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Newest Articles
Article
| September 17 2021
Featured Figure
TIMP1-dependent sex disparity in pancreatic cancer
Chris D. Hermann, Benjamin Schoeps, Celina Eckfeld, Enkhtsetseg Munkhbaatar, Lukas Kniep, Olga Prokopchuk, Nils Wirges, Katja Steiger, Daniel Häußler, Percy Knolle, Emily Poulton, Rama Khokha, Barbara T. Grünwald, Ihsan Ekin Demir, Achim Krüger
Hermann et al. reveal a lifestyle-independent sex disparity in liver metastasis and survival of pancreatic cancer caused by TIMP1. Increased TIMP1 expression in males predicts liver metastasis in various cancer entities. Such insight into the basis of sex differences substantiates the necessity of considering sex in cancer medicine.
Article
| September 16 2021
Featured Figure
Sentinel macrophages trigger epithelial NF-κB activation
Annika Hausmann, Boas Felmy, Leo Kunz, Sanne Kroon, Dorothée Lisa Berthold, Giverny Ganz, Ioana Sandu, Toshihiro Nakamura, Nathan Sébastien Zangger, Yang Zhang, Tamas Dolowschiak, Stefan Alexander Fattinger, Markus Furter, Anna Angelika Müller-Hauser, Manja Barthel, Katerina Vlantis, Laurens Wachsmuth, Jan Kisielow, Luigi Tortola, Danijela Heide, Mathias Heikenwälder, Annette Oxenius, Manfred Kopf, Timm Schroeder, Manolis Pasparakis, Mikael Erik Sellin, Wolf-Dietrich Hardt
Hausmann et al. describe a sentinel intercrypt macrophage population in the intestine, which detects Gram-negative microbes breaching the epithelial barrier and elicits epithelial NF-κB signaling in neighboring crypts. The tunability of this crypt-scale response allows the induction of appropriately scaled defenses according to the localization and intensity of microbial triggers.
Article
| September 08 2021
Featured Figure
Autoimmunity can fuel cancer immunosurveillance
Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour, Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli, Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune, Franck Letourneur, Gwennhael Autret, Patrick S.C. Leung, M. Eric Gershwin, Jie S. Zhu, Mark J. Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim, Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel, Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri, Guido Kroemer, Jonathan G. Pol
The present study shows in murine models that autoimmunity, which targets normal cholangiocytes upon primary biliary cholangitis, fuels the immunosurveillance of malignant cholangiocytes and protects from the emergence of cholangiocarcinoma.
Article
| September 07 2021
Featured Figure
Gene expression in progression and resolution of TB
Olivier Tabone, Raman Verma, Akul Singhania, Probir Chakravarty, William J. Branchett, Christine M. Graham, Jo Lee, Tran Trang, Frederic Reynier, Philippe Leissner, Karine Kaiser, Marc Rodrigue, Gerrit Woltmann, Pranabashis Haldar, Anne O’Garra
TB results in 1.5 million deaths per year, yet a low percentage of M. tuberculosis–infected individuals progress to TB. Knowledge of the early immune response during TB progression and on treatment will inform clinical management of the disease.
Article
| September 03 2021
Featured Figure
Dominant-negative Aire mutations reveal Aire autoregulation
Yael Goldfarb, Tal Givony, Noam Kadouri, Jan Dobeš, Cristina Peligero-Cruz, Itay Zalayat, Golda Damari, Bareket Dassa, Shifra Ben-Dor, Yael Gruper, Bergithe E. Oftedal, Eirik Bratland, Martina M. Erichsen, Amund Berger, Ayelet Avin, Shir Nevo, Uku Haljasorg, Yael Kuperman, Adi Ulman, Rebecca Haffner-Krausz, Ziv Porat, Ulus Atasoy, Dena Leshkowitz, Eystein S. Husebye, Jakub Abramson
Aire is a master of central tolerance. Goldfarb et al. compare mice with recessive or dominant-negative Aire patient mutations to dissect the mechanisms that underlie dominance and identify an autoregulatory mechanism by which Aire negatively modulates its own expression.
Brief Definitive Report
| September 03 2021
Featured Figure
Role of neutrophils in CAPS
Julien Stackowicz, Nicolas Gaudenzio, Nadine Serhan, Eva Conde, Ophélie Godon, Thomas Marichal, Philipp Starkl, Bianca Balbino, Axel Roers, Pierre Bruhns, Friederike Jönsson, Philippe Moguelet, Sophie Georgin-Lavialle, Lori Broderick, Hal M. Hoffman, Stephen J. Galli, Laurent L. Reber
CAPS is an IL-1β–mediated autoinflammatory disease due to gain-of-function mutations in NLRP3. This work shows that skin-infiltrating neutrophils represent a substantial source of IL-1β in CAPS patients. In mice, gain-of-function mutations in Nlrp3 restricted to neutrophils are sufficient to trigger severe CAPS.
Brief Definitive Report
| September 02 2021
Featured Figure
TLR7 antagonism alleviates severe influenza
Julie C.F. Rappe, Katja Finsterbusch, Stefania Crotta, Matthias Mack, Simon L. Priestnall, Andreas Wack
Distinct types of cytokine storms aggravate respiratory viral infection. This study shows that in severe influenza, TLR7 antagonist treatment ameliorates both type I interferon–driven and interferon-independent immunopathology by blocking TLR7-dependent cytokine production by immune cells, without affecting RIG-I–dependent responses in lung epithelia.

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Volume 218,
Issue 9,
September 6, 2021
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Insights
| September 16 2021
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Dismantling the origin of mantle cell lymphoma
Anna E. Beaudin
Pieters et al. establish a novel mouse model of MCL driven by overexpression of cyclin D2 and identify fetal-derived B1a cells as putative cell of origin for MCL.
Insights
| September 13 2021
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A new fungal antigen for Löfgren's syndrome
Clarice X. Lim, Thomas Weichhart
A peptide derived from the airborne mold species Aspergillus nidulans that stimulates T cells of Löfgren's syndrome patients has been identified.
Insights
| September 07 2021
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Alveolar macrophages and epithelial cells: The art of living together
Derek Clements, Juliana Idoyaga
In this issue of JEM, Gschwend et al. reveal the indispensable role of alveolar epithelial cells type 2 in controlling the density of alveolar macrophages. This study highlights the intricate crosstalk that lung stroma and macrophages undergo to maintain homeostasis.
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The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

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  • Online ISSN 1540-9538
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