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Newest Articles
Brief Definitive Report
Maria Shubina, Bart Tummers, David F. Boyd, Ting Zhang, Chaoran Yin, Avishekh Gautam, Xi-zhi J. Guo, Diego A. Rodriguez, William J. Kaiser, Peter Vogel, Douglas R. Green, Paul G. Thomas, Siddharth Balachandran
Necroptosis is considered a fail-safe death modality deployed when apoptosis pathways are compromised, but whether necroptosis can limit a virus in the absence of apoptosis is unknown. This study demonstrates that necroptosis drives highly effective antiviral immunity when apoptosis is absent.
Article
Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Yuki Sugiura, Tomofumi Miyamoto, Hiro Kohda, Ayaka Ito, Taiki Miyazawa, Akira Matsumoto, Seiichiro Aoe, Yoshihiro Miyamoto, Naotake Tsuboi, Shoichi Maruyama, Makoto Suematsu, Sho Yamasaki, Yoshihiro Ogawa, Takayoshi Suganami
This study demonstrates that β-glucosylceramide in combination with free cholesterol acts on Mincle as an endogenous ligand to induce cell death–triggered sustained inflammation after renal ischemia–reperfusion injury.
Article
Elaine Thai, Giulia Costa, Anna Weyrich, Rajagopal Murugan, David Oyen, Yevel Flores-Garcia, Katherine Prieto, Alexandre Bosch, Angelo Valleriani, Nicholas C. Wu, Tossapol Pholcharee, Stephen W. Scally, Ian A. Wilson, Hedda Wardemann, Jean-Philippe Julien, Elena A. Levashina
Molecular characterization of inhibitory and non-inhibitory antibodies contributes to vaccine design. Here, we show that the high-affinity mAb 5D5 against the PfCSP N-terminus of sporozoites does not inhibit Pf invasion. This information is critical for the prioritization of functional sites of vulnerability to include in next-generation malaria immunogen designs.
Brief Definitive Report
Matteo Donadon, Guido Torzilli, Nina Cortese, Cristiana Soldani, Luca Di Tommaso, Barbara Franceschini, Roberta Carriero, Marialuisa Barbagallo, Alessandra Rigamonti, Achille Anselmo, Federico Simone Colombo, Giulia Maggi, Ana Lleo, Javier Cibella, Clelia Peano, Paolo Kunderfranco, Massimo Roncalli, Alberto Mantovani, Alberto Mantovani, Federica Marchesi, Federica Marchesi
Morphometric characterization of TAMs in human colorectal liver metastases captures individual populations, corresponding to single-cell clusters and associated with distinct clinical outcome and transcriptional profiles. Quantitative analysis of macrophage morphology can serve as a simple readout of functional diversity with prognostic significance.
Article
Grace J. Liu, Markus Jaritz, Miriam Wöhner, Benedikt Agerer, Andreas Bergthaler, Stephen G. Malin, Meinrad Busslinger
Due to cross-antagonism of the B cell factor Pax5 and plasma cell regulator Blimp1, it was hypothesized that plasma cells develop only upon Pax5 repression by Blimp1. Unexpectedly, Liu et al. show that ectopic Pax5 expression in plasma cells does not interfere with their development and function.
Article
Ruo-Yu Ma, Hui Zhang, Xue-Feng Li, Cheng-Bin Zhang, Cigdem Selli, Giulia Tagliavini, Alyson D. Lam, Sandrine Prost, Andrew H. Sims, Hai-Yan Hu, Tianlei Ying, Zhan Wang, Zhaoming Ye, Jeffrey W. Pollard, Bin-Zhi Qian
This study identifies a novel population of CD204+IL4R+ bone metastasis–associated macrophages (BoMAMs) in mouse models and patient samples. These BoMAMs, derived from CCR2-recruited monocytes but not from CD169+ resident macrophages, significantly promote metastatic outgrowth of breast cancer in vivo.
Brief Definitive Report
Carla Noemi Castro, Michelle Rosenzwajg, Raphael Carapito, Mohammad Shahrooei, Martina Konantz, Amjad Khan, Zhichao Miao, Miriam Groß, Thibaud Tranchant, Mirjana Radosavljevic, Nicodème Paul, Tristan Stemmelen, Fabien Pitoiset, Aurélie Hirschler, Benoit Nespola, Anne Molitor, Véronique Rolli, Angélique Pichot, Laura Eva Faletti, Bruno Rinaldi, Sylvie Friant, Mark Mednikov, Hatice Karauzum, M. Javad Aman, Christine Carapito, Claudia Lengerke, Vahid Ziaee, Wafaa Eyaid, Stephan Ehl, Fayhan Alroqi, Nima Parvaneh, Seiamak Bahram, Seiamak Bahram
Biallelic mutations in NCKAP1L, a regulator of the actin cytoskeleton, cause immunodeficiency, lymphoproliferation, and hyperinflammation with features of hemophagocytic lymphohistiocytosis. Impaired immune synapse formation, early T cell activation and leading edge formation, and defective neutrophil migration characterize this novel “actinopathy.”

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 8,
August 3, 2020
Reviews & Opinions
Insights
Davide F. Robbiani
The role of human potent neutralizing antibodies in the control of chronic HBV infection.
Insights
Michael S. Krangel
Vβ-to-DβJβ rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal Vβ recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.
People & Ideas
Stephanie Houston
Lessons of COVID-19: Virtual conferences

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