Journal of Experimental Medicine | Rockefeller University Press

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Stem Cell Collection 2020

A special collection of recent stem cell research from JCB and JEM
Targeting Sirt1-Nox4 signaling in cancer cachexia
Restriction of memory B cell differentiation
Optimized gene disruption in primary myeloid cells

JEM staff members are working remotely in line with New York City’s efforts to contain COVID-19. While our offices are physically closed, editorial and publication operations continue. JEM staff can be reached via email and phone, as we tend to our family, friends and community. Thank you for your patience and understanding.

Newest Articles

Article

| July 10 2020

ADAMTS5 proteolysis of versican drives CCM disease

Courtney C. Hong, Alan T. Tang, Matthew R. Detter, Jaesung P. Choi, Rui Wang, Xi Yang, Andrea A. Guerrero, Carl F. Wittig, Nicholas Hobson, Romuald Girard, Rhonda Lightle, Thomas Moore, Robert Shenkar, Sean P. Polster, Lauren M. Goddard, Aileen A. Ren, N. Adrian Leu, Stephanie Sterling, Jisheng Yang, Li Li, Mei Chen, Patricia Mericko-Ishizuka, Lukas E. Dow, Hideto Watanabe, Markus Schwaninger, Wang Min, Douglas A. Marchuk, Xiangjian Zheng, Issam A. Awad, Mark L. Kahn

CCMs arise due to increased MEKK3-KLF2/4 signaling in brain endothelial cells, but the downstream mechanisms of CCM formation remain unclear. Hong et al. show that expression of the ADAMTS5 protease and proteolytic cleavage of the matrix proteoglycan versican by CCM-deficient endothelial cells contribute to CCM formation.

Brief Definitive Report

| July 10 2020

Macrophages in nerve regeneration

Alexandre Boissonnas, Floriane Louboutin, Marie Laviron, Pierre-Louis Loyher, Elodie Reboussin, Sandrine Barthelemy, Annabelle Réaux-Le Goazigo, Christian S. Lobsiger, Béhazine Combadière, Stéphane Mélik Parsadaniantz, Christophe Combadière

This work describes the spatiotemporal orchestration of recently recruited monocyte-derived and resident macrophages during Wallerian degeneration induced by chronic constriction injury of the sciatic nerve and unveils distinct contribution of these two macrophage subsets in myelin degradation and neurofiber regeneration.

Article

| July 09 2020

T cell immunodominance to hemagglutinin

Antonino Cassotta, Philipp Paparoditis, Roger Geiger, Ramgopal R. Mettu, Samuel J. Landry, Alessia Donati, Marco Benevento, Mathilde Foglierini, David J.M. Lewis, Antonio Lanzavecchia, Federica Sallusto

We explored the nature of the human CD4 T cell immunodominance to influenza H1 hemagglutinin and demonstrate that the naïve repertoire is very broad, while the memory repertoire becomes selected toward peptides with a high likelihood to be processed and presented by dendritic cells.

Article

| July 08 2020

Protective role of LCN2 in obesity and diabetes

Ioanna Mosialou, Steven Shikhel, Na Luo, Peristera Ioanna Petropoulou, Konstantinos Panitsas, Brygida Bisikirska, Nyanza J. Rothman, Roxane Tenta, Bertrand Cariou, Matthieu Wargny, Elisabeth Sornay-Rendu, Thomas Nickolas, Mishaela Rubin, Cyrille B. Confavreux, Stavroula Kousteni

LCN2 is an osteoblast-enriched secreted protein that regulates food intake. Here, the authors show that LCN2 is upregulated during obesity and diabetes as a protective mechanism to counteract obesity-induced glucose intolerance by decreasing food intake and promoting adaptive β-cell proliferation.

Article

| July 08 2020

High microbiota reactivity of human intestinal IgA

Johanna Kabbert, Julia Benckert, Tim Rollenske, Thomas C.A. Hitch, Thomas Clavel, Vuk Cerovic, Hedda Wardemann, Oliver Pabst

The authors reveal a mechanism of SIgA–microbiota interaction in the adult human gut. They describe antibodies with a high capacity to bind phylogenetically distant members of the microbiota. Such cross-species reactivity does not correlate with antibody polyreactivity but crucially depends on somatic mutations.

Article

| July 08 2020

EXOC2 mutations cause brain developmental defects

Nicole J. Van Bergen, Syed Mukhtar Ahmed, Felicity Collins, Mark Cowley, Annalisa Vetro, Russell C. Dale, Daniella H. Hock, Christian de Caestecker, Minal Menezes, Sean Massey, Gladys Ho, Tiziana Pisano, Seana Glover, Jovanka Gusman, David A. Stroud, Marcel Dinger, Renzo Guerrini, Ian G. Macara, Ian G. Macara, John Christodoulou, John Christodoulou

Patients with severe developmental delay, dysmorphism, and brain abnormalities were identified as having pathogenic mutations in EXOC2, a critical component of the exocyst complex involved in vesicle trafficking, which caused secretory vesicle transport defects in patient-derived cell lines.

Article

| July 07 2020

SOAT1 dependency in pancreatic cancer

Tobiloba E. Oni, Giulia Biffi, Lindsey A. Baker, Yuan Hao, Claudia Tonelli, Tim D.D. Somerville, Astrid Deschênes, Pascal Belleau, Chang-il Hwang, Francisco J. Sánchez-Rivera, Hilary Cox, Erin Brosnan, Abhishek Doshi, Rebecca P. Lumia, Kimia Khaledi, Youngkyu Park, Lloyd C. Trotman, Scott W. Lowe, Alexander Krasnitz, Christopher R. Vakoc, David A. Tuveson

Uncovering mechanisms that drive pancreatic cancer could lead to effective therapies for this lethal disease. This study reveals how pancreatic cancer cells hyperactivate a pathway to sustain their proliferation. Inhibiting this pathway affects cancer cells, but not normal cells, highlighting a new therapeutic opportunity.

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