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JEM Clinical Immunology Collection 2021
A selection of the latest breakthroughs to coincide with the
FOCIS 2021 Virtual Annual Meeting
Inhibition of IL1β release prevents VIPN
Role of Regnase-1 in B cells

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Article

| June 04 2021

Coordination of Foxp3 enhancers

Xinying Zong, Xiaolei Hao, Beisi Xu, Jeremy Chase Crawford, Shaela Wright, Jun Li, Yang Zhang, Lu Bai, Minghong He, Menglin Jiang, Yiping Fan, Jon P. Connelly, Shondra M. Pruett-Miller, Hartmut Berns, Laura Janke, Chunliang Li, Yongqiang Feng

Expression of regulatory T cell lineage–specifying factor Foxp3 is governed by distinct cis-regulatory elements of the Foxp3 gene. Systematic analyses indicate that these elements coordinate to maximize regulatory T cell suppressive capacity by enhancing their induction and lineage stability.

Article

| June 04 2021

Loss of direct adrenergic innervation induces IFN-γ

Chien-Sin Chen, Jasmin Weber, Stephan Jonas Holtkamp, Louise Madeleine Ince, Alba de Juan, Chen Wang, Lydia Lutes, Coline Barnoud, Burak Kizil, Sophia Martina Hergenhan, Johanna Salvermoser, Manuel Lasch, Elisabeth Deindl, Barbara Schraml, Dirk Baumjohann, Christoph Scheiermann

This study shows loss of sympathetic innervation to the popliteal lymph node to induce IFN-γ expression in CD8 T cells, causing expansion. This is rescued by β2 adrenergic receptor agonists, demonstrating the pro-inflammatory effect of loss of direct adrenergic input.

Article

| June 02 2021

Mechanisms of ILC memory for asthma

Mukesh Verma, Lidia Michalec, Anand Sripada, Jerome McKay, Kapil Sirohi, Divya Verma, Dipa Sheth, Richard Martin, Nathan Dyjack, Max A. Seibold, Jennifer R. Knapp, Ting-Hui Tu, Brian P. O’Connor, Magdalena M. Gorska, Rafeul Alam

Verma et al. present an experimental approach for generation of ILC2 memory for allergic asthma. scRNA-seq and ATAC-seq identify a set of preparedness- and repression-inducing genes with memory formation. Their approach demonstrates a critical role for Fhl2 and ICOS in ILC2 memory.

Brief Definitive Report

| May 26 2021

Chronic post-stroke T cell proliferation

Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger, Nikolett Lenart, Nicolai Franzmeier, Tibor Hortobagyi, Peter T. Nelson, Ann M. Stowe, Adam Denes, Dieter Edbauer, Arthur Liesz

Heindl et al. describe the local proliferation and clustering of T cells in the brain of mice and humans after stroke. This previously unrecognized phenomenon could explain why blocking cerebral leukocyte invasion might fail to improve long-term stroke recovery.

Brief Definitive Report

| May 26 2021

BRD4 regulates CD8 T cell differentiation

J. Justin Milner, Clara Toma, Sara Quon, Kyla Omilusik, Nicole E. Scharping, Anup Dey, Miguel Reina-Campos, Hongtuyet Nguyen, Adam J. Getzler, Huitian Diao, Bingfei Yu, Arnaud Delpoux, Tomomi M. Yoshida, Deyao Li, Jun Qi, Adam Vincek, Stephen M. Hedrick, Takeshi Egawa, Ming-Ming Zhou, Shane Crotty, Keiko Ozato, Matthew E. Pipkin, Ananda W. Goldrath

Milner et al. reveal the chromatin reader BRD4 controls the differentiation and maintenance of a terminally differentiated CD8 T cell state. This study provides molecular insights into the manipulation of T cell differentiation for improved protection from infection and malignancy.

Brief Definitive Report

| May 25 2021

SERCA activity is required for V(D)J recombination

Chun-Chin Chen, Bo-Ruei Chen, Yinan Wang, Philip Curman, Helen A. Beilinson, Ryan M. Brecht, Catherine C. Liu, Ryan J. Farrell, Jaime de Juan-Sanz, Louis-Marie Charbonnier, Shingo Kajimura, Timothy A. Ryan, David G. Schatz, Talal A. Chatila, Jakob D. Wikstrom, Jessica K. Tyler, Barry P. Sleckman

We show that the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) family proteins SERCA2 and SERCA3 have redundant functions that are required for RAG gene expression and DNA breaks during V(D)J recombination. Loss of SERCA activity leads to B lymphopenia in mice and humans.

Article

| May 25 2021

Old HSCs are refractory to bloodborne systemic rejuvenation

Theodore T. Ho, Paul V. Dellorusso, Evgenia V. Verovskaya, Sietske T. Bakker, Johanna Flach, Lucas K. Smith, Patrick B. Ventura, Olivia M. Lansinger, Aurélie Hérault, Si Yi Zhang, Yoon-A Kang, Carl A. Mitchell, Saul A. Villeda, Emmanuelle Passegué

Ho et al. demonstrate that old HSCs are extremely resistant to bloodborne systemic rejuvenation approaches and long-term exposure to a young BM niche microenvironment, maintaining a cell-intrinsic aged state. They also show that young HSCs are not affected by old blood or blood-derived factors, an important finding for transplantations in older patients and other emerging anti-aging interventions.

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Volume 218,

Issue 5,

May 3, 2021

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Viewpoint | JEM 125th Anniversary

| May 26 2021

The discovery of dendritic cells

Carol L. Moberg

An excerpt from Ralph Steinman’s Harvey Lecture describing the discovery of dendritic cells.

Viewpoint

| May 26 2021

Sterilizing immunity: New opportunities for rational TB vaccine design

Alan Sher, Joanne L. Flynn

Sher and Flynn discuss how sterilizing immunity observed in different TB models could be an opportunity for the identification of novel targets for TB vaccine design.

Viewpoint | JEM 125th Anniversary

| May 26 2021

Taking regulatory T cells into medicine

Shimon Sakaguchi

Shimon Sakaguchi recounts the work that lead to the identification of regulatory T cells.

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Special Collections

The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

View all collections

JEM Clinical Immunology Collection 2021 A selection of the latest breakthroughs to coincide with the FOCIS 2021 Virtual Annual Meeting

Inhibition of IL1β release prevents VIPN

Role of Regnase-1 in B cells

Related Articles from Rockefeller University Press

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Special Collections

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JEM Clinical Immunology Collection 2021
A selection of the latest breakthroughs to coincide with the
FOCIS 2021 Virtual Annual Meeting