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Article
Chengsan Sun et al.
Microglia aid in refining central gustatory circuits during normal postnatal development. This process is arrested by merely restricting the mother’s dietary sodium during a limited, early prenatal period when microglia progenitors migrate from the yolk sac to the brain.
Article
Farhad Farjood et al.
This study characterizes an adult retinal pigment epithelial stem cell–derived cell product through transplantation in RCS rats and bulk and single-cell RNA sequencing, identifying distinct subpopulations and a predictive lncRNA marker (TREX) affecting cell integration and vision rescue in rats.
Article
Sarah Gruenbacher et al.
In vivo deletion in the mouse reveals an essential role of the Pax5 C-terminal domain in B cell commitment and development by activating or repressing most Pax5 target genes. This domain induces chromatin changes by interacting with chromatin-remodeling and histone-modifying complexes.
Article
Michiko Itoh et al.
Lysosomal cholesterol overload triggers phenotypic changes and profibrotic activation of macrophages around dead hepatocytes containing cholesterol crystals in the development of NASH. Cholesterol excretion from macrophages using β-cyclodextrin polyrotaxane, which is designed to release β-cyclodextrin in lysosomes, alleviates liver fibrosis.
Article
Charles Bayard et al.
In this study, we have discovered that hemifacial myohyperplasia results from a somatic gain-of-function mutation in PI3KCA. Using a new mouse model, we investigated the underlying mechanisms and demonstrated that alpelisib, a pharmacological inhibitor, significantly enhances both the preclinical model and patients.
Article
Lisa Sandner et al.
Sandner et al. uncover a key role for the guanine nucleotide exchange factor Rinl in restraining Tfh differentiation via CD28 signaling in homeostasis, immunization models, virus infection, and aging in mice, and in cultures of human CD4+ T cells.
Article
Sytse J. Piersma et al.
Piersma et al. identify a crucial role for posttranscriptional regulation by HuR in NK cell proliferation. This study reveals that HuR-dependent NK cell expansion is required for control of long-term virus infection and solid tumors without affecting acute infection or tumor metastases.
Issue Cover
Current Issue
Volume 220,
Issue 9,
4 September 2023
Reviews & Opinions
Insights
Shiv Pillai
In this issue of JEM, the work of Joachim et al. (2023) on knockin mice with a specific tail mutation in LAT provides valuable insights about cytotoxic CD4+ T cells and human inflammatory diseases.
Viewpoint
Lucie Van Emmenis
In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher. As well as being able to celebrate the positives of becoming an independent researcher, we would also like to use this platform to discuss the unique challenges they face as women scientists in their respective scientific environments.
People & Ideas
Lucie Van Emmenis
Nina Cabezas Wallscheid is a group leader at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany. Taking a multidisciplinary approach, her lab investigates the mechanisms by which metabolites regulate the epigenetic and metabolic state of hematopoietic stem cell fate in young and upon aging, with the aim to identify therapeutic strategies for nutritional and hematological diseases.

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Our annual series highlighting some of the research articles that were of greatest interest to our readers in 2022.

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