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Ensong Guo, Rourou Xiao, Yifan Wu, Funian Lu, Chen Liu, Bin Yang, Xi Li, Yu Fu, Zizhuo Wang, Yuan Li, Yuhan Huang, Fuxia Li, Xue Wu, Lixin You, Tianyu Qin, Yiling Lu, Xiaoyuan Huang, Ding Ma, Gordon B. Mills, Chaoyang Sun, Gang Chen
WEE1 inhibition modulates the efficacy of cancer immunotherapy by regulating dsRNA and interferon responses, which increases recruitment of anti-tumor T cells with concurrent PD-L1 elevation. This study provides a rationale for combination strategies between WEE1 inhibitors and anti–PD-L1 therapies.
Tomonori Kaifu, Rikio Yabe, Takumi Maruhashi, Soo-Hyun Chung, Hiroaki Tateno, Noriyuki Fujikado, Jun Hirabayashi, Yoichiro Iwakura
Asialo-biantennary N-glycan is identified as a ligand for the inhibitory C-type lectin receptor DCIR, which is important for the homeostasis of the immune and bone system. The interaction between DCIR and asialo-biantennary N-glycans negatively regulates antigen presentation by DCs and osteoclastogenesis.
Brief Definitive Report
Nouraiz Ahmed, Martin Etzrodt, Philip Dettinger, Tobias Kull, Dirk Loeffler, Philipp S. Hoppe, James S. Chavez, Yang Zhang, Germán Camargo Ortega, Oliver Hilsenbeck, Hideaki Nakajima, Eric M. Pietras, Timm Schroeder
By manipulating and quantifying the dynamics of PU.1 protein expression in live differentiating adult HSPCs in vitro, Ahmed et al. report that PU.1 upregulation is not caused by fast direct autoregulation but occurs as a later consequence of hematopoietic differentiation.
Bassem D. Khalil, Roberto Sanchez, Tasrina Rahman, Carolina Rodriguez-Tirado, Stefan Moritsch, Alba Rodriguez Martinez, Brett Miles, Eduardo Farias, Mihaly Mezei, Ana Rita Nobre, Deepak Singh, Nupura Kale, Karl Christoph Sproll, Maria Soledad Sosa, Julio A. Aguirre-Ghiso
Computational screening identifies a novel agonist for NR2F1, a master activator of cancer cell dormancy. Agonist-mediated activation of NR2F1 induces a novel long-lived dormancy program with neural crest-like features and prevents disseminated squamous carcinoma cancer cell progression to overt metastasis.
Takahiro Nakajima, Toshio Kanno, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Damon J. Tumes, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
The authors find that lung and skin pathogenic CD4+ T cells express high levels of ACC1. ACC1 controls the inflammatory function of the pathogenic CD4+ T cell population to promote type 2 inflammation in the lung and skin.
Chuan Li, Yee Peng Phoon, Keaton Karlinsey, Ye F. Tian, Samjhana Thapaliya, Angkana Thongkum, Lili Qu, Alyssa Joyce Matz, Mark Cameron, Cheryl Cameron, Antoine Menoret, Pauline Funchain, Jung-Min Song, C. Marcela Diaz-Montero, Banumathi Tamilselvan, Jackelyn B. Golden, Michael Cartwright, Annabelle Rodriguez, Christopher Bonin, Anthony Vella, Beiyan Zhou, Brian R. Gastman
Single-cell transcriptomics from paired autologous peripheral and tumor lymphocytes from melanoma patients reveal an understudied population of metabolically active, dysfunctional CD8 T cells. This subpopulation is associated with immunotherapy resistance and was leveraged to develop a therapeutic response predictive model.
Brief Definitive Report
Thomas Ciucci, Melanie S. Vacchio, Ting Chen, Jia Nie, Laura B. Chopp, Dorian B. McGavern, Michael C. Kelly, Rémy Bosselut
Single-cell RNA and ATAC sequencing identify transcriptomic and epigenomic features of acute- and memory-phase virus-responding CD4+ T cells and show that, unlike follicular helper T cells, memory CD4+ T cells develop despite lacking Bcl6 and Blimp1 transcription factors.

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