Journal of Experimental Medicine (JEM) | Rockefeller University Press

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Metabolism Signaling

A special collection of recent articles from JEM.
Neuroimmunology and Neurodegeneration 2023.
New CME activity

SARS-CoV-2 infection and recovery in children. Learn more.
JEM Immunology Collection 2023.
FN-γ signature-driven patient selection in DONIMI trial.

Newest Articles

Article

| June 05 2023

Dominant-negative mutations in human RELA

Kunihiko Moriya et al.

This report establishes a novel form of IEI due to DN RELA mutations as a cause of chronic mucocutaneous ulcerations with autoinflammatory and/or autoimmune manifestations. This also expands the clinical spectrum of human RELA-associated diseases.

Article

| June 01 2023

Neutrophil NETs jump-start periodontal inflammation

Tae Sung Kim et al.

Neutrophil extracellular traps and extracellular histones potentiate Th17 inflammation and bone destruction in animal models of periodontitis. Findings in patients with periodontitis provide human relevance and support further exploration of NET-mediated pathology in human disease.

Article

| May 30 2023

Metabolic requirements of myelopoiesis

Hannah A. Pizzato et al.

Steady-state and emergency myelopoiesis require different rates of mature cell production to maintain or restore homeostasis. This study demonstrates that mitochondrial pyruvate is specifically required for steady-state but not emergency myelopoiesis. Reciprocally, glutaminolysis specifically promotes emergency but not steady-state myelopoiesis.

Article

| May 16 2023

Dietary protein shapes intestinal CD4⁺ T cells

Ainsley Lockhart et al.

Lockhart et al. demonstrate that exposure to food protein drives an antigen-specific CD4⁺ T cell response characterized at steady state by accumulation at the intestinal epithelium and tissue-specialized transcriptional imprinting. This process is disrupted upon either allergic sensitization or tolerance.

Article

| May 15 2023

Activation of anergic B cells in young-onset T1D

Zachary C. Stensland et al.

The role of B cells in T1D remains poorly understood. We identified an activated B cell subset that is enriched in insulin reactivity and increased in the blood and pLN of T1D donors. This subset has capacity to secrete antibodies and potential to serve as APCs to T cells.

Article

| May 11 2023

Obesity alters monocyte states in cancer

Sheri A.C. McDowell et al.

Obesity is associated with enhanced breast cancer mortality, yet the mechanisms underlying this relationship remain poorly understood. McDowell et al. provide insight into the role of obesity on myeloid-driven cancer metastasis by identifying how monocyte development is skewed to promote prometastatic neutrophil effector functions.

Article

| May 10 2023

Novel IL-4⁺ ILC2 cells in intestinal homeostasis

Wanlin Cui et al.

A novel ILC2 subset was identified in the mouse intestine that constitutively expresses IL-4. Although the absence of the gut microbiota had marginal effects, feeding mice with a vitamin B1-deficient diet compromised the number of intestinal IL-4⁺ ILC2s.

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Current Issue

Volume 220,

Issue 6,

5 June 2023

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Reviews & Opinions

Review

| June 05 2023

Human B cells and IEI

Stuart G. Tangye et al.

The fundamental importance of the role of human B cells in host defense against infectious diseases has been established by the discovery of inborn errors of immunity that disrupt B cell development, differentiation, or function. These findings have laid the groundwork for understanding mechanisms of disease and revealing pathways to improve humoral immunity and treat disease.

Review | Th2 responses

| June 02 2023

Type 2 inflammation and biological therapies in asthma

Imran Howell et al.

In this Review, we discuss the key features of type 2 inflammation in asthma, summarize the clinical trial evidence of monoclonal antibody asthma treatments, and explore future avenues for targeted asthma treatment.

Insights

| May 15 2023

Guardians of the oral barriers

Marcus Buggert

Stolley et al. discovered that the oral mucosa houses CD8⁺ CD103⁺ resident memory T cells, which are important for protecting against local viral infections in mice.

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Special Collections

The Year in Experimental Medicine

Our annual series highlighting some of the research articles that were of greatest interest to our readers in 2022.

View all collections

A special collection of recent articles from JEM.

Neuroimmunology and Neurodegeneration 2023.

SARS-CoV-2 infection and recovery in children. Learn more.

JEM Immunology Collection 2023.

FN-γ signature-driven patient selection in DONIMI trial.

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