Journal of Experimental Medicine | Rockefeller University Press

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Stem Cell Collection 2020

A special collection of recent stem cell research from JCB and JEM
Targeting Sirt1-Nox4 signaling in cancer cachexia
Restriction of memory B cell differentiation
Optimized gene disruption in primary myeloid cells

JEM staff members are working remotely in line with New York City’s efforts to contain COVID-19. While our offices are physically closed, editorial and publication operations continue. JEM staff can be reached via email and phone, as we tend to our family, friends and community. Thank you for your patience and understanding.

Newest Articles

Article

| July 01 2020

Pdap1 supports mature B cell survival and function

Verónica Delgado-Benito, Maria Berruezo-Llacuna, Robert Altwasser, Wiebke Winkler, Devakumar Sundaravinayagam, Sandhya Balasubramanian, Marieta Caganova, Robin Graf, Ali Rahjouei, Marie-Thérèse Henke, Madlen Driesner, Lisa Keller, Alessandro Prigione, Martin Janz, Altuna Akalin, Michela Di Virgilio

Delgado-Benito et al. identify the protein Pdap1 as a regulator of mature B cell homeostasis. Pdap1 protects mature B cells against chronic induction of the integrated stress response and promotes both their survival and antibody gene diversification by CSR and SHM.

Brief Definitive Report

| June 30 2020

Human liver-resident immunity

Laura J. Pallett, Alice R. Burton, Oliver E. Amin, Sergio Rodriguez-Tajes, Amit A. Patel, Nekisa Zakeri, Anna Jeffery-Smith, Leo Swadling, Nathalie M. Schmidt, Anna Baiges, Amir Gander, Dominic Yu, David Nasralla, Farid Froghi, Satheesh Iype, Brian R. Davidson, Douglas Thorburn, Simon Yona, Xavier Forns, Mala K. Maini

Pallett et al. identify mononuclear phagocyte and T cell subsets able to reside in the human liver for over a decade, probing their retention and replenishment using HLA-mismatched allografts and hepatic venous sampling.

Article

| June 30 2020

Single-cell analysis of germinal-center B cells

Antony B. Holmes, Clarissa Corinaldesi, Qiong Shen, Rahul Kumar, Nicolo Compagno, Zhong Wang, Mor Nitzan, Eli Grunstein, Laura Pasqualucci, Riccardo Dalla-Favera, Katia Basso

Single-cell transcriptomic analysis of germinal center B cells identifies multiple linked populations, most of which represent cell of origin of lymphomas. The newly identified cell of origin of diffuse large B cell lymphoma informs on novel prognostic subgroups.

Article

| June 30 2020

Vaccination with leukocidins protects from bloodstream infection

Kayan Tam, Keenan A. Lacey, Joseph C. Devlin, Maryaline Coffre, Alexis Sommerfield, Rita Chan, Aidan O’Malley, Sergei B. Koralov, P’ng Loke, Victor J. Torres

Staphylococcus aureus secretes pore-forming leukocidins that kill leukocytes as part of the bacterium’s evasion strategy. Leukocidin-based vaccination results in toxin-neutralizing antibodies and toxin-specific CD4 lymphocytes that block the toxins and boost host-mediated antimicrobial responses to protect mice from bloodstream infection.

Article

| June 25 2020

Cbls regulate the entry checkpoint of GC reaction

Xin Li, Liying Gong, Alexandre P. Meli, Danielle Karo-Atar, Weili Sun, Yongrui Zou, Irah L. King, Hua Gu

Antigen uptake and presentation by naive and germinal center (GC) B cells are different, with the former expressing even low-affinity BCRs efficiently capture and present sufficient antigen to T cells, whereas the latter do so more efficiently after acquiring high-affinity BCRs. We show here that antigen uptake and ...

Article

| June 25 2020

Role of NS1 in dengue pathogenesis

Pei Xuan Lee, Donald Heng Rong Ting, Clement Peng Hee Boey, Eunice Tze Xin Tan, Janice Zuo Hui Chia, Fakhriedzwan Idris, Yukei Oo, Li Ching Ong, Yen Leong Chua, Chanditha Hapuarachchi, Lee Ching Ng, Sylvie Alonso

Lee et al. show that circulating NS1 protein does not contribute to dengue pathogenesis in mice infected with highly virulent DENV2 strains. Instead, structural prME region is found to play a critical role in the in vivo fitness and virulence of these strains.

Article

| June 24 2020

A mAb targeting human TREM2 in Alzheimer’s disease

Shoutang Wang, Meer Mustafa, Carla M. Yuede, Santiago Viveros Salazar, Philip Kong, Hua Long, Michael Ward, Omer Siddiqui, Robert Paul, Susan Gilfillan, Adiljan Ibrahim, Hervé Rhinn, Ilaria Tassi, Arnon Rosenthal, Tina Schwabe, Marco Colonna

Wang et al. demonstrate that a mAb specific for the human microglial receptor TREM2 induces microglia proliferation, ameliorates Aβ-induced pathology in a mouse model of Alzheimer’s disease, and can be given safely in a first-in-human phase I clinical trial.

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