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Victoria E. Rael et al.
This work reports a mutagenesis screen of the TLR chaperone protein UNC93B1 that reveals regulatory regions affecting TLR3, TLR7, and TLR9 responses. Autoimmune patients are identified with coding variants in UNC93B1 that map to regions identified by the screen, and the introduction of these human variants into mice leads to TLR-driven autoimmune disease.
Article
Ximena León-Lara et al.
Léon-Lara et al. define age-driven postnatal adaptation of γδ T cells and identify CD83+ γδ T cells in preterm infants with sepsis. CD83 expression specifically relates to neonatal γδ T cells and points to functional diversity of neonatal γδ T cells in this inflammatory setting.
Article
Takeshi Inoue et al.
Inoue et al. show that an augmentation of BCR signaling in GC B cells by inducible depletion of Csk results in decreased GC B cell competitiveness and impaired affinity maturation, partly due to enhanced ROS-mediated apoptosis.
Article
Tamara Kögl et al.
CD4 T helper cells use the SNARE protein SYNTAXIN-11 to promote B cell differentiation, germinal center formation, and class switching by facilitating CD40L mobilization and IL-2 and IL-10 secretion. Variable hypogammaglobulinemia is a novel phenotype of human STX11 deficiency.
Brief Definitive Report
Yuexiao Tang et al.
Tang et al. demonstrate that hepatic IRE1α acts as a molecular driver of GDF15-mediated anorexia, and blocking IRE1α activity offers a potential therapeutic approach to alleviate anorexia in chemotherapy.
Brief Definitive Report
Andrew J. MacLean et al.
The authors show that following influenza virus rechallenge, lung resident, but not circulating memory B cells differentiate into PCs near infected alveoli. In these sites, outside of iBALTs, BRM cells’ activation is regulated by innate cells and signals.
Technical Advances and Resources
Maria Belen Rodrigo et al.
Dual fluorescence reporter mice were developed to identify cells that secrete and/or sense chemokines and to delete producing cells. Thereby, the authors found that the chemokine Ccl3 facilitates auto/paracrine NK cell crosstalk to amplify their response against cytomegalovirus infection.
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Current Issue
Volume 221,
Issue 5,
6 May 2024
Reviews & Opinions
People & Ideas
Lucie Van Emmenis
Irene Salinas’s lab uses multiple animal models to study nasal immunity and neuroimmune interactions in the olfactory–central nervous system axis in response to microorganisms. We spoke with Irene about her lab work and her diversity, equity, and inclusion (DEI) work.
Review | Cancer Focus
Liangliang Wang et al.
The majority of cancer patients receive radiotherapy. Wang et al. review preclinical and clinical data related to the importance of immune responses to radiotherapy-induced anti-tumor effects, as well as blockade of immune checkpoints PD-1/PD-L1 and/or CTLA-4 in combination with radiotherapy.
Viewpoint
Matthias Eberl, Sheena M. Cruickshank
Matthias Eberl and Sheena Cruickshank discuss the need for public involvement and engagement in biomedical research and ongoing major systemic challenges.

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