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Tumor Microenvironment and Metastasis 2023.
TAOK3 regulates adipose tissue Tregs.
PRMT1 regulates activated B cell fate.

Newest Articles

Article

| September 21 2023

Wiring of developing central gustatory circuits

Chengsan Sun et al.

Microglia aid in refining central gustatory circuits during normal postnatal development. This process is arrested by merely restricting the mother’s dietary sodium during a limited, early prenatal period when microglia progenitors migrate from the yolk sac to the brain.

Article

| September 20 2023

RPE biomarkers of transplant efficacy

Farhad Farjood et al.

This study characterizes an adult retinal pigment epithelial stem cell–derived cell product through transplantation in RCS rats and bulk and single-cell RNA sequencing, identifying distinct subpopulations and a predictive lncRNA marker (TREX) affecting cell integration and vision rescue in rats.

Article

| September 19 2023

Gene regulation by C-terminal domains of Pax5

Sarah Gruenbacher et al.

In vivo deletion in the mouse reveals an essential role of the Pax5 C-terminal domain in B cell commitment and development by activating or repressing most Pax5 target genes. This domain induces chromatin changes by interacting with chromatin-remodeling and histone-modifying complexes.

Article

| September 19 2023

Cholesterol overload to macrophages promotes NASH

Michiko Itoh et al.

Lysosomal cholesterol overload triggers phenotypic changes and profibrotic activation of macrophages around dead hepatocytes containing cholesterol crystals in the development of NASH. Cholesterol excretion from macrophages using β-cyclodextrin polyrotaxane, which is designed to release β-cyclodextrin in lysosomes, alleviates liver fibrosis.

Article

| September 15 2023

Hemifacial myohyperplasia and PI3KCA mutations

Charles Bayard et al.

In this study, we have discovered that hemifacial myohyperplasia results from a somatic gain-of-function mutation in PI3KCA. Using a new mouse model, we investigated the underlying mechanisms and demonstrated that alpelisib, a pharmacological inhibitor, significantly enhances both the preclinical model and patients.

Article

| September 13 2023

Rinl as a gatekeeper of Tfh cell differentiation

Lisa Sandner et al.

Sandner et al. uncover a key role for the guanine nucleotide exchange factor Rinl in restraining Tfh differentiation via CD28 signaling in homeostasis, immunization models, virus infection, and aging in mice, and in cultures of human CD4⁺ T cells.

Article

| September 12 2023

HuR in NK cell–mediated innate immune defense

Sytse J. Piersma et al.

Piersma et al. identify a crucial role for posttranscriptional regulation by HuR in NK cell proliferation. This study reveals that HuR-dependent NK cell expansion is required for control of long-term virus infection and solid tumors without affecting acute infection or tumor metastases.

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Current Issue

Volume 220,

Issue 9,

4 September 2023

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Reviews & Opinions

Insights

| September 27 2023

A twist in the tail: Of T cell subsets and disease

Shiv Pillai

In this issue of JEM, the work of Joachim et al. (2023) on knockin mice with a specific tail mutation in LAT provides valuable insights about cytotoxic CD4⁺ T cells and human inflammatory diseases.

Viewpoint

| September 20 2023

Women in STEM becoming independent: Great mentors make all the difference

Lucie Van Emmenis

In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher. As well as being able to celebrate the positives of becoming an independent researcher, we would also like to use this platform to discuss the unique challenges they face as women scientists in their respective scientific environments.

People & Ideas

| September 19 2023

Nina Cabezas Wallscheid: Enjoying the freedom to decide my research path

Lucie Van Emmenis

Nina Cabezas Wallscheid is a group leader at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg, Germany. Taking a multidisciplinary approach, her lab investigates the mechanisms by which metabolites regulate the epigenetic and metabolic state of hematopoietic stem cell fate in young and upon aging, with the aim to identify therapeutic strategies for nutritional and hematological diseases.

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Special Collections

The Year in Experimental Medicine

Our annual series highlighting some of the research articles that were of greatest interest to our readers in 2022.

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Tumor Microenvironment and Metastasis 2023.

TAOK3 regulates adipose tissue Tregs.

PRMT1 regulates activated B cell fate.

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