Journal of Experimental Medicine | Rockefeller University Press

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Targeting CLK3 reprograms nucleotide metabolism
LC lipids drive metabolic T cell exhaustion
Repositioning lung resident memory to draining LN

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Newest Articles

Brief Definitive Report

| August 14 2020

Necroptosis is a stand-alone antiviral mechanism

Maria Shubina, Bart Tummers, David F. Boyd, Ting Zhang, Chaoran Yin, Avishekh Gautam, Xi-zhi J. Guo, Diego A. Rodriguez, William J. Kaiser, Peter Vogel, Douglas R. Green, Paul G. Thomas, Siddharth Balachandran

Necroptosis is considered a fail-safe death modality deployed when apoptosis pathways are compromised, but whether necroptosis can limit a virus in the absence of apoptosis is unknown. This study demonstrates that necroptosis drives highly effective antiviral immunity when apoptosis is absent.

Article

| August 14 2020

Mincle accelerates necroinflammation in AKI

Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Yuki Sugiura, Tomofumi Miyamoto, Hiro Kohda, Ayaka Ito, Taiki Miyazawa, Akira Matsumoto, Seiichiro Aoe, Yoshihiro Miyamoto, Naotake Tsuboi, Shoichi Maruyama, Makoto Suematsu, Sho Yamasaki, Yoshihiro Ogawa, Takayoshi Suganami

This study demonstrates that β-glucosylceramide in combination with free cholesterol acts on Mincle as an endogenous ligand to induce cell death–triggered sustained inflammation after renal ischemia–reperfusion injury.

Article

| August 13 2020

High-affinity monoclonal antibody 5D5 does not inhibit Plasmodium sporozoites

Elaine Thai, Giulia Costa, Anna Weyrich, Rajagopal Murugan, David Oyen, Yevel Flores-Garcia, Katherine Prieto, Alexandre Bosch, Angelo Valleriani, Nicholas C. Wu, Tossapol Pholcharee, Stephen W. Scally, Ian A. Wilson, Hedda Wardemann, Jean-Philippe Julien, Elena A. Levashina

Molecular characterization of inhibitory and non-inhibitory antibodies contributes to vaccine design. Here, we show that the high-affinity mAb 5D5 against the PfCSP N-terminus of sporozoites does not inhibit Pf invasion. This information is critical for the prioritization of functional sites of vulnerability to include in next-generation malaria immunogen designs.

Brief Definitive Report

| August 12 2020

Morphology of macrophages is prognostic in CLM

Matteo Donadon, Guido Torzilli, Nina Cortese, Cristiana Soldani, Luca Di Tommaso, Barbara Franceschini, Roberta Carriero, Marialuisa Barbagallo, Alessandra Rigamonti, Achille Anselmo, Federico Simone Colombo, Giulia Maggi, Ana Lleo, Javier Cibella, Clelia Peano, Paolo Kunderfranco, Massimo Roncalli, Alberto Mantovani, Alberto Mantovani, Federica Marchesi, Federica Marchesi

Morphometric characterization of TAMs in human colorectal liver metastases captures individual populations, corresponding to single-cell clusters and associated with distinct clinical outcome and transcriptional profiles. Quantitative analysis of macrophage morphology can serve as a simple readout of functional diversity with prognostic significance.

Article

| August 11 2020

Plasma cell development without Pax5 repression

Grace J. Liu, Markus Jaritz, Miriam Wöhner, Benedikt Agerer, Andreas Bergthaler, Stephen G. Malin, Meinrad Busslinger

Due to cross-antagonism of the B cell factor Pax5 and plasma cell regulator Blimp1, it was hypothesized that plasma cells develop only upon Pax5 repression by Blimp1. Unexpectedly, Liu et al. show that ectopic Pax5 expression in plasma cells does not interfere with their development and function.

Article

| August 11 2020

Macrophages promote bone metastases

Ruo-Yu Ma, Hui Zhang, Xue-Feng Li, Cheng-Bin Zhang, Cigdem Selli, Giulia Tagliavini, Alyson D. Lam, Sandrine Prost, Andrew H. Sims, Hai-Yan Hu, Tianlei Ying, Zhan Wang, Zhaoming Ye, Jeffrey W. Pollard, Bin-Zhi Qian

This study identifies a novel population of CD204+IL4R+ bone metastasis–associated macrophages (BoMAMs) in mouse models and patient samples. These BoMAMs, derived from CCR2-recruited monocytes but not from CD169+ resident macrophages, significantly promote metastatic outgrowth of breast cancer in vivo.

Brief Definitive Report

| August 06 2020

NCKAP1L deficiency

Carla Noemi Castro, Michelle Rosenzwajg, Raphael Carapito, Mohammad Shahrooei, Martina Konantz, Amjad Khan, Zhichao Miao, Miriam Groß, Thibaud Tranchant, Mirjana Radosavljevic, Nicodème Paul, Tristan Stemmelen, Fabien Pitoiset, Aurélie Hirschler, Benoit Nespola, Anne Molitor, Véronique Rolli, Angélique Pichot, Laura Eva Faletti, Bruno Rinaldi, Sylvie Friant, Mark Mednikov, Hatice Karauzum, M. Javad Aman, Christine Carapito, Claudia Lengerke, Vahid Ziaee, Wafaa Eyaid, Stephan Ehl, Fayhan Alroqi, Nima Parvaneh, Seiamak Bahram, Seiamak Bahram

Biallelic mutations in NCKAP1L, a regulator of the actin cytoskeleton, cause immunodeficiency, lymphoproliferation, and hyperinflammation with features of hemophagocytic lymphohistiocytosis. Impaired immune synapse formation, early T cell activation and leading edge formation, and defective neutrophil migration characterize this novel “actinopathy.”

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Reviews & Opinions

Insights

| August 13 2020

Neutralizing hepatitis B

Davide F. Robbiani

The role of human potent neutralizing antibodies in the control of chronic HBV infection.

Insights

| August 13 2020

RSSs set the odds for exclusion

Michael S. Krangel

Vβ-to-DβJβ rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal Vβ recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.

People & Ideas

| July 31 2020