Issues

Arends et al. show that DUX4-induction of stable intranuclear RNA, including pericentromeric human satellite II (HSATII) repeat RNA, leads to nuclear protein aggregation. HSATII ribonucleoprotein complexes impact RNA processing downstream of DUX4 expression.

Joly and Pintard uncover how the enzyme Katanin avoids wasting energy during microtubule remodeling. Their findings reveal how Katanin couples activation to microtubule binding, preventing futile ATP consumption and providing insights relevant to cell biology and disease.

Leikina et al. propose a novel signaling pathway linking together intracellular Ca²⁺ signaling, phosphatidylserine exposure, annexin A5 binding and actin cortex detachment that facilitates osteoclast fusion and, possibly, other cell–cell fusions by promoting membrane deformations and increasing local membrane tension.

The study reveals that newly synthesized integrins can bypass the Golgi to be actively delivered to specific plasma membrane regions, where they enhance cell protrusion and adhesion. This targeted secretion rapidly increases integrin availability, giving cells dynamic flexibility to adjust to their environment.

Yamasaki et al. show that GARLH proteins assemble with neuroligins to dictate synapse-type preference. Contrary to prevailing views, endogenous NL1 localizes to both excitatory and inhibitory synapses; when NL2/4 are absent or NL1-GARLH4 binding is enforced, NL1/3 assemble with GARLH4–GABA_A receptor complexes, linking neuroligins to inhibitory targeting.