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Article
Meng-Yin Lin et al.
Cytokine release syndrome (CRS) is a significant side effect associated with chimeric antigen receptor (CAR)-T cell therapy for cancer. CAR-T cells engineered to secrete cytokine modulators can reduce CRS-related toxicity while simultaneously improving in vivo antitumor efficacy.
Article
Pauline Schmitt et al.
Schmitt, Duval, et al. show that TL1A is an epithelial cytokine that cooperates with IL-33 in the initiation of allergic airway inflammation. Similar to IL-33, TL1A functions as an alarmin important for early induction of IL-9high ILC2s after allergen exposure.
Article
Timothy Ting-Hsuan Wu et al.
SARS-CoV-2 cell tropism and infection cycle are defined at the cellular resolution by infection of healthy human lung tissue and single-cell profiling. Interstitial macrophages are a dominant target of viral takeover, inflammation, and destruction in COVID-19 initiation, and use DC-SIGN/CD209, but not ACE2, for entry.
Article
Michael E. Horesh et al.
Horesh et al. use forward and reverse genetics to identify four novel gain-of-function JAK1 mutations in 59 patients. These individuals present with autoimmunity, atopy, colitis, and/or dermatitis, suggestive of a novel syndrome termed JAK1-associated atopy colitis and/or dermatitis (JAACD).
Technical Advances and Resources
Francesca Lucibello et al.
The poor prognosis of M3 uveal melanomas generates a local adaptive immune response, which does not recirculate, while the better prognosis of SF3B1-mutated uveal melanomas induces a systemic immune response in the absence of a detectable local response.
Article
Guilhem Lalle et al.
CD4+ T cells exhibit pleiotropic roles in autoimmunity and cancer. Lalle et al. demonstrate that their function is selectively controlled by different NF-κB subunits depending on the disease context. This work unravels critical regulators of T cell function and paves the way toward NF-κB subunit–targeted immunotherapies.
Article
Antoine Guérin et al.
This study describes clinical features and cellular and molecular mechanisms underlying immune deficiency in seven patients with biallelic germline variants in CD4. The data reveal important roles for CD4 in host defense against a range of pathogens, particularly human papilloma virus.
Issue Cover
Current Issue
Volume 221,
Issue 4,
1 April 2024
Reviews & Opinions
Perspective
Aakanksha Jain et al.
Immune cells instruct the development and persistence of adaptive and maladaptive pain states by modifying neural activity in the end organs, nerves, dorsal root ganglia, spinal cord, and brain, therefore opening the neuroimmune axis as a target to treat pain.
Viewpoint
Yuan Pan, Jian Hu
The cognitive side effects of cancer treatment are common. Jian Hu and Yuan Pan explore the role of hormones as mediators between cancer therapy and cognitive impairment, discussing potential future directions.
Insights
Silvia Pires, Randy S. Longman
In this issue, Schmitt et al. identify TNF-like protein 1A (TL1A) as an epithelial alarmin constitutively expressed by a subset of lung epithelial cells, which is released in response to airborne microbial challenge and synergizes with IL-33 to drive allergic disease.

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