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Article
Rina Matsuda et al.
Monocytes restrict Yersinia infection within intestinal pyogranulomas. Here, we report that monocyte-intrinsic TNF signaling drives the production of IL-1 that signals non-hematopoietic cells to control intestinal Yersinia infection within pyogranulomas.
Brief Definitive Report
Mariah Hassert et al.
Lung resident memory CD8+ T cells (TRM) control heterosubtypic influenza infection and potentially cancer. We show that thorax-targeted irradiation depletes lung TRM and diminishes protection, but spares circulating memory CD8+ T cells that can be boosted to regenerate lung TRM.
Brief Definitive Report
Cuifeng Li et al.
This study illuminates that TRPV2 augments B cell activation and function through membrane depolarization and cytoskeletal remodeling. Consequently, TRPV2 is implicated in antibody responses and SLE. The study underscores the indispensable role of TRPV2 in immune regulation and potential therapeutic interventions.
Article
Lei Wang et al.
The study introduces a new immunotherapy for treating melanoma and other cancers by developing a PROTAC that degrades NR4A1, an intracellular nuclear factor that plays a crucial role in immune suppression.
Article
Zhen Qin et al.
TCR signaling (signal 1) induces STAT3 phosphorylation through Lck/Fyn and, synergistically with cytokine signal (signal 3), induces optimal STAT3 phosphorylation to drive TH17 cell differentiation. Selective inhibition of TCR stimulation–induced STAT3 phosphorylation significantly inhibits TH17 differentiation and ameliorates TH17 cell–related autoimmune diseases.
Brief Definitive Report
Kaiyi Zhang et al.
Shedding of infected enterocytes into the gut lumen is a hallmark of the adult mucosal antimicrobial response. In contrast, enterocyte shedding is rare in the neonatal intestine. Instead, we observe internalization and degradation of infected enterocytes by neighboring epithelial cells.
Article
Chen Yu et al.
Microglia are thought to drive neuroinflammation in age-related macular degeneration (AMD). Here, Yu et al. identified a protective microglia population that mitigates degeneration via atrophic debris elimination in disease models. This population is present and highly conserved in human AMD.
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Current Issue
Volume 221,
Issue 2,
5 February 2024
Reviews & Opinions
Insights
Melanie Lancien, Mathias Lichterfeld
Kufera et al. demonstrate that proliferative growth of cells infected with genome-intact HIV-1 is not limitless; rather, these cells seem to be at least partially refractory to TCR stimulation.
Insights
Zi Yan Chen, Arthur Mortha
Peng et al. identify inositol polyphosphate 4-phosphatase type II (Inpp4b) as regulator of ILC1 and NK cell tissue residency.
Insights
Noah Ollikainen, Ranjan Sen
In this issue of JEM, Allyn et al. provide mechanistic insights into the nuclear organization of the Tcrb locus that permits long-range genomic rearrangements.

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