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Linda Viol, Shoji Hata, Ana Pastor-Peidro, Annett Neuner, Florian Murke, Patrick Wuchter, Anthony D. Ho, Bernd Giebel, Gislene Pereira
Viol et al. show that the conserved Never-in-mitosis-A–related kinase-2 (Nek2) removes distal appendage components from the mother centriole prior to mitosis in every cell cycle. These findings suggest that Nek2 prevents cilia maintenance during mitosis via distal appendage regulation.
Article
Gisela Cairo, Anne M. MacKenzie, Soni Lacefield
Cairo et al. show that in S. cerevisiae meiosis, spindle checkpoint proteins Bub1 and Bub3 have a critical role in preventing chromosome missegregation and setting the normal duration of anaphase I and II onset by regulating the kinetochore-localization of Ipl1 and PP1.
Article
Jorge Larios, Vincent Mercier, Aurélien Roux, Aurélien Roux, Jean Gruenberg, Jean Gruenberg
ALIX recruits ESCRT-III onto endosomes in a process that does not depend on other ESCRTs but requires the late endosome–specific lipid LBPA in vivo and in vitro. This novel pathway of ILV formation promotes tetraspanin sorting and delivery to exosomes.
Article
Matthäus Mittasch, Vanna M. Tran, Manolo U. Rios, Anatol W. Fritsch, Stephen J. Enos, Beatriz Ferreira Gomes, Alec Bond, Moritz Kreysing, Jeffrey B. Woodruff
Centrosomes withstand microtubule-mediated forces during spindle assembly, yet they are disassembled by similar forces during mitotic exit. Mittasch et al. use nanorheology to probe the material properties of centrosomes and how they change during the cell cycle. In anaphase, the centrosome scaffold becomes weak and brittle, thus allowing force-induced disassembly.
Article
Xi Yang, Weichao Zhang, Xin Wen, Patrick J. Bulinski, Dominic A. Chomchai, Felichi Mae Arines, Yun-Yu Liu, Simon Sprenger, David Teis, Daniel J. Klionsky, Ming Li
Yang et al. demonstrated TORC1 inactivation not only up-regulates macroautophagy and vacuole recycling but also leads to the degradation of many vacuole membrane proteins. The degradation is initiated by ubiquitination and followed by ESCRT-dependent microautophagy. Furthermore, TORC1 directly regulates the activity of vacuole ubiquitination machinery.
Article
Cheng-I J. Ma, Yitong Yang, Taeah Kim, Chang Hua Chen, Gordon Polevoy, Miluska Vissa, Jason Burgess, Julie A. Brill
Ma et al. describe a novel retrograde trafficking pathway in which type II PI 4-kinase (PI4KII), Past1/EHD1, and Syntaxin-16 are needed for accumulation of PI4P on regulated secretory granules and for the tetraspanin CD63 to promote granule maturation.
Article
Joshua Titlow, Francesca Robertson, Aino Järvelin, David Ish-Horowicz, Carlas Smith, Enrico Gratton, Ilan Davis
Local mRNA translation in neurons at a distance from the nucleus is key to new synapse formation. Titlow et al. find that the Syncrip RNA binding protein acts directly on msp300 mRNA to modulate activity-dependent synaptic plasticity. Single-molecule imaging reveals an activity-dependent increase in mRNP complex size and colocalization with ribosomes and the translation initiation factor eIF4E at the synapse.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 2,
February 3, 2020
Reviews & Opinions
Review
Daniel Blumenthal, Janis K. Burkhardt
T cell activation requires force production at the immunological synapse. Blumenthal and Burkhardt describe how distinct actin structures contribute to this process, addressing canonical immunological models from a mechanobiology perspective.
Spotlight
Neel S. Singhal, Evan M. Lee, Dengke K. Ma
Singhal et al. highlight new findings from Schulz et al. regarding the survival-promoting effects of GDPGP1 in neural cells.
Spotlight
Linda Ma, Daniel A. Starr
Ma and Starr highlight new work from Rahman et al. that reveals new insight into the mechanisms controlling embryonic pronuclei fusion.

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