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Article
Jérémie Rosain et al.
Heterozygosity for null NEMO mutations underlies hypotrophic and dysplastic thymus in mice and humans. Women with incontinentia pigmenti therefore have a high prevalence of autoantibodies neutralizing type I interferons, which predisposes them to severe viral diseases.
Article
Ian W. Folkert et al.
Iron-rich tumor-associated macrophages (iTAMs) are characterized by high intracellular iron, heme metabolism, and expression of the endothelin receptor type B. iTAMs promote angiogenesis and immunosuppression in tumors. Heme-mediated degradation of the transcriptional repressor BACH1 induces the iTAM transcriptional program in macrophages.
Article
Maki Niihori et al.
This work reveals the crucial role of impaired mitochondrial function in pulmonary angiogenesis deficiency, a key factor in the mortality of pulmonary arterial hypertension (PAH) patients. Chronic lipoic acid supplementation improves mitochondrial function, prevents angiogenic deficiency, and may offer a promising therapeutic option.
Technical Advances and Resources
Deeksha Deep et al.
Trajectory analysis of CD4+ T cell differentiation during a type I inflammatory immune response identified two distinct differentiation paths for effector and precursor central memory T cells arising from heterogeneous naïve CD4+ T cells.
Brief Definitive Report
Adrian Gervais et al.
Infection with tick-borne encephalitis (TBE) virus (TBEV) is usually benign but may cause severe encephalitis in rare cases. Pre-existing autoantibodies neutralizing type I IFNs underlie ∼10% of these severe cases, strongly increasing the risk of severe disease relative to the absence of these autoantibodies.
Article
Qiuchen Cao et al.
The article identifies a direct connection between the brain and the eyes where Aβ from the brain can be transported to the eyes via the brain–eye pathway, leading to Alzheimer’s disease retinopathy.
Article
Liat Stoler-Barak et al.
B cells undergo extensive genomic reorganization during their proliferation and differentiation into germinal center and antibody-secreting cells. Stoler-Barak et al. demonstrate that SMARCA5, a component of the ISWI-complex, plays a critical role in gene accessibility and expression, facilitating the antibody-mediated immune response.
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Current Issue
Volume 221,
Issue 10,
7 October 2024
Reviews & Opinions
Insights
James Walsh
In this issue of the Journal of Experimental Medicine, Cao et al. demonstrate that the connection between the eye and the brain goes beyond the impulses carried by the optic nerve and that in Alzheimer’s disease (AD), the influx of toxic Aβ from the brain to the retina underlies AD-induced retinal degeneration.
People & Ideas
Montserrat Cols
Terez Shea-Donohue is the program director of the Division of Digestive Diseases and Nutrition at the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health. As a program director, Terez supports basic and translational research related to neurogastroenterology, gastrointestinal (GI), and GI epithelial barrier function.
Insights
Lijuan Sun, Mikala Egeblad
Folkert et al. define an “iron-rich” subset of tumor-associated macrophages (iTAMs). The metabolism of heme leads to the degradation of the transcriptional repressor Bach1 and shapes the transcriptional profile of iTAMs. The endothelin receptor B in iTAMs signals tumor-supportive functions.

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