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Technical Advances and Resources
Maryam Ghaedi, Zi Yi Shen, Mona Orangi, Itziar Martinez-Gonzalez, Lisa Wei, Xiaoxiao Lu, Arundhoti Das, Alireza Heravi-Moussavi, Marco A. Marra, Avinash Bhandoola, Fumio Takei
Ghaedi et al. identify IL-18R+IL-33R− ILC progenitors, which differentiate into multiple ILC lineages, in the lung of neonatal and adult RORα lineage tracer mice. ILC2s in neonatal mouse lungs are divided into distinct cytokine and amphiregulin-producing effector ILC2s.
Article
Subhankar Mukhopadhyay, Eva Heinz, Immacolata Porreca, Kaur Alasoo, Amy Yeung, Huei-Ting Yang, Tobias Schwerd, Jessica L. Forbester, Christine Hale, Chukwuma A. Agu, Yoon Ha Choi, Julia Rodrigues, Melania Capitani, Luke Jostins-Dean, David C. Thomas, Simon Travis, Daniel Gaffney, William C. Skarnes, Nicholas Thomson, Holm H. Uhlig, Gordon Dougan, Fiona Powrie
Cytokines and lipid mediators are key regulators of inflammation; but how they are mechanistically linked is poorly understood. Here, Mukhopadhyay et al. show a novel regulation between cytokine IL-10 and lipid mediator PGE2 that functionally connects them to intestinal inflammation.
Article
Paola Tieppo, Maria Papadopoulou, Deborah Gatti, Naomi McGovern, Jerry K.Y. Chan, Françoise Gosselin, Glenn Goetgeluk, Karin Weening, Ling Ma, Nicolas Dauby, Alexandra Cogan, Catherine Donner, Florent Ginhoux, Bart Vandekerckhove, David Vermijlen
Tieppo et al. show that the human fetal thymus generates invariant γδ T cells with programmed effector functions. This is due to an intrinsic property of fetal HSPCs caused by high expression of the RNA-binding protein Lin28b.
Article
Yirong Wang, Siqi Wu, Xun Zhu, Liyuan Zhang, Jieqiong Deng, Fang Li, Binbin Guo, Shenghua Zhang, Rui Wu, Zheng Zhang, Kexin Wang, Jiachun Lu, Yifeng Zhou
In this study, Wang et al. demonstrate that lncRNA-encoded polypeptide ASRPS is down-regulated in TNBC. ASRPS regulates angiogenesis and may serve as a novel prognostic marker and therapeutic target for TNBC.
Article
Hector Huerga Encabo, Laia Traveset, Jordi Argilaguet, Ana Angulo, Estanislao Nistal-Villán, Rahul Jaiswal, Carlos R. Escalante, Christos Gekas, Andreas Meyerhans, Jose Aramburu, Cristina López-Rodríguez
Huerga Encabo et al. show that NFAT5, previously characterized as a pro-inflammatory transcription factor, limits the IFN-I response to control antiviral defenses and preserve HSC quiescence. NFAT5 represses IFN-I and ISG expression through an evolutionarily conserved DNA element that prevents IRF3 recruitment to the IFNB1 enhanceosome.
Article
Tingting Weng, Jingjing Huang, Eric J. Wagner, Junsuk Ko, Minghua Wu, Nancy E. Wareing, Yu Xiang, Ning-Yuan Chen, Ping Ji, Jose G. Molina, Kelly A. Volcik, Leng Han, Maureen D. Mayes, Michael R. Blackburn, Shervin Assassi
This study implicates the key regulator of alternative polyadenylation, CFIm25 in dermal fibrosis and in systemic sclerosis (scleroderma) pathogenesis. CFIm25 downregulation promotes the expression of profibrotic factors, exaggerates bleomycin-induced skin fibrosis, while CFIm25 restoration attenuates skin fibrosis.
Article
Haiyan Zhao, Lily Xu, Robin Bombardi, Rachel Nargi, Zengqin Deng, John M. Errico, Christopher A. Nelson, Kimberly A. Dowd, Theodore C. Pierson, James E. Crowe, Jr., Michael S. Diamond, Daved H. Fremont
Evaluation of the human antibody response to Zika virus has identified common germline-derived mAbs capable of cross flavivirus neutralization. Zhao et al. provide a detailed mechanistic understanding of how flavivirus infections are prevented in a strain-specific manner by a representative mAb.

Related Articles from Rockefeller University Press

  • Conservation of cell-intrinsic immune responses in diverse nonhuman primate species

    The transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.

  • Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis

    Enhanced carbonyl stress results in neurodevelopmental deficits by affecting microtubule function through the formation of irreversible dysfunctional multimer of carbonylated CRMP2.

  • Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness

    IFNγ is shown to silence Ifngr1 transcription by altering enhancer occupancy, reducing myeloid cell IFNGR1 as a feedback mechanism to attenuate macrophage responses associated with inflammation.

  • PHLPP2 promotes prostate cancer progression

    Nowak et al. show that loss of the AKT-inactivating phosphatase PHLPP2 paradoxically blocks prostate tumor growth and metastasis. PHLPP2, they find, is critical for MYC stability, suggesting that PHLPP2 inhibitors may present a therapeutic opportunity to target MYC.

  • The RIPK3-MLKL pathway attacks cytosolic Listeria

    The RIPK3-MLKL pathway protects epithelial cells from Listeria monocytogenes invasion. Sai et al. find that Listeria infection activates MLKL but does not induce its oligomerization or necroptotic cell death. Instead, Listeria-activated MLKL directly targets intracellular bacteria and suppresses their replication

  • Ral GTPases promote axonal sorting

    Schwann cell–resident Ral GTPases foster radial sorting of axons in developing peripheral nerves and are involved in exocyst-dependent control of Schwann cell process extensions.

Current Issue
Volume 216,
Issue 12,
December 2, 2019
Reviews & Opinions
Cytokines Focus
Hung-Jen Chen, Sander W. Tas, Menno P.J. de Winther
Chen et al. review the effects of type-I IFNs and the potential of anti–type-I IFN therapies in atherosclerosis.
Cytokines Focus
Stuart G. Tangye, Cindy S. Ma
Here we review the critical and non-redundant functions of IL-21 in regulating humoral immune responses. We particularly focus on studies in natura—from individuals from inborn errors of immunity that impact on IL-21 production and/or function.
Cytokines Focus
Thomas A. Waldmann, Milos D. Miljkovic, Kevin C. Conlon
IL-15 supports NK, NK-T, γδ, ILC1, and memory CD8 T cell function, and dysregulated IL-15 is associated with many autoimmune diseases. Striking IL-15–driven increases in NK and CD8 T cells in patients highlight the potential for combination therapy of cancers.

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