Related Articles from Rockefeller University Press
Conservation of cell-intrinsic immune responses in diverse nonhuman primate speciesJenna M Gaska ... Alexander Ploss | Life Sci. Alliance
The transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.
Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesisManabu Toyoshima ... Nobutaka Hirokawa | Life Sci. Alliance
Enhanced carbonyl stress results in neurodevelopmental deficits by affecting microtubule function through the formation of irreversible dysfunctional multimer of carbonylated CRMP2.
Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsivenessWilliam J Crisler ... Laurel L Lenz | Life Sci. Alliance
IFNγ is shown to silence Ifngr1 transcription by altering enhancer occupancy, reducing myeloid cell IFNGR1 as a feedback mechanism to attenuate macrophage responses associated with inflammation.
PHLPP2 promotes prostate cancer progressionDawid G. Nowak ... Lloyd C. Trotman | J. Cell Biol.
Nowak et al. show that loss of the AKT-inactivating phosphatase PHLPP2 paradoxically blocks prostate tumor growth and metastasis. PHLPP2, they find, is critical for MYC stability, suggesting that PHLPP2 inhibitors may present a therapeutic opportunity to target MYC.
The RIPK3-MLKL pathway attacks cytosolic ListeriaKazuhito Sai ... Jun Ninomiya-Tsuji | J. Cell Biol.
The RIPK3-MLKL pathway protects epithelial cells from Listeria monocytogenes invasion. Sai et al. find that Listeria infection activates MLKL but does not induce its oligomerization or necroptotic cell death. Instead, Listeria-activated MLKL directly targets intracellular bacteria and suppresses their replication
Ral GTPases promote axonal sortingAndrea Ommer ... Ueli Suter | J. Cell Biol.
Schwann cell–resident Ral GTPases foster radial sorting of axons in developing peripheral nerves and are involved in exocyst-dependent control of Schwann cell process extensions.