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Anja Göder, Chrystelle Antoinat Maric, Michael D. Rainey, Aisling O’Connor, Chiara Cazzaniga, Daniel Shamavu, Jean-Charles Cadoret, Corrado Santocanale
In human cells, the S-phase-promoting kinase CDC7 exists in two alternative complexes: CDC7-DBF4 or CDC7-DRF1. Here, Göder et al. show that while CDC7’s essential function can be supported by both subunits, DBF4 is the primary mediator of CDC7 activity during DNA replication.
Article
Shariq S. Ansari, Miriam E. Dillard, Yan Zhang, Mary Ashley Austria, Naoko Boatwright, Elaine L. Shelton, Daniel P. Stewart, Amanda Johnson, Christina E. Wang, Brandon M. Young, Zoran Rankovic, Baranda S. Hansen, Shondra M. Pruett-Miller, Alexandre F. Carisey, John D. Schuetz, Camenzind G. Robinson, Stacey K. Ogden
This study reveals crosstalk between Sonic Hedgehog (SHH) and prostaglandin signaling pathways. SHH signaling leads to the secretion of PGE2, which activates the ciliary EP4 receptor to promote primary cilium length stability. Disruption of SHH-to-EP4 communication leads to primary cilium shortening and reduced SHH signal output.
Article
Erica C. Dresselhaus, Kathryn P. Harris, Cassandra R. Blanchette, Kate Koles, Steven J. Del Signore, Matthew F. Pescosolido, Biljana Ermanoska, Mark Rozencwaig, Rebecca C. Soslowsky, Michael J. Parisi, Bryan A. Stewart, Timothy J. Mosca, Avital A. Rodal
ESCRT depletion disrupts synaptic extracellular vesicle (EV) release without affecting signaling by several EV cargoes. EVs are phagocytosed by adjacent cells, and ESCRT disruption causes compensatory autophagy. These results suggest that EV release serves proteostatic rather than intercellular signaling functions for these cargoes at synapses.
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Sophie Gray, Cecile Fort, Richard John Wheeler
We used high-frame-rate, dual-color fluorescence microscopy to visualize IFT trafficking in the beating flagella of Leishmania mexicana, a uniflagellate human parasite. This revealed differing sensitivity of IFT train speed to genetically induced, mechanical, and natural changes in beating.
Article
Morgan L. Pimm, Brian K. Haarer, Alexander D. Nobles, Laura M. Haney, Alexandra G. Marcin, Marcela Alcaide Eligio, Jessica L. Henty-Ridilla
IQGAP1 coordinates actin assembly via transient pausing of events and by displacing prominent plus-end binding proteins including formin (mDia1), capping protein (CP), and mDia1-CP “decision complexes.”
Article
Kosuke Sako, Ayako Furukawa, Ryu-Suke Nozawa, Jun-ichi Kurita, Yoshifumi Nishimura, Toru Hirota
Maintenance of ploidy relies on Aurora-B, supported by HP1. Sako et al. report that INCENP binds to HP1 not only through the HP1-binding consensus PVI motif but also its downstream α-helical segment. This unique interface ensures a strong bond with HP1, Aurora-B activity, and mitotic fidelity.
Article
Jason C. Casler, Clare S. Harper, Antoineen J. White, Heidi L. Anderson, Laura L. Lackner
Casler et al. identify that the ER-localized protein Scs2 interacts with a FFAT motif in the C-terminus of the mitochondria–PM tether Num1 to form a tripartite mitochondria–ER–PM contact site. Loss of the Num1–Scs2 interaction severely perturbs mitochondrial division rates. Unexpectedly, they also identify a novel role of mitochondria–ER–PM contact sites in regulating PM PI(4)P metabolism.
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Current Issue
Volume 223,
Issue 6,
3 June 2024
Reviews & Opinions
Perspective
Ivan R. Nabi, Ben Cardoen, Ismail M. Khater, Guang Gao, Timothy H. Wong, Ghassan Hamarneh
Nabi and colleagues discuss supervision paradigms for biological discovery from super-resolution microscopy to enable AI-accelerated exploration of the nanoscale architecture of subcellular macromolecules and organelles.
Perspective
Anda Huna, Amélie Massemin, Gabriela Makulyte, Jean-Michel Flaman, Nadine Martin, David Bernard
Huna et al. provide insights into the shifting perception of cellular senescence: from a mere cell proliferation arrest to a reinforcement or change of cell identity.
Spotlight
G.W. Gant Luxton
G.W. Gant Luxton discusses new findings from the Roux group that show how changes in cellular GTP levels alter the rates of nucleocytoplasmic transport.

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