Skip to Main Content

Advertisement

Skip Nav Destination
Newest Articles
Brief Definitive Report
Hannah van Dijk et al.
Plasmodium falciparum circumsporozoite protein harbors conserved human T cell epitopes that may serve as targets for broad strain-transcending immunity. The findings offer guidance for the design of improved malaria vaccines.
Article
Sangya Chatterjee et al.
In this study, we report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activation and T cell infiltration. Administration of the bacteria-derived metabolite N,N,N-trimethyl-5-aminovaleric acid could rescue both microglial activation and associated neurocognitive deficits.
Article
Heather J. Faust et al.
Type I IFN signaling contributes to arthritis pathogenesis in obesity through activation and expansion of CD8 T cells in visceral adipose tissue and synovium. Deletion of IFNAR1 in T cells reduces arthritis severity in obese mice.
Brief Definitive Report
Aneesha Dasgupta et al.
Cachexia is a devastating cancer comorbidity that impacts numerous cancer outcomes, including therapeutic efficacy, quality of life, and overall survival. This work describes a novel metabolic pathway/target with clinical implications for the treatment of cachectic pancreatic cancer patients.
Article
Xin Geng et al.
TLOs are LN-like structures that are observed in certain inflammatory diseases. Geng et al. demonstrate that S1PR1 activity in the lymphatic vasculature is necessary to prevent TLO formation in the terminal ileum.
Article
Jorden I. Lane et al.
Lane et al. discover that the lymphatic vasculature is functionally and transcriptionally distinct along the gut. Duodenal lymphatic vessels appear optimized for dietary lipid uptake. Duodenal helminths compromise this property, providing an alternative explanation for worm-induced resistance to weight gain.
Brief Definitive Report
Kun Peng et al.
Current mRNA vaccines have either limited efficacy or severe toxicity. This study highlights that next-generation mRNA vaccines encoding membrane-tethered cytokine adjuvants can generate potent pre-effector cells, offering effective tumor control with reduced toxicity.
Journal of Experimental Medicine Cover Image for Volume 222, Issue 7
Current Issue
Volume 222,
Issue 7,
7 July 2025
Reviews & Opinions
Insights
Lawrence P. Kane
In this issue of JEM, Malissen and colleagues report that a gain-of-function mutation in CARMIL2, previously identified in patients, is sufficient to replace the contribution of CD28 to NF-κB activation and downstream effects in T cells, including in the setting of an anti-tumor response.
Review | Cancer Focus
Chuangyu Wen et al.
This review highlights how YTHDF proteins regulate tumor responses to radiotherapy by modulating DNA repair and the immune microenvironment and discusses their potential as therapeutic targets to enhance the efficacy of radiotherapy and immunotherapy in cancer treatment.
Review
Natalia Reglero-Real et al.
This review explores how aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic inflammation. The authors highlight key molecular changes and propose therapeutic strategies targeting vascular aging to mitigate age-related inflammatory diseases.

Most Read

Advertisement

null

Special Collections

Our annual series highlighting articles that were of greatest interest to our readers in 2024.

View collections >

 

or Create an Account

Close Modal
Close Modal