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Nan Liu, Kai Liu, Chonglin Yang
Liu et al. identify WDR91 as an important player in retromer-dependent recycling. WDR91 promotes the interaction of Rab7 with SNX-retromer components and interacts with FAM21, facilitating the formation of the endosomal retrieval subdomain.
Article
Jingyue Jia, Fulong Wang, Zambarlal Bhujabal, Ryan Peters, Michal Mudd, Thabata Duque, Lee Allers, Ruheena Javed, Michelle Salemi, Christian Behrends, Brett Phinney, Terje Johansen, Vojo Deretic
Lysosomal damage induces stress granule (SG) formation and translational reprograming. The newly appreciated process of atg8ylation affects SG formation and concomitantly recruits SG core proteins NUFIP2 and G3BP1 to damaged lysosomes. These proteins independently of SG condensates and in coordination with galectin-8 inactivate mTOR via the Ragulator–Rag complex.
Article
Fabio Lolicato, Roberto Saleppico, Alessandra Griffo, Annalena Meyer, Federica Scollo, Bianca Pokrandt, Hans-Michael Müller, Helge Ewers, Hendrik Hähl, Jean-Baptiste Fleury, Ralf Seemann, Martin Hof, Britta Brügger, Karin Jacobs, Ilpo Vattulainen, Walter Nickel
This work demonstrates the lipid composition and the corresponding biophysical properties of biological membranes to tune highly specific protein–lipid interactions. Specifically, cholesterol is shown to affect phosphoinositide-dependent membrane recruitment and translocation into the extracellular space of FGF2, a survival factor involved in tumor-induced angiogenesis.
Article
Anup Parchure, Meng Tian, Danièle Stalder, Cierra K. Boyer, Shelby C. Bearrows, Kristen E. Rohli, Jianchao Zhang, Felix Rivera-Molina, Bulat R. Ramazanov, Sushil K. Mahata, Yanzhuang Wang, Samuel B. Stephens, David C. Gershlick, Julia von Blume
The biogenesis of secretory granules (SGs) is poorly understood. Here, we show that chromogranin proteins form a liquid scaffold upon entry into the milieu of the trans-Golgi network (TGN). These scaffolds recruit clients such as proinsulin and facilitate their transport to SGs.
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Orestis Faklaris, Leslie Bancel-Vallée, Aurélien Dauphin, Baptiste Monterroso, Perrine Frère, David Geny, Tudor Manoliu, Sylvain de Rossi, Fabrice P. Cordelières, Damien Schapman, Roland Nitschke, Julien Cau, Thomas Guilbert
Faklaris et al. present tools, fast and robust acquisition protocols, and automated analysis methods to assess quality control metrics for light fluorescence microscopy. The authors collected data from 10 light microscopy core facilities and propose guidelines to ensure quantifiable and reproducible results among laboratories.
Article
Riddhi Atul Jani, Aurélie Di Cicco, Tal Keren-Kaplan, Silvia Vale-Costa, Daniel Hamaoui, Ilse Hurbain, Feng-Ching Tsai, Mathilde Di Marco, Anne-Sophie Macé, Yueyao Zhu, Maria João Amorim, Patricia Bassereau, Juan S. Bonifacino, Agathe Subtil, Michael S. Marks, Daniel Lévy, Graça Raposo, Cédric Delevoye
Tubular recycling endosomes originate from early endosomes to deliver contents to target membranes. Jani et al. show that BLOC-1 and PI4P (synthesized by PI4KIIs) remodel membranes to generate and stabilize recycling tubules for cargo trafficking and exploitation by pathogens.
Article
Yueyao Zhu, Shuixing Li, Alexa Jaume, Riddhi Atul Jani, Cédric Delevoye, Graça Raposo, Michael S. Marks
Contents are delivered to maturing melanosomes from early endosomal intermediates through tubular transport carriers. Zhu et al. show that two type II phosphatidylinositol kinases, PI4KIIα and PI4KIIβ, sequentially generate phosphatidylinositol-4-phosphate during tubule initiation and elongation for ultimate melanosome content delivery.

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Current Issue
Volume 221,
Issue 9,
5 September 2022
Reviews & Opinions
Spotlight
André Barros-Carvalho, Eurico Morais-de-Sá
André Barros-Carvalho and Eurico Morais-de-Sá highlight work from Calvi and colleagues that demonstrates a role for PP1 in establishing embryo polarity via regulation of PAR-2 localization.
Spotlight
Elise Marsan, Eric J. Huang
Marsan and Huang discuss work from Chhetri et al. demonstrating that mutant huntingtin interferes with XK surface recycling and reduces divalent ion transport across the membrane.
Spotlight
Zheng Wang, Hong Zhang
Wang and Zhang preview work from the Mizushima lab showing that NCOA4 mediates formation of ferritin condensates that are destined for degradation by macroautophagy and microautophagy.

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