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Technical Advances and Resources
Zhen Zhuang, Xiaomin Lai, Jing Sun, Zhao Chen, Zhaoyong Zhang, Jun Dai, Donglan Liu, Yuming Li, Fang Li, Yanqun Wang, Airu Zhu, Junxiang Wang, Wenhui Yang, Jicheng Huang, Xiaobo Li, Lingfei Hu, Liyan Wen, Jianfen Zhuo, Yanjun Zhang, Dingbin Chen, Suxiang Li, Shuxiang Huang, Yongxia Shi, Kui Zheng, Nanshan Zhong, Jingxian Zhao, Dongsheng Zhou, Jincun Zhao
Zhuang et al. identify SARS-CoV-2–specific T cell epitopes recognized by CD4+ and CD8+ T cells in BALB/c and C57BL/6 mice. SARS-CoV-2–specific T cells are protective and cross-reactive in vivo, and are shaped by type I IFN signaling.
Article
Masahiro Kiuchi, Atsushi Onodera, Kota Kokubo, Tomomi Ichikawa, Yuki Morimoto, Eiryo Kawakami, Naoya Takayama, Koji Eto, Haruhiko Koseki, Kiyoshi Hirahara, Toshinori Nakayama
The Trithorax Cxxc1 molecule specifically regulates the chromatin accessibility of the genes that are downregulated during priming and reactivated in the later phase in differentiating CD4 T cells. The authors show Cxxc1 deletion induces CD4 T cell hyperactivation and enhanced allergic airway inflammation.
Technical Advances and Resources
Rih-Sheng Huang, Min-Chi Lai, Hsin-An Shih, Steven Lin
Huang et al. report an integrated, robust CRISPR genome editing platform for natural killer (NK) cells that combines the advantages of feeder-free ex vivo expansion and Cas9 RNP nucleofection to replace inefficient plasmid transfection and viral transduction, which have long hindered the advance of NK cell research.
Article
Eric Song, Ce Zhang, Benjamin Israelow, Alice Lu-Culligan, Alba Vieites Prado, Sophie Skriabine, Peiwen Lu, Orr-El Weizman, Feimei Liu, Yile Dai, Klara Szigeti-Buck, Yuki Yasumoto, Guilin Wang, Christopher Castaldi, Jaime Heltke, Evelyn Ng, John Wheeler, Mia Madel Alfajaro, Etienne Levavasseur, Benjamin Fontes, Neal G. Ravindra, David Van Dijk, Shrikant Mane, Murat Gunel, Aaron Ring, Syed A. Jaffar Kazmi, Kai Zhang, Craig B. Wilen, Tamas L. Horvath, Isabelle Plu, Stephane Haik, Jean-Leon Thomas, Angeliki Louvi, Shelli F. Farhadian, Anita Huttner, Danielle Seilhean, Nicolas Renier, Kaya Bilguvar, Akiko Iwasaki
Neurological symptoms are frequently observed in COVID-19. Here, we examine the neuroinvasive potential of SARS-CoV-2 and demonstrate infection of neurons in three separate approaches: mouse model, human brain organoid, and autopsy of COVID-19 patients.
Article
Eleni Louka, Benjamin Povinelli, Alba Rodriguez-Meira, Gemma Buck, Wei Xiong Wen, Guanlin Wang, Nikolaos Sousos, Neil Ashley, Angela Hamblin, Christopher A.G. Booth, Anindita Roy, Natalina Elliott, Deena Iskander, Josu de la Fuente, Nicholas Fordham, Sorcha O’Byrne, Sarah Inglott, Ruggiero Norfo, Mariolina Salio, Supat Thongjuea, Anupama Rao, Irene Roberts, Adam J. Mead
Juvenile myelomonocytic leukemia is a rare cancer of childhood with a poor prognosis. Through phenotypic, functional, and molecular analyses of blood and bone marrow samples, Louka et al. identify and characterize the disease-propagating population(s), paving the way for leukemia stem cell–directed disease monitoring and therapy.
Article
Tobias Deuse, Xiaomeng Hu, Sean Agbor-Enoh, Moon K. Jang, Malik Alawi, Ceren Saygi, Alessia Gravina, Grigol Tediashvili, Vinh Q. Nguyen, Yuan Liu, Hannah Valantine, Lewis L. Lanier, Sonja Schrepfer
NK cells are able to upregulate SIRPα, which transmits a strong inhibitory signal upon CD47 engagement. Modulation of this immune checkpoint can enable the generation of universal allogeneic regenerative cell products or enhance NK cell–mediated tumor cell killing.
Article
Nuo Xu, Douglas C. Palmer, Alexander C. Robeson, Peishun Shou, Hemamalini Bommiasamy, Sonia J. Laurie, Caryn Willis, Gianpietro Dotti, Benjamin G. Vincent, Nicholas P. Restifo, Jonathan S. Serody
CAR T cell therapy remains suboptimal for the treatment of solid tumors. Xu et al. demonstrate that CAR T cell migration and persistence in locally advanced breast cancer are enhanced by coadministration of CAR T cells with STING agonists.

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