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Jin Huk Choi, Xue Zhong, Zhao Zhang, Lijing Su, William McAlpine, Takuma Misawa, Tzu-Chieh Liao, Xiaoming Zhan, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Priscilla Anderton, Eva Marie Y. Moresco, Bruce Beutler
Choi et al. identify mice with a metabolic disorder and severe lymphoid and myeloid hypoplasia resulting from mutation of PDIA6. The ER-resident oxidoreductase PDIA6 is necessary for folding of stroma-derived Wnt3a, BAFF, and IL-7 proteins, which are necessary for hematopoiesis.
Carsten Deppermann, Rachel M. Kratofil, Moritz Peiseler, Bruna A. David, Joel Zindel, Fernanda Vargas E Silva Castanheira, Fardau van der Wal, Agostina Carestia, Craig N. Jenne, Jamey D. Marth, Paul Kubes
Deppermann et al. investigate how aged platelets are removed from circulation. Using intravital microscopy they observe rapid accumulation of desialylated platelets on Kupffer cells through collaboration of macrophage galactose lectin and Ashwell-Morell receptor. Effective clearance is critical, as mice with an aged platelet population bleed.
Brief Definitive Report
Erin G. Reed-Geaghan, Andrew L. Croxford, Burkhard Becher, Gary E. Landreth
Fate mapping of resident microglia and peripheral monocytes reveals that the myeloid cells that migrate to and associate with amyloid plaques in a mouse model of Alzheimer’s disease are exclusively derived from resident microglia.
Brief Definitive Report
Yajing Gao, Krystin Deason, Aakanksha Jain, Ricardo A. Irizarry-Caro, Igor Dozmorov, Laura A. Coughlin, Isabella Rauch, Bret M. Evers, Andrew Y. Koh, Edward K. Wakeland, Chandrashekhar Pasare
Gao et al. reveal that DCs shape a distinct pathogen-specific CD4 T cell transcriptome and discover an unexpected role for T cell–intrinsic caspase-1 in promoting Th17 differentiation.
Miao Liu, Yuanyuan Wang, Chuanzhen Yang, Yuxia Ruan, Changsen Bai, Qiaoyun Chu, Yanfen Cui, Ceshi Chen, Guoguang Ying, Binghui Li
Liu et al. build up an electron balance model for central carbon metabolism in cancer cells and reveal that simultaneous inhibitions of proline biosynthesis and lipogenesis can block cancer cell growth under hypoxia and in vivo tumor progress.
Longfei Chen, David A. Christian, Joshua A. Kochanowsky, Anthony T. Phan, Joseph T. Clark, Shuai Wang, Corbett Berry, Jung Oh, Xiaoguang Chen, David S. Roos, Daniel P. Beiting, Anita A. Koshy, Christopher A. Hunter
The ability of T. gondii to promote a STAT3- and STAT6-dependent M2 phenotype in macrophages by injecting the virulence factor ROP16 in cis and trans subsequently limits the magnitude of the parasite-specific T cell response.
Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh-Keller, Marc Bajenoff, Michael H. Sieweke, Søren Kragh Moestrup, Nathalie Auphan-Anezin, Toby Lawrence
Etzerodt et al. identify a unique subset of CD163+ Tim4+ tissue-resident macrophages in omentum that are maintained independently of bone marrow–derived monocytes and have a specific role in the metastatic spread of ovarian cancer cells.

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