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Immunology Update Winter 2022.
2021: The Year in Experimental Medicine

Highlighting 10 research articles published in 2021 that were of greatest interest to our readers during our 125th year.
ADAM17-metastasis
JEM's 125th Anniversary

Watch our workshop featuring guest investigators, dive into a timeline of discoveries, and more.
Complimentary CME for all, presented by JEM and Memorial Sloan Kettering Cancer Center

RUP response to COVID-19 crisis: Learn about the steps we are taking and find relevant content.

We are hiring: Scientific Editor/Senior Scientific Editor, Journal of Experimental Medicine.

Newest Articles

Article

| January 19 2022

Regulation of ILC2s responses via Ang II–AT1a axis

Gaoyu Liu, Yingying Chen, Ying Wang, Xiaohui Deng, Qiang Xiao, Lijuan Zhang, Haixu Xu, Xu Han, Aihua Lei, Juan He, Xing Li, Yingjiao Cao, Pan Zhou, Chunhui He, Peiqiong Wu, Wenhui Jiang, Meizheng Tan, Chun Chen, Quan Yang, Liwei Lu, Kai Deng, Zhi Yao, Jie Zhou

Liu et al. demonstrate the regulation of ILC2 by Ang II–AT1 signaling during the allergen challenge. Bone marrow chimera, deletion or pharmacological inhibition of AT1a, and ILC2 transfer into NCG mice collectively indicate that targeting lung RAS alleviates airway inflammation.

Article

| January 14 2022

Fibroblasts sustain lung tumor MHCII immunity

Dimitra Kerdidani, Emmanouil Aerakis, Kleio-Maria Verrou, Ilias Angelidis, Katerina Douka, Maria-Anna Maniou, Petros Stamoulis, Katerina Goudevenou, Alejandro Prados, Christos Tzaferis, Vasileios Ntafis, Ioannis Vamvakaris, Evangelos Kaniaris, Konstantinos Vachlas, Evangelos Sepsas, Anastasios Koutsopoulos, Konstantinos Potaris, Maria Tsoumakidou

Kerdidani et al. show that immunological hot spots in lung tumors are sustained by fibroblasts. Lung fibroblasts present MHCII cancer antigens locally and at the same time prevent CD4 T cells from apoptosis by activating the complement receptor C1qbp.

Article

| January 13 2022

The role of HIF-1α in NKp46⁺ innate lymphoid cells

Ewelina Krzywinska, Michal Sobecki, Shunmugam Nagarajan, Julian Zacharjasz, Murtaza M. Tambuwala, Abigaelle Pelletier, Eoin Cummins, Dagmar Gotthardt, Joachim Fandrey, Yann M. Kerdiles, Carole Peyssonnaux, Cormac T. Taylor, Veronika Sexl, Christian Stockmann

Krzywinska et al. have studied the impact of the transcription factor HIF-1α on the phenotype of intestinal NKp46+ innate lymphoid cells and how it affects gut homeostasis.

Brief Definitive Report

| January 12 2022

Humoral memory from T-independent germinal centers

Xin Liu, Yongshan Zhao, Hai Qi

T-independent antigens are known to induce transient germinal center formation. Liu et al. show that these germinal centers output memory B cells and plasma cells and condition their persistence.

Article

| January 12 2022

Human progenitor of human lung macrophages

Elza Evren, Emma Ringqvist, Jean-Marc Doisne, Anna Thaller, Natalie Sleiers, Richard A. Flavell, James P. Di Santo, Tim Willinger

Evren et al. identify CD116+ fetal liver cells as precursors of human alveolar macrophages in early life and determine the impact of cell origin on lung macrophage identity and function in the human context with a unique in vivo model.

Article

| January 11 2022

CD127 imprints hypoinflammatory human monocytes

Bin Zhang, Yuan Zhang, Lei Xiong, Yuzhe Li, Yunliang Zhang, Jiuliang Zhao, Hui Jiang, Can Li, Yunqi Liu, Xindong Liu, Haofei Liu, Yi-Fang Ping, Qiangfeng Cliff Zhang, Zheng Zhang, Xiu-Wu Bian, Yan Zhao, Xiaoyu Hu

Zhang et al. analyzed human monocytes in acute and chronic inflammatory disease conditions with multiomics approaches and identified a subset of CD127+ hypoinflammatory monocytes within the inflammatory environment, uncovering functional heterogeneity of human inflammatory monocytes imprinted by CD127.

Article

| December 27 2021

Natural rodent model of virus transmission

Elizabeth J. Fay, Keir M. Balla, Shanley N. Roach, Frances K. Shepherd, Dira S. Putri, Talia D. Wiggen, Stephen A. Goldstein, Mark J. Pierson, Martin T. Ferris, Claire E. Thefaine, Andrew Tucker, Mark Salnikov, Valerie Cortez, Susan R. Compton, Sergei V. Kotenko, Ryan C. Hunter, David Masopust, Nels C. Elde, Ryan A. Langlois

Viruses are diverse and ubiquitous, but many infection models do not recapitulate natural transmission and evolution. Here we bridge natural and experimental systems to study real-time transmission dynamics within and between hosts, identify novel viruses, and infer virus–pathogen relationships.

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Current Issue

Volume 219,

Issue 1,

January 3, 2022

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Reviews & Opinions

Insights

| January 12 2022

Goldilocks and the three TILs

Hannah Dada, Michael L. Dustin

Shakiba et al. show that TCR signal strength determines T cell differentiation and function in tumors.

Review

| January 10 2022

Humoral immunity against PfCSP

Ilka Wahl, Hedda Wardemann

Antibodies against Plasmodium falciparum circumsporozoite protein (PfCSP) can protect from malaria. However, the efficacy of anti-PfCSP vaccine responses is limited. This review summarizes our molecular and cellular understanding of humoral anti-PfCSP immune responses and discusses implications for vaccine design.

Insights

| December 28 2021

Playing dirty with virus transmission

Christin Herrmann, Ken Cadwell

Fay et al. investigate viral infection dynamics by cohousing dirty pet store mice and rats with clean laboratory mice.

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Special Collections

The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

View all collections

Immunology Update Winter 2022.

Highlighting 10 research articles published in 2021 that were of greatest interest to our readers during our 125th year.

ADAM17-metastasis

Watch our workshop featuring guest investigators, dive into a timeline of discoveries, and more.

Complimentary CME for all, presented by JEM and Memorial Sloan Kettering Cancer Center

Related Articles from Rockefeller University Press

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Special Collections

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