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Article
Marie Jeanpierre et al.
Exome sequencing in pediatric systemic lupus and Evans syndrome identified six novel monoallelic PTPN2 mutations, impairing its regulatory function. This caused T cell hyperproliferation and high inflammatory cytokines, highlighting the druggable JAK/STAT pathway’s importance in systemic autoimmunity.
Brief Definitive Report
Yi-Hao Chan et al.
Chan et al. report inherited DBR1 deficiency as a genetic etiology of isolated SARS-CoV-2 brainstem encephalitis. DBR1 I120T/I120T patient-specific hPSC-derived hindbrain neurons display enhanced accumulation of RNA lariats resulting in increased susceptibility to SARS-CoV-2 infection, thereby underlying SARS-CoV-2 brainstem encephalitis.
Article
Sonja Fernbach et al.
Rare autoantibodies neutralizing type I IFNs can underlie viral disease severity. Here, the authors dissect immunological and age-related factors associated with anti-IFN-I autoantibody development in individuals over a 35-year period and further reveal the lifelong infection susceptibility that results.
Article
Erika Valeri et al.
Valeri et al. identify a novel STING variant (F269S) that causes SAVI disease. They highlight the activation of interferon and inflammation across patient cell types and underscore the importance of the crosstalk between endothelial and immune cells in disease pathology.
Article
Timothy A. Watkins et al.
Children being tested for SARS-CoV-2 show heightened nasal innate immune responses compared with adults. Here, comprehensive PCR testing and cytokine profiling reveal that nasal respiratory viruses and bacterial pathobionts are highly prevalent in children and drive heightened nasal innate immunity.
Article
Katherine M. McIntire et al.
This study analyzes persistent germinal center (GC) reactions in two individuals vaccinated with the inactivated, cell line–derived seasonal influenza vaccine. These sustained GC reactions support the maturation of responding B cells by enhancing their binding affinity and breadth.
Article
Minghong He et al.
Although considered as a master transcription factor controlling Treg fate and function statically, He et al. report that Foxp3 dynamically binds to chromatin via other DNA-binding proteins, acting like a transcriptional cofactor sensing immunological contexts to tune Treg function.
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Current Issue
Volume 221,
Issue 7,
1 July 2024
Reviews & Opinions
Insights
Joshua M. Tobin, Megan A. Cooper
Identification of monogenic causes of immune dysregulation provides insight into human immune response and signaling pathways associated with autoimmunity. Jeanpierre et al. identify new germline variants in the gene encoding PTPN2 associated with loss of regulatory function, enhanced JAK/STAT signaling, and early-onset autoimmunity.
Insights
Mandy J. McGeachy
In a model of periodontitis, McClure et al. describe location-dependent divergence in Th17 plasticity, with surprisingly limited conversion in inflamed gingiva but emergence of protective exTh17-TfH cells in draining LN that enhance anti-microbial antibody.
Review | Thymus and T Cell Development Focus
Isabel Baldwin, Ellen A. Robey
This review covers recent advances in our understanding of how developing T cells sense and adjust to their self-reactivity and how this impacts their decision to become a CD8 T cell, a CD4 T cell, or a regulatory T cell.

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