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Article
Tae Sung Kim et al.
Neutrophil extracellular traps and extracellular histones potentiate Th17 inflammation and bone destruction in animal models of periodontitis. Findings in patients with periodontitis provide human relevance and support further exploration of NET-mediated pathology in human disease.
Article
Hannah A. Pizzato et al.
Steady-state and emergency myelopoiesis require different rates of mature cell production to maintain or restore homeostasis. This study demonstrates that mitochondrial pyruvate is specifically required for steady-state but not emergency myelopoiesis. Reciprocally, glutaminolysis specifically promotes emergency but not steady-state myelopoiesis.
Article
Ainsley Lockhart et al.
Lockhart et al. demonstrate that exposure to food protein drives an antigen-specific CD4+ T cell response characterized at steady state by accumulation at the intestinal epithelium and tissue-specialized transcriptional imprinting. This process is disrupted upon either allergic sensitization or tolerance.
Article
Zachary C. Stensland et al.
The role of B cells in T1D remains poorly understood. We identified an activated B cell subset that is enriched in insulin reactivity and increased in the blood and pLN of T1D donors. This subset has capacity to secrete antibodies and potential to serve as APCs to T cells.
Article
Sheri A.C. McDowell et al.
Obesity is associated with enhanced breast cancer mortality, yet the mechanisms underlying this relationship remain poorly understood. McDowell et al. provide insight into the role of obesity on myeloid-driven cancer metastasis by identifying how monocyte development is skewed to promote prometastatic neutrophil effector functions.
Article
Wanlin Cui et al.
A novel ILC2 subset was identified in the mouse intestine that constitutively expresses IL-4. Although the absence of the gut microbiota had marginal effects, feeding mice with a vitamin B1-deficient diet compromised the number of intestinal IL-4+ ILC2s.
Article
You-Sheng Lin et al.
E3 ubiquitin ligase ZNRF1 is activated by c-Src kinase following TLR3 activation and, in turn, promotes TLR3 ubiquitination and trafficking to lysosomes for degradation. This leads to properly regulated interferon production and alveolar barrier repair to prevent secondary bacterial superinfection.
Issue Cover
Current Issue
Volume 220,
Issue 5,
1 May 2023
Reviews & Opinions
Review | Th2 responses
Imran Howell et al.
In this Review, we discuss the key features of type 2 inflammation in asthma, summarize the clinical trial evidence of monoclonal antibody asthma treatments, and explore future avenues for targeted asthma treatment.
Insights
Marcus Buggert
Stolley et al. discovered that the oral mucosa houses CD8+ CD103+ resident memory T cells, which are important for protecting against local viral infections in mice.
Review | Th2 responses
James A. Harker, Clare M. Lloyd
Harker and Lloyd review the multifaceted roles of Th2 cells in human asthma, highlighting their influence of tissue location and disease severity. They also explore how Th2 cells and their cytokines have been targeted for biologic therapies for asthma patients.

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