The diversity of coronaviruses renders neutralization breadth key for vaccine and monoclonal antibody development. Using immunoglobulin knock-in mice, Nair et al. rediversify germline and mature versions of the human anti-SARS-CoV-2 spike antibody CR3022 to obtain broadened reactivity against human and bat coronaviruses.

This paper uncovers an unexplored metabolic symbiosis between tumor cells, CAFs, and TAMs. The authors show how tumor-derived lipids can induce an IL-6–dependent increased glutamine synthesis pathway in CAFs, supporting CAFs ability to promote pro-tumorigenic TAMs.

Monoallelic mutations, p.A116V and p.R126P, in MMD2 disturb fMLP-induced activation of Ras/ERK signaling and underlie the impairment of neutrophil chemotaxis, which leads to the development of the autosomal dominant form of aggressive periodontitis.

This study describes a Mycn-nGEMM for neuroblastoma. Murine and human neuroblastomas showed profound immunosuppression mediated by PD-L1–expressing, TAMs. Anti–PD-L1 immunotherapy depleted TAMs and inhibited tumor growth, demonstrating the potential for myeloid-targeted immunotherapies to overcome the immuno-inhibitory barriers.

NGLY1 deficiency is an early-onset neurodegenerative disorder with no effective therapy. Here, we describe an inducible Ngly1 knockout mouse model, iNgly1^−/−, that reveals pronounced loss of Purkinje cells in the cerebellum without neuroinflammation. Sting1 knockout or STING inhibitor VS-X4 significantly rescues iNgly1^−/− disease in mice.

During obesity, the bone marrow is dysregulated to overproduce myeloid cells that drive systemic inflammation. Neutrophil migration is a key mediator of this process, and targeting neutrophil movement during obesity or weight loss improves inflammatory and metabolic outcomes.

Plasmodium falciparum circumsporozoite protein harbors conserved human T cell epitopes that may serve as targets for broad strain-transcending immunity. The findings offer guidance for the design of improved malaria vaccines.