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Rachana Mishra, Trongha Phan, Pavan Kumar, Zachery Morrissey, Muskan Gupta, Carolyn Hollands, Aashutosh Shetti, Kyra Lauren Lopez, Mark Maienschein-Cline, Hoonkyo Suh, Rene Hen, Orly Lazarov
Deficits in hippocampal neurogenesis cause cognitive impairments in Alzheimer’s disease by compromising memory storage. Augmenting neurogenesis rescues memory by recruiting more new neurons with restored spine density and transcription profile. AD-linked genes regulate the memory-storing neurons.
Chaoyu Ma, Liwen Wang, Wei Liao, Yong Liu, Shruti Mishra, Guo Li, Xin Zhang, Yuanzheng Qiu, Qianjin Lu, Nu Zhang
The signals that control the differentiation of Tcf-1+ CD8+ T cells are not entirely known. Here, the authors find that TGF-β promotes lymphoid residency and inhibits the effector differentiation of Tcf-1+ T cells partially via controlling the expression of α4 integrins.
Yinghong Hu, William H. Hudson, Haydn T. Kissick, Christopher B. Medina, Antonio P. Baptista, Chaoyu Ma, Wei Liao, Ronald N. Germain, Shannon J. Turley, Nu Zhang, Rafi Ahmed
This study demonstrates the role of TGF-β on virus-specific CD8 T cell differentiation during chronic LCMV infection. TGF-β maintains the stem-like state of TCF-1+ CD8 T cells and promotes terminal differentiation of exhausted cells by suppressing effector- and proliferation-associated programs.
Xue Liu, Yan Geng, Jiurong Liang, Ana Lucia Coelho, Changfu Yao, Nan Deng, Yizhou Wang, Kristy Dai, Guanling Huang, Ting Xie, Ningshan Liu, Simon C. Rowan, Forough Taghavifar, Vrishika Kulur, Zhenqiu Liu, Barry R. Stripp, Cory M. Hogaboam, Dianhua Jiang, Paul W. Noble
This study demonstrates the regulatory pathways closely associated with a metastatic cancer signature regulated by HER2 in invasive IPF lung fibroblasts. Manipulation of HER2 in vitro and in vivo shows that HER2 signaling is a key driver of fibroblast invasion and progressive lung fibrosis.
Zhuoqiong Qiu, Zhenlai Zhu, Xiaochun Liu, Baichao Chen, Huibin Yin, Chaoying Gu, Xiaokai Fang, Ronghui Zhu, Tianze Yu, Wenli Mi, Hong Zhou, Yufeng Zhou, Xu Yao, Wei Li
This study demonstrates that a dysregulated sebum–microbial metabolite–IL-33 axis is involved in the pathogenesis of atopic dermatitis, possibly by playing an initiating role in the induction of skin inflammation.
Brief Definitive Report
Joey Ming Er Lim, Anthony Tanoto Tan, Nina Le Bert, Shou Kit Hang, Jenny Guek Hong Low, Antonio Bertoletti
Virus-specific T cells in the nasal cavity might provide an immediate layer of protection against SARS-CoV-2. This study detected SARS-CoV-2–specific nasal-resident T cells in vaccinees only after infection, highlighting the significance of nasal challenge in the formation of antiviral immunity at the site of infection.
Fabian M.P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A.S.H. Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D. Katsikis, Joyce H.G. Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I. De Zeeuw, Aleksandra Badura, Meinrad Busslinger
A mouse model carrying biallelic Pax5 mutations identified in a patient with hypogammaglobulinemia and autism spectrum disorder shows a B cell developmental arrest and autistic-like behavior caused by abnormal development of the cerebellum and loss of ventral midbrain GABAergic neurons.

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Current Issue
Volume 219,
Issue 8,
1 August 2022
Reviews & Opinions
John R. Grainger, Rufus H. Daw
Karo-Atar et al. demonstrate that products released by a gut-dwelling helminth modify intestinal stem cells, which is associated with a loss of secretory cell types that support helminth expulsion.
David Hoyos, Benjamin D. Greenbaum
Benjamin D. Greenbaum and David Hoyos discuss the challenges of antigen modeling to design vaccines for infectious diseases and cancer.
Sandro Da Mesquita
In this issue, Jacob et al. employ imaging techniques to provide a more comprehensive chart of the meningeal lymphatic vasculature and draw a parallel for lymphatic drainage of cerebrospinal fluid in mice and humans.

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