Skip to Main Content

Advertisement

JCB staff members are working remotely in line with New York City’s efforts to contain COVID-19. While our offices are physically closed, editorial and publication operations continue. JCB staff can be reached via email and phone, as we tend to our family, friends and community. Thank you for your patience and understanding.

Journal of Cell Biology (JCB) seeks a talented individual for the role of Scientific Editor or Senior Scientific Editor, dependent on experience. Learn more

New Articles
Article
Ann L. Wozniak, Abby Adams, Kayla E. King, Winston Dunn, Lane K. Christenson, Wei-Ting Hung, Steven A. Weinman
Wozniak et al. define a novel connection between cleavage of the Rab7 adaptor protein, RILP, and exosome secretion. They demonstrate that inflammasome-mediated RILP cleavage influences sequence-specific miRNA loading into exosomes via interactions with unique cargo vesicles and association with RNA binding proteins.
Report
Georgia E. Hulmes, John D. Hutchinson, Noa Dahan, James M. Nuttall, Ellen G. Allwood, Kathryn R. Ayscough, Ewald H. Hettema
Organelle inheritance in yeast is a balance between two opposing processes, retention and inheritance. Hulmes et al. propose a new model for peroxisome retention involving contact with the plasma membrane and identify the plasma membrane–peroxisome tether responsible.
Article
Camille Valérie De Jamblinne, Barbara Decelle, Mehrnoush Dehghani, Mathieu Joseph, Neera Sriskandarajah, Kévin Leguay, Basile Rambaud, Sébastien Lemieux, Philippe P. Roux, David R. Hipfner, Sébastien Carréno
Cell and tissue morphogenesis are fundamental during development. The authors previously characterized Slik kinase and its effector, moesin, as regulators of mitotic morphogenesis and epithelial integrity. Here, they identify dSTRIPAK as a new regulator of Slik localization to promote moesin activation and functions.
Report
Katrina B. Velle, Lillian K. Fritz-Laylin
Naegleria diverged from the “yeast-to-human” lineage >1 billion years ago. Velle and Fritz-Laylin found that Naegleria, which lacks interphase microtubules, has a robust actin cytoskeletal repertoire and uses conserved, Arp2/3–derived actin networks to drive cell crawling and enhance phagocytosis. These findings support an evolutionarily ancient origin for these phenotypes.
Article
Chloé Shard, Juan Luna-Escalante, François Schweisguth
Shard et al. show that the emergence of neural stem cells from the Drosophila optic lobe neuroepithelium is an EMT-like process involving tissue-wide coordination. Neuralized acts downstream of NSC fate acquisition to downregulate the Crumbs complex to facilitate epithelium remodeling.
Article
Anjaneyulu Murari, Shauna-Kay Rhooms, Naga Sri Goparaju, Maximino Villanueva, Edward Owusu-Ansah
During mitochondrial complex I (CI) assembly, independently formed assembly intermediates (AIs) merge with each other to form the mature complex. Murari et al. generate a toolbox of 21 antibodies to various mitochondrial proteins and use classical Drosophila genetics and immunoblotting of AIs to define AIF’s role in CI biogenesis.
Article
Maria Casas, Rut Fadó, José Luis Domínguez, Aina Roig, Moena Kaku, Shigeru Chohnan, Montse Solé, Mercedes Unzeta, Alfredo Jesús Miñano-Molina, José Rodríguez-Álvarez, Eamonn James Dickson, Núria Casals
GuA1-containing AMPA receptors play a key role in synaptic plasticity and cognition. Casas et al. demonstrate that the sensing of nutrients by CPT1C regulates the phosphatase activity of SAC1, and consequently PI(4)P levels, at the contact sites between the endoplasmic reticulum and the trans-Golgi network to control the trafficking of GluA1 receptors to the cell surface of neurons.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 9,
September 7, 2020
Reviews & Opinions
Spotlight
Sampsa Matikainen, Tuula A. Nyman, Wojciech Cypryk
Matikainen et al. preview work from Wozniak et al. that reveals that inflammasomes mediate sequence-specific miRNA loading into exosomes.
Spotlight
Shafali Gupta, Alpha S. Yap
Gupta and Yap preview work by Ozawa and colleagues that elucidates new roles for adherens junctions and cryptic lamellipodia in the collective migration of epithelial cells.
Spotlight
Cara J. Gottardi, Cara J. Gottardi, G.W. Gant Luxton, G.W. Gant Luxton
Gottardi and Luxton preview work from the Borghi laboratory implicating LINC complex proteins as mechanotransducers that fine-tune Wnt/β-catenin signaling during epithelial–mesenchymal transition.

Most Popular

Advertisement

Tweets by @JCellBiol

Special Collections

Special Collections

We are delighted to present this collection of cutting-edge research published over the past year in the Journal of Cell Biology.

View Collections
Close Modal

or Create an Account

Close Modal
Close Modal