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COVID-19: From Basic Science to Therapeutics
A collection highlighting the latest findings on potential drivers of COVID-19 pathology, therapeutic targets and neutralizing antibodies.
SARS-CoV-2, the causative agent of COVID-19, emerged in December 2019 and resulted in a global pandemic with more than 1.8 million deaths. A worldwide effort has been undertaken to assess the key drivers of COVID-19 pathology, identify therapeutic targets and boost vaccine development. To date, two vaccines have been FDA approved and more are undergoing testing. COVID-19 treatment options remain limited. Highly potent human monoclonal antibodies against SARS-CoV-2 are emerging as potential therapeutics for COVID-19 but clinical trials are still ongoing.
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Image © 2020 Veras et al.
Brief Definitive Report
Fanny Onodi; Lucie Bonnet-Madin; Laurent Meertens; Léa Karpf; Justine Poirot; Shen-Ying Zhang; Capucine Picard; Anne Puel; Emmanuelle Jouanguy; Qian Zhang; Jérôme Le Goff; Jean-Michel Molina; Constance Delaugerre; Jean-Laurent Casanova; Ali Amara; Vassili Soumelis
Article
Gaëlle Breton; Pilar Mendoza; Thomas Hägglöf; Thiago Y. Oliveira; Dennis Schaefer-Babajew; Christian Gaebler; Martina Turroja; Arlene Hurley; Marina Caskey; Michel C. Nussenzweig
Technical Advances and Resources
Zhen Zhuang; Xiaomin Lai; Jing Sun; Zhao Chen; Zhaoyong Zhang; Jun Dai; Donglan Liu; Yuming Li; Fang Li; Yanqun Wang; Airu Zhu; Junxiang Wang; Wenhui Yang; Jicheng Huang; Xiaobo Li; Lingfei Hu; Liyan Wen; Jianfen Zhuo; Yanjun Zhang; Dingbin Chen; Suxiang Li; Shuxiang Huang; Yongxia Shi; Kui Zheng; Nanshan Zhong; Jingxian Zhao; Dongsheng Zhou; Jincun Zhao
Article
Eric Song; Ce Zhang; Benjamin Israelow; Alice Lu-Culligan; Alba Vieites Prado; Sophie Skriabine; Peiwen Lu; Orr-El Weizman; Feimei Liu; Yile Dai; Klara Szigeti-Buck; Yuki Yasumoto; Guilin Wang; Christopher Castaldi; Jaime Heltke; Evelyn Ng; John Wheeler; Mia Madel Alfajaro; Etienne Levavasseur; Benjamin Fontes; Neal G. Ravindra; David Van Dijk; Shrikant Mane; Murat Gunel; Aaron Ring; Syed A. Jaffar Kazmi; Kai Zhang; Craig B. Wilen; Tamas L. Horvath; Isabelle Plu; Stephane Haik; Jean-Leon Thomas; Angeliki Louvi; Shelli F. Farhadian; Anita Huttner; Danielle Seilhean; Nicolas Renier; Kaya Bilguvar; Akiko Iwasaki
Brief Definitive Report
Tamara S. Rodrigues; Keyla S.G. de Sá; Adriene Y. Ishimoto; Amanda Becerra; Samuel Oliveira; Leticia Almeida; Augusto V. Gonçalves; Debora B. Perucello; Warrison A. Andrade; Ricardo Castro; Flavio P. Veras; Juliana E. Toller-Kawahisa; Daniele C. Nascimento; Mikhael H.F. de Lima; Camila M.S. Silva; Diego B. Caetite; Ronaldo B. Martins; Italo A. Castro; Marjorie C. Pontelli; Fabio C. de Barros; Natália B. do Amaral; Marcela C. Giannini; Letícia P. Bonjorno; Maria Isabel F. Lopes; Rodrigo C. Santana; Fernando C. Vilar; Maria Auxiliadora-Martins; Rodrigo Luppino-Assad; Sergio C.L. de Almeida; Fabiola R. de Oliveira; Sabrina S. Batah; Li Siyuan; Maira N. Benatti; Thiago M. Cunha; José C. Alves-Filho; Fernando Q. Cunha; Larissa D. Cunha; Fabiani G. Frantz; Tiana Kohlsdorf; Alexandre T. Fabro; Eurico Arruda; Renê D.R. de Oliveira; Paulo Louzada-Junior; Dario S. Zamboni
