell function to mediating pathogen recognition. Li... -
A collection highlighting the latest discoveries related to stem cell research. Articles featured in the collection were published within the past 12 months and include origin... -
A collection of JEM articles that covers the latest breakthroughs in clinical immunology to coincide with the FOCIS 2021 Virtual Annual Meeting. There has never been a more im... -
As part of the Journal of Experimental Medicine’s 125th anniversary, a collection showcasing some of the most exciting advances in immunology. There has never been ... -
An overview of the role of innate immune signaling in pathogen infections, cancer, inflammatory diseases, and tissue homeostasis. The collection covers a range of innate immun... -
A selection examining molecular, cellular, clinical, and translational aspects of neurodegeneration. The collection features studies of genetic variants and plasma biomarkers ... -
A collection featuring recent JEM articles that address the impact of metabolic enzymes and substrates on diverse aspects of homeostasis and disease, such as immune cell funct... -
A collection highlighting the latest discoveries related to therapeutic antibody generation and applicability across a diverse range of biological processes. We hope you will ... -
Our understanding of cancer cells and their interactions with metabolic pathways, microbiota, the immune system and the tumor microenvironment is rapidly evolving and speeding... -
In addition to host-pathogen interaction, this collection also includes new inroads in cancer immunology and immunotherapy, Alzheimer’s disease and aging-associated cognitive ... -
A collection highlighting the latest findings on potential drivers of COVID-19 pathology, therapeutic targets and neutralizing antibodies. SARS-CoV-2, the causative agent of C... -
A collection of clinical studies that aim to understand the immune response and vaccination strategies against viral infections. Concerted response of both the innate and adap... -
A collection highlighting the latest discoveries related to neurodegeneration and neuroinflammation. Neurodegeneration is the progressive loss of neuronal function which leads... -
A collection relevant to the Cytokines 2020 Structure-Function and Systems Biology of Cytokine Actions virtual meeting, as well as the JEM Review Focus on Cytokines. We congra... -
A collection of latest discoveries related to germinal center biology, from immune cell interaction and dynamics, to generation of germinal center immune cell subsets, gene ex... -
A collection to highlight the Nobel Prize in Physiology or Medicine 2020 that was awarded jointly to Charles M. Rice of The Rockefeller University, Michael Houghton of the Uni... -
A collection highlighting recently published studies on the biology of cancer and therapeutic approaches to treating the disease. The top 10 papers are selected by the editori... -
A collection on hematopoiesis, stem cells and stem cell niches, hematological malignancies, and immunology. Articles featured in the collection were published within the past ... -
A collection on inflammasome signaling to coincide with the InflammaZoom Webinar Series organized by the Cambridge Immunology Network.
Image © 2019 Malireddi et al.
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This collection includes some of our most highly read papers and articles selected to reflect the breadth of stem cell research published in our journals, Journal of Cell Biol... -
A collection of articles published on neurodegeneration and neuroinflammation. Interested in discussing your latest research with our editors and learning how we are making th... -
A collection of seminal studies in the field of immunology, from basic concepts to translational science, which paved the way for major advances including ground-breaking ther... -
A collection on developmental hematopoiesis, adult stem cell self-renewal, and stem cell niches, novel hematopoietic regulators, and the pathogenesis of leukemia. Articles fea... -
A collection which builds upon a broad array of disease-related topics, including cancer biology, tumor immunity and immunotherapy. In the last few years, we have made a conce... -
This collection highlights recent advances in vaccine development and therapies, with a focus on HIV, ZIKV, IAV, and MAYV infection.
Image © 2019 Liechti et al.
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This collection highlights the roles and implications of innate immunity, adaptive immunity, and cytokines in cancer immunology and immunotherapy research. Image © 2020 Etzero... -
This collection examines gender bias in scientific research and the challenges faced, and accomplishments gained, by women in the field of science and coincides with Internati... -
A collection coinciding with the 2020 Keystone Symposia joint conferences on T Cell Memory and B Cell Renaissance: Epigenetics, Regulation, and Immunotherapy. Interested in di... -
A collection to coincide with the Next Gen Immunology 2020 conference. Interested in discussing your latest research with JEM editors and learning how we are making the publis... -
Presenting the annual Best of JEM series to highlight groundbreaking research. The top 10 papers are selected by the editorial team based, in part, on the number of requests f... -
A collection relevant to the 59th Midwinter Conference of Immunologists at Asilomar.
