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1 September 2025
In Progress
ISSN 0021-9525
EISSN 1540-8140
In this Issue
Article
Arc controls organ architecture through modulation of Crb and MyoII
Ji Hoon Kim,Rika Maruyama,Kwon Kim,Devin A. Vertrees,Parama Paul,Kyla Britson,Nathaniel R. Laughner,Deborah J. Andrew
Kim et al. report on Arc, a large PDZ domain–containing cell membrane–associated protein that controls Drosophila salivary gland architecture. Arc facilitates apical membrane delivery of Crumbs; in turn, Crumbs limits accumulation and activity of non-muscle myosin II to regulate the number of salivary gland cells that internalize at a given time.
Visualizing nuclear pore complex plasticity with pan-expansion microscopy
Morgan et al. demonstrate that pan-expansion microscopy is an exceptional tool for probing the molecular composition and structural plasticity of individual NPCs: they reveal LINC complex–dependent NPC diameter biases across the nuclear surface and changing nucleoporin positions in an ALS model.
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Reproducibility
What's in a picture? The temptation of image manipulation
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