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Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh-Keller, Marc Bajenoff, Michael H. Sieweke, Søren Kragh Moestrup, Nathalie Auphan-Anezin, Toby Lawrence
Etzerodt et al. identify a unique subset of CD163+ Tim4+ tissue-resident macrophages in omentum that are maintained independently of bone marrow–derived monocytes and have a specific role in the metastatic spread of ovarian cancer cells.
Lan Kang, Xiang Zhang, Liangliang Ji, Tiantian Kou, Sinead M. Smith, Baohong Zhao, Xiaohuan Guo, Inés Pineda-Torra, Li Wu, Xiaoyu Hu
Transcription factor RBP-J in intestinal macrophages dynamically controls antibacterial immunity by interfacing with T cells and ILCs. Macrophage-intrinsic RBP-J supports intestinal Th17 cell responses via IL-6 production, whereas RBP-J deficiency unexpectedly reveals a compensatory role for ILC3 late during infection.
Aude-Hélène Capietto, Aude-Hélène Capietto, Suchit Jhunjhunwala, Samuel B. Pollock, Patrick Lupardus, Jim Wong, Lena Hänsch, James Cevallos, Yajun Chestnut, Ajay Fernandez, Nicolas Lounsbury, Tamaki Nozawa, Manmeet Singh, Zhiyuan Fan, Cecile C. de la Cruz, Qui T. Phung, Lucia Taraborrelli, Benjamin Haley, Jennie R. Lill, Ira Mellman, Richard Bourgon, Lélia Delamarre
Cancer mutations create neoantigens that are of great interest for immunotherapy, but their accurate identification remains a challenge. Capietto et al. show that mutation position is an important determinant for immunogenicity, and incorporating this feature into prediction algorithms improves their identification.
Wei Liu, Yonju Ha, Fan Xia, Shuang Zhu, Yi Li, Shuizhen Shi, Fang C. Mei, Kevin Merkley, Gianmarco Vizzeri, Massoud Motamedi, Xiaodong Cheng, Hua Liu, Wenbo Zhang
This study shows that the cAMP/Epac1 pathway plays a critical role in retinal neurodegeneration via CaMKII activation in mouse models of ocular hypertension and suggests that Epac1 is a therapeutic target for neuroprotection in glaucoma.
Brief Definitive Report
Adam J. Byrne, Joseph E. Powell, Brendan J. O’Sullivan, Patricia P. Ogger, Ashley Hoffland, James Cook, Katie L. Bonner, Richard J. Hewitt, Simone Wolf, Poonam Ghai, Simone A. Walker, Samuel W. Lukowski, Philip L. Molyneaux, Sejal Saglani, Daniel C. Chambers, Toby M. Maher, Clare M. Lloyd
We characterized monocyte/macrophage populations from infants to older adults and lineage traced these cells using sex-mismatched lung transplant recipients. Classical monocytes peak in adulthood and decline in older adults. Importantly, our data show that after transplant, donor human airway macrophages (AMs) are readily replaced by recipient-derived monocytes.
Brief Definitive Report
Yin-Huai Chen, Giedre Grigelioniene, Phillip T. Newton, Jacob Gullander, Maria Elfving, Anna Hammarsjö, Dominyka Batkovskyte, Hessa S. Alsaif, Wesam I.Y. Kurdi, Firdous Abdulwahab, Veerabahu Shanmugasundaram, Luke Devey, Séverine Bacrot, Jana Brodszki, Celine Huber, Ben Hamel, David Gisselsson, Nikos Papadogiannakis, Katarina Jedrycha, Barbara Gürtl-Lackner, Andrei S. Chagin, Gen Nishimura, Dominik Aschenbrenner, Fowzan S. Alkuraya, Arian Laurence, Valérie Cormier-Daire, Holm H. Uhlig
Chen et al. identify patients with homozygous essential loss-of-function variants in human IL6ST that result in a complete loss of signaling of the whole family of GP130-dependent cytokines. This study identifies GP130 deficiency as the cause of an extended Stüve-Wiedemann syndrome.
Technical Advances and Resources
Delphine Sterlin, Jehane Fadlallah, Olivia Adams, Claire Fieschi, Christophe Parizot, Karim Dorgham, Asok Rajkumar, Gaëlle Autaa, Hela El-Kafsi, Jean-Luc Charuel, Catherine Juste, Friederike Jönsson, Thomas Candela, Hedda Wardemann, Alexandra Aubry, Carmen Capito, Hélène Brisson, Christophe Tresallet, Richard D. Cummings, Martin Larsen, Hans Yssel, Stephan von Gunten, Guy Gorochov
Intestinal IgA is a key player in host-commensal symbiosis. Sterlin et al. report that human IgAs are microbiota cross-reactive at the clonal level. IgA1 and IgA2 mostly converge toward common gut microbiota targets but possess distinct carbohydrate repertoires.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 1,
January 6, 2020
Reviews & Opinions
Cytokines Focus Review
Iva Lelios, Dilay Cansever, Sebastian G. Utz, Wiebke Mildenberger, Sebastian A. Stifter, Melanie Greter
IL-34 is an alternative ligand for the colony stimulating factor-1 receptor. Here, the authors summarize recent advances of IL-34 in macrophage development and function and its role in health and disease.
Xi C. He, Linheng Li
Using a single-cell RNA-seq approach, the work by Wang et al. establishes an atlas of human colon, rectum, and ileum epithelial cells. Their study reveals that different regions have specialized nutrient absorption preferences, microbe defenses, and endocrine function. They also identify new markers for a variety of cell types.
Matthew T. Witkowski, Stavroula Kousteni, Iannis Aifantis
Upon leukemic transformation, extensive remodeling of the bone marrow microenvironment results in altered cellular and biochemical interactions promoting tumor cell development and survival or reducing treatment responsiveness. Therapeutic targeting of the “malignant” leukemic niche may treat or mitigate disease relapse.

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