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Zijun Wang et al.
Wang et al. analyze memory B cell and antibody responses in SARS-CoV-2 mRNA vaccines to breakthrough infections with Delta or Omicron BA.1 variants. Breakthrough infection after two or three doses of mRNA vaccination was comparable to three doses of vaccination in eliciting broad and potent memory B cells. The findings provide insights on broad and strain-specific memory responses after mRNA vaccination with Wuhan-Hu-1.
Brief Definitive Report
Rhea Nadkarni et al.
Nadkarni et al. show that human endothelial cells (EC) engage both NLRP1 and CARD8 inflammasomes. CARD8 is activated by Coxsackie B3 protease-mediated N-terminal cleavage. Knocking out CARD8 attenuates CVB3 propagation and dampens inflammation in a cellular model of viral myocarditis.
Article
Cameron S. McAlpine et al.
Sleep interruption restructures the epigenome of hematopoietic stem and progenitor cells (HSPCs) and increases their proliferation, priming them for exaggerated inflammatory bursts and reducing hematopoietic clonal diversity through accelerated genetic drift. In humans, sleep restriction alters the HSPC epigenome and activates hematopoiesis.
Article
Julius Beer et al.
Advanced age is the most critical risk factor for severe COVID-19. Using a newly established mouse model, Beer et al. demonstrate that the age-dependent exacerbation of disease is driven by a diminished innate and adaptive immune response due to impaired type I and type II interferon responses.
Article
Cuiyu Zhang et al.
This study demonstrates that GABA regulates intestinal stem cell apoptosis through its A receptor in chemoradiotherapy-induced intestinal injury. FDA-approved GABAAR antagonist flumazenil may be a promising drug for reducing the gastrointestinal side effects brought by chemoradiotherapy.
Brief Definitive Report
Alejandra González-Loyola et al.
c-MAF, highly expressed in villus small intestinal enterocytes, coordinates transcriptional programs for nutrient absorption. Enterocyte-specific c-MAF inactivation impairs dietary lipid handling but also leads to tuft cell expansion and adaptive gut lengthening, revealing crosstalk between enterocytes and tuft cells during intestinal adaptation.
Brief Definitive Report
Catalina Cosovanu et al.
This study identifies c-Maf as an enterocyte-specific transcription factor within the small intestinal epithelium. c-Maf governs the spatial and functional specialization of enterocytes, especially gene programs controlling intestinal nutrient absorption. Thus, epithelial c-Maf deletion results in impaired enterocyte maturation, nutrient uptake, and alterations of the immune system and microbiota.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 219,
Issue 9,
5 September 2022
Reviews & Opinions
Insights
Qiankun Wang, Liang Shan
In this issue of JEM, Nadkarni et al. identify CARD8 as an innate sensor triggered by coxsackievirus B3 proteases to drive pyroptosis of aortic endothelial cells and cardiac myocytes, fueling viral replication and heart inflammation.
Insights
Mohamed Khalil, Subramaniam Malarkannan
Shemesh et al. report that the development of FcRγ−/low adaptive-like NK cells requires reduced mTOR activity and depends on TGF-β or IFN-α.
Found in Translation
Laura Chiossone, Eric Vivier
Laura Chiossone and Eric Vivier discuss the recent advances of NK cell therapies in cancer, which include adoptive NK cell therapies and the harnessing of NK cells using immune checkpoint inhibitors, NK cell engagers, cytokines, and the combination thereof.

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