Journal of Experimental Medicine (JEM) | Rockefeller University Press

Skip Nav Destination

Introducing CME Activities with JEM and Memorial Sloan Kettering Cancer Center
JEM Cancer Immunotherapy 2021
Targeting EYA2 Kills Glioblastoma Stem Cells
Human monoclonal GABAA receptor antibodies
Maternal microbiome impacts neonatal RSV response

RUP response to COVID-19 crisis: Learn about the steps we are taking and find relevant content.

We are hiring: Scientific Editor/Senior Scientific Editor, Journal of Experimental Medicine.

Newest Articles

Article

| November 26 2021

WEE1 inhibition induces anti-tumor immunity

Ensong Guo, Rourou Xiao, Yifan Wu, Funian Lu, Chen Liu, Bin Yang, Xi Li, Yu Fu, Zizhuo Wang, Yuan Li, Yuhan Huang, Fuxia Li, Xue Wu, Lixin You, Tianyu Qin, Yiling Lu, Xiaoyuan Huang, Ding Ma, Gordon B. Mills, Chaoyang Sun, Gang Chen

WEE1 inhibition modulates the efficacy of cancer immunotherapy by regulating dsRNA and interferon responses, which increases recruitment of anti-tumor T cells with concurrent PD-L1 elevation. This study provides a rationale for combination strategies between WEE1 inhibitors and anti–PD-L1 therapies.

Article

| November 24 2021

The DCIR-NA2 in the immune and bone system

Tomonori Kaifu, Rikio Yabe, Takumi Maruhashi, Soo-Hyun Chung, Hiroaki Tateno, Noriyuki Fujikado, Jun Hirabayashi, Yoichiro Iwakura

Asialo-biantennary N-glycan is identified as a ligand for the inhibitory C-type lectin receptor DCIR, which is important for the homeostasis of the immune and bone system. The interaction between DCIR and asialo-biantennary N-glycans negatively regulates antigen presentation by DCs and osteoclastogenesis.

Brief Definitive Report

| November 24 2021

No fast PU.1 autoregulation in HSPCs in vitro

Nouraiz Ahmed, Martin Etzrodt, Philip Dettinger, Tobias Kull, Dirk Loeffler, Philipp S. Hoppe, James S. Chavez, Yang Zhang, Germán Camargo Ortega, Oliver Hilsenbeck, Hideaki Nakajima, Eric M. Pietras, Timm Schroeder

By manipulating and quantifying the dynamics of PU.1 protein expression in live differentiating adult HSPCs in vitro, Ahmed et al. report that PU.1 upregulation is not caused by fast direct autoregulation but occurs as a later consequence of hematopoietic differentiation.

Article

| November 23 2021

NR2F1 agonist induces cancer cell dormancy

Bassem D. Khalil, Roberto Sanchez, Tasrina Rahman, Carolina Rodriguez-Tirado, Stefan Moritsch, Alba Rodriguez Martinez, Brett Miles, Eduardo Farias, Mihaly Mezei, Ana Rita Nobre, Deepak Singh, Nupura Kale, Karl Christoph Sproll, Maria Soledad Sosa, Julio A. Aguirre-Ghiso

Computational screening identifies a novel agonist for NR2F1, a master activator of cancer cell dormancy. Agonist-mediated activation of NR2F1 induces a novel long-lived dormancy program with neural crest-like features and prevents disseminated squamous carcinoma cancer cell progression to overt metastasis.

Article

| November 23 2021

ACC1 controls lung and skin allergic inflammation

Takahiro Nakajima, Toshio Kanno, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Damon J. Tumes, Osamu Ohara, Toshinori Nakayama, Yusuke Endo

The authors find that lung and skin pathogenic CD4+ T cells express high levels of ACC1. ACC1 controls the inflammatory function of the pathogenic CD4+ T cell population to promote type 2 inflammation in the lung and skin.

Article

| November 22 2021

Unique CD8 T cells define immunotherapy resistance

Chuan Li, Yee Peng Phoon, Keaton Karlinsey, Ye F. Tian, Samjhana Thapaliya, Angkana Thongkum, Lili Qu, Alyssa Joyce Matz, Mark Cameron, Cheryl Cameron, Antoine Menoret, Pauline Funchain, Jung-Min Song, C. Marcela Diaz-Montero, Banumathi Tamilselvan, Jackelyn B. Golden, Michael Cartwright, Annabelle Rodriguez, Christopher Bonin, Anthony Vella, Beiyan Zhou, Brian R. Gastman

Single-cell transcriptomics from paired autologous peripheral and tumor lymphocytes from melanoma patients reveal an understudied population of metabolically active, dysfunctional CD8 T cells. This subpopulation is associated with immunotherapy resistance and was leveraged to develop a therapeutic response predictive model.

Brief Definitive Report

| November 18 2021

Transcriptional control of memory CD4⁺ T cell development

Thomas Ciucci, Melanie S. Vacchio, Ting Chen, Jia Nie, Laura B. Chopp, Dorian B. McGavern, Michael C. Kelly, Rémy Bosselut

Single-cell RNA and ATAC sequencing identify transcriptomic and epigenomic features of acute- and memory-phase virus-responding CD4+ T cells and show that, unlike follicular helper T cells, memory CD4+ T cells develop despite lacking Bcl6 and Blimp1 transcription factors.

Browse All >

Related Articles from Rockefeller University Press

NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

Snehlata Kumari ... Manolis Pasparakis | Life Sci. Alliance

TNFR1 was found to cause skin inflammation in mice with epidermal keratinocyte-specific ablation of IKK2 or of both the NF-kB subunits RelA and cRel by triggering RIPK1-dependent, RIPK3-MLKL–mediated necroptosis of keratinocytes.
Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages

Samantha B Kemp ... Marina Pasca di Magliano | Life Sci. Alliance

This study uses biomaterial scaffolds to identify a macrophage gene signature defined by high expression of C1qa, C1qb, and Trem2 that is elevated systemically in mouse and human pancreatic cancer.
DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria

Barbara Killy ... Roland Lang | Life Sci. Alliance

Lack of miRNA biosynthesis in DGCR8-deficient macrophages did not block macrophage differentiation but caused overshooting type I IFN responses to mycobacterial glycolipids.

Current Issue

Volume 218,

Issue 11,

November 1, 2021

View This Issue

Submit Your Research

Manage Email Alerts

Reviews & Opinions

Viewpoint

| November 22 2021

Can repurposing drugs play a role in malaria control?

Roland A. Cooper, Laura Kirkman

Laura Kirkman and Roland Cooper discuss how repurposing drugs can play a role in controlling malaria.

Insights

| November 18 2021

Making memories with Bcl-6

Kaitlin A. Read, Kenneth J. Oestreich

Mutual antagonism between the transcriptional repressors Bcl-6 and Blimp-1 has been appreciated as a key mechanistic determinant of lymphoid differentiation programs. Now, in this issue of JEM, Ciucci et al. demonstrate that this relationship is central to the generation of T cell memory.

Found in Translation

| November 16 2021