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Immunology Update Winter 2022.
2021: The Year in Experimental Medicine

Highlighting 10 research articles published in 2021 that were of greatest interest to our readers during our 125th year.
ADAM17-metastasis
JEM's 125th Anniversary

Watch our workshop featuring guest investigators, dive into a timeline of discoveries, and more.
Complimentary CME for all, presented by JEM and Memorial Sloan Kettering Cancer Center

RUP response to COVID-19 crisis: Learn about the steps we are taking and find relevant content.

We are hiring: Scientific Editor/Senior Scientific Editor, Journal of Experimental Medicine.

Newest Articles

Brief Definitive Report

| January 26 2022

Alpelisib in infants with PIK3CA-related overgrowth spectrum

Gabriel Morin, Caroline Degrugillier-Chopinet, Marie Vincent, Antoine Fraissenon, Hélène Aubert, Célia Chapelle, Clément Hoguin, François Dubos, Benoit Catteau, Florence Petit, Aurélie Mezel, Olivia Domanski, Guillaume Herbreteau, Marie Alesandrini, Nathalie Boddaert, Nathalie Boutry, Christine Broissand, Tianxiang Kevin Han, Fabrice Branle, Sabine Sarnacki, Thomas Blanc, Laurent Guibaud, Guillaume Canaud

Here, the authors report the first description of two infants with PIK3CA-related overgrowth spectrum treated by alpelisib. Patients were monitored with pharmacokinetics. Alpelisib was associated with clinical, biological, and radiological improvements.

Technical Advances and Resources

| January 21 2022

Fast-track interactomics in primary human T cells

Philippe Nicolas, Jocelyn Ollier, Daiki Mori, Guillaume Voisinne, Javier Celis-Gutierrez, Claude Gregoire, Jeanne Perroteau, Régine Vivien, Mylène Camus, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Béatrice Clémenceau, Romain Roncagalli, Henri Vié, Bernard Malissen

Nicolas et al. exploited traceable gene tagging in primary human T cells to establish at the systems level the composition and dynamics of TCR-induced signalosomes. It provides a decision-support tool accelerating definition of the mechanism of action of drugs targeting T cells.

Technical Advances and Resources

| January 21 2022

Single-cell profiling of T cell in TPE

Yi Cai, Yejun Wang, Chenyan Shi, Youchao Dai, Fuxiang Li, Yuzhong Xu, Peize Zhang, Fanhui Kong, Guofang Deng, Zhihua Wen, Qi Zhou, Boxi Chris Kang, Amit Singhal, Qianting Yang, Carl G. Feng, Xinchun Chen

Cai et al. describe their finding of cellular diversity in tuberculous pleural effusion (TPE). They establish a link between clonal expansion and lineage plasticity of T cells and reveal the involvement of granzyme K–expressing CD8 T cells in TPE pathogenesis.

Article

| January 20 2022

Organotypic maintenance of vessels by VEGFRs

Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar, Yoshiaki Kubota, Kari Alitalo

Using VEGF receptor deletions in mice, the authors show that VEGFR1 and VEGFR3 can support vessel maintenance in the absence of VEGFR2 in an organ-specific manner in postnatal and adult mice.

Article

| January 19 2022

Regulation of ILC2s responses via Ang II–AT1a axis

Gaoyu Liu, Yingying Chen, Ying Wang, Xiaohui Deng, Qiang Xiao, Lijuan Zhang, Haixu Xu, Xu Han, Aihua Lei, Juan He, Xing Li, Yingjiao Cao, Pan Zhou, Chunhui He, Peiqiong Wu, Wenhui Jiang, Meizheng Tan, Chun Chen, Quan Yang, Liwei Lu, Kai Deng, Zhi Yao, Jie Zhou

Liu et al. demonstrate the regulation of ILC2 by Ang II–AT1 signaling during the allergen challenge. Bone marrow chimera, deletion or pharmacological inhibition of AT1a, and ILC2 transfer into NCG mice collectively indicate that targeting lung RAS alleviates airway inflammation.

Article

| January 14 2022

Fibroblasts sustain lung tumor MHCII immunity

Dimitra Kerdidani, Emmanouil Aerakis, Kleio-Maria Verrou, Ilias Angelidis, Katerina Douka, Maria-Anna Maniou, Petros Stamoulis, Katerina Goudevenou, Alejandro Prados, Christos Tzaferis, Vasileios Ntafis, Ioannis Vamvakaris, Evangelos Kaniaris, Konstantinos Vachlas, Evangelos Sepsas, Anastasios Koutsopoulos, Konstantinos Potaris, Maria Tsoumakidou

Kerdidani et al. show that immunological hot spots in lung tumors are sustained by fibroblasts. Lung fibroblasts present MHCII cancer antigens locally and at the same time prevent CD4 T cells from apoptosis by activating the complement receptor C1qbp.

Article

| January 13 2022

The role of HIF-1α in NKp46⁺ innate lymphoid cells

Ewelina Krzywinska, Michal Sobecki, Shunmugam Nagarajan, Julian Zacharjasz, Murtaza M. Tambuwala, Abigaelle Pelletier, Eoin Cummins, Dagmar Gotthardt, Joachim Fandrey, Yann M. Kerdiles, Carole Peyssonnaux, Cormac T. Taylor, Veronika Sexl, Christian Stockmann

Krzywinska et al. have studied the impact of the transcription factor HIF-1α on the phenotype of intestinal NKp46+ innate lymphoid cells and how it affects gut homeostasis.

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Current Issue

Volume 219,

Issue 1,

January 3, 2022

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Reviews & Opinions

Insights

| January 12 2022

Goldilocks and the three TILs

Hannah Dada, Michael L. Dustin

Shakiba et al. show that TCR signal strength determines T cell differentiation and function in tumors.

Review

| January 10 2022

Humoral immunity against PfCSP

Ilka Wahl, Hedda Wardemann

Antibodies against Plasmodium falciparum circumsporozoite protein (PfCSP) can protect from malaria. However, the efficacy of anti-PfCSP vaccine responses is limited. This review summarizes our molecular and cellular understanding of humoral anti-PfCSP immune responses and discusses implications for vaccine design.

Insights

| December 28 2021

Playing dirty with virus transmission

Christin Herrmann, Ken Cadwell

Fay et al. investigate viral infection dynamics by cohousing dirty pet store mice and rats with clean laboratory mice.

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Special Collections

The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

View all collections

Immunology Update Winter 2022.

Highlighting 10 research articles published in 2021 that were of greatest interest to our readers during our 125th year.

ADAM17-metastasis

Watch our workshop featuring guest investigators, dive into a timeline of discoveries, and more.

Complimentary CME for all, presented by JEM and Memorial Sloan Kettering Cancer Center

Related Articles from Rockefeller University Press

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