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Hematologic Malignancies 2021

A special collection of recent articles and reviews
Reversal of emphysema by endothelial cell infusion
GSAP modulates mitochondria-associated membranes
STAT3-GOF disrupts CD8 Tolerance to cause T1D

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Newest Articles

Article

| July 29 2021

Macrophage HIFs in myocardial infarction

Matthew DeBerge, Connor Lantz, Shirley Dehn, David P. Sullivan, Anja M. van der Laan, Hans W.M. Niessen, Margaret E. Flanagan, Daniel J. Brat, Matthew J. Feinstein, Sunjay Kaushal, Lisa D. Wilsbacher, Edward B. Thorp

Following myocardial infarction, tissue ischemia leads to activation of hypoxia-inducible factors. DeBerge et al. demonstrate that HIF-1α and HIF-2α activation in myeloid cells antagonizes cardiac repair pathways through cleavage of cardioprotective MerTK and suppression of anti-inflammatory mitochondrial metabolism, respectively.

Article

| July 29 2021

AIM2 in melanoma microenvironment

Keitaro Fukuda, Ken Okamura, Rebecca L. Riding, Xueli Fan, Khashayar Afshari, Nazgol-Sadat Haddadi, Sean M. McCauley, Mehmet H. Guney, Jeremy Luban, Takeru Funakoshi, Tomonori Yaguchi, Yutaka Kawakami, Anastasia Khvorova, Katherine A. Fitzgerald, John E. Harris

Fukuda et al. demonstrate that AIM2 expression in DCs within human melanoma is a poor prognostic sign and that AIM2-deficient DC vaccination enhances melanoma immunotherapeutic responses by promoting STING-induced IFN secretion as well as limiting IL-1β and IL-18 production.

Article

| July 27 2021

Lung B cells dampen neutrophil inflammation

John Podstawka, Sarthak Sinha, Carlos H. Hiroki, Nicole Sarden, Elise Granton, Elodie Labit, Jung Hwan Kim, Graciela Andonegui, Yuefei Lou, Brendan D. Snarr, Donald C. Sheppard, Nicole L. Rosin, Jeff Biernaskie, Bryan G. Yipp

Genetically diverse IgM+ peripheral B cells reside in the lung microvasculature and dampen neutrophil-mediated lung inflammation via lipoxins. Podstawka et al. reveal that transitional B cells marginate in the lung capillaries, where they dampen neutrophil inflammation. These discoveries help elucidate regulatory mechanisms that attenuate acute lung inflammation, which, when unchecked, can lead to acute respiratory distress syndrome and pulmonary failure.

Article

| July 23 2021

Anti-tumor immunity requires CCL5 and CXCL10

Courtney Mowat, Shayla R. Mosley, Afshin Namdar, Daniel Schiller, Kristi Baker

Mowat et al. show that anti-tumor immunity in dMMR CRCs relies on recruitment and retention of systemic CD8+ T cells. This is driven by extensive genomic instability that upregulates CCL5 and CXCL10 in the CRC cells by endogenously activating cGAS/STING and type I IFN signaling.

Article

| July 23 2021

Type I IFN synergy of ADAR and hnRNPC deficiency

Anna-Maria Herzner, Zia Khan, Eric L. Van Nostrand, Sara Chan, Trinna Cuellar, Ronald Chen, Ximo Pechuan-Jorge, Laszlo Komuves, Margaret Solon, Zora Modrusan, Benjamin Haley, Gene W. Yeo, Timothy W. Behrens, Matthew L. Albert

hnRNPC prevents release of inverted-repeat Alu double-stranded RNA into the cytosol by masking cryptic splice sites. Herzner et al. found that deficiency in hnRNPC led to dysregulation of splicing and increased abundance of intronic double-stranded RNA, which together with ADAR deficiency resulted in a synergistic increase in spontaneous MDA5-dependent IFN responses.

Technical Advances and Resources

| July 22 2021

scRNA-seq of host macrophages in tuberculosis

Davide Pisu, Lu Huang, Vipin Narang, Monique Theriault, Gabrielle Lê-Bury, Bernett Lee, Agnes E. Lakudzala, David T. Mzinza, David V. Mhango, Steven C. Mitini-Nkhoma, Kondwani C. Jambo, Amit Singhal, Henry C. Mwandumba, David G. Russell

Through scRNA-seq and ATAC-seq, Pisu et al. characterize specific lung macrophage subsets that either restrict or promote M. tuberculosis growth. Comparable macrophage populations are present in the human airways, and cells show evidence of epigenetic imprinting.

Article

| July 22 2021

ZIKV NS1 induces sustained autoantibody production

Cecilia B. Cavazzoni, Vicente B.T. Bozza, Tostes C.V. Lucas, Luciana Conde, Bruno Maia, Luka Mesin, Ariën Schiepers, Jonatan Ersching, Romulo L.S. Neris, Jonas N. Conde, Diego R. Coelho, Tulio M. Lima, Renata G.F. Alvim, Leda R. Castilho, Heitor A. de Paula Neto, Ronaldo Mohana-Borges, Iranaia Assunção-Miranda, Alberto Nobrega, Gabriel D. Victora, Andre M. Vale

Using an immunocompetent mouse model of ZIKV infection, Cavazzoni et al. describe an immunodominant anti-NS1 humoral response characterized by autoreactive germinal center B cells, both cross-reactive and non-cross-reactive with NS1, exhibiting a paucity of somatic hypermutations, suggesting a broad breakage of self-tolerance in this viral infection model.

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Volume 218,

Issue 8,

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Insights

| July 28 2021

A dark side to NS1 antibodies?

Davide F. Robbiani, Daniel Růžek

The NS1 protein of flaviviruses is taking center stage. Recent work has made it an attractive target for development of vaccines and immunotherapeutics. Cavazzoni and colleagues now reveal a dark side to NS1, linking it to the development of self-reactive antibodies.

Viewpoint

| July 27 2021

Translation from bats to humans beyond infectious diseases

Matae Ahn, Lin-Fa Wang

Ahn and Wang discuss the translational potential of the bat model for treating human diseases.

Viewpoint

| July 23 2021

Epigenetic and transcriptional control of interferon-β

Andrew W. Daman, Steven Z. Josefowicz

Here, we will summarize the historical and current understanding of the stepwise assembly and function of factors that regulate ifnb gene transcription.

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Special Collections

The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

View all collections

A special collection of recent articles and reviews

Reversal of emphysema by endothelial cell infusion

GSAP modulates mitochondria-associated membranes

STAT3-GOF disrupts CD8 Tolerance to cause T1D

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