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Newest Articles
Teresa Manzo, Boone M. Prentice, Kristin G. Anderson, Ayush Raman, Aislyn Schalck, Gabriela S. Codreanu, Carina B. Nava Lauson, Silvia Tiberti, Andrea Raimondi, Marissa A. Jones, Michelle Reyzer, Breanna M. Bates, Jeffrey M. Spraggins, Nathan H. Patterson, John A. McLean, Kunal Rai, Carlo Tacchetti, Sara Tucci, Jennifer A. Wargo, Simona Rodighiero, Karen Clise-Dwyer, Stacy D. Sherrod, Michael Kim, Nicholas E. Navin, Richard M. Caprioli, Philip D. Greenberg, Giulio Draetta, Luigi Nezi
Metabolic constrains induce transcriptional deregulation of CD8+ T cells in pancreatic tumor microenvironment, driving progressive dysfunction. Here, metabolic reprogramming through enforced very-long-chain acyl-CoA dehydrogenase expression enhances intratumor T cells survival and persistence, overcoming a major hurdle to immunotherapy for PDA.
Marcin Bączyk, Najwa Ouali Alami, Nicolas Delestrée, Clémence Martinot, Linyun Tang, Barbara Commisso, David Bayer, Nicolas Doisne, Wayne Frankel, Marin Manuel, Francesco Roselli, Daniel Zytnicki, Daniel Zytnicki
This study demonstrates that, in a mouse model of ALS, excitatory synapses on spinal motoneurons are disrupted. Activation of the cAMP/PKA pathway reverts the functional and structural synaptic deficits and ameliorates disease markers by increasing motoneuron firing.
Kevin P. Meng, Fatemeh S. Majedi, Timothy J. Thauland, Manish J. Butte
Meng et al. identify YAP as a mechanosensor in T cells that suppresses metabolism and effector activity in mechanically soft tissues and accentuates in stiff ones.
Brief Definitive Report
Dan Wu, Chi Kin Wong, Jonathan M. Han, Paul C. Orban, Qing Huang, Jana Gillies, Majid Mojibian, William T. Gibson, Megan K. Levings
Insulin receptor deletion in T regs improves metabolic outcomes in models of diet- and age-induced obesity and hyperinsulinemia. Direct effects of hyperinsulinemia on T regs is a previously unknown mechanism controlling T reg function in metabolic syndrome.
Qingxin Zhou, Meihua Lin, Xing Feng, Fei Ma, Yuekun Zhu, Xing Liu, Chao Qu, Hong Sui, Bei Sun, Anlong Zhu, Heng Zhang, He Huang, Zhi Gao, Yongxiang Zhao, Jiangyun Sun, Yuxian Bai, Junfei Jin, Xuehui Hong, Chang Zou, Zhiyong Zhang
Zhou et al. characterize a critical role of CLK3 on purine metabolism in cholangiocarcinoma (CCA). Overexpressed or mutated CLK3 promotes CCA progression in vitro and in vivo. Therefore, CLK3 may serve as a biomarker and potential drug target for CCA.
Jeffrey H. Lin, Austin P. Huffman, Max M. Wattenberg, David M. Walter, Erica L. Carpenter, David M. Feldser, Gregory L. Beatty, Emma E. Furth, Robert H. Vonderheide
Type 1 conventional dendritic cells are progressively and systemically dysregulated during pancreatic carcinogenesis, subject to semimaturation and IL-6–driven apoptosis. Yet, CD40 agonist synergizes with Flt3L to rescue cDC1 abundance and maturation, enabling a return to full CD8+ T cell priming.
Marina Babic, Christoforos Dimitropoulos, Quirin Hammer, Christina Stehle, Frederik Heinrich, Assel Sarsenbayeva, Almut Eisele, Pawel Durek, Mir-Farzin Mashreghi, Berislav Lisnic, Jacques Van Snick, Max Löhning, Simon Fillatreau, David R. Withers, Nicola Gagliani, Samuel Huber, Richard A. Flavell, Bojan Polic, Chiara Romagnani
NKG2D is a danger sensor expressed on different subsets of innate and adaptive lymphocytes. This study demonstrates how NKG2D enforces proinflammatory features of Th1 and Th17 cells and promotes inflammation in vivo, identifying NKG2D as an important target for the amelioration of Th1/ Th17-mediated inflammatory diseases.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 6,
June 1, 2020
Reviews & Opinions
Carolina Magdalen Greco, Paolo Sassone-Corsi
Personalized medicine and circadian rhythms: Opportunities for modern society
Luc Van Kaer, Sebastian Joyce
The Hippo signaling pathway controls the maturation and effector differentiation of iNKT cells.
Santosha A. Vardhana, Jedd D. Wolchok
This Perspective explores the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offers suggestions to both understand and therapeutically modulate anti-COVID immunity.

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