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Technical Advances and Resources
Bailey B. Banach, Prabhanshu Tripathi, Lais Da Silva Pereira, Jason Gorman, Thuy Duong Nguyen, Marlon Dillon, Ahmed S. Fahad, Patience K. Kiyuka, Bharat Madan, Jacy R. Wolfe, Brian Bonilla, Barbara Flynn, Joseph R. Francica, Nicholas K. Hurlburt, Neville K. Kisalu, Tracy Liu, Li Ou, Reda Rawi, Arne Schön, Chen-Hsiang Shen, I-Ting Teng, Baoshan Zhang, Marie Pancera, Azza H. Idris, Robert A. Seder, Peter D. Kwong, Brandon J. DeKosky
This study applied innovative antibody screening technologies to discover antimalarial antibody variants with enhanced protective potency. Study authors applied precision DNA library generation, high-throughput screening, and analysis of next generation sequencing data to identify mutations that improved malaria protection following in vivo infectious challenge.
Brief Definitive Report
Qian Zhang, Daniela Matuozzo et al.
In an international cohort of 112 children hospitalized for moderate to critical COVID-19 pneumonia, we identified 12 children with one of four known recessive inborn errors of type I interferon immunity: X-linked TLR7 and autosomal IFNAR1, STAT2, and TYK2 deficiencies.
Article
Xuefang Pan, Mahsa Taherzadeh, Poulomee Bose, Rachel Heon-Roberts, Annie L.A. Nguyen, TianMeng Xu, Camila Pará, Yojiro Yamanaka, David A. Priestman, Frances M. Platt, Shaukat Khan, Nidhi Fnu, Shunji Tomatsu, Carlos R. Morales, Alexey V. Pshezhetsky
The study demonstrates that dominant-negative effects of the misfolded HGSNAT variant in the mouse model of mucopolysaccharidosis IIIC are treatable by glucosamine. This suggests that patients affected with mutations causing the enzyme misfolding can potentially benefit from chaperone therapy.
Article
Cyril Planchais, Ignacio Fernández, Timothée Bruel, Guilherme Dias de Melo, Matthieu Prot, Maxime Beretta, Pablo Guardado-Calvo, Jérémy Dufloo, Luis M. Molinos-Albert, Marija Backovic, Jeanne Chiaravalli, Emilie Giraud, Benjamin Vesin, Laurine Conquet, Ludivine Grzelak, Delphine Planas, Isabelle Staropoli, Florence Guivel-Benhassine, Thierry Hieu, Mikaël Boullé, Minerva Cervantes-Gonzalez, Marie-Noëlle Ungeheuer, Pierre Charneau, Sylvie van der Werf, Fabrice Agou, French COVID Cohort Study Group, CORSER Study Group, Jordan D. Dimitrov, Etienne Simon-Lorière, Hervé Bourhy, Xavier Montagutelli, Félix A. Rey, Olivier Schwartz, Hugo Mouquet
This study identifies broadly SARS-CoV-2–neutralizing IgA and IgG antibodies from Wuhan COVID-19 convalescents active against the variants of concern Alpha, Beta, Gamma, Delta, and Omicron BA.1 and BA.2.
Article
Carly E. Whyte, Kailash Singh, Oliver T. Burton, Meryem Aloulou, Lubna Kouser, Rafael Valente Veiga, Amy Dashwood, Hanneke Okkenhaug, Samira Benadda, Alena Moudra, Orian Bricard, Stephanie Lienart, Pascal Bielefeld, Carlos P. Roca, Francisco José Naranjo-Galindo, Félix Lombard-Vadnais, Steffie Junius, David Bending, Tino Hochepied, Timotheus Y.F. Halim, Susan Schlenner, Sylvie Lesage, James Dooley, Adrian Liston
Network analysis of IL-2 identifies a context-dependent hierarchy of consumption and response. IL-2 sourced from different leukocytes drives different circuits of responding cells, independent of concentration. Targeting IL-2 localization may therefore allow fine-tuning of therapeutic responses.
Article
Yang Zhang, Yicong Ye, Xiaoqiang Tang, Hui Wang, Toshiko Tanaka, Ran Tian, Xufei Yang, Lun Wang, Ying Xiao, Xiaomin Hu, Ye Jin, Haiyu Pang, Tian Du, Honghong Liu, Lihong Sun, Shuo Xiao, Ruijia Dong, Luigi Ferrucci, Zhuang Tian, Shuyang Zhang
Zhang et al. identified chemokine CCL17 as a contributor to age-related heart failure in humans and mice via regulating plasticity and differentiation of T cells. Their findings suggested CCL17 as a novel therapeutic target in age-related heart failure.
Article
Yong Ge, Mojgan Zadeh, Mansour Mohamadzadeh
Vitamin B12 shapes gut microbiome and supports mitochondrial metabolism of ileal epithelial cells to synergistically regulate epithelial oxygenation, controlling aerobic Salmonella infection. This mechanistic interplay highlights the significance of this crucial micronutrient in maintaining intestinal homeostasis against pathogen infections.

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Issue Cover
Current Issue
Volume 219,
Issue 6,
6 June 2022
Reviews & Opinions
Perspective
Greg Lemke, Youtong Huang
Microglia, the tissue macrophages of the central nervous system, use phagocytosis of loosely organized amyloid beta (Aβ) to construct dense-core plaques, one of the defining histopathological features of Alzheimer’s disease. The biology of this process parallels macrophage construction of granulomas in tuberculosis and other settings.
Insights
Chia-Hao Lin, Li-Fan Lu
Gut dysbiosis has long been associated with the development of Crohn's disease and other gastrointestinal disorders. Otake-Kasamoto et al. report that dysbiotic microbiota–derived bioactive lipids, lysophosphatidylserines, can promote pathological Th1 cell responses through inducing metabolic reprogramming and epigenetic changes.
Review
Carl F. Ware, Michael Croft, Garry A. Neil
The cytokine LIGHT (TNFSF14) has emerged as an important modulator of innate and adaptive immune responses. Accumulating basic and clinical evidence points to the dysregulation of the LIGHT network as a disease-driving mechanism and supports the application of target-modifying therapeutics for disease intervention.

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