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Newest Articles
Brief Definitive Report
Carla Noemi Castro, Michelle Rosenzwajg, Raphael Carapito, Mohammad Shahrooei, Martina Konantz, Amjad Khan, Zhichao Miao, Miriam Groß, Thibaud Tranchant, Mirjana Radosavljevic, Nicodème Paul, Tristan Stemmelen, Fabien Pitoiset, Aurélie Hirschler, Benoit Nespola, Anne Molitor, Véronique Rolli, Angélique Pichot, Laura Eva Faletti, Bruno Rinaldi, Sylvie Friant, Mark Mednikov, Hatice Karauzum, M. Javad Aman, Christine Carapito, Claudia Lengerke, Vahid Ziaee, Wafaa Eyaid, Stephan Ehl, Fayhan Alroqi, Nima Parvaneh, Seiamak Bahram, Seiamak Bahram
Biallelic mutations in NCKAP1L, a regulator of the actin cytoskeleton, cause immunodeficiency, lymphoproliferation, and hyperinflammation with features of hemophagocytic lymphohistiocytosis. Impaired immune synapse formation, early T cell activation and leading edge formation, and defective neutrophil migration characterize this novel “actinopathy.”
Brief Definitive Report
Valeria Fumagalli, Pietro Di Lucia, Valentina Venzin, Elisa B. Bono, Robert Jordan, Christian R. Frey, William Delaney, Francis V. Chisari, Luca G. Guidotti, Luca G. Guidotti, Matteo Iannacone, Matteo Iannacone
Antibody-mediated clearance of circulating HBsAg has minimal impact on the expansion of HBV-specific CD8+ T cells undergoing intrahepatic priming. It does not alter their differentiation into dysfunctional cells, nor does it enhance their functional restoration by immunotherapeutic strategies.
Julia Varga, Adele Nicolas, Valentina Petrocelli, Marina Pesic, Abdelrahman Mahmoud, Birgitta E. Michels, Emre Etlioglu, Diego Yepes, Björn Häupl, Paul K. Ziegler, Katrin Bankov, Peter J. Wild, Stefan Wanninger, Hind Medyouf, Henner F. Farin, Sabine Tejpar, Thomas Oellerich, Jürgen Ruland, Christian W. Siebel, Florian R. Greten
Varga et al. describe a novel genetically modified mouse model of human, poor-prognosis mesenchymal colorectal cancer. Using this model, they identify NOTCH3 as a potential therapeutic target for this specific colorectal cancer subtype.
Benjamin Israelow, Eric Song, Tianyang Mao, Peiwen Lu, Amit Meir, Feimei Liu, Mia Madel Alfajaro, Jin Wei, Huiping Dong, Robert J. Homer, Aaron Ring, Craig B. Wilen, Akiko Iwasaki
Israelow et al. show that AAV-mediated expression of human ACE2 allows for SARS-CoV-2 infection and disease investigation in mice. This pathology is in part driven by type I interferon signaling, which recruits inflammatory immune cells without aborting viral replication.
Kirby D. Johnson, Daniel J. Conn, Evgenia Shishkova, Koichi R. Katsumura, Peng Liu, Siqi Shen, Erik A. Ranheim, Sean G. Kraus, Weixin Wang, Katherine R. Calvo, Amy P. Hsu, Steven M. Holland, Joshua J. Coon, Sunduz Keles, Emery H. Bresnick
By elevating levels of the GATA2 transcription factor in hematopoietic progenitor cells, a transcriptional enhancer establishes multilineage differentiation potential. During embryogenesis, deleting the enhancer upregulates innate immune machinery and deconstructs multilineage potential to favor monocytic differentiation.
Lianne Kok, Feline E. Dijkgraaf, Jos Urbanus, Kaspar Bresser, David W. Vredevoogd, Rebeca F. Cardoso, Leïla Perié, Joost B. Beltman, Ton N. Schumacher
Following local inflammation, CD8+ T cells develop into tissue-resident memory T cells (TRM). Through combined lineage tracing and single-cell transcriptome analysis, the authors show that the circulating T cell pool harbors TRM precursors that commit to the TRM fate before tissue entry.
Brief Definitive Report
Ting Tao, Ting Tao, Hui Shi, Meng Wang, Antonio R. Perez-Atayde, Wendy B. London, Alejandro Gutierrez, Bernardo Lemos, Adam D. Durbin, Adam D. Durbin, A. Thomas Look, A. Thomas Look
Activated AKT is a tumorigenic driver in ganglioneuroma, and inhibition of the downstream AKT target mTOR may serve as a means to shrink large ganglioneuromas prior to resection in order to reduce surgical morbidity.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 8,
August 3, 2020
Reviews & Opinions
People & Ideas
Stephanie Houston
Lessons of COVID-19: Virtual conferences
Tanya S. Freedman, Mark B. Headley, Nina Serwas, Megan Ruhland, Carlos A. Castellanos, Alexis J. Combes, Matthew F. Krummel
Matthew Krummel and colleagues discuss the positive trends and initiatives that emerged among scientists during the COVID-19 lockdown.
Björn E. Clausen
In dendritic cells, talin1 links integrin binding to efficient TLR downstream signaling through interaction with MyD88 and PIP5K.

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