Skip to Main Content

Advertisement

Skip Nav Destination
Newest Articles
Article
Pooja Parameswaran et al.
The guard protein NLRP1 senses pathogen-encoded effector activities, but whether successful pathogens evade the consequences of NLRP1 activation is less clear. Parameswaran et al. demonstrate that HSV-1 inhibits the antiviral NLRP1 pathway via production of a viral E3 ubiquitin ligase.
Article
Kelsey A. Toth et al.
STAT3 gain-of-function syndrome causes early-onset autoimmunity and immune dysregulation in patients. Here, we report spontaneous and stimulus-driven skin disease in a mouse model associated with locally increased Th17 that is partially dependent on IL-22 signaling.
Article
Lingzi Hong et al.
Hong et al. report that IL-17/Act1 induces chemoresistance by modulating redox homeostasis through epitranscriptomic regulation of antioxidant RNA metabolism. Antisense oligonucleotide that specifically disrupts Act1’s binding to Wtap mRNA inhibits IL-17/Act1–WTAP-mediated antioxidant protein production, offering a potential therapeutic strategy for chemoresistance.
Technical Advances and Resources
Michelle A. Tran et al.
Tran et al. use single-cell RNA-sequencing to discover diverse immune cell populations in bladder cancer patient urine that have highly similar gene expression programs to those in tumor.
Brief Definitive Report
Zhoujie Ding et al.
Ding and Hagan et al. discover a unique requirement for Ki67 in regulating chromatin accessibility in the early stages of lymphocyte development undergoing V(D)J rearrangement, thus ensuring normal immunoglobulin gene recombination, cell maturation, and peripheral representation.
Article
Yingzi Cui et al.
This study uncovers that the CV-A10 virus contributes to onychomadesis in hand-foot-and-mouth disease by inhibiting Wnt/β-catenin signaling through KRM1 receptor invasion. It highlights the activation of the Wnt pathway as a potential treatment and offers novel insights into virus–host cellular signaling interactions.
Article
Ian S. Cohn et al.
Cryptosporidium is an enteric pathogen that is a major cause of diarrheal disease worldwide. In this work, the authors engineer transgenic C. parvum to express MHCII-restricted model antigens and thereby dissect priming and effector functions in parasite-specific CD4+ T cells.
Issue Cover
Current Issue
Volume 221,
Issue 6,
3 June 2024
Reviews & Opinions
Viewpoint
Clarissa Campbell et al.
This year at JEM, we are highlighting women in science by sharing their stories and amplifying their voices. In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher.
Found in Translation
Johanna Chiffelle, Alexandre Harari
Recent studies suggest that personalized cellular therapies using T cells transduced with private TCRs hold the potential to transform the field and provide new treatment options for cancer patients, reflecting significant analogies with the evolution of cancer vaccines toward personalization.
Perspective
Lewis L. Lanier
NK cells were first described five decades ago and named in 1975. This brief Perspective highlights a timeline of a few selected advancements in NK cell biology in each decade from a personal perspective of being involved in this quest.

Most Read

Advertisement

Special Collections

Special Collections

Our annual series highlighting articles that were of greatest interest to our readers in 2023.

View collections >

 

Close Modal

or Create an Account

Close Modal
Close Modal