Image © 2018 Aden et al.
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A collection to coincide with the 2020 Keystone Symposia on “Tissue Immunity”. Interested in discussing your latest research with JEM editors and learning how we a... -
A collection coinciding with the launch of JEM's Review Focus on Cytokines, relevant to Cytokines 2019, the annual meeting of the International Cytokine & Interferon Society i... -
A collection on neurodegeneration in Alzheimer’s, Parkinson’s, and prion diseases, to neuropathic pain and stroke, as well as the role of innate immunity, microglia, and macro... -
A collection to coincide with the 9th International Conference on Autoimmunity: Mechanisms and Novel Treatments. Interested in discussing your latest research with JEM editors... -
A collection of top reviews published in 2017 and 2018, including immunology, cancer, neuroscience, vascular disease and much more. We hope you enjoy this collection and encou... -
The adaptive immune system is fundamentally organized around two distinct classes of lymphocytes, B and T cells. By discovering and delineating these two cell types, Max D. Co... -
A collection to coincide with the CSHL meeting on "Biology of Cancer: Microenvironment & Metastasis". Interested in discussing your latest research with JEM editors and le... -
A collection to coincide with the 14th World Congress on Inflammation. Interested in discussing your latest research with JEM editors and learning how we are making the publis... -
Fundamental and translational studies examining the interactions between tumor cells and their microenvironment, including the immune system, and dissecting the metabolic, epi... -
A collection to coincide with the Keystone Symposia on “Vascular Biology and Human Disease.” To learn more about publishing in JEM, visit our Instructions for Auth...
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A collection to coincide with the 2019 Keystone Symposia on “Tumor Metabolism”. Interested in discussing your latest research with JEM editors and learning how we ... -
A collection on the topic of translational immunology to coincide with the annual meeting of the Federation of Clinical Immunology Societies, FOCiS 2018. Image © 2017 Ant... -
A collection to coincide with the Keystone Symposia on “T Cell Dysfunction, Cancer and Infection.” To learn more about publishing in JEM, visit our Instructions fo... -
A collection to coincide with the 2019 ISSCR Annual Meeting in Los Angeles.
Image © 2019 Chen et al.
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A collection to coincide with the 2019 Keystone Symposia on “Skin Health and Disease: Immune, Epithelial and Microbiome Crosstalk”. Interested in discussing your l... -
A collection to coincide with the Cold Spring Harbor Asia conference on Scientific and Technical Advances in Cancer Immunology. Interested in discussing your latest research w... -
A collection to coincide with the Keystone Symposia on “Regulation and Dysregulation of Innate Immunity in Disease.” To learn more about publishing in JEM, visit o...
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A collection to coincide with the 2019 Keystone Symposia on “Transcription and RNA Regulation in Inflammation and Immunity”. Interested in discussing your latest r... -
A collection to coincide with the 2019 Keystone Symposia on “Obesity and Adipose Tissue Biology”. Interested in discussing your latest research with JEM editors an... -
Mechanisms, models, and potential therapies for neurological diseases, ranging from neurodegeneration and cognitive decline, to neuropathic pain and Autism, as well as the rol... -
A collection to coincide with the Keystone Symposia “Myeloid Cells.” To learn more about publishing in JEM, visit our Instructions for Authors.Image © 2017 Mossade... -
A collection to coincide with the 2019 Keystone Symposia “Myeloid Cells” conference. Interested in discussing your latest research with JEM editors and learning ho... -
The Henry Kunkel Society and Journal of Experimental Medicine have had a long standing relationship and shared mission of disseminating groundbreaking biological research and ... -
A collection to coincide with the Keystone Symposia on “Lymphocytes and their Roles in Cancer.” To learn more about publishing in JEM, visit our Instructions for A...
