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Isaac S. Chan, Hildur Knútsdóttir, Gayathri Ramakrishnan, Veena Padmanaban, Manisha Warrier, Juan Carlos Ramirez, Matthew Dunworth, Hao Zhang, Elizabeth M. Jaffee, Joel S. Bader, Andrew Josef Ewald
Chan et al. show that natural killer (NK) cells can be reprogrammed by breast cancer cells to promote metastasis. Reprogramming can be blocked by targeting NK cell inhibitory receptors TIGIT or KLRG1 or inhibiting DNA methyltransferases, which suggests new approaches to prevent or treat metastasis.
Article
Keyu Chen, Rui Yang, Rui Yang, Yubing Li, Jin Chuan Zhou, Mingjie Zhang
Chen et al. identified a bipartite motif from the 440-kD giant ankyrin-B, which bundles and avidly binds to microtubules in vitro. They further demonstrated that giant ankyrin-B suppresses axon collateral branching and prevents microtubule invasion of nascent axon branches through direct interaction with microtubules.
Article
Gilles Moulay, Jeanne Lainé, Mégane Lemaître, Masayuki Nakamori, Ichizo Nishino, Ghislaine Caillol, Kamel Mamchaoui, Laura Julien, Florent Dingli, Damarys Loew, Marc Bitoun, Christophe Leterrier, Denis Furling, Denis Furling, Stéphane Vassilopoulos, Stéphane Vassilopoulos
A single alternatively spliced exon in the CLTC gene contributes to clathrin coat organization. This event participates in the plasticity from clathrin-coated pits to plaques, structures that are essential for muscle fiber function and maintenance.
Article
Yu-Yang Jiang, Wolfgang Maier, Uzoamaka N. Chukka, Michael Choromanski, Chinkyu Lee, Ewa Joachimiak, Dorota Wloga, Wayland Yeung, Natarajan Kannan, Joseph Frankel, Jacek Gaertig
Jiang and colleagues investigate how locations of sites of organelle assembly are determined during cell division in the ciliate Tetrahymena thermophila. They find that correct placement of new organelles involves antagonistic influences of a cyclin E and a Hippo/Mst kinase.
Article
Kostika Sofroni, Hirotomo Takatsuka, Chao Yang, Nico Dissmeyer, Shinichiro Komaki, Yuki Hamamura, Lev Böttger, Masaaki Umeda, Arp Schnittger
CDKA;1, the Arabidopsis orthologue of Cdk1 and Cdk2, controls microtubule organization in meiosis. Sofroni et al. find that reducing CDKA;1 activity converts simultaneous cytokinesis—the separation of all four meiotic products concomitantly—into two successive cytokineses after the first and second meiotic divisions, as found in many crop species.
Article
Kyle Begovich, Anthony Q. Vu, Gene Yeo, James E. Wilhelm
Begovich et al. identify 17 metabolic enzymes that are stress-specific components of yeast stress granules (SGs). The product of one of these enzymes, AdoMet, is an evolutionarily conserved regulator of SG assembly and blocks the recruitment of pathogenic TDP-43 into SGs in ALS models, highlighting its therapeutic potential.
Article
Kwang Woo Ko, Jeffrey Milbrandt, Aaron DiAntonio
Ko et al. demonstrate that SARM1 is required for loss of axons and neurons in a neuroinflammatory model of glaucoma. Neuroinflammatory signaling induces an axonal necroptosis that triggers SARM1-dependent axon degeneration. These findings delineate unexpected molecular and functional relationships among neuroinflammation, necroptosis, and axon degeneration.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 7,
July 6, 2020
Reviews & Opinions
Viewpoint
Jack Houston, Pablo Lara-Gonzalez, Arshad Desai
Houston et al. synthesize recent work analyzing Mad1–cyclin B1 complex function in mitosis.
Review
Michelle Grace Acoba, Nanami Senoo, Steven M. Claypool
In this review, Acoba et al. discuss the surprisingly complicated mechanisms, regulation, and functions of mitochondrial membrane building.
Review
Nobuo N. Noda, Zheng Wang, Hong Zhang
Zhang and colleagues summarize phase separation and transition in the assembly of autophagosome formation sites and triage of protein condensates for degradation.

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