Inhibition of CDK4/6 and lysosome function overcomes c-MYC–mediated cell cycle entry in the face of trametinib and chloroquine co-treatment in pancreatic cancer.

Collaboration between myeloid and lymphoid lineages on hematopoiesis has not been fully elucidated. Here, we showed that during systemic infection, a unique B cell subset expressing myeloid markers emerged to enhance on-demand emergency myelopoiesis by producing IL-10.

Tingible body macrophages (TBMs) were discovered more than 100 yr ago, yet their origins and cellular dynamics were unknown. Gurwicz et al. demonstrate that TBMs arise from lymph node–resident precursors and consume germinal center B cells by highly dynamic dendrites to prevent intracellular-content dissemination.

Sun et al. found that STAT3, activated by IL-10 and IL-21, regulates the terminal differentiation of effector CD8⁺ T cells in cancer and also plays an important role in effector CD8⁺ T cells in acute infection.

Petkova et al. identify a new Ptx3-positive immune-interacting subtype of lymphatic endothelial cells, iLECs, that drive oncogenic PI3K-driven lymphatic malformations. These cells produce chemokines that recruit pro-lymphangiogenic macrophages, which in turn promote pathological lymphatic vessel growth.

The authors use single-cell RNA-sequencing and TCR tracking to analyze blood and tumors from breast and ovarian cancer patients treated with PD-1 blockade and CDK4/6 inhibition. They find that both therapies are immunologically active and enhance T cell effector function and memory, respectively.

The WNK1 kinase is essential in B cells for T-dependent antibody responses because it is activated by signaling from BCR, CXCR5, and CD40, and regulates B cell migration, adhesion, T-dependent activation, and differentiation into germinal center B cells and plasma cells.