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Katharina Richard, Kurt H. Piepenbrink, Kari Ann Shirey, Archana Gopalakrishnan, Shreeram Nallar, Daniel J. Prantner, Darren J. Perkins, Wendy Lai, Alexandra Vlk, Vladimir Y. Toshchakov, Chiguang Feng, Rachel Fanaroff, Andrei E. Medvedev, Jorge C.G. Blanco, Stefanie N. Vogel
We developed mice expressing Tlr4 SNPs homologous to those expressed in humans and associated with infectious and inflammatory diseases. Cellular and molecular analyses of TLR4 signaling in wild-type vs. TLR4-SNP mice revealed novel mechanisms of LPS hyporesponsiveness and altered disease susceptibility.
Article
Alexandra Schäfer, Frauke Muecksch, Julio C.C. Lorenzi, Sarah R. Leist, Melissa Cipolla, Stylianos Bournazos, Fabian Schmidt, Rachel M. Maison, Anna Gazumyan, David R. Martinez, Ralph S. Baric, Davide F. Robbiani, Theodora Hatziioannou, Jeffrey V. Ravetch, Paul D. Bieniasz, Richard A. Bowen, Michel C. Nussenzweig, Timothy P. Sheahan
Human monoclonal antibody potency in vitro does not uniformly correlate with its in vivo neutralization of SARS-CoV-2. Antibody Fc-effector function is important for in vivo neutralization, and antibody combinations show superior efficacy compared with single antibodies.
Brief Definitive Report
Achia Khatun, Moujtaba Y. Kasmani, Ryan Zander, David M. Schauder, Jeremy P. Snook, Jian Shen, Xiaopeng Wu, Robert Burns, Yi-Guang Chen, Chien-Wei Lin, Matthew A. Williams, Weiguo Cui
The naive polyclonal CD4 T cell repertoire can differentiate into multiple lineages during acute viral infection, with some clones exhibiting a preferred lineage choice, as revealed by scRNA-seq and scTCR-seq. TCR motifs can partially skew clone-intrinsic lineage preferences toward the TFH fate.
Article
Celina Jin, Jennifer Hill, Bronwyn M. Gunn, Wen-Han Yu, Lindsay C. Dahora, Elizabeth Jones, Mari Johnson, Malick M. Gibani, Rachel L. Spreng, S. Munir Alam, Anna Nebykova, Helene B. Juel, S. Moses Dennison, Kelly E. Seaton, Jonathan K. Fallon, Georgia D. Tomaras, Galit Alter, Andrew J. Pollard
Distinct protective humoral signatures are induced by Vi-conjugate and Vi-polysaccharide vaccines. Shared humoral features across both vaccines suggest that protection against typhoid fever is mediated through a combination of qualitative features of the polyclonal humoral response (avidity and innate immune cell functional responses) in addition to antibody quantity.
Technical Advances and Resources
Allyson L. Byrd, Menghan Liu, Kei E. Fujimura, Svetlana Lyalina, Deepti R. Nagarkar, Bruno Charbit, Jacob Bergstedt, Etienne Patin, Oliver J. Harrison, Lluís Quintana-Murci, Ira Mellman, Darragh Duffy, Matthew L. Albert, the Milieu Intérieur Consortium
By characterizing gut microbiome composition across 946 healthy donors, Byrd et al. demonstrate strong influences of age and biological sex. Additionally, they define global shifts in the gut microbiome composition of patients with non-gastrointestinal tumors compared with healthy donors.
Article
Maria Elena Maccari, Sebastian Fuchs, Patrick Kury, Geoffroy Andrieux, Simon Völkl, Bertram Bengsch, Myriam Ricarda Lorenz, Maximilian Heeg, Jan Rohr, Sabine Jägle, Carla N. Castro, Miriam Groß, Ursula Warthorst, Christoph König, Ilka Fuchs, Carsten Speckmann, Julian Thalhammer, Friedrich G. Kapp, Markus G. Seidel, Gregor Dückers, Stefan Schönberger, Catharina Schütz, Marita Führer, Robin Kobbe, Dirk Holzinger, Christian Klemann, Petr Smisek, Stephen Owens, Gerd Horneff, Reinhard Kolb, Nora Naumann-Bartsch, Maurizio Miano, Julian Staniek, Marta Rizzi, Tomas Kalina, Pascal Schneider, Anika Erxleben, Rolf Backofen, Arif Ekici, Charlotte M. Niemeyer et al.
Maccari et al. identify a physiological population of highly proliferative CD38+CD45RA+, IL-10–producing TCRαβ+ T cells. They can be CD4+, CD8+, or double-negative and are controlled by FAS and CTLA4, while their survival is enhanced by mTOR and STAT3 signals.
Technical Advances and Resources
Evripidis Lanitis, Giorgia Rota, Paris Kosti, Catherine Ronet, Aodrenn Spill, Bili Seijo, Pedro Romero, Denarda Dangaj, George Coukos, Melita Irving
This work presents robust tools for the transduction and expansion of murine CAR-T cells and demonstrates the impact of murine IL-15 co-expression on CAR-T cell expansion, phenotype, function, and tumor microenvironment reprogramming in immunocompetent mice.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 11,
November 2, 2020
Reviews & Opinions
Found in Translation
Tamara Laskowski, Katayoun Rezvani
Tamara Laskowski and Katayoun Rezvani discuss the recent advances of adoptive cell therapy in cancer.
Insights
Megan Bywater, Steven W. Lane
Arsenic trioxide in combination with IFNα is able to deplete MPN stem cells, leading to reduced transplantation and even long-term treatment-free remission in disease control.
Insights
Jeremy F. Brooks, Julie Zikherman
The pathways involved in the persistence of memory B cells are largely unknown. In this issue, two groups (Müller-Winkler et al. and Lau et al.) take complementary approaches to identify an essential role for BAFFR in the survival of memory B cells.

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