Article
Alexandra Schäfer; Frauke Muecksch; Julio C.C. Lorenzi; Sarah R. Leist; Melissa Cipolla; Stylianos Bournazos; Fabian Schmidt; Rachel M. Maison; Anna Gazumyan; David R. Martinez; Ralph S. Baric; Davide F. Robbiani; Theodora Hatziioannou; Jeffrey V. Ravetch; Paul D. Bieniasz; Richard A. Bowen; Michel C. Nussenzweig; Timothy P. Sheahan
Brief Definitive Report
Coraline Radermecker; Nancy Detrembleur; Julien Guiot; Etienne Cavalier; Monique Henket; Céline d’Emal; Céline Vanwinge; Didier Cataldo; Cécile Oury; Philippe Delvenne; Thomas Marichal
Brief Definitive Report
Flavio Protasio Veras; Marjorie Cornejo Pontelli; Camila Meirelles Silva; Juliana E. Toller-Kawahisa; Mikhael de Lima; Daniele Carvalho Nascimento; Ayda Henriques Schneider; Diego Caetité; Lucas Alves Tavares; Isadora M. Paiva; Roberta Rosales; David Colón; Ronaldo Martins; Italo Araujo Castro; Glaucia M. Almeida; Maria Isabel Fernandes Lopes; Maíra Nilson Benatti; Letícia Pastorelli Bonjorno; Marcela Cavichioli Giannini; Rodrigo Luppino-Assad; Sérgio Luna Almeida; Fernando Vilar; Rodrigo Santana; Valdes R. Bollela; Maria Auxiliadora-Martins; Marcos Borges; Carlos Henrique Miranda; Antônio Pazin-Filho; Luis Lamberti P. da Silva; Larissa Dias Cunha; Dario S. Zamboni; Felipe Dal-Pizzol; Luiz O. Leiria; Li Siyuan; Sabrina Batah; Alexandre Fabro; Thais Mauad; Marisa Dolhnikoff; Amaro Duarte-Neto; Paulo Saldiva; Thiago Mattar Cunha; José Carlos Alves-Filho; Eurico Arruda; Paulo Louzada-Junior; Renê Donizeti Oliveira; Fernando Queiroz Cunha
Perspective
Ting Zhou; Tina Tianjiao Su; Tenny Mudianto; Jun Wang
Brief Definitive Report
Youenn Jouan; Antoine Guillon; Loïc Gonzalez; Yonatan Perez; Chloé Boisseau; Stephan Ehrmann; Marion Ferreira; Thomas Daix; Robin Jeannet; Bruno François; Pierre-François Dequin; Mustapha Si-Tahar; Thomas Baranek; Christophe Paget
Article
Benjamin Israelow; Eric Song; Tianyang Mao; Peiwen Lu; Amit Meir; Feimei Liu; Mia Madel Alfajaro; Jin Wei; Huiping Dong; Robert J. Homer; Aaron Ring; Craig B. Wilen; Akiko Iwasaki
Technical Advances and Resources
Fabian Schmidt; Yiska Weisblum; Frauke Muecksch; Hans-Heinrich Hoffmann; Eleftherios Michailidis; Julio C.C. Lorenzi; Pilar Mendoza; Magdalena Rutkowska; Eva Bednarski; Christian Gaebler; Marianna Agudelo; Alice Cho; Zijun Wang; Anna Gazumyan; Melissa Cipolla; Marina Caskey; Davide F. Robbiani; Michel C. Nussenzweig; Charles M. Rice; Theodora Hatziioannou; Paul D. Bieniasz
Perspective
Santosha A. Vardhana; Jedd D. Wolchok
Perspective
Betsy J. Barnes; Jose M. Adrover; Amelia Baxter-Stoltzfus; Alain Borczuk; Jonathan Cools-Lartigue; James M. Crawford; Juliane Daßler-Plenker; Philippe Guerci; Caroline Huynh; Jason S. Knight; Massimo Loda; Mark R. Looney; Florencia McAllister; Roni Rayes; Stephane Renaud; Simon Rousseau; Steven Salvatore; Robert E. Schwartz; Jonathan D. Spicer; Christian C. Yost; Andrew Weber; Yu Zuo; Mikala Egeblad
