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Hematologic Malignancies 2021

A special collection of recent articles and reviews
Lipid Mediators in Immunity

A special collection of recent articles from JEM
Mechanisms of ILC memory for Asthma
GIMAP5 deficiency causes portal hypertension

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Newest Articles

Article

| July 23 2021

Anti-tumor immunity requires CCL5 and CXCL10

Courtney Mowat, Shayla R. Mosley, Afshin Namdar, Daniel Schiller, Kristi Baker

Mowat et al. show that anti-tumor immunity in dMMR CRCs relies on recruitment and retention of systemic CD8+ T cells. This is driven by extensive genomic instability that upregulates CCL5 and CXCL10 in the CRC cells by endogenously activating cGAS/STING and type I IFN signaling.

Article

| July 23 2021

Type I IFN synergy of ADAR and hnRNPC deficiency

Anna-Maria Herzner, Zia Khan, Eric L. Van Nostrand, Sara Chan, Trinna Cuellar, Ronald Chen, Ximo Pechuan-Jorge, Laszlo Komuves, Margaret Solon, Zora Modrusan, Benjamin Haley, Gene W. Yeo, Timothy W. Behrens, Matthew L. Albert

hnRNPC prevents release of inverted-repeat Alu double-stranded RNA into the cytosol by masking cryptic splice sites. Herzner et al. found that deficiency in hnRNPC led to dysregulation of splicing and increased abundance of intronic double-stranded RNA, which together with ADAR deficiency resulted in a synergistic increase in spontaneous MDA5-dependent IFN responses.

Technical Advances and Resources

| July 22 2021

scRNA-seq of host macrophages in tuberculosis

Davide Pisu, Lu Huang, Vipin Narang, Monique Theriault, Gabrielle Lê-Bury, Bernett Lee, Agnes E. Lakudzala, David T. Mzinza, David V. Mhango, Steven C. Mitini-Nkhoma, Kondwani C. Jambo, Amit Singhal, Henry C. Mwandumba, David G. Russell

Through scRNA-seq and ATAC-seq, Pisu et al. characterize specific lung macrophage subsets that either restrict or promote M. tuberculosis growth. Comparable macrophage populations are present in the human airways, and cells show evidence of epigenetic imprinting.

Article

| July 22 2021

ZIKV NS1 induces sustained autoantibody production

Cecilia B. Cavazzoni, Vicente B.T. Bozza, Tostes C.V. Lucas, Luciana Conde, Bruno Maia, Luka Mesin, Ariën Schiepers, Jonatan Ersching, Romulo L.S. Neris, Jonas N. Conde, Diego R. Coelho, Tulio M. Lima, Renata G.F. Alvim, Leda R. Castilho, Heitor A. de Paula Neto, Ronaldo Mohana-Borges, Iranaia Assunção-Miranda, Alberto Nobrega, Gabriel D. Victora, Andre M. Vale

Using an immunocompetent mouse model of ZIKV infection, Cavazzoni et al. describe an immunodominant anti-NS1 humoral response characterized by autoreactive germinal center B cells, both cross-reactive and non-cross-reactive with NS1, exhibiting a paucity of somatic hypermutations, suggesting a broad breakage of self-tolerance in this viral infection model.

Article

| July 21 2021

Reversal of emphysema by endothelial cell infusion

Shu Hisata, Alexandra C. Racanelli, Pouneh Kermani, Ryan Schreiner, Sean Houghton, Brisa Palikuqi, Balvir Kunar, Aiyuan Zhou, Keith McConn, Allyson Capili, David Redmond, Daniel J. Nolan, Michael Ginsberg, Bi-Sen Ding, Fernando J. Martinez, Joseph M. Scandura, Suzanne M. Cloonan, Shahin Rafii, Augustine M.K. Choi

We tested the role of endothelial dysfunction in the development of COPD/emphysema. We found that restoration of lung endothelial cells and blockade of endothelial-derived leucine-rich α-2-glycoprotein perturbs the pathogenesis of COPD/emphysema.

Article

| July 21 2021

Foxo1 regulates intestinal mucus homeostasis

Zuojia Chen, Jialie Luo, Jian Li, Girak Kim, Eric S. Chen, Sheng Xiao, Scott B. Snapper, Bin Bao, Dingding An, Richard S. Blumberg, Cheng-hui Lin, Sui Wang, Jiaxin Zhong, Kuai Liu, Qiyuan Li, Chuan Wu, Vijay K. Kuchroo

The host-derived regulatory network that controls mucus secretion and thereby changes gut microbiota has not been fully illustrated. Here, we identify that Forkhead box protein O1 (Foxo1) is critical for gut commensalism and intestinal barrier integrity by regulating goblet cell function.

Article

| July 21 2021

Targeting mitochondrial translation in melanoma

Roberto Vendramin, Vicky Katopodi, Sonia Cinque, Angelina Konnova, Zorica Knezevic, Sara Adnane, Yvessa Verheyden, Panagiotis Karras, Ewout Demesmaeker, Francesca M. Bosisio, Lukas Kucera, Jan Rozman, Ivan Gladwyn-Ng, Lara Rizzotto, Erik Dassi, Stefania Millevoi, Oliver Bechter, Jean-Christophe Marine, Eleonora Leucci

Vendramin et al. demonstrate that the integrated stress response in melanoma promotes cell plasticity and drives therapy resistance by boosting mitochondrial translation. Therefore, repurposing of mitoribosome-targeting antibiotics offers a salvage strategy for the treatment of patients with limited therapeutic options.

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NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

Snehlata Kumari ... Manolis Pasparakis | Life Sci. Alliance

TNFR1 was found to cause skin inflammation in mice with epidermal keratinocyte-specific ablation of IKK2 or of both the NF-kB subunits RelA and cRel by triggering RIPK1-dependent, RIPK3-MLKL–mediated necroptosis of keratinocytes.
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Volume 218,

Issue 7,

July 5, 2021

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Reviews & Opinions

Viewpoint

| July 23 2021

Epigenetic and transcriptional control of interferon-β

Andrew W. Daman, Steven Z. Josefowicz

Here, we will summarize the historical and current understanding of the stepwise assembly and function of factors that regulate ifnb gene transcription.

Review | Neuro-Immune Interactions Focus

| July 22 2021

Insight into microglia’s role in Alzheimer’s disease

Yun Chen, Marco Colonna

scRNA-seq analyses of microglial responses to AD pathology in patients and mouse models have provided fundamental insights but also exposed some heterogeneity and discrepancies. Here, we identify consistent microglial response patterns and discuss parallels and incongruities between humans and mice.

Review | Neuro-Immune Interactions Focus

| July 22 2021

Astrocyte–immune cell communication

Liliana M. Sanmarco, Carolina M. Polonio, Michael A. Wheeler, Francisco J. Quintana

Astrocytes are glial cells of the central nervous system (CNS) that are strategically positioned to control CNS immunity in the context of health and disease. Here, Sanmarco, Polonio, Wheeler, and Quintana review progress in elucidating astrocyte–immune interactions in multiple sclerosis.

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Special Collections

The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

View all collections

A special collection of recent articles and reviews

A special collection of recent articles from JEM

Mechanisms of ILC memory for Asthma

GIMAP5 deficiency causes portal hypertension

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