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Nicole J. Van Bergen, Syed Mukhtar Ahmed, Felicity Collins, Mark Cowley, Annalisa Vetro, Russell C. Dale, Daniella H. Hock, Christian de Caestecker, Minal Menezes, Sean Massey, Gladys Ho, Tiziana Pisano, Seana Glover, Jovanka Gusman, David A. Stroud, Marcel Dinger, Renzo Guerrini, Ian G. Macara, Ian G. Macara, John Christodoulou, John Christodoulou
Patients with severe developmental delay, dysmorphism, and brain abnormalities were identified as having pathogenic mutations in EXOC2, a critical component of the exocyst complex involved in vesicle trafficking, which caused secretory vesicle transport defects in patient-derived cell lines.
Article
Johanna Kabbert, Julia Benckert, Tim Rollenske, Thomas C.A. Hitch, Thomas Clavel, Vuk Cerovic, Hedda Wardemann, Oliver Pabst
The authors reveal a mechanism of SIgA–microbiota interaction in the adult human gut. They describe antibodies with a high capacity to bind phylogenetically distant members of the microbiota. Such cross-species reactivity does not correlate with antibody polyreactivity but crucially depends on somatic mutations.
Article
Ioanna Mosialou, Steven Shikhel, Na Luo, Peristera Ioanna Petropoulou, Konstantinos Panitsas, Brygida Bisikirska, Nyanza J. Rothman, Roxane Tenta, Bertrand Cariou, Matthieu Wargny, Elisabeth Sornay-Rendu, Thomas Nickolas, Mishaela Rubin, Cyrille B. Confavreux, Stavroula Kousteni
LCN2 is an osteoblast-enriched secreted protein that regulates food intake. Here, the authors show that LCN2 is upregulated during obesity and diabetes as a protective mechanism to counteract obesity-induced glucose intolerance by decreasing food intake and promoting adaptive β-cell proliferation.
Article
Tobiloba E. Oni, Giulia Biffi, Lindsey A. Baker, Yuan Hao, Claudia Tonelli, Tim D.D. Somerville, Astrid Deschênes, Pascal Belleau, Chang-il Hwang, Francisco J. Sánchez-Rivera, Hilary Cox, Erin Brosnan, Abhishek Doshi, Rebecca P. Lumia, Kimia Khaledi, Youngkyu Park, Lloyd C. Trotman, Scott W. Lowe, Alexander Krasnitz, Christopher R. Vakoc, David A. Tuveson
Uncovering mechanisms that drive pancreatic cancer could lead to effective therapies for this lethal disease. This study reveals how pancreatic cancer cells hyperactivate a pathway to sustain their proliferation. Inhibiting this pathway affects cancer cells, but not normal cells, highlighting a new therapeutic opportunity.
Article
Verónica Delgado-Benito, Maria Berruezo-Llacuna, Robert Altwasser, Wiebke Winkler, Devakumar Sundaravinayagam, Sandhya Balasubramanian, Marieta Caganova, Robin Graf, Ali Rahjouei, Marie-Thérèse Henke, Madlen Driesner, Lisa Keller, Alessandro Prigione, Martin Janz, Altuna Akalin, Michela Di Virgilio
Delgado-Benito et al. identify the protein Pdap1 as a regulator of mature B cell homeostasis. Pdap1 protects mature B cells against chronic induction of the integrated stress response and promotes both their survival and antibody gene diversification by CSR and SHM.
Article
Antony B. Holmes, Clarissa Corinaldesi, Qiong Shen, Rahul Kumar, Nicolo Compagno, Zhong Wang, Mor Nitzan, Eli Grunstein, Laura Pasqualucci, Riccardo Dalla-Favera, Katia Basso
Single-cell transcriptomic analysis of germinal center B cells identifies multiple linked populations, most of which represent cell of origin of lymphomas. The newly identified cell of origin of diffuse large B cell lymphoma informs on novel prognostic subgroups.
Article
Kayan Tam, Keenan A. Lacey, Joseph C. Devlin, Maryaline Coffre, Alexis Sommerfield, Rita Chan, Aidan O’Malley, Sergei B. Koralov, P’ng Loke, Victor J. Torres
Staphylococcus aureus secretes pore-forming leukocidins that kill leukocytes as part of the bacterium’s evasion strategy. Leukocidin-based vaccination results in toxin-neutralizing antibodies and toxin-specific CD4 lymphocytes that block the toxins and boost host-mediated antimicrobial responses to protect mice from bloodstream infection.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 7,
July 6, 2020
Reviews & Opinions
Insights
Sannula Kesavardhana, Thirumala-Devi Kanneganti
Deciphering ZBP1 activation and its role in sterile or viral-induced cell death.
People & Ideas
Stephanie Houston
Siamon Gordon: A half-century fascination with macrophages
Viewpoint
Betty Diamond
Betty Diamond discusses the potential contribution of the renin–angiotensin system to the pathogenies of COVID-19.

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