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Article
Ainsley Lockhart et al.
Lockhart et al. demonstrate that exposure to food protein drives an antigen-specific CD4+ T cell response characterized at steady state by accumulation at the intestinal epithelium and tissue-specialized transcriptional imprinting. This process is disrupted upon either allergic sensitization or tolerance.
Article
Zachary C. Stensland et al.
The role of B cells in T1D remains poorly understood. We identified an activated B cell subset that is enriched in insulin reactivity and increased in the blood and pLN of T1D donors. This subset has capacity to secrete antibodies and potential to serve as APCs to T cells.
Article
Sheri A.C. McDowell et al.
Obesity is associated with enhanced breast cancer mortality, yet the mechanisms underlying this relationship remain poorly understood. McDowell et al. provide insight into the role of obesity on myeloid-driven cancer metastasis by identifying how monocyte development is skewed to promote prometastatic neutrophil effector functions.
Article
Wanlin Cui et al.
A novel ILC2 subset was identified in the mouse intestine that constitutively expresses IL-4. Although the absence of the gut microbiota had marginal effects, feeding mice with a vitamin B1-deficient diet compromised the number of intestinal IL-4+ ILC2s.
Article
You-Sheng Lin et al.
E3 ubiquitin ligase ZNRF1 is activated by c-Src kinase following TLR3 activation and, in turn, promotes TLR3 ubiquitination and trafficking to lysosomes for degradation. This leads to properly regulated interferon production and alveolar barrier repair to prevent secondary bacterial superinfection.
Article
Ning Yang et al.
This study shows that intratumoral injection of engineered non-replicative recombinant modified vaccinia virus Ankara depletes and reprograms tumor-infiltrating regulatory T cells via OX40L–OX40 interaction and IFNAR signaling to enhance antitumor immunity.
Article
Wanlin He et al.
Understanding the unique features of immune functions of HLA-E to inform future clinical exploitation requires detailed knowledge of HLA-E transport. He et al. characterize the basic trafficking patterns of HLA-E within cells and how this trafficking is regulated.
Issue Cover
Current Issue
Volume 220,
Issue 5,
1 May 2023
Reviews & Opinions
Insights
Marcus Buggert
Stolley et al. discovered that the oral mucosa houses CD8+ CD103+ resident memory T cells, which are important for protecting against local viral infections in mice.
Review | Th2 responses
James A. Harker, Clare M. Lloyd
Harker and Lloyd review the multifaceted roles of Th2 cells in human asthma, highlighting their influence of tissue location and disease severity. They also explore how Th2 cells and their cytokines have been targeted for biologic therapies for asthma patients.
Insights
Abigail R. Gress, Tyler D. Bold
In this issue of JEM, Foreman et al. report that, in tuberculosis granuloma, CD4 T effector cells require signals through CD30, potentially provided co-operatively by other T cells, to completely differentiate and protect against disease.

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