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Article
Mark R. Silvis et al.
Inhibition of CDK4/6 and lysosome function overcomes c-MYC–mediated cell cycle entry in the face of trametinib and chloroquine co-treatment in pancreatic cancer.
Article
Masashi Kanayama et al.
Collaboration between myeloid and lymphoid lineages on hematopoiesis has not been fully elucidated. Here, we showed that during systemic infection, a unique B cell subset expressing myeloid markers emerged to enhance on-demand emergency myelopoiesis by producing IL-10.
Article
Neta Gurwicz et al.
Tingible body macrophages (TBMs) were discovered more than 100 yr ago, yet their origins and cellular dynamics were unknown. Gurwicz et al. demonstrate that TBMs arise from lymph node–resident precursors and consume germinal center B cells by highly dynamic dendrites to prevent intracellular-content dissemination.
Article
Milena Petkova et al.
Petkova et al. identify a new Ptx3-positive immune-interacting subtype of lymphatic endothelial cells, iLECs, that drive oncogenic PI3K-driven lymphatic malformations. These cells produce chemokines that recruit pro-lymphangiogenic macrophages, which in turn promote pathological lymphatic vessel growth.
Article
Qinli Sun et al.
Sun et al. found that STAT3, activated by IL-10 and IL-21, regulates the terminal differentiation of effector CD8+ T cells in cancer and also plays an important role in effector CD8+ T cells in acute infection.
Brief Definitive Report
Lestat R. Ali et al.
The authors use single-cell RNA-sequencing and TCR tracking to analyze blood and tumors from breast and ovarian cancer patients treated with PD-1 blockade and CDK4/6 inhibition. They find that both therapies are immunologically active and enhance T cell effector function and memory, respectively.
Article
Darryl A. Hayward et al.
The WNK1 kinase is essential in B cells for T-dependent antibody responses because it is activated by signaling from BCR, CXCR5, and CD40, and regulates B cell migration, adhesion, T-dependent activation, and differentiation into germinal center B cells and plasma cells.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 220,
Issue 1,
2 January 2023
Reviews & Opinions
Review
Devon Jeltema et al.
STING signaling is at the center of multiple autoinflammatory and neurodegenerative diseases. The authors review how STING trafficking influences signaling, propose a model of tonic STING signaling, and discuss an emerging link between dysregulated STING trafficking and neurodegenerative disease.
Viewpoint
Andre G. Buret, Thibault Allain
Andre Buret and Thibault Allain discuss the mechanisms that regulate gut microbiota biofilms integrity and highlight the importance of studying phenotypic biofilm damage, beyond the characterization of relative bacterial abundance.
People & Ideas
Lucie Van Emmenis
Sara Suliman is an assistant professor in the Department of Experimental Medicine at UCSF. Her lab uses multiple approaches to identify candidate tuberculosis (TB) risk pathways and to determine their role in TB progression.

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