Newest Articles

Brief Definitive Report
Yuki Honda Keith et al.
Tissue-resident CSF1R-dependent CD169+ macrophages localize deep in the skin. They surround growing tumors and directly suppress their growth independent of T and B cells. CD169+ skin macrophages ingest live tumors, and this phagocytosis is independent of the phosphatidylserine receptor MERTK.
Article
Chenyun Song et al.
This study shows that a secondary microglial expansion center has been identified in fetal brains with oSVZ.
Technical Advances and Resources
Rih-Sheng Huang et al.
We developed a highly efficient nonviral knock-in platform for NK cells, enabling plasmid-based genome editing with up to ∼90% knock-in efficiency and ∼100% recovery. Targeted integration rewires endogenous circuits for context-dependent therapeutic functions and supports GMP-compatible production of CAR-NK cells for clinical translation applications.
Article
Rafael Blanco-Domínguez et al.
Blanco-Domínguez et al. demonstrate that regulatory T cells constrain IFNγ-producing γδ T cells by competing for IL-2, thereby limiting their expansion and anti-tumor function. IL-2Rβγc agonism can overcome this suppression to enhance γδ T cell–mediated tumor control.
Article
Jie Li et al.
The chemokine CCL25 is expressed in the thymus and the small intestine. Li et al. show that thymic epithelial CCL25 facilitates T cell positive selection in the thymic cortex, whereas intestinal epithelial CCL25 promotes nutrient sensing in the small intestine. Epithelial CCL25 directs thymic T cell development and intestinal homeostasis in a tissue-specific paracrine manner.
Article
Megumi Tatematsu et al.
CNOT3 promotes the degradation of Tbx21 and Rorc mRNAs through Roquin and ZFP36L1 in ILC2 cells, thereby inhibiting type 1 and type 3 plasticity and maintaining ILC2 function.
Article
Shibo Liu et al.
Liu et al. develop PRECISE-seq, a single-cell platform linking TCR specificity and avidity to T cell phenotypes in vivo. They reveal that high-potency antiviral T cells become exhausted, while tumor-reactive CD8+ T cells acquire a regulatory Ly49+ state that is restrained by PD-1 blockade, resulting in effector revival within tumors.
Journal of Experimental Medicine Cover Image for Volume 223, Issue 5
Current Issue
Volume 223,
Issue 5,
4 May 2026

Reviews & Opinions

Insights
Rundi Zhu et al.
In this issue of JEM, Liu et al. report PRECISE-seq, a proximity labeling platform that integrates T cell receptor specificity, functional potency, and cellular phenotype at a single-cell resolution. Using this approach, they identify an immunosuppressive Ly49+ T cell state within tumors that is alleviated by PD-1 blockade.
Insights
Sangwoo Park, Marcela V. Maus
Repeated tumor contact leaves more behind than simple CAR-T exhaustion. This study shows that chronic antigen exposure impairs a Rab5-dependent endocytic program, allowing trogocytosed antigen to accumulate, functional CAR to decline, and fratricide to increase.
Review | Genes and Immunity Focus
Ahmet Eken et al.
Human LCK deficiency syndromes demonstrate that T cell fate is set by signal amplitude, not molecular identity. This review synthesizes clinical observations with emerging views of thymic microenvironments to illuminate how TCR signal calibration shapes immunity and tolerance.

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