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Article
Wael Awad et al.
Cigarette smoke is a diverse mix of chemicals that bind the antigen-presenting protein MR1 and modulate MAIT cell function in the lung through diverse mechanisms, impacting their ability to respond to respiratory infections and potentially contributing to disease.
Article
Quentin Riller et al.
IKKα kinase deficiency causes syndromic immunodeficiency and immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway as well as a partial defect in the canonical NF-κB pathway.
Brief Definitive Report
Zachary Papadopoulos et al.
This study investigates how different lymphatic drainage pathways from the central nervous system regulate cerebrospinal fluid homeostasis, highlights the role of lymphatic pathways in maintaining CSF dynamics, and suggests therapeutic potential in modulating these pathways in CNS disorders.
Technical Advances and Resources
Márcia Mesquita Peixoto et al.
This work shows that hepatoblasts in the fetal liver are the primary source of factors that sustain blood cell production. Different hematopoietic progenitors exhibit distinct preferences for neighboring stromal cells and show developmental changes in spatial distribution.
Article
Douglas S. Prado et al.
We discovered that PIKFYVE and its product PtdIns(3,5)P2 are essential regulators of Th17 differentiation. Our findings identify molecular mechanisms by which PIKFYVE promotes Th17 differentiation and suggest that PIKFYVE is a potential therapeutic target in Th17-driven autoimmune diseases.
Article
Xianbin Tian et al.
Rapid capture of potentially harmful bacteria in blood by liver macrophages is vital for blood sterility and health. This work reports how naturally occurring antibodies in the plasma enable macrophages to capture and kill blood-borne bacteria in the liver.
Brief Definitive Report
Yuki Hosono et al.
α-Galactosylceramide (α-GalCer), a marine sponge-derived canonical antigen for invariant natural killer T (iNKT) cells, has not been detected in mammals. In this study, we report the molecular detection of α-GalCer in mammals using supercritical fluid chromatography tandem mass spectrometry.
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Current Issue
Volume 222,
Issue 1,
6 January 2025
Reviews & Opinions
Insights
Nikhil Jiwrajka, Montserrat C. Anguera
Systemic sclerosis (SSc) is a debilitating autoimmune disease that preferentially afflicts women. The molecular origins of this female bias are unclear. A new study of plasmacytoid dendritic cells from SSc patients by Du et al. suggests the X chromosome may play a key role.
Insights
Jacob A. Myers et al.
Sparano et al. show that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. In these environments, TGF-β1, IL-15, and other factors collaboratively induce a Hobit-dependent cytotoxicity program. In the salivary glands, trNK cells limit murine cytomegalovirus persistence.
Insights
Mitchell Kronenberg, Gabriel Ascui
In this issue, Hosono and co-workers characterize a putative self-glycolipid that engages the iNKT cell TCR when bound to CD1d. The expression and distribution of this compound help to explain some of the unusual properties of invariant NKT cells.

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