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Andrea C. Bohrer, Ehydel Castro, Zhidong Hu, Artur T.L. Queiroz, Claire E. Tocheny, Maike Assmann, Shunsuke Sakai, Christine Nelson, Paul J. Baker, Hui Ma, Lin Wang, Wen Zilu, Elsa du Bruyn, Catherine Riou, Keith D. Kauffman, Tuberculosis Imaging Program, Ian N. Moore, Franca Del Nonno, Linda Petrone, Delia Goletti, Adrian R. Martineau, David M. Lowe, Mark R. Cronan, Robert J. Wilkinson, Clifton E. Barry, III, Laura E. Via, Daniel L. Barber, Amy D. Klion, Bruno B. Andrade, Yanzheng Song, Ka-Wing Wong, Katrin D. Mayer-Barber
Host resistance to Mycobacterium tuberculosis infection is mediated through cellular type I immunity. Bohrer et al. reveal an unexpected association between type II immunity-related eosinophils and TB in humans, nonhuman primates, and mice, where eosinophil deficiency results in increased disease susceptibility.
Ian C. Michelow, Sangshin Park, Shu-Whei Tsai, Bonnie Rayta, Charisse Flerida A. Pasaje, Sara Nelson, Angela M. Early, Anne P. Frosch, George Ayodo, Dipak K. Raj, Christina E. Nixon, Christian P. Nixon, Sunthorn Pond-Tor, Jennifer F. Friedman, Michal Fried, Patrick E. Duffy, Karine G. Le Roch, Jacquin C. Niles, Jonathan D. Kurtis
Plasmodium falciparum erythrocyte membrane and merozoite antigen 1 (PfEMMA1) is a newly characterized malaria protein expressed on the surface of parasitized erythrocytes and merozoites that induces protective antibodies in functional assays, a human epidemiological study, and a mouse immunization model.
Shuhang Li, Linlin Wang, Zhihao Xu, Yuanyuan Huang, Rufeng Xue, Ting Yue, Linfeng Xu, Fanwu Gong, Shiyu Bai, Qielan Wu, Jiwei Liu, Bolong Lin, Huimin Zhang, Yanhong Xue, Pingyong Xu, Junjie Hou, Xiaofei Yang, Tengchuan Jin, Rongbin Zhou, Jizhong Lou, Tao Xu, Li Bai
Mechanisms negatively controlling activation of NLRP3 inflammasome remain unclear. Li et al. demonstrate that glutathionylation of ASC represses NLRP3 inflammasome activation, and that GSTO1-promoted deglutathionylation of ASC at ER, under metabolic control, is a checkpoint for activating NLRP3 inflammasome.
Matthew DeBerge, Connor Lantz, Shirley Dehn, David P. Sullivan, Anja M. van der Laan, Hans W.M. Niessen, Margaret E. Flanagan, Daniel J. Brat, Matthew J. Feinstein, Sunjay Kaushal, Lisa D. Wilsbacher, Edward B. Thorp
Following myocardial infarction, tissue ischemia leads to activation of hypoxia-inducible factors. DeBerge et al. demonstrate that HIF-1α and HIF-2α activation in myeloid cells antagonizes cardiac repair pathways through cleavage of cardioprotective MerTK and suppression of anti-inflammatory mitochondrial metabolism, respectively.
Keitaro Fukuda, Ken Okamura, Rebecca L. Riding, Xueli Fan, Khashayar Afshari, Nazgol-Sadat Haddadi, Sean M. McCauley, Mehmet H. Guney, Jeremy Luban, Takeru Funakoshi, Tomonori Yaguchi, Yutaka Kawakami, Anastasia Khvorova, Katherine A. Fitzgerald, John E. Harris
Fukuda et al. demonstrate that AIM2 expression in DCs within human melanoma is a poor prognostic sign and that AIM2-deficient DC vaccination enhances melanoma immunotherapeutic responses by promoting STING-induced IFN secretion as well as limiting IL-1β and IL-18 production.
John Podstawka, Sarthak Sinha, Carlos H. Hiroki, Nicole Sarden, Elise Granton, Elodie Labit, Jung Hwan Kim, Graciela Andonegui, Yuefei Lou, Brendan D. Snarr, Donald C. Sheppard, Nicole L. Rosin, Jeff Biernaskie, Bryan G. Yipp
Genetically diverse IgM+ peripheral B cells reside in the lung microvasculature and dampen neutrophil-mediated lung inflammation via lipoxins. Podstawka et al. reveal that transitional B cells marginate in the lung capillaries, where they dampen neutrophil inflammation. These discoveries help elucidate regulatory mechanisms that attenuate acute lung inflammation, which, when unchecked, can lead to acute respiratory distress syndrome and pulmonary failure.
Courtney Mowat, Shayla R. Mosley, Afshin Namdar, Daniel Schiller, Kristi Baker
Mowat et al. show that anti-tumor immunity in dMMR CRCs relies on recruitment and retention of systemic CD8+ T cells. This is driven by extensive genomic instability that upregulates CCL5 and CXCL10 in the CRC cells by endogenously activating cGAS/STING and type I IFN signaling.

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Volume 218,
Issue 8,
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Davide F. Robbiani, Daniel Růžek
The NS1 protein of flaviviruses is taking center stage. Recent work has made it an attractive target for development of vaccines and immunotherapeutics. Cavazzoni and colleagues now reveal a dark side to NS1, linking it to the development of self-reactive antibodies.
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