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Recent and exciting advances in immunology are included in this collection, which celebrates our commitment to publishing outstanding basic immunology as well as innovative st... -
From basic research into fundamental cellular and molecular processes in the immune system to innovative translational studies with therapeutic implications, this collection e... -
The advent of new lines of cancer research, ranging from basic in vivo tumor model to clinical research are included in this collection that celebrates the progress made to un... -
A collection on ILCs as well as NKT, MAIT, and γδ T cells. They have been identified in almost every tissue and contribute to tissue homeostasis, host defense, inf... -
A collection to coincide with the 2019 Keystone Symposia on “Innate Immune Receptors: Roles in Immunology and Beyond”. Interested in discussing your latest researc... -
A collection to coincide with the Keystone Symposia on "Innate and Non-Classical Immune Cells in Cancer Immunotherapy". Interested in discussing your latest research with JEM ... -
The Henry Kunkel Society and Journal of Experimental Medicine have had a long standing relationship and shared mission of disseminating groundbreaking biological research and ... -
A collection of articles to coincide with the 4th International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism. Interested in discussing your ... -
A collection to coincide with the Keystone Symposia “Immunological Memory.” To learn more about publishing in JEM, visit our Instructions for Authors.
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A collection to coincide with the 2019 FASEB Hematologic Malignancies conference. Interested in discussing your latest research with JEM editors and learning how we are making... -
A collection to coincide with the 2019 FASEB Autoimmunity conference. Interested in discussing your latest research with JEM editors and learning how we are making the publish... -
A collection relevant to the Cytokines 2018 conference in Boston on October 27-30. This year, conference organizers include JEM Editor Anne O’Garra, and JEM Advisory Edi... -
Recent biomedical advances that provide fresh insights into the pathogenesis of human disease are highlighted in this collection, including some of the most exciting discoveri... -
Recent biomedical advances that provide fresh insights into the pathogenesis of human disease are highlighted in this collection, including some of the most exciting discoveri... -
A collection of articles to coincide with the Keystone Symposia on “Cell Death, Inflammation and Adaptation to Tissue Stress.” To learn more about publishing in JE...
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A collection to coincide with the Keystone Symposia on “Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment“. Interested in discussing you... -
The link between immune targets for cancer therapy and development of autoimmunity are highlighted in this JEM collection to coincide with the 2019 Keystone Symposia "Uncoveri... -
In the past few years, the advancement in the understanding of cancer biology and its relationship with the immune system has triggered an unprecedented burst of different str... -
A collection to coincide with the Keystone Symposia on “Bioenergetics and Metabolic Diseases.” To learn more about publishing in JEM, visit our Instructions for Au...
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A special collection to coincide with the Keystone Symposia on B Cells: Mechanisms in Immunity and Autoimmunity. To learn more about publishing in JEM, visit our Instructions ... -
A collection to coincide with the Keystone Symposia on “B Cell-T Cell Interactions” joint with “Molecular Approaches to Vaccines and Immune Monitoring.”... -
A collection to coincide with the 2019 Gordon Research Conference on Growing Organotypically Differentiated Vasculatures from Vascular Sprouts. Interested in discussing your l... -
A collection to coincide with the Keystone Symposia on Advances in Neurodegenerative Diseases and Therapy. To learn more about publishing in JEM, visit our Instructions for Au... -
A collection of exciting discoveries published in JEM in 2018. The collection is representative of the areas of research covered by JEM and highlights articles that were of gr... -
Immunotherapy has changed the direction of cancer treatment. James P. Allison at the University of Texas MD Anderson Cancer Center and Tasuku Honjo at Kyoto University have be... -
Exciting discoveries published in JEM in 2017. The collection is representative of the areas of research covered by JEM and highlights articles that were of great interest to ... -
A collection to coincide with the 2019 Keystone Symposia on “Neural Environment in Disease: Glial Responses and Neuroinflammation” and “Neurodegenerative Dis...
