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Lore Billiet et al.
Billiet et al. identify the post-thymic progeny of the agonist-selected CD10+ PD-1+ precursors in humans based on shared characteristics of the T cell receptor repertoire and the transcriptome. This lineage represents a well-defined but heterogeneous, unconventional TCRαβ+ lineage mostly confined within the CD8+ Helios+ T cells.
Huan Qin et al.
Qin and colleagues develop a genome-editing tool characterized by the versatility of prime editors and unconstrained PAM requirement of SpRY. In vivo gene correction is successfully implemented in the mouse model of Pde6b-associated retinitis pigmentosa, leading to substantial functional rescue of vision.
Keenan A. Lacey et al.
Extracellular nucleases of the DNASE1 family are conserved in vertebrates, yet their physiological function remains unclear. This study shows that DNASE1 and its homolog DNASE1L3 jointly facilitate resistance to systemic infection with Staphylococcus aureus by digesting bacterial biofilms.
Hesham D. Abdulla et al.
Abdulla et al. show that the LMO2 transcription factor, a key driver of human T-lymphoblastic leukemia, inhibits thymocyte competition in a transgenic mouse model and that this enables LMO2 to promote T-lymphoblastic leukemia.
Irene L.M. Reijers et al.
In the DONIMI trial, a baseline IFN-γ signature enables prospective selection of patients who can benefit from anti-PD-1 monotherapy. In contrast to results of our murine melanoma model, domatinostat (a class I HDAC inhibitor) does not add benefit to neoadjuvant anti-PD-1 ± anti-CTLA-4 in patients.
Technical Advances and Resources
Andrew J. Sawyer et al.
Sawyer et al. reveal the diversity of human tuberculosis granulomas by profiling 726 individual lesions by multiplex imaging. As well as necrotizing lesions, they identify four distinct lesion types that organize in a histopathological superstructure around necrotic granulomas.
Romane Thouenon et al.
Thouenon et al. describe a novel primary immunodeficiency associated with defective plasma cell differentiation. They reveal that an amino acid exchange located within the interferon activation domain of IRF4 downregulates transcription on ISRE sites because of altered protein interaction.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 220,
Issue 3,
6 March 2023
Reviews & Opinions
People & Ideas
Lucie Van Emmenis
Soyon Hong is a group leader at the UK Dementia Research Institute at UCL. Her lab is interested in investigating how cell types work together to maintain brain function, and how these interactions are dysregulated during neurodegenerative disease states such as Alzheimer’s disease.
Samuel W. Du, Krzysztof Palczewski
CRISPR/Cas9 genome editing techniques have the potential to treat previously untreatable inherited genetic disorders of vision by correcting mutations that cause these afflictions. Using a prime editor, Qin et al. restored visual functions in a mouse model (rd10) of retinitis pigmentosa.
Keitaro Fukuda
In this issue of JEM, Reijers et al. demonstrate that pre- and post-treatment IFNγ-related gene expression scores are promising markers for choosing neoadjuvant immunotherapy for stage III melanoma.

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