Journal of Experimental Medicine (JEM) | Rockefeller University Press

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Cholesterol overload to macrophages promotes NASH.
New CME activity on First-in-human therapy with Treg produced from thymic tissue in a heart transplant infant. Learn more.
IL-22 Suppresses MHC II in Epithelial Cells.

Newest Articles

Article

| November 14 2023

Partial LCK defect and CID with autoimmunity

Victor G. Lui et al.

Lui et al. describe a human LCK variant causing partial loss-of-function (LOF), including defective TCR signaling and T cell development. Using mouse models, they show that while complete LCK LOF results in SCID, partial LCK LOF causes CID with autoimmunity.

Article

| November 08 2023

Affinity-based selection of plasma cells

Mohamed A. ElTanbouly et al.

We show in polyclonal settings that GC B cell differentiation into plasma cells is affinity dependent, resulting in the generation of high-affinity serum responses. We profile GC cells poised for PC differentiation compared with GC B cells selected for further affinity maturation.

Article

| November 07 2023

ARL6IP1 is therapeutic target for HSP disease

Jung Hwa Lim et al.

We established an Arl6ip1^−/− mouse model mimicking HSP with severe spastic paralysis and gait abnormalities. Neuroinflammation was identified as a key pathophysiological change. AAV9-ARL6IP1 delivery reduced limb paraplegia and gait abnormality, making ARL6IP1 a potential target for HSP gene therapy.

Article

| November 06 2023

PAX5::ELN reprograms B-progenitors into pre-LSCs

Vincent Fregona et al.

The work demonstrates that a primary oncogene of B-ALL (i.e., PAX5-ELN) confers stem cell–like features to a subset of committed B cell progenitors, converting them to quiescent/resistant pre-LSCs. Moreover, EGR1 represents a strong candidate to control the quiescence/resistance of murine pre-LSCs and of blasts from patients.

Article

| November 01 2023

Lasting Flt3⁺ MPP activity in native hematopoiesis

Michael Solomon et al.

Solomon et al. establish that the Flt3⁺ multipotent progenitor (MPP4) compartment contains a quiescent/slow-cycling cell subpopulation, which has a prolonged in vivo hematopoietic potential and which constitutes a key transitional cell population between the hematopoietic stem cell and the lineage-biased MPP compartments.

Brief Definitive Report

| October 31 2023

First administration of thyTreg in a transplanted infant

Esther Bernaldo-de-Quirós et al.

The authors describe the first patient treated with a new cell therapy consisting of Tregs purified from pediatric thymus (thyTreg). 2 years after thyTreg administration in a heart-transplant child, no adverse effects have been reported and the peripheral Treg pool is preserved.

Article

| October 30 2023

STIM regulates the maintenance and selection of GC B cells

Yutaro Yada et al.

STIM-dependent calcium signaling after antigen recognition promotes GC B cell survival, leading to the maintenance and selection of high-affinity B cells during the GC reaction.

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Current Issue

Volume 220,

Issue 11,

6 November 2023

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Reviews & Opinions

Review

| December 01 2023

FRCs in health and disease

Angelina De Martin et al.

Lymphoid organ fibroblasts, known as fibroblastic reticular cells (FRCs), generate specialized niches in the tissue and coordinate immune cell interactions. De Martin and colleagues discuss basic concepts of FRC biology and how FRCs determine activation or attenuation of immune responses.

Found in Translation

| November 30 2023

Immunopeptidomics

Saketh Kapoor et al.

Étienne Caron and colleagues discuss how immunopeptidomics and other peptide sequencing technologies could revolutionize the research for vaccine development, cancer immunotherapy, and treatment of neurodegenerative diseases and aging.

Viewpoint

| November 17 2023

Women in STEM becoming independent: Science thrives on diverse perspectives

Lucie Van Emmenis

In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher. As well as being able to celebrate the positives of becoming an independent researcher, we would also like to use this platform to discuss the unique challenges they face as women scientists in their respective scientific environments.

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Special Collections

The Year in Experimental Medicine

Our annual series highlighting some of the research articles that were of greatest interest to our readers in 2022.

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Cholesterol overload to macrophages promotes NASH.

New CME activity on First-in-human therapy with Treg produced from thymic tissue in a heart transplant infant. Learn more.

IL-22 Suppresses MHC II in Epithelial Cells.

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Special Collections

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