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Yujin Lee, Yoonji Jung, Dae-Eun Jeong, Wooseon Hwang, Seokjin Ham, Hae-Eun H. Park, Sujeong Kwon, Jasmine M. Ashraf, Coleen T. Murphy, Seung-Jae V. Lee
Immunosenescence, or immune aging, is a hallmark of aging. This study shows that inhibition of insulin/IGF-1 receptor reverses immunosenescence in the roundworm Caenorhabditis elegans through a feedback circuit comprising FOXO, HSF-1, and bZIP transcription factors and an insulin-like peptide, INS-7.
Alexander Dünkler, Marcin Leda, Jan-Michael Kromer, Joachim Neller, Thomas Gronemeyer, Andrew B. Goryachev, Nils Johnsson
Dünkler et al. discover that the subunit Pea2 recruits type V myosin Myo2 to the yeast polarisome. Experimental evidence and biophysical modeling indicate that this interaction generates an actin-dependent force to physically compact and thus spatially focus the polarisome and to mold the bud into its characteristic pointed shape.
Junxiu Nong, Kexin Kang, Qiaoni Shi, Xuechen Zhu, Qinghua Tao, Ye-Guang Chen
Assembly of the destruction complex is critical for Wnt/β-catenin signaling. Nong et al. find that Axin undergoes liquid–liquid phase separation, which is promoted by APC. Phase-separated Axin provides a scaffold for recruitment of GSK3β, CK1α, and β-catenin and facilitates GSK3β-mediated β-catenin phosphorylation and thus degradation.
Weronika Fic, Rebecca Bastock, Francesco Raimondi, Erinn Los, Yoshiko Inoue, Jennifer L. Gallop, Robert B. Russell, Daniel St Johnston
Fic et al. identify Drosophila RhoGAP19D as a novel epithelial polarity factor that excludes active Cdc42 from the lateral domain. Loss of RhoGAP19D causes apical domain expansion, lateral contractility, and invasion of adjacent tissues, a phenotype resembling that of precancerous breast lesions.
Yoana Rabanal-Ruiz, Adam Byron, Alexander Wirth, Ralitsa Madsen, Lucia Sedlackova, Graeme Hewitt, Glyn Nelson, Julian Stingele, Jimi C. Wills, Tong Zhang, André Zeug, Reinhard Fässler, Bart Vanhaesebroeck, Oliver D.K. Maddocks, Evgeni Ponimaskin, Bernadette Carroll, Viktor I. Korolchuk
Rabanal-Ruiz and Byron et al. present a novel mechanism of nutrient signaling that identifies FAs as key cellular hubs that coordinate growth factor signaling and amino acid input into the cell and are required for efficient downstream activation of mTORC1.
Dakota L. Jones, Jeffrey A. Meridew, Patrick A. Link, Merrick T. Ducharme, Katherine L. Lydon, Kyoung M. Choi, Nunzia Caporarello, Qi Tan, Ana Maria Diaz Espinosa, Yuning Xiong, Jeong-Heon Lee, Zhenqing Ye, Huihuang Yan, Tamas Ordog, Giovanni Ligresti, Xaralabos Varelas, Daniel J. Tschumperlin
Jones et al. determine the role of matrix stiffness in regulating chromatin accessibility in freshly isolated lung fibroblasts. They identify ZNF416 as a key transcriptional regulator controlling fibroblast activation by the mechanical environment with relevance to wound healing and fibrosis.
Roshan L. Shrestha, Austin Rossi, Darawalee Wangsa, Ann K. Hogan, Kimberly S. Zaldana, Evelyn Suva, Yang Jo Chung, Chelsea L. Sanders, Simone Difilippantonio, Tatiana S. Karpova, Baktiar Karim, Daniel R. Foltz, Daniele Fachinetti, Peter D. Aplan, Thomas Ried, Munira A. Basrai
Restricting the localization of CENP-A to centromeres is essential to prevent chromosomal instability (CIN). CENP-A is overexpressed and mislocalized in several cancers. Shrestha et al. show that overexpression of CENP-A leads to its mislocalization, CIN, and aneuploidy with karyotypic heterogeneity.

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Current Issue
Volume 220,
Issue 3,
March 1, 2021
Reviews & Opinions
People & Ideas
Melina Casadio, Dan Simon
JCB asks early career investigators to share their experience launching a lab during the COVID-19 pandemic.
Karin M. Reinisch, William A. Prinz
Reinisch and Prinz review the emerging understanding of the mechanisms, regulation, and functions of nonvesicular lipid transport in eukaryotic cells.
Andreas Merdes
Merdes previews two studies (Wieczorek et al. and Zimmermann et al.) revealing the γ-TuRC complex structure and elucidating microtubule nucleation mechanisms.

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