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Chong Zuo et al.
Stromal desmoplasia drives local proliferation of TAMs and induces their immunosuppressive ability through altering p21 expression. These changes in p21 in TAMs also potentially render tumors more sensitive to CD40 agonist therapy.
Brief Definitive Report
Kavita Rawat et al.
Both DCs and monocytes capture antigen for presentation to lymph node T cells. Here, Rawat et al. show that DCs use the chemokine receptor CCR7, while monocytes follow chemokines secreted by migratory DCs to reach the nodes and control immunity.
Tina Nguyen et al.
Detailed analysis of patients with APDS2 and a novel mouse model of Pik3r1 LOF reveals multiple cellular defects, some of which are unique to APDS2 and not seen in APDS1. This is associated with unique signaling changes caused by Pik3r1 LOF.
Lore Billiet et al.
Billiet et al. identify the post-thymic progeny of the agonist-selected CD10+ PD-1+ precursors in humans based on shared characteristics of the T cell receptor repertoire and the transcriptome. This lineage represents a well-defined but heterogeneous, unconventional TCRαβ+ lineage mostly confined within the CD8+ Helios+ T cells.
Huan Qin et al.
Qin and colleagues develop a genome-editing tool characterized by the versatility of prime editors and unconstrained PAM requirement of SpRY. In vivo gene correction is successfully implemented in the mouse model of Pde6b-associated retinitis pigmentosa, leading to substantial functional rescue of vision.
Keenan A. Lacey et al.
Extracellular nucleases of the DNASE1 family are conserved in vertebrates, yet their physiological function remains unclear. This study shows that DNASE1 and its homolog DNASE1L3 jointly facilitate resistance to systemic infection with Staphylococcus aureus by digesting bacterial biofilms.
Hesham D. Abdulla et al.
Abdulla et al. show that the LMO2 transcription factor, a key driver of human T-lymphoblastic leukemia, inhibits thymocyte competition in a transgenic mouse model and that this enables LMO2 to promote T-lymphoblastic leukemia.

Related Articles from Rockefeller University Press

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Current Issue
Volume 220,
Issue 3,
6 March 2023
Reviews & Opinions
People & Ideas
Lucie Van Emmenis
Soyon Hong is a group leader at the UK Dementia Research Institute at UCL. Her lab is interested in investigating how cell types work together to maintain brain function, and how these interactions are dysregulated during neurodegenerative disease states such as Alzheimer’s disease.
Samuel W. Du, Krzysztof Palczewski
CRISPR/Cas9 genome editing techniques have the potential to treat previously untreatable inherited genetic disorders of vision by correcting mutations that cause these afflictions. Using a prime editor, Qin et al. restored visual functions in a mouse model (rd10) of retinitis pigmentosa.
Keitaro Fukuda
In this issue of JEM, Reijers et al. demonstrate that pre- and post-treatment IFNγ-related gene expression scores are promising markers for choosing neoadjuvant immunotherapy for stage III melanoma.

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