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Neuroimmunology and Neurodegeneration 2025.
Zebrafish axillary lymphoid organ.

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Article

| June 12 2025

Lymphatics along the gut and after helminths

Jorden I. Lane et al.

Lane et al. discover that the lymphatic vasculature is functionally and transcriptionally distinct along the gut. Duodenal lymphatic vessels appear optimized for dietary lipid uptake. Duodenal helminths compromise this property, providing an alternative explanation for worm-induced resistance to weight gain.

Brief Definitive Report

| June 06 2025

mtIL12 mRNA vaccine enhances anti-tumor immunity

Kun Peng et al.

Current mRNA vaccines have either limited efficacy or severe toxicity. This study highlights that next-generation mRNA vaccines encoding membrane-tethered cytokine adjuvants can generate potent pre-effector cells, offering effective tumor control with reduced toxicity.

Article

| June 05 2025

Edited filamin A protects from colitis

Riem Gawish et al.

In this study, Gawish et al. show that RNA editing of the actin cross-linker FLNA is similarly regulated in mice and humans and that the targeted induction of edited FLNAR in myeloid cells governs resistance to DSS-induced colitis, revealing its potential in IBD therapy.

Article

| June 04 2025

Role of HDAC1 in effector-like exhausted T cells

Ramona Rica et al.

Rica et al. demonstrate that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells, which is essential for controlling viral load during chronic infection.

Article

| May 29 2025

IRF7 control of autoimmune GC and PC checkpoints

Adam J. Fike et al.

Fike et al. describe mechanisms of IRF7-driven autoimmune B cell and autoantibody responses. Mechanistic studies guided by OMICs data reveal that IRF7 promotes lupus-prone germinal center and plasma cell responses by regulating transcriptome, translation, and metabolism of B cells.

Article

| May 28 2025

Targeting ILC2s and ILC3s in intestinal fibrosis

Ahmed Kabil et al.

This study identifies a balance between ILC2s and ILC3s as critical for gut tissue repair. Selective deletion experiments reveal that ILC2 loss promotes fibrosis, while ILC3 depletion protects against it, highlighting ILC3s as key drivers of intestinal fibrosis.

Article

| May 22 2025

High-salt diet promotes glioma progression

Chae Won Kim et al.

A high-salt diet increases Bacteroides abundance and intestinal propionate, activating the HIF-1α–TGF-β1 axis and promoting glioma invasion. This study reveals new insights into how gut microbiota and their metabolites contribute to glioma development and progression.

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Current Issue

Volume 222,

Issue 6,

2 June 2025

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Reviews & Opinions

Review | Cancer Focus

| June 05 2025

YTHDFs in radiotherapy and tumor immunity

Chuangyu Wen et al.

This review highlights how YTHDF proteins regulate tumor responses to radiotherapy by modulating DNA repair and the immune microenvironment and discusses their potential as therapeutic targets to enhance the efficacy of radiotherapy and immunotherapy in cancer treatment.

Review

| June 02 2025

Aging microvasculature and immune cell trafficking

Natalia Reglero-Real et al.

This review explores how aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic inflammation. The authors highlight key molecular changes and propose therapeutic strategies targeting vascular aging to mitigate age-related inflammatory diseases.

Insights

| May 29 2025

Emerging in vivo tools for ILC2 research

Timotheus Y.F. Halim

ILC2 are critical regulators of inflammation and tissue homeostasis in diverse anatomical sites. ILC2-targeted mouse models have underpinned this emerging field of research. Kabil et al. (2025) developed a novel Il17rbCreERT2.eGFP mouse to study the role of Rora in mature ILC2.

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The Year in Experimental Medicine

Our annual series highlighting articles that were of greatest interest to our readers in 2024.

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Neuroimmunology and Neurodegeneration 2025.

Zebrafish axillary lymphoid organ.

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