Journal of Experimental Medicine (JEM) | Rockefeller University Press

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JEM Immunology Collection 2022.
E-prostanoid 3 receptor and liver fibrosis.
γδT cells promote muscle repair.
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Article

| May 20 2022

Jad N. Kanbar, Shengyun Ma, Eleanor S. Kim, Nadia S. Kurd, Matthew S. Tsai, Tiffani Tysl, Christella E. Widjaja, Abigail E. Limary, Brian Yee, Zhaoren He, Yajing Hao, Xiang-Dong Fu, Gene W. Yeo, Wendy J. Huang, John T. Chang

Kanbar et al. show that the long noncoding RNA Malat1 impacts the differentiation of effector and memory CD8⁺ T cell subsets by virtue of preferential epigenetic repression of memory-associated genes in terminal effector cells through an interaction with Ezh2.

Article

| May 19 2022

IL-4R modulates neuronal activity

Nicholas Hanuscheck, Carine Thalman, Micaela Domingues, Samantha Schmaul, Muthuraman Muthuraman, Florian Hetsch, Manuela Ecker, Heiko Endle, Mohammadsaleh Oshaghi, Gianvito Martino, Tanja Kuhlmann, Katarzyna Bozek, Tim van Beers, Stefan Bittner, Jakob von Engelhardt, Johannes Vogt, Christina Francisca Vogelaar, Frauke Zipp

Neuroimmune interaction influences essential CNS processes. Hanuscheck et al. report on the expression of interleukin-4 receptor alpha at presynaptic terminals in mouse and the human brain. The modulation of neuronal IL-4R signaling alters the neuronal transcriptome, impacts synaptic transmission, and causes anxiety-related behavior.

Brief Definitive Report

| May 17 2022

Neural circuits and ATP for spreading inflammation

Rie Hasebe, Kaoru Murakami, Masaya Harada, Nada Halaka, Hiroshi Nakagawa, Fuminori Kawano, Yoshinobu Ohira, Tadafumi Kawamoto, Fiona E. Yull, Timothy S. Blackwell, Junko Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, Nobuhiro Watanabe, Harumi Hotta, Toshihide Yamashita, Daisuke Kamimura, Yuki Tanaka, Masaaki Murakami

Local inflammation spreads to remote positions via sensory neuron–interneuron crosstalk using ATP. This neural pathway, or remote inflammation gateway reflex, may be a therapeutic target for inflammatory diseases with remote inflammation, such as rheumatoid arthritis.

Article

| May 13 2022

Genetic deficiency of GIMAP6

Yikun Yao, Ping Du Jiang et al.

Yao et al. describe GIMAP6 deficiency in humans and mice showing immune dysfunction and susceptibility to bacterial infections. They find impaired autophagy in GIMAP6-deficient immune cells and define a functional complex composed of GIMAP6, GIMAP7, and GABARAPL2.

Article

| May 09 2022

Hypoxia-induced adrenomedullin activates ILC2

Jihye Han, Qingqing Wan, Goo-Young Seo, Kenneth Kim, Sarah el Baghdady, Jee H. Lee, Mitchell Kronenberg, Yun-Cai Liu

Hypoxia in club cells in the lung epithelium induces increased ILC2 responses, leading to enhanced inflammation and immunity. The mechanism, revealed by VHL deletion, is increased HIF2α driving the secretion of adrenomedullin, which activates ILC2.

Article

| May 05 2022

Adaptive resistance to RET inhibition

Renuka Raman, Jacques A. Villefranc, Timothy M. Ullmann, Jessica Thiesmeyer, Viviana Anelli, Jun Yao, James R. Hurley, Chantal Pauli, Rohan Bareja, Kenneth Wha Eng, Princesca Dorsaint, David C. Wilkes, Shaham Beg, Sarah Kudman, Reid Shaw, Michael Churchill, Adnan Ahmed, Laurel Keefer, Ian Misner, Donna Nichol, Naveen Gumpeni, Theresa Scognamiglio, Mark A. Rubin, Carla Grandori, James Patrick Solomon, Wei Song, Juan Miguel Mosquera, Noah Dephoure, Andrea Sboner, Olivier Elemento, Yariv Houvras

Genetic alterations in RET lead to activation of ERK and AKT signaling and are associated with hereditary and sporadic thyroid cancer and lung cancer. Highly selective RET inhibitors have recently entered clinical use after demonstrating efficacy in treating patients with diverse tumor types harboring RET gene ...

Article

| April 28 2022

Pyrin overactivation by CDC42 C-terminal variants

Masahiko Nishitani-Isa, Kojiro Mukai, Yoshitaka Honda, Hiroshi Nihira, Takayuki Tanaka, Hirofumi Shibata, Kumi Kodama, Eitaro Hiejima, Kazushi Izawa, Yuri Kawasaki, Mitsujiro Osawa, Yu Katata, Sachiko Onodera, Tatsuya Watanabe, Takashi Uchida, Shigeo Kure, Junko Takita, Osamu Ohara, Megumu K. Saito, Ryuta Nishikomori, Tomohiko Taguchi, Yoji Sasahara, Takahiro Yasumi

Using induced pluripotent stem cells carrying CDC42^R186C, trapping of CDC42 C-terminal variants within the Golgi apparatus is shown to trigger autoinflammation by promoting pyrin inflammasome assembly through a mechanism independent of their GTPase activity.

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