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Newest Articles
Article
Yin Xiao, Musga Qureischi, Lena Dietz, Martin Vaeth, Subrahmanya D. Vallabhapurapu, Stefan Klein-Hessling, Matthias Klein, Chunguang Liang, Anika König, Edgar Serfling, Anja Mottok, Tobias Bopp, Andreas Rosenwald, Mathias Buttmann, Ingolf Berberich, Andreas Beilhack, Friederike Berberich-Siebelt
A novel transgenic mouse, in which the transcription factor NFATc1 bears lysine-to-arginine mutations that prevent modification by SUMO, develops normally and is healthy. However, SUMO-insensitive NFATc1 transmits strong tolerogenic signals, thus preventing autoimmune and alloimmune T cell responses.
Article
Christina Megli, Stefanie Morosky, Dhivyaa Rajasundaram, Carolyn B. Coyne
Immune profiling of secreted factors from human placentas across gestation identifies inflammasome hyperactivation in placental trophoblasts resulting in constitutive IL-1β and IL-18 secretion. Trophoblast-secreted IL-1β primes circulating monocytes for inflammasome activation and is important for control of placental Listeria monocytogenes infection.
Article
Isabelle C. Arnold, Mariela Artola-Boran, Alessandra Gurtner, Katrin Bertram, Michael Bauer, Ziva Frangez, Burkhard Becher, Manfred Kopf, Shida Yousefi, Hans-Uwe Simon, Alexandar Tzankov, Anne Müller
Arnold et al. report that eosinophils in intestinal tumors are conditioned by GM-CSF to promote antitumor immunity through the activation of Th1 and CD8+ T cell responses. GM-CSF activates IRF5 and can be administered recombinantly to reduce tumor growth. Colorectal cancer patients exhibiting high intratumoral eosinophil infiltration also have better prognosis.
Article
Prarthana J. Dalal, David P. Sullivan, Evan W. Weber, David B. Sacks, Matthias Gunzer, Isabella M. Grumbach, Joan Heller Brown, William A. Muller
Spatiotemporally restricted endothelial cell calcium influx along with CaM and CaMKIIδ function are required for leukocyte diapedesis. Pharmacologic and genetic approaches show that disruption of this pathway significantly affects inflammation in vitro and in vivo.
Article
Yoshiaki Nishimura, Olivia K. Donau, Joana Dias, Sara Ferrando-Martinez, Eric Jesteadt, Reza Sadjadpour, Rajeev Gautam, Alicia Buckler-White, Romas Geleziunas, Richard A. Koup, Michel C. Nussenzweig, Malcolm A. Martin
Macaque recipients of anti–HIV-1 combination NAb treatment starting on PI day 3 or week 2 generate CD8+ cellular immunity that maintains durable suppression of SHIV replication and circulating CD4+ T cell levels during a 3–6-yr observation period.
Technical Advances and Resources
Tahereh Derakhshan, Sachin K. Samuchiwal, Nils Hallen, Lora G. Bankova, Joshua A. Boyce, Nora A. Barrett, K. Frank Austen, Daniel F. Dwyer
Mast cells (MCs) comprise two lineages that differ in tissue localization and ontologic origin. Derakhshan et al. define the transcriptomes of these lineages during airway inflammation, identifying distinct programs associated with each lineage and a role for TGF-β signaling in inducible MC development.
Technical Advances and Resources
Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, LuLin Jiang, Andrew P. Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E. Tanzi, Timothy Y. Huang, Huaxi Xu
Liu et al. compare epigenetic and expression profiles in isogenic ESC-derived human microglia-like cells (hMGLs) comprising Alzheimer’s disease (AD)–associated mutations. Using this model, convergent dysregulation at the APOE locus is observed with AD-associated mutations in SORL1 and TREM2.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 9,
September 7, 2020
Reviews & Opinions
Insights
Emilie K. Grasset, Andrea Cerutti
Intestinal antibodies from healthy subjects or patients with Crohn’s disease cross-target distinct communities of the gut microbiota by a mechanism involving somatic hypermutation.
Review
Hao Guo, Sara A. Gibson, Jenny P.Y. Ting
An extensive crosstalk between host and intestinal microbiota contributes to the development and maturation of intestinal epithelium and immune system. This review details the interplay between nucleotide-binding domain leucine-rich repeat containing proteins (NLR, or NOD-like receptors) signaling to host-microbiota homeostasis.
Insights
William A. Muller
In this commentary on Hong et al., Bill Muller explains the significance of their findings as a mechanism for the non–cell autonomous pathogenesis of CCMs and the potential relevance of targeting ADAMTS5 therapeutically in this condition, for which the only current option is surgery.

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