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Article
Jonathan J. Hodgins et al.
Cell-intrinsic PD-L1 signaling inhibits the type I interferon pathway in cancer cells via a mechanism that involves metabolic alterations. PD-L1 activity is triggered by a variety of stimuli, including PD-L1 antibodies, and ultimately increases the efficacy of oncolytic virus therapy.
Brief Definitive Report
Clémence David et al.
David et al. describe UNC93B1 missense substitutions causing systemic lupus erythematosus or chilblain lupus, inherited as either autosomal dominant or autosomal recessive traits. In vitro and ex vivo assays show that these variants confer differential hypermorphic TLR7 and TLR8 signaling.
Article
Kelsey A. Toth et al.
STAT3 gain-of-function syndrome causes early-onset autoimmunity and immune dysregulation in patients. Here, we report spontaneous and stimulus-driven skin disease in a mouse model associated with locally increased Th17 that is partially dependent on IL-22 signaling.
Article
Lingzi Hong et al.
Hong et al. report that IL-17/Act1 induces chemoresistance by modulating redox homeostasis through epitranscriptomic regulation of antioxidant RNA metabolism. Antisense oligonucleotide that specifically disrupts Act1’s binding to Wtap mRNA inhibits IL-17/Act1–WTAP-mediated antioxidant protein production, offering a potential therapeutic strategy for chemoresistance.
Article
Pooja Parameswaran et al.
The guard protein NLRP1 senses pathogen-encoded effector activities, but whether successful pathogens evade the consequences of NLRP1 activation is less clear. Parameswaran et al. demonstrate that HSV-1 inhibits the antiviral NLRP1 pathway via production of a viral E3 ubiquitin ligase.
Technical Advances and Resources
Michelle A. Tran et al.
Tran et al. use single-cell RNA-sequencing to discover diverse immune cell populations in bladder cancer patient urine that have highly similar gene expression programs to those in tumor.
Brief Definitive Report
Zhoujie Ding et al.
Ding and Hagan et al. discover a unique requirement for Ki67 in regulating chromatin accessibility in the early stages of lymphocyte development undergoing V(D)J rearrangement, thus ensuring normal immunoglobulin gene recombination, cell maturation, and peripheral representation.
Issue Cover
Current Issue
Volume 221,
Issue 6,
3 June 2024
Reviews & Opinions
Insights
Justin Taft, Dusan Bogunovic
In this issue, two studies report the analysis of seven patient variants combined with a comprehensive alanine screen and reveal that different regions of UNC93B1 selectively regulate different TLRs.
Viewpoint
Clarissa Campbell et al.
This year at JEM, we are highlighting women in science by sharing their stories and amplifying their voices. In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher.
Found in Translation
Johanna Chiffelle, Alexandre Harari
Recent studies suggest that personalized cellular therapies using T cells transduced with private TCRs hold the potential to transform the field and provide new treatment options for cancer patients, reflecting significant analogies with the evolution of cancer vaccines toward personalization.

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