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Article

| July 01 2022

Meningeal lymphatic drainage in mice and humans

Laurent Jacob, Jose de Brito Neto, Stephanie Lenck, Celine Corcy, Farhat Benbelkacem, Luiz Henrique Geraldo, Yunling Xu, Jean-Mickael Thomas, Marie-Renee El Kamouh, Myriam Spajer, Marie-Claude Potier, Stephane Haik, Michel Kalamarides, Bruno Stankoff, Stephane Lehericy, Anne Eichmann, Jean-Leon Thomas

The present study characterizes the 3D anatomy of meningeal lymphatic vasculature and associated CSF drainage by postmortem light-sheet imaging in mice and by real-time magnetic resonance imaging in humans, demonstrating conserved lymphatic circuitries in contact with dural venous sinuses.

Article

| July 01 2022

Human B cell responses to Ad26.COV2.S vaccination

Alice Cho, Frauke Muecksch, Zijun Wang, Tarek Ben Tanfous, Justin DaSilva, Raphael Raspe, Brianna Johnson, Eva Bednarski, Victor Ramos, Dennis Schaefer-Babajew, Irina Shimeliovich, Juan P. Dizon, Kai-Hui Yao, Fabian Schmidt, Katrina G. Millard, Martina Turroja, Mila Jankovic, Thiago Y. Oliveira, Anna Gazumyan, Christian Gaebler, Marina Caskey, Theodora Hatziioannou, Paul D. Bieniasz, Michel C. Nussenzweig

Cho et al. describe the antibody immune response after a single dose of the Ad26.COV2.S vaccine compared with mRNA vaccines. They find that Ad26.COV2.S vaccination produces fewer memory B cells but with a potency and breadth comparable to those found after mRNA vaccination.

Article

| June 29 2022

Phostensin enables population of lymphoid organs

Ho-Sup Lee, Hao Sun, Frédéric Lagarrigue, Sarah Hyun Ji Kim, Jay W. Fox, Nicholas E. Sherman, Alexandre R. Gingras, Mark H. Ginsberg

Phostensin, a protein phosphatase 1 regulatory subunit, supports lymphocyte integrin-dependent functions by mediating dephosphorylation of Rap1 to stabilize the MIT complex, thereby enabling the population of peripheral lymphoid organs and T cell–mediated colitis.

Article

| June 27 2022

IL-12–mediated human NK cell memory-like expansion

Avishai Shemesh, Harry Pickering, Kole T. Roybal, Lewis L. Lanier

Low IL-12 concentrations are sufficient to induce expansion of human NK cells by innate-activating NK receptor-orchestrated differential IL-12 signaling.

Technical Advances and Resources

| June 23 2022

Antimalarial antibodies with enhanced protection

Bailey B. Banach, Prabhanshu Tripathi, Lais Da Silva Pereira, Jason Gorman, Thuy Duong Nguyen, Marlon Dillon, Ahmed S. Fahad, Patience K. Kiyuka, Bharat Madan, Jacy R. Wolfe, Brian Bonilla, Barbara Flynn, Joseph R. Francica, Nicholas K. Hurlburt, Neville K. Kisalu, Tracy Liu, Li Ou, Reda Rawi, Arne Schön, Chen-Hsiang Shen, I-Ting Teng, Baoshan Zhang, Marie Pancera, Azza H. Idris, Robert A. Seder, Peter D. Kwong, Brandon J. DeKosky

This study applied innovative antibody screening technologies to discover antimalarial antibody variants with enhanced protective potency. Study authors applied precision DNA library generation, high-throughput screening, and analysis of next generation sequencing data to identify mutations that improved malaria protection following in vivo infectious challenge.

Brief Definitive Report

| June 16 2022

Type I IFN defect in children with COVID pneumonia

Qian Zhang, Daniela Matuozzo et al.

In an international cohort of 112 children hospitalized for moderate to critical COVID-19 pneumonia, we identified 12 children with one of four known recessive inborn errors of type I interferon immunity: X-linked TLR7 and autosomal IFNAR1, STAT2, and TYK2 deficiencies.

Article

| June 15 2022

MPS IIIC knock-in mice respond to glucosamine

Xuefang Pan, Mahsa Taherzadeh, Poulomee Bose, Rachel Heon-Roberts, Annie L.A. Nguyen, TianMeng Xu, Camila Pará, Yojiro Yamanaka, David A. Priestman, Frances M. Platt, Shaukat Khan, Nidhi Fnu, Shunji Tomatsu, Carlos R. Morales, Alexey V. Pshezhetsky

The study demonstrates that dominant-negative effects of the misfolded HGSNAT variant in the mouse model of mucopolysaccharidosis IIIC are treatable by glucosamine. This suggests that patients affected with mutations causing the enzyme misfolding can potentially benefit from chaperone therapy.

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Volume 219,

Issue 7,

4 July 2022

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Insights

| July 05 2022

Charting the meningeal lymphatic network

Sandro Da Mesquita

In this issue, Jacob et al. employ imaging techniques to provide a more comprehensive chart of the meningeal lymphatic vasculature and draw a parallel for lymphatic drainage of cerebrospinal fluid in mice and humans.

Perspective

| June 22 2022

Dense-core plaques are granulomas

Greg Lemke, Youtong Huang

Microglia, the tissue macrophages of the central nervous system, use phagocytosis of loosely organized amyloid beta (Aβ) to construct dense-core plaques, one of the defining histopathological features of Alzheimer’s disease. The biology of this process parallels macrophage construction of granulomas in tuberculosis and other settings.

Insights

| May 27 2022

Fueling the fire in the gut

Chia-Hao Lin, Li-Fan Lu

Gut dysbiosis has long been associated with the development of Crohn's disease and other gastrointestinal disorders. Otake-Kasamoto et al. report that dysbiotic microbiota–derived bioactive lipids, lysophosphatidylserines, can promote pathological Th1 cell responses through inducing metabolic reprogramming and epigenetic changes.

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The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

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