IKKα kinase deficiency causes syndromic immunodeficiency and immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway as well as a partial defect in the canonical NF-κB pathway.

This study investigates how different lymphatic drainage pathways from the central nervous system regulate cerebrospinal fluid homeostasis, highlights the role of lymphatic pathways in maintaining CSF dynamics, and suggests therapeutic potential in modulating these pathways in CNS disorders.

This work shows that hepatoblasts in the fetal liver are the primary source of factors that sustain blood cell production. Different hematopoietic progenitors exhibit distinct preferences for neighboring stromal cells and show developmental changes in spatial distribution.

We discovered that PIKFYVE and its product PtdIns(3,5)P2 are essential regulators of Th17 differentiation. Our findings identify molecular mechanisms by which PIKFYVE promotes Th17 differentiation and suggest that PIKFYVE is a potential therapeutic target in Th17-driven autoimmune diseases.

Rapid capture of potentially harmful bacteria in blood by liver macrophages is vital for blood sterility and health. This work reports how naturally occurring antibodies in the plasma enable macrophages to capture and kill blood-borne bacteria in the liver.

α-Galactosylceramide (α-GalCer), a marine sponge-derived canonical antigen for invariant natural killer T (iNKT) cells, has not been detected in mammals. In this study, we report the molecular detection of α-GalCer in mammals using supercritical fluid chromatography tandem mass spectrometry.

Sparano et al. show that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. In these environments, TGF-β1, IL-15, and other factors collaboratively induce a Hobit-dependent cytotoxicity program. In the salivary glands, trNK cells limit murine cytomegalovirus persistence.