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Technical Advances and Resources
Raphaël Jeger-Madiot et al.
We developed a lymphoid organ-chip that models human recall responses to vaccination. This microfluidic-based system recapitulates antigen capture/expression, CD4+ T cell/B cell clustering, memory B cell amplification, plasmablast differentiation, and antibody secretion in response to perfused proteins or mRNA vaccines.
Technical Advances and Resources
William O. Hahn et al.
Hahn et al., present data from a first-in-human HIV vaccine trial with a novel TLR-7/8-signaling adjuvant (3M-052AF/Alum). The vaccine appears safe and is the first vaccine reported to induce serum antibodies that neutralize non-lab-adapted HIV strains matched to the vaccine.
Article
Ana Portelinha et al.
SETD1B (KMT2G) is a histone H3K4 trimethyl transferase and a mutational target in lymphoma. SETD1B inactivation disables critical cell death programs and causes Venetoclax resistance. Inhibition of the corresponding histone demethylase KDM5 restores cell death and Venetoclax sensitivity.
Article
Anne Doye et al.
This study shows NLRP3 inflammasome activation in circulating myeloid cells by human RAC2 gain-of-function variants that are linked to rare immune disorders. This work unravels a RAC2–PAK1–NLRP3 signaling axis as a potential drug target to treat patients.
Article
Apostolia M. Tsimberidou et al.
The AMADEUS trial reveals key biomarkers in blood and tumor tissue that could predict patient response to immunotherapy, offering a potential breakthrough for treating various solid tumors. This discovery addresses the pressing need for personalized cancer treatment strategies.
Article
Naijun Miao et al.
Miao et al. report that tumor cell–intrinsic mechanical force sensor, Piezo2, impedes stemness maintenance of CD8+ T cells by downregulating IL-15 production after radiotherapy, thereby leading to cancer radioresistance.
Article
Irem Kaymak et al.
How cell-intrinsic metabolism regulates T cell function to shape immune outcomes is unclear. Kaymak, Watson, and colleagues demonstrate production of cytosolic acetyl-CoA by ACLY and ACSS2 links CD8 T cell metabolic state and effector function through effects on chromatin accessibility.
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Current Issue
Volume 221,
Issue 9,
2 September 2024
Reviews & Opinions
Review | Thymus and T Cell Development Focus
Francesca Pala et al.
This review highlights how novel cutting-edge technologies, including high-resolution imaging, single-cell omics, and organoid cultures, have improved our understanding of human thymus biology, in terms of developmental trajectories, cellular heterogeneity, and spatial organization.
Review | Thymus and T Cell Development Focus
Boyoung Shin et al.
Multipotent blood progenitors begin T cell development in the thymus, activating a multistep gene regulatory network. This review explores how the dynamic interplay between Notch signals, Notch-induced factors, and progenitor-associated factors control T-development progression by synergizing and opposing each other’s action.
Review | Thymus and T Cell Development Focus
Wan-Lin Lo, Eric S. Huseby
TCR rearrangement endows the preselection thymocyte repertoire with wide-ranging ligand specificity. Here, we discuss how thymic selection matures or eliminates clonotypes with particular specificities and develops T cell sublineages and microrepertoires according to their antigen-recognition capabilities.

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Thymus and T Cell Development Focus
The partitioning of TCR repertoires by thymic selection

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