Journal of Experimental Medicine (JEM) | Rockefeller University Press

Skip Nav Destination

Tumor Microenvironment and Metastasis 2023.
Type I IFNs control MAIT cell activation.
Single cell mast cell atlas.

Newest Articles

Brief Definitive Report

| October 03 2023

B cell innate signaling sustains lupus in mice

Jeremy S. Tilstra et al.

Both B cells and TLR signaling have been implicated in lupus pathogenesis. B cell–specific MyD88, when targeted after disease onset resulted in the stabilization of autoantibody levels and amelioration of disease, suggesting a possible therapeutic efficacy of targeting MyD88-related pathways in the treatment of SLE.

Article

| September 29 2023

TLR9 requirement for central B cell tolerance

Elif Çakan et al.

TLR9 displays an important early tolerogenic function essential for central B cell tolerance, and CXCL4 inhibits TLR9 function in B cells from SSc patients by sequestering TLR9 ligands away from endosomal TLR9, leading to autoreactive B cell and autoantibody production.

Article

| September 29 2023

Epitope-engineered human hematopoietic stem cells withstand targeted immunotherapy

Romina Marone et al.

This work demonstrates that engineering a single amino acid substitution into the cell surface protein CD123 in hematopoietic stem cells protects them from targeted immunotherapies. Transplantation of the modified stem cells may enable posttransplant therapy to reduce disease recurrence.

Article

| September 29 2023

Retinoic acid mediates intestinal ILC2 adaptation

Nikhat Shaikh et al.

Effector ILC2s retain phenotypic flexibility after hematogenous trafficking and can adapt to distant tissue niches, irrespective of their origin. Retinoic acid signaling is an important driver of intestine-specific ILC2 adaptation with functional implications for acute helminth infections.

Article

| September 21 2023

Wiring of developing central gustatory circuits

Chengsan Sun et al.

Microglia aid in refining central gustatory circuits during normal postnatal development. This process is arrested by merely restricting the mother’s dietary sodium during a limited, early prenatal period when microglia progenitors migrate from the yolk sac to the brain.

Article

| September 20 2023

RPE biomarkers of transplant efficacy

Farhad Farjood et al.

This study characterizes an adult retinal pigment epithelial stem cell–derived cell product through transplantation in RCS rats and bulk and single-cell RNA sequencing, identifying distinct subpopulations and a predictive lncRNA marker (TREX) affecting cell integration and vision rescue in rats.

Article

| September 19 2023

Cholesterol overload to macrophages promotes NASH

Michiko Itoh et al.

Lysosomal cholesterol overload triggers phenotypic changes and profibrotic activation of macrophages around dead hepatocytes containing cholesterol crystals in the development of NASH. Cholesterol excretion from macrophages using β-cyclodextrin polyrotaxane, which is designed to release β-cyclodextrin in lysosomes, alleviates liver fibrosis.

Browse All >

Current Issue

Volume 220,

Issue 10,

2 October 2023

View This Issue

Submit Your Research

Manage Email Alerts

Reviews & Opinions

Insights

| September 29 2023

For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity

Stuart G. Tangye

In this issue of JEM, Çakan et al. explore a CXCL4-mediated mechanism by which TLRs cause autoimmunity in human B cells, breaching bone marrow tolerance.

Insights

| September 27 2023

A twist in the tail: Of T cell subsets and disease

Shiv Pillai

In this issue of JEM, the work of Joachim et al. (2023) on knockin mice with a specific tail mutation in LAT provides valuable insights about cytotoxic CD4⁺ T cells and human inflammatory diseases.

Viewpoint

| September 20 2023

Women in STEM becoming independent: Great mentors make all the difference

Lucie Van Emmenis

In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher. As well as being able to celebrate the positives of becoming an independent researcher, we would also like to use this platform to discuss the unique challenges they face as women scientists in their respective scientific environments.

Browse All

Special Collections

The Year in Experimental Medicine

Our annual series highlighting some of the research articles that were of greatest interest to our readers in 2022.

View all collections

Tumor Microenvironment and Metastasis 2023.

Type I IFNs control MAIT cell activation.

Single cell mast cell atlas.

Most Read

Special Collections

This Feature Is Available To Subscribers Only