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Brief Definitive Report
Charlotte J. Imianowski et al.
NK cells play a critical role in immune surveillance, yet negative regulators of their maturation and function are poorly characterized. Imianowski et al. show that the transcriptional repressor BACH2 restricts NK cell maturation and anti-tumor function, with implications for immunotherapeutic development.
Article
Karmele Valencia et al.
Valencia et al. show DSTYK, a dual serine/threonine and tyrosine kinase, altered in lung cancer and associated with poor clinical outcome. DSTYK controls cellular processes encompassing cytoprotective autophagy and mitochondrial fitness and its ablation sensitizes cancer cells to T cell–mediated killing.
Brief Definitive Report
Jiao Shen et al.
The authors engineer an anti-PD-1–concealed sIL-15 fusion protein (αPD-1-IL-15-R), eliciting extraordinary antitumor immunity with negligible toxicity. αPD-1-IL-15-R largely expands tumor-specific CD8+T for effective tumor rejection through cis-delivery and further controls metastasis.
Article
Iara M. Backes et al.
Neonatal HSV (nHSV) infections cause significant morbidity and mortality. This study demonstrates the efficacy of monoclonal antibody therapy via direct administration and AAV vectored expression. Antibodies administered either maternally or to mouse pups improve survival and time-dependent viral clearance.
Article
Zijun Wang et al.
Wang et al. analyze memory B cell and antibody responses in SARS-CoV-2 mRNA vaccines to breakthrough infections with Delta or Omicron BA.1 variants. Breakthrough infection after two or three doses of mRNA vaccination was comparable to three doses of vaccination in eliciting broad and potent memory B cells. The findings provide insights on broad and strain-specific memory responses after mRNA vaccination with Wuhan-Hu-1.
Brief Definitive Report
Rhea Nadkarni et al.
Nadkarni et al. show that human endothelial cells (EC) engage both NLRP1 and CARD8 inflammasomes. CARD8 is activated by Coxsackie B3 protease-mediated N-terminal cleavage. Knocking out CARD8 attenuates CVB3 propagation and dampens inflammation in a cellular model of viral myocarditis.
Article
Cameron S. McAlpine et al.
Sleep interruption restructures the epigenome of hematopoietic stem and progenitor cells (HSPCs) and increases their proliferation, priming them for exaggerated inflammatory bursts and reducing hematopoietic clonal diversity through accelerated genetic drift. In humans, sleep restriction alters the HSPC epigenome and activates hematopoiesis.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 219,
Issue 9,
5 September 2022
Reviews & Opinions
Insights
Qiankun Wang, Liang Shan
In this issue of JEM, Nadkarni et al. identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.
Insights
Mohamed Khalil, Subramaniam Malarkannan
Shemesh et al. report that the development of FcRγ−/low adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α.
Found in Translation
Laura Chiossone, Eric Vivier
Laura Chiossone and Eric Vivier discuss the recent advances of NK cell therapies in cancer, which include adoptive NK cell therapies and the harnessing of NK cells using immune checkpoint inhibitors, NK cell engagers, cytokines, and the combination thereof.

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