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Jorden I. Lane et al.
Lane et al. discover that the lymphatic vasculature is functionally and transcriptionally distinct along the gut. Duodenal lymphatic vessels appear optimized for dietary lipid uptake. Duodenal helminths compromise this property, providing an alternative explanation for worm-induced resistance to weight gain.
Brief Definitive Report
Kun Peng et al.
Current mRNA vaccines have either limited efficacy or severe toxicity. This study highlights that next-generation mRNA vaccines encoding membrane-tethered cytokine adjuvants can generate potent pre-effector cells, offering effective tumor control with reduced toxicity.
Article
Riem Gawish et al.
In this study, Gawish et al. show that RNA editing of the actin cross-linker FLNA is similarly regulated in mice and humans and that the targeted induction of edited FLNAR in myeloid cells governs resistance to DSS-induced colitis, revealing its potential in IBD therapy.
Article
Ramona Rica et al.
Rica et al. demonstrate that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells, which is essential for controlling viral load during chronic infection.
Article
Adam J. Fike et al.
Fike et al. describe mechanisms of IRF7-driven autoimmune B cell and autoantibody responses. Mechanistic studies guided by OMICs data reveal that IRF7 promotes lupus-prone germinal center and plasma cell responses by regulating transcriptome, translation, and metabolism of B cells.
Article
Ahmed Kabil et al.
This study identifies a balance between ILC2s and ILC3s as critical for gut tissue repair. Selective deletion experiments reveal that ILC2 loss promotes fibrosis, while ILC3 depletion protects against it, highlighting ILC3s as key drivers of intestinal fibrosis.
Article
Chae Won Kim et al.
A high-salt diet increases Bacteroides abundance and intestinal propionate, activating the HIF-1α–TGF-β1 axis and promoting glioma invasion. This study reveals new insights into how gut microbiota and their metabolites contribute to glioma development and progression.
Journal of Experimental Medicine Cover Image for Volume 222, Issue 6
Current Issue
Volume 222,
Issue 6,
2 June 2025
Reviews & Opinions
Review | Cancer Focus
Chuangyu Wen et al.
This review highlights how YTHDF proteins regulate tumor responses to radiotherapy by modulating DNA repair and the immune microenvironment and discusses their potential as therapeutic targets to enhance the efficacy of radiotherapy and immunotherapy in cancer treatment.
Review
Natalia Reglero-Real et al.
This review explores how aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic inflammation. The authors highlight key molecular changes and propose therapeutic strategies targeting vascular aging to mitigate age-related inflammatory diseases.
Insights
Timotheus Y.F. Halim
ILC2 are critical regulators of inflammation and tissue homeostasis in diverse anatomical sites. ILC2-targeted mouse models have underpinned this emerging field of research. Kabil et al. (2025) developed a novel Il17rbCreERT2.eGFP mouse to study the role of Rora in mature ILC2.

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