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Article
Ryota Sato et al.
Sato et al. report that the lack of RNase T2 activates TLR13, the sensor of bacterial 23S ribosomal RNAs, leading to the accumulation of tissue-protective Kupffer cells. Consequently, Rnaset2−/− mice are resistant against acute liver injury caused by acetaminophen.
Brief Definitive Report
Carlos Gomez-Diaz et al.
Mice lacking RNase T2 display an inflammatory phenotype in vivo in a TLR13-dependent manner, which is also observed under germ-free conditions. This suggests that RNase T2 plays an important role in limiting self-RNA recognition by preventing erroneous activation of TLR13.
Article
Ying He et al.
This study identifies the PTPN23-PI3KC2α-AKT2 signaling axis as a critical pathway in BRAF-mutant cancers. Pharmacological targeting of this axis selectively kills BRAF-mutant tumor cells, offering a promising therapeutic strategy for treating BRAF-mutant cancers.
Brief Definitive Report
Amir Ferry et al.
Differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. Modulation of the XCL1–XCR1 chemokine axis influences intestinal tissue residency and antitumor immunity.
Article
Zhe Chen et al.
Chen et al. report that DEK accumulates in Fancd2−/− HSCs and CD34+ cells from patients with Fanconi anemia, causing chromatin relaxation failure under replication stress. Inhibition of DEK promotes function recovery of Fancd2−/− HSCs, suggesting DEK as a potential target.
Article
Wael Awad et al.
Cigarette smoke is a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms, impacting their ability to respond to respiratory infections and potentially contributing to disease.
Article
Quentin Riller et al.
IKKα kinase deficiency causes syndromic immunodeficiency and immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway as well as a partial defect in the canonical NF-κB pathway.
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Current Issue
Volume 222,
Issue 1,
6 January 2025
Reviews & Opinions
Insights
Nikhil Jiwrajka, Montserrat C. Anguera
Systemic sclerosis (SSc) is a debilitating autoimmune disease that preferentially afflicts women. The molecular origins of this female bias are unclear. A new study of plasmacytoid dendritic cells from SSc patients by Du et al. suggests the X chromosome may play a key role.
Insights
Jacob A. Myers et al.
Sparano et al. show that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. In these environments, TGF-β1, IL-15, and other factors collaboratively induce a Hobit-dependent cytotoxicity program. In the salivary glands, trNK cells limit murine cytomegalovirus persistence.
Insights
Mitchell Kronenberg, Gabriel Ascui
In this issue, Hosono and co-workers characterize a putative self-glycolipid that engages the iNKT cell TCR when bound to CD1d. The expression and distribution of this compound help to explain some of the unusual properties of invariant NKT cells.

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