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Brief Definitive Report
Joey Ming Er Lim, Anthony Tanoto Tan, Nina Le Bert, Shou Kit Hang, Jenny Guek Hong Low, Antonio Bertoletti
Virus-specific T cells in the nasal cavity might provide an immediate layer of protection against SARS-CoV-2. This study detected SARS-CoV-2–specific nasal-resident T cells in vaccinees only after infection, highlighting the significance of nasal challenge in the formation of antiviral immunity at the site of infection.
Article
Zhuoqiong Qiu, Zhenlai Zhu, Xiaochun Liu, Baichao Chen, Huibin Yin, Chaoying Gu, Xiaokai Fang, Ronghui Zhu, Tianze Yu, Wenli Mi, Hong Zhou, Yufeng Zhou, Xu Yao, Wei Li
This study demonstrates that a dysregulated sebum–microbial metabolite–IL-33 axis is involved in the pathogenesis of atopic dermatitis, possibly by playing an initiating role in the induction of skin inflammation.
Article
Fabian M.P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A.S.H. Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D. Katsikis, Joyce H.G. Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I. De Zeeuw, Aleksandra Badura, Meinrad Busslinger
A mouse model carrying biallelic Pax5 mutations identified in a patient with hypogammaglobulinemia and autism spectrum disorder shows a B cell developmental arrest and autistic-like behavior caused by abnormal development of the cerebellum and loss of ventral midbrain GABAergic neurons.
Technical Advances and Resources
Sara A. Rubin, Chloé S. Baron, Cecilia Pessoa Rodrigues, Madeleine Duran, Alexandra F. Corbin, Song P. Yang, Cole Trapnell, Leonard I. Zon
Single-cell RNA sequencing of zebrafish hematopoiesis provides new insights into zebrafish B- and T-cell development and cellular diversity within the primary lymphoid organs (kidney marrow and thymus). This work advances the current understanding of zebrafish immunology and will facilitate future genetic and developmental studies.
Brief Definitive Report
Danielle Karo-Atar, Shaida Ouladan, Tanvi Javkar, Loick Joumier, Macy K. Matheson, Sydney Merritt, Susan Westfall, Annie Rochette, Maria E. Gentile, Ghislaine Fontes, Gregory J. Fonseca, Marc Parisien, Luda Diatchenko, Jakob von Moltke, Mohan Malleshaiah, Alex Gregorieff, Irah L. King
Karo-Atar et al. demonstrate direct regulation of the intestinal stem cell compartment by an enteric helminth, resulting in expansion of fetal-like stem cells and inhibition of secretory cells. They establish how a helminth parasite co-opts a tissue development program to counter type 2 immune-mediated expulsion.
Brief Definitive Report
Malika Hale, Jason Netland, Yu Chen, Christopher D. Thouvenel, Katherine Nabel Smith, Lucille M. Rich, Elizabeth R. Vanderwall, Marcos C. Miranda, Julie Eggenberger, Linhui Hao, Michael J. Watson, Charles C. Mundorff, Lauren B. Rodda, Neil P. King, Miklos Guttman, Michael Gale, Jr, Jonathan Abraham, Jason S. Debley, Marion Pepper, David J. Rawlings
Using monoclonal antibodies built from SARS-CoV-2–specific memory B cells, Hale et al. demonstrate that IgM antibodies outperform IgG in neutralization assays against mutated variants. The authors suggest that IgM antibodies may be useful therapeutically, and that IgM memory B cells may be underappreciated protectors against rapidly evolving pathogens.
Technical Advances and Resources
Michael Beckstette, Chia-Wen Lu, Susanne Herppich, Elia C. Diem, Anna Ntalli, Aaron Ochel, Friederike Kruse, Beate Pietzsch, Katrin Neumann, Jochen Huehn, Stefan Floess, Matthias Lochner
In this study, the authors perform a genome-wide methylation analysis to define epigenetic signatures for murine ILCs and to assess similarities and differences to CD4+ T cells. Models of IL-33–mediated inflammatory challenge reveal tissue-specific epigenetic changes within ILC2 signature regions.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 219,
Issue 8,
1 August 2022
Reviews & Opinions
Viewpoint
David Hoyos, Benjamin D. Greenbaum
Benjamin D. Greenbaum and David Hoyos discuss the challenges of antigen modeling to design vaccines for infectious diseases and cancer.
Insights
John R. Grainger, Rufus H. Daw
Karo-Atar et al. demonstrate that products released by a gut-dwelling helminth modify intestinal stem cells, which is associated with a loss of secretory cell types that support helminth expulsion.
Insights
Sandro Da Mesquita
In this issue, Jacob et al. employ imaging techniques to provide a more comprehensive chart of the meningeal lymphatic vasculature and draw a parallel for lymphatic drainage of cerebrospinal fluid in mice and humans.

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