Journal of Experimental Medicine (JEM) | Rockefeller University Press

Skip Nav Destination

Take the steps to transfer your paper to JEM.
Th2 cells block breast cancer development.
Broadly SARS-CoV-2 Neutralizing Antibodies.
CD137L deficiency with EBV+ smooth muscle tumors.

JEM seeks a talented individual to join our editorial team as a Scientific Editor or Senior Editor.

RUP seeks a talented individual to join JEM and JGP editorial teams as a Scientific Editor.

Newest Articles

Article

| July 07 2022

Anorectic actions of antimigraine drugs

Li Li, Steven C. Wyler, Luis A. León-Mercado, Baijie Xu, Youjin Oh, Swati, Xiameng Chen, Rong Wan, Amanda G. Arnold, Lin Jia, Guanlin Wang, Katherine Nautiyal, René Hen, Jong-Woo Sohn, Chen Liu

Li et al. report the appetite-suppressing effect of a class of commonly prescribed antimigraine drugs in mice and illustrate the underlying neural pathway using a combination of genetic, metabolic, and transcriptomic analyses.

Article

| July 07 2022

Plasma and memory antibody responses to Gamma SARS-CoV-2

Marianna Agudelo, Frauke Muecksch, Dennis Schaefer-Babajew, Alice Cho, Justin DaSilva, Eva Bednarski, Victor Ramos, Thiago Y. Oliveira, Melissa Cipolla, Anna Gazumyan, Shuai Zong, Danielle A.S. Rodrigues, Guilherme S. Lira, Luciana Conde, Renato Santana Aguiar, Orlando C. Ferreira, Jr., Amilcar Tanuri, Katia C. Affonso, Rafael M. Galliez, Terezinha Marta Pereira Pinto Castineiras, Juliana Echevarria-Lima, Marcelo Torres Bozza, Andre M. Vale, Paul D. Bieniasz, Theodora Hatziioannou, Michel C. Nussenzweig

This paper describes the plasma and memory antibody response in a cohort of SARS-CoV-2 Gamma-infected individuals in Brazil. Potent antibody neutralization was shown to be limited to Gamma and Beta, and epitope recognition skewed to Class 3 epitopes.

Article

| July 06 2022

Epithelial HNF4A shapes the IEL compartment

Xuqiu Lei, Natalia Ketelut-Carneiro, Liraz Shmuel-Galia, Weili Xu, Ruth Wilson, Tim Vierbuchen, Yongzhi Chen, Andrea Reboldi, Joonsoo Kang, Karen L. Edelblum, Doyle Ward, Katherine A. Fitzgerald

The nuclear receptor HNF4A is associated with susceptibility to inflammatory bowel disease. This study identifies the importance of HNF4A in controlling crosstalk between intestinal epithelial cells and intraepithelial lymphocytes. Epithelial HNF4A serves as a transcription factor for immune signaling molecules and promotes the development of natural intraepithelial lymphocytes.

Article

| July 01 2022

Meningeal lymphatic drainage in mice and humans

Laurent Jacob, Jose de Brito Neto, Stephanie Lenck, Celine Corcy, Farhat Benbelkacem, Luiz Henrique Geraldo, Yunling Xu, Jean-Mickael Thomas, Marie-Renee El Kamouh, Myriam Spajer, Marie-Claude Potier, Stephane Haik, Michel Kalamarides, Bruno Stankoff, Stephane Lehericy, Anne Eichmann, Jean-Leon Thomas

The present study characterizes the 3D anatomy of meningeal lymphatic vasculature and associated CSF drainage by postmortem light-sheet imaging in mice and by real-time magnetic resonance imaging in humans, demonstrating conserved lymphatic circuitries in contact with dural venous sinuses.

Article

| July 01 2022

Human B cell responses to Ad26.COV2.S vaccination

Alice Cho, Frauke Muecksch, Zijun Wang, Tarek Ben Tanfous, Justin DaSilva, Raphael Raspe, Brianna Johnson, Eva Bednarski, Victor Ramos, Dennis Schaefer-Babajew, Irina Shimeliovich, Juan P. Dizon, Kai-Hui Yao, Fabian Schmidt, Katrina G. Millard, Martina Turroja, Mila Jankovic, Thiago Y. Oliveira, Anna Gazumyan, Christian Gaebler, Marina Caskey, Theodora Hatziioannou, Paul D. Bieniasz, Michel C. Nussenzweig

Cho et al. describe the antibody immune response after a single dose of the Ad26.COV2.S vaccine compared with mRNA vaccines. They find that Ad26.COV2.S vaccination produces fewer memory B cells but with a potency and breadth comparable to those found after mRNA vaccination.

Article

| June 29 2022

Phostensin enables population of lymphoid organs

Ho-Sup Lee, Hao Sun, Frédéric Lagarrigue, Sarah Hyun Ji Kim, Jay W. Fox, Nicholas E. Sherman, Alexandre R. Gingras, Mark H. Ginsberg

Phostensin, a protein phosphatase 1 regulatory subunit, supports lymphocyte integrin-dependent functions by mediating dephosphorylation of Rap1 to stabilize the MIT complex, thereby enabling the population of peripheral lymphoid organs and T cell–mediated colitis.

Article

| June 27 2022

IL-12–mediated human NK cell memory-like expansion

Avishai Shemesh, Harry Pickering, Kole T. Roybal, Lewis L. Lanier

Low IL-12 concentrations are sufficient to induce expansion of human NK cells by innate-activating NK receptor-orchestrated differential IL-12 signaling.

Browse All >

Related Articles from Rockefeller University Press

Current Issue

Volume 219,

Issue 7,

4 July 2022

View This Issue

Submit Your Research

Manage Email Alerts

Reviews & Opinions

Insights

| July 05 2022

Charting the meningeal lymphatic network

Sandro Da Mesquita

In this issue, Jacob et al. employ imaging techniques to provide a more comprehensive chart of the meningeal lymphatic vasculature and draw a parallel for lymphatic drainage of cerebrospinal fluid in mice and humans.

Perspective

| June 22 2022

Dense-core plaques are granulomas

Greg Lemke, Youtong Huang

Microglia, the tissue macrophages of the central nervous system, use phagocytosis of loosely organized amyloid beta (Aβ) to construct dense-core plaques, one of the defining histopathological features of Alzheimer’s disease. The biology of this process parallels macrophage construction of granulomas in tuberculosis and other settings.

Insights

| May 27 2022

Fueling the fire in the gut

Chia-Hao Lin, Li-Fan Lu

Gut dysbiosis has long been associated with the development of Crohn's disease and other gastrointestinal disorders. Otake-Kasamoto et al. report that dysbiotic microbiota–derived bioactive lipids, lysophosphatidylserines, can promote pathological Th1 cell responses through inducing metabolic reprogramming and epigenetic changes.

Browse All

Special Collections

The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

View all collections

Take the steps to transfer your paper to JEM.

Th2 cells block breast cancer development.

Broadly SARS-CoV-2 Neutralizing Antibodies.

CD137L deficiency with EBV+ smooth muscle tumors.

Related Articles from Rockefeller University Press

Most Read

Special Collections

This Feature Is Available To Subscribers Only