Related Articles from Rockefeller University Press

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  NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

  Snehlata Kumari ... Manolis Pasparakis | Life Sci. Alliance

  TNFR1 was found to cause skin inflammation in mice with epidermal keratinocyte-specific ablation of IKK2 or of both the NF-kB subunits RelA and cRel by triggering RIPK1-dependent, RIPK3-MLKL–mediated necroptosis of keratinocytes.

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  Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages

  Samantha B Kemp ... Marina Pasca di Magliano | Life Sci. Alliance

  This study uses biomaterial scaffolds to identify a macrophage gene signature defined by high expression of C1qa, C1qb, and Trem2 that is elevated systemically in mouse and human pancreatic cancer.

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  DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria

  Barbara Killy ... Roland Lang | Life Sci. Alliance

  Lack of miRNA biosynthesis in DGCR8-deficient macrophages did not block macrophage differentiation but caused overshooting type I IFN responses to mycobacterial glycolipids.