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Mechanisms and Models of Cancer 2022 Update.
Anorectic actions of antimigraine drugs.
Meningeal lymphatic drainage in mice and humans.

JEM seeks a talented individual to join our editorial team as a Scientific Editor or Senior Editor.

RUP seeks a talented individual to join JEM and JGP editorial teams as a Scientific Editor.

Newest Articles

Article

| August 19 2022

Augmenting neurogenesis rescues the engram in AD

Rachana Mishra, Trongha Phan, Pavan Kumar, Zachery Morrissey, Muskan Gupta, Carolyn Hollands, Aashutosh Shetti, Kyra Lauren Lopez, Mark Maienschein-Cline, Hoonkyo Suh, Rene Hen, Orly Lazarov

Deficits in hippocampal neurogenesis cause cognitive impairments in Alzheimer’s disease by compromising memory storage. Augmenting neurogenesis rescues memory by recruiting more new neurons with restored spine density and transcription profile. AD-linked genes regulate the memory-storing neurons.

Article

| August 18 2022

TGF-β promotes lymphoid residency of stem CD8

Chaoyu Ma, Liwen Wang, Wei Liao, Yong Liu, Shruti Mishra, Guo Li, Xin Zhang, Yuanzheng Qiu, Qianjin Lu, Nu Zhang

The signals that control the differentiation of Tcf-1⁺ CD8⁺ T cells are not entirely known. Here, the authors find that TGF-β promotes lymphoid residency and inhibits the effector differentiation of Tcf-1⁺ T cells partially via controlling the expression of α4 integrins.

Article

| August 18 2022

TGF-β regulates CTLs during chronic infection

Yinghong Hu, William H. Hudson, Haydn T. Kissick, Christopher B. Medina, Antonio P. Baptista, Chaoyu Ma, Wei Liao, Ronald N. Germain, Shannon J. Turley, Nu Zhang, Rafi Ahmed

This study demonstrates the role of TGF-β on virus-specific CD8 T cell differentiation during chronic LCMV infection. TGF-β maintains the stem-like state of TCF-1⁺ CD8 T cells and promotes terminal differentiation of exhausted cells by suppressing effector- and proliferation-associated programs.

Article

| August 18 2022

HER2 activation in fibroblasts drives lung fibrosis

Xue Liu, Yan Geng, Jiurong Liang, Ana Lucia Coelho, Changfu Yao, Nan Deng, Yizhou Wang, Kristy Dai, Guanling Huang, Ting Xie, Ningshan Liu, Simon C. Rowan, Forough Taghavifar, Vrishika Kulur, Zhenqiu Liu, Barry R. Stripp, Cory M. Hogaboam, Dianhua Jiang, Paul W. Noble

This study demonstrates the regulatory pathways closely associated with a metastatic cancer signature regulated by HER2 in invasive IPF lung fibroblasts. Manipulation of HER2 in vitro and in vivo shows that HER2 signaling is a key driver of fibroblast invasion and progressive lung fibrosis.

Article

| August 16 2022

Sebum–propionate–IL-33 axis in atopic dermatitis

Zhuoqiong Qiu, Zhenlai Zhu, Xiaochun Liu, Baichao Chen, Huibin Yin, Chaoying Gu, Xiaokai Fang, Ronghui Zhu, Tianze Yu, Wenli Mi, Hong Zhou, Yufeng Zhou, Xu Yao, Wei Li

This study demonstrates that a dysregulated sebum–microbial metabolite–IL-33 axis is involved in the pathogenesis of atopic dermatitis, possibly by playing an initiating role in the induction of skin inflammation.

Brief Definitive Report

| August 16 2022

SARS-CoV-2–specific nasal resident T cells

Joey Ming Er Lim, Anthony Tanoto Tan, Nina Le Bert, Shou Kit Hang, Jenny Guek Hong Low, Antonio Bertoletti

Virus-specific T cells in the nasal cavity might provide an immediate layer of protection against SARS-CoV-2. This study detected SARS-CoV-2–specific nasal-resident T cells in vaccinees only after infection, highlighting the significance of nasal challenge in the formation of antiviral immunity at the site of infection.

Article

| August 10 2022

Hypogammaglobulinemia and ASD upon PAX5 deficiency

Fabian M.P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A.S.H. Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D. Katsikis, Joyce H.G. Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I. De Zeeuw, Aleksandra Badura, Meinrad Busslinger

A mouse model carrying biallelic Pax5 mutations identified in a patient with hypogammaglobulinemia and autism spectrum disorder shows a B cell developmental arrest and autistic-like behavior caused by abnormal development of the cerebellum and loss of ventral midbrain GABAergic neurons.

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Volume 219,

Issue 8,

1 August 2022

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Insights

| August 16 2022

Helminths revive to survive

John R. Grainger, Rufus H. Daw

Karo-Atar et al. demonstrate that products released by a gut-dwelling helminth modify intestinal stem cells, which is associated with a loss of secretory cell types that support helminth expulsion.

Viewpoint

| August 16 2022

Perfecting antigen prediction

David Hoyos, Benjamin D. Greenbaum

Benjamin D. Greenbaum and David Hoyos discuss the challenges of antigen modeling to design vaccines for infectious diseases and cancer.

Insights

| July 05 2022

Charting the meningeal lymphatic network

Sandro Da Mesquita

In this issue, Jacob et al. employ imaging techniques to provide a more comprehensive chart of the meningeal lymphatic vasculature and draw a parallel for lymphatic drainage of cerebrospinal fluid in mice and humans.

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Special Collections

The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

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Transfer your paper to JEM in any format.

Mechanisms and Models of Cancer 2022 Update.

Anorectic actions of antimigraine drugs.

Meningeal lymphatic drainage in mice and humans.

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