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Takao Sudo, Yasutaka Motomura, Daisuke Okuzaki, Tetsuo Hasegawa, Takafumi Yokota, Junichi Kikuta, Tomoka Ao, Hiroki Mizuno, Takahiro Matsui, Daisuke Motooka, Ryosuke Yoshizawa, Takashi Nagasawa, Yuzuru Kanakura, Kazuyo Moro, Masaru Ishii
Sudo et al. demonstrate that group 2 innate lymphoid cells (ILC2s) in the bone marrow become activated following chemotherapy-induced stress and support hematopoietic recovery by producing GM-CSF. Adoptive transfer of ILC2s has therapeutic potential for myelosuppressive conditions.
Christopher D. Thouvenel, Mary F. Fontana, Jason Netland, Akshay T. Krishnamurty, Kennidy K. Takehara, Yu Chen, Suruchi Singh, Kazutoyo Miura, Gladys J. Keitany, Eric M. Lynch, Silvia Portugal, Marcos C. Miranda, Neil P. King, Justin M. Kollman, Peter D. Crompton, Carole A. Long, Marie Pancera, David J. Rawlings, Marion Pepper
Thouvenel et al. isolate BCR sequences from Plasmodium-specific IgM+ human memory B cells, expressing them as both IgM and IgG molecules. Multimerization confers superior antigen binding and parasite restriction, highlighting an important role for memory B cell–derived IgM in immunity.
Marcel S. Woo, Friederike Ufer, Nicola Rothammer, Giovanni Di Liberto, Lars Binkle, Undine Haferkamp, Jana K. Sonner, Jan Broder Engler, Sönke Hornig, Simone Bauer, Ingrid Wagner, Kristof Egervari, Jacob Raber, Robert M. Duvoisin, Ole Pless, Doron Merkler, Manuel A. Friese
Systematic analysis of the neuronal receptor interactome in multiple sclerosis brains reveals the metabotropic glutamate receptor 8 as a disbalanced hub. Its activation constitutes a novel treatment strategy to enhance neuronal resilience by inhibiting pathological calcium overload in inflammation-induced neurodegeneration.
Christine S. Hopp, Padmapriya Sekar, Ababacar Diouf, Kazutoyo Miura, Kristin Boswell, Jeff Skinner, Christopher M. Tipton, Mary E. Peterson, Michael J. Chambers, Sarah Andrews, Jinghua Lu, Joshua Tan, Shanping Li, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Silvia Portugal, Peter D. Sun, Carole Long, Richard A. Koup, Eric O. Long, Adrian B. McDermott, Peter D. Crompton
The role of IgM in human malaria is unclear. In a cohort study in Mali, Hopp et al. find that malaria-specific memory B cells are disproportionally IgM in children, are activated during acute malaria, and produce IgM that inhibits malaria parasite growth.
Hana Starobova, Mercedes Monteleone, Christelle Adolphe, Lena Batoon, Cheyenne J. Sandrock, Bryan Tay, Jennifer R. Deuis, Alexandra V. Smith, Alexander Mueller, Evelyn Israel Nadar, Grace Pamo Lawrence, Amanda Mayor, Elissa Tolson, Jean-Pierre Levesque, Allison R. Pettit, Brandon J. Wainwright, Kate Schroder, Irina Vetter
Starobova et al. demonstrate that vincristine-induced peripheral neuropathy (VIPN) is driven by activation of the NLRP3 inflammasome and release of IL-1β. Moreover, inhibition of NLRP3-mediated IL-1β release prevents VIPN in a murine model without affecting chemotherapy efficacy.
Kristen E. Pauken, Osmaan Shahid, Kaitlyn A. Lagattuta, Kelly M. Mahuron, Jacob M. Luber, Margaret M. Lowe, Linglin Huang, Conor Delaney, Jaclyn M. Long, Megan E. Fung, Kathleen Newcomer, Katy K. Tsai, Melissa Chow, Samantha Guinn, Juhi R. Kuchroo, Kelly P. Burke, Jason M. Schenkel, Michael D. Rosenblum, Adil I. Daud, Arlene H. Sharpe, Meromit Singer
Using single-cell RNA sequencing and TCR sequencing, Pauken et al. detect CD8+ T cell clones shared between blood and tumor in mice or melanoma patients, characterize matching clones in blood and tumor, and identify potential biomarkers for their isolation in blood.
Brief Definitive Report
Liliana E. Lucca, Pierre-Paul Axisa, Benjamin Lu, Brian Harnett, Shlomit Jessel, Le Zhang, Khadir Raddassi, Lin Zhang, Kelly Olino, James Clune, Meromit Singer, Harriet M. Kluger, David A. Hafler
Combining transcriptomic and TCRαβ repertoire analysis of circulating and tumor-infiltrating CD8 T cells from patients with metastatic melanoma, Lucca et al. identify a blood-based population with effector properties that reflect those of clonally related tumor-resident T cells.

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