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RUP response to COVID-19 crisis: Learn about the steps we are taking and find relevant content.

We are hiring: Scientific Editor/Senior Scientific Editor, Journal of Experimental Medicine.

Newest Articles
Article
| September 24 2021
Featured Figure
CD47 blockade enhances anti-tumor effects of cGAMP
Akemi Kosaka, Kei Ishibashi, Toshihiro Nagato, Hidemitsu Kitamura, Yukio Fujiwara, Syunsuke Yasuda, Marino Nagata, Shohei Harabuchi, Ryusuke Hayashi, Yuki Yajima, Kenzo Ohara, Takumi Kumai, Naoko Aoki, Yoshihiro Komohara, Kensuke Oikawa, Yasuaki Harabuchi, Masahiro Kitada, Hiroya Kobayashi, Takayuki Ohkuri
Blockade of CD47 signaling enhances the anti-tumor effects of intratumoral STING stimulation by activating monocyte/macrophage phagocytosis and tumor-specific T cells. This combination therapy induces systemic anti-tumor immune responses, which rely on STING and type I IFN signaling.
Article
| September 23 2021
Featured Figure
BTK phosphorylates NLRP3, regulating its activity
Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N.R. Weber
Bittner et al. discovered that direct phosphorylation of the inflammasome sensor NLRP3, by the well-established drug target Bruton’s tyrosine kinase (BTK), promotes inflammasome assembly and boosts IL-1β release. NLRP3 phosphorylation by BTK may thus represent a novel target for therapeutic intervention in inflammation.
Brief Definitive Report
| September 23 2021
Featured Figure
Gut epithelial IL-27 promotes CD8αα + CD4 + IELs
Chia-Hao Lin, Mei-Chi Chen, Ling-Li Lin, David A. Christian, Booki Min, Christopher A. Hunter, Li-Fan Lu
IL-27 is a pleiotropic cytokine that plays important immunological roles in many disease settings. This study demonstrates that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 confers barrier immunity through promoting a distinct intraepithelial lymphocyte population.
Article
| September 21 2021
Featured Figure
Human monoclonal GABA A receptor antibodies
Jakob Kreye, Sukhvir K. Wright, Adriana van Casteren, Laura Stöffler, Marie-Luise Machule, S. Momsen Reincke, Marc Nikolaus, Scott van Hoof, Elisa Sanchez-Sendin, Marie A. Homeyer, César Cordero Gómez, Hans-Christian Kornau, Dietmar Schmitz, Angela M. Kaindl, Philipp Boehm-Sturm, Susanne Mueller, Max A. Wilson, Manoj A. Upadhya, Divya R. Dhangar, Stuart Greenhill, Gavin Woodhall, Paul Turko, Imre Vida, Craig C. Garner, Jonathan Wickel, Christian Geis, Yuko Fukata, Masaki Fukata, Harald Prüss
Kreye et al. report the isolation of human monoclonal GABAAR antibodies and demonstrate their direct pathogenicity in vitro and in vivo independent of Fc-mediated effector functions. These encephalitis patient-derived antibodies explain the clinical phenotype and can expedite the development of selective immunotherapies.
Brief Definitive Report
| September 21 2021
Featured Figure
Understanding SPG56 disease with Cyp2u1 −/− mice
Claire Pujol, Anne Legrand et al.
This study characterizes a Cyp2u1−/− mouse model and connects neurodevelopmental deficits to mitochondrial dysfunctions and folate, which could be prevented by folate supplementation in a mouse model. It also validates biochemical and imaging biomarkers in SPG56 patients, which are critical to allow drug development.
Article
| September 21 2021
Featured Figure
Novel roles for cGMP in gut inflammation
Vishwas Mishra, Avipsa Bose, Shashi Kiran, Sanghita Banerjee, Idrees A. Shah, Pooja Chaukimath, Mudasir M. Reshi, Swarna Srinivas, Anaxee Barman, Sandhya S. Visweswariah
A novel preclinical mouse model harboring an activating mutation in Gucy2c demonstrates features seen in patients with familial GUCY2C diarrhea syndrome. Fecal microbiome changes and colonic gene expression identify cell intrinsic and extrinsic roles of cGMP in gut inflammation.
Article
| September 17 2021
Featured Figure
TIMP1-dependent sex disparity in pancreatic cancer
Chris D. Hermann, Benjamin Schoeps, Celina Eckfeld, Enkhtsetseg Munkhbaatar, Lukas Kniep, Olga Prokopchuk, Nils Wirges, Katja Steiger, Daniel Häußler, Percy Knolle, Emily Poulton, Rama Khokha, Barbara T. Grünwald, Ihsan Ekin Demir, Achim Krüger
Hermann et al. reveal a lifestyle-independent sex disparity in liver metastasis and survival of pancreatic cancer caused by TIMP1. Increased TIMP1 expression in males predicts liver metastasis in various cancer entities. Such insight into the basis of sex differences substantiates the necessity of considering sex in cancer medicine.

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Volume 218,
Issue 9,
September 6, 2021
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Insights
| September 16 2021
Featured Figure
Dismantling the origin of mantle cell lymphoma
Anna E. Beaudin
Pieters et al. establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL.
Insights
| September 13 2021
Featured Figure
A new fungal antigen for Löfgren's syndrome
Clarice X. Lim, Thomas Weichhart
A peptide derived from the airborne mold species Aspergillus nidulans that stimulates T cells of Löfgren's syndrome patients has been identified.
Insights
| September 07 2021
Featured Figure
Alveolar macrophages and epithelial cells: The art of living together
Derek Clements, Juliana Idoyaga
In this issue of JEM, Gschwend et al. reveal the indispensable role of alveolar epithelial cells type 2 in controlling the density of alveolar macrophages. This study highlights the intricate crosstalk that lung stroma and macrophages undergo to maintain homeostasis.
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The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

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  • Online ISSN 1540-9538
  • Print ISSN 0022-1007
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