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Brief Definitive Report
Saskia Hemmers, Michail Schizas, Alexander Y. Rudensky
ST2 expression was largely dispensable for T reg cell accumulation and maintenance in tissues at steady state. However, ST2 deficiency limited to T reg cells was important in limiting the size of IL-17A–producing γδT cells in a mouse model of neuroinflammation.
Article
Ida Lindeman, Chunyan Zhou, Linn M. Eggesbø, Zhichao Miao, Justyna Polak, Knut E.A. Lundin, Jørgen Jahnsen, Shuo-Wang Qiao, Rasmus Iversen, Ludvig M. Sollid
Single-cell analysis reveals an accumulation of short-lived disease-specific as well as non–disease-specific intestinal plasma cells in untreated and short-term–treated celiac disease. Plasma cells differ transcriptionally depending on specificity, longevity, and disease status and may contribute to formation of the celiac lesion.
Article
Brendan Reed, Frances Crawford, Ryan C. Hill, Niyun Jin, Janice White, S. Harsha Krovi, Philippa Marrack, Kirk Hansen, John W. Kappler
The lysosomal protease cathepsin L uses pancreatic secretory granule protein precursors and a reverse proteolysis mechanism, transpeptidation, to generate chimeric super-epitopes specific for diabetogenic CD4 T cells.
Article
Fares Bassil, Emily S. Meymand, Hannah J. Brown, Hong Xu, Timothy O. Cox, Shankar Pattabhiraman, Chantal M. Maghames, Qihui Wu, Bin Zhang, John Q. Trojanowski, Virginia M.-Y. Lee
Bassil et al. model the crosstalk of α-syn and tau under copathology conditions. They show evidence of α-syn–dependent tau pathology in the human brain. Moreover, they demonstrate the role of α-syn in the modulation of tau pathology in mice.
Brief Definitive Report
Tracy Dagher, Nabih Maslah, Valérie Edmond, Bruno Cassinat, William Vainchenker, Stéphane Giraudier, Florence Pasquier, Emmanuelle Verger, Michiko Niwa-Kawakita, Valérie Lallemand-Breitenbach, Isabelle Plo, Jean-Jacques Kiladjian, Jean-Luc Villeval, Hugues de Thé
Myeloproliferative neoplasms are partly sensitive to interferon α therapy. Dagher et al. demonstrate that arsenic trioxide sharply potentiates interferon’s ability to eliminate patients’ progenitors or disease-initiating cells from mouse models by targeting PML, an interferon target and key senescence gene.
Article
Jake R. Thomas, Anna Appios, Xiaohui Zhao, Roksana Dutkiewicz, Maria Donde, Colin Y.C. Lee, Praveena Naidu, Christopher Lee, Joana Cerveira, Bing Liu, Florent Ginhoux, Graham Burton, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Naomi McGovern
Hofbauer cells are primitive placental macrophages with a unique phenotype and role in fetal defense. Using transcriptomic and proteomic data, Thomas et al. analyze human first-trimester placental macrophages and delineate markers that identify them. They also reveal that Hofbauer cells have microbicidal capacity, providing the fetus with an additional layer of protection from certain microbes.
Article
Begüm Alankus, Veronika Ecker, Nathalie Vahl, Martina Braun, Wilko Weichert, Stephan Macher-Göppinger, Torben Gehring, Tanja Neumayer, Thorsten Zenz, Maike Buchner, Jürgen Ruland
Enforced RANK signaling in B cells drives systemic autoimmunity and CLL development. The survival of CLL cells depends on microenvironmental RANKL, and inhibition of RANKL–RANK signaling kills murine and human CLL cells.

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Volume 217,
Issue 10,
October 5, 2020
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A COVID-19 vaccine must first be proven to be safe and effective, but making billions of doses of high quality vaccine and using it equitably and accessibly may present an equal if not greater challenge to the global community.
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JEM’s academic editors discuss the benefits of immigration in science.

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