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Xuli Qi, Youhong Liu, Yuchong Peng, Yuxin Fu, Yongming Fu, Linglong Yin, Xiong Li
Qi et al. report a novel UHRF1 function as a nuclear protein catalyzing EG5 polyubiquitination for proper spindle architecture and faithful genomic transmission, which is independent of its roles in epigenetics and DNA damage repair. These findings reveal a previously unknown mechanism of UHRF1 controlling mitotic spindle architecture and chromosome behavior.
Article
Christabel Xin Tan, Dhanesh Sivadasan Bindu, Evelyn J. Hardin, Kristina Sakers, Ryan Baumert, Juan J. Ramirez, Justin T. Savage, Cagla Eroglu
Tan et al. show that δ-catenin, previously thought to be neuron specific, is expressed by astrocytes and required both in astrocytes and neurons to control astrocyte morphogenesis. Furthermore, they provide evidence demonstrating how the cadherin–δ-catenin adhesion complex controls astrocyte morphology in a layer-specific manner.
Article
Tom Biton, Nadav Scher, Shari Carmon, Yael Elbaz-Alon, Eyal D. Schejter, Ben-Zion Shilo, Ori Avinoam
Biton et al. elucidate how large secretory vesicles in Drosophila larval salivary glands employ a distinct machinery comprised of branched actin, myosin-II, and BAR-domain proteins to control fusion pore dynamics. This process facilitates a unique mode of exocytosis, which maintains apical membrane homeostasis during secretion.
Report
Catherine Sullenberger, Dong Kong, Pegah Avazpour, Delgermaa Luvsanjav, Jadranka Loncarek
Sullenberger et al. dissect the centrosomal patterning of Plk4 during centriole duplication and amplification and the positioning of Plk4 and procentrioles in relation to mother centriole microtubules. They build a molecular map of Cep57, Cep63, Cep192, and Cep152 and investigate their requirements for Plk4 localization.
Article
Amber M. Cheatham, Nishi Raj Sharma, Prasanna Satpute-Krishnan
Misfolded GPI-APs are released from the ER to the Golgi for rapid degradation in lysosomes by the constitutively active and stress-inducible RESET pathway. Using multiple complementary approaches, the authors demonstrate that competition by nascent glycoproteins for calnexin-binding promotes the release of misfolded GPI-APs for RESET.
Article
Zihan Zhu, Isabelle Becam, Corinne A. Tovey, Abir Elfarkouchi, Eugenie C. Yen, Fred Bernard, Antoine Guichet, Paul T. Conduit
Zhu et al. use Drosophila gentics and cell imaging to show that different types of γ-tubulin complexes can be recruited to mitotic centrosomes via different molecular pathways, that these centrosomes can nucleate microtubules even when they fail to recruit γ-tubulin, and that the dynamic properties of microtubules appear to be influenced by how they are nucleated.
Article
Lauren Penfield, Denise J. Montell
During Drosophila border cell migration, the B-type lamin, Lam, maintains nuclear envelope integrity, stabilizes the lead cell protrusion, and promotes cluster invasion between nurse cells. The nucleus may function as a wedge to promote this collective, confined in vivo movement.
Issue Cover
Current Issue
Volume 222,
Issue 9,
4 September 2023
Reviews & Opinions
Spotlight
Arisa Ikeda, Miho Iijima, Hiromi Sesaki
Ikeda et al. highlight work from Su and colleagues that describes the mechanism by which NME3 and phosphatidic acid promote mitochondrial tethering prior to fusion.
Spotlight
Wen Lu, Vladimir I. Gelfand
Lu and Gelfand preview work from Song et al., which reveals a role for the microtubule-binding protein DCX-EMAP in the 3D organization of mechanosensory organelles of Drosophila.
Spotlight
Benedikt Westermann
Westermann discusses two related studies examining a novel protein that plays a key role in mitochondrial division.

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