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Brief Definitive Report
Madeline J. Churchill et al.
PGD2 released after NAIP-NLRC4 inflammasome activation in tuft cells signals onto ILC3s and mediates host defense mechanisms against Salmonella Typhimurium within the small intestine. Tuft cells therefore not only promote immune reactions against parasites, but also bacteria.
Article
Kathleen Pestal et al.
This work demonstrates that group 2 KLF family transcription factors are critical for specifying the identity of distinct tissue-resident macrophages. KLF2 directly controls expression of genes previously shown to be necessary in cavity macrophages, while KLF4 may play a similar role in alveolar macrophages.
Article
Geunhyo Jang et al.
Jang et al. report that when the activating Kras mutation arises in hematopoietic stem cells, it causes the expansion and reprogramming of multipotent progenitors. These hypercompetitive progenitors lack self-renewal but rapidly spread the mutation throughout the blood system.
Article
Benjamin J. Broomfield et al.
Broomfield et al. demonstrate that early type I interferon blockade alters CXCR3 chemokine regulation and cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells for enhanced protection following viral infection and mRNA–lipid nanoparticle vaccination.
Article
Wenxing Qin et al.
This study unveils a novel mechanism by which the metabolic enzyme PCK1 hinders cGAS-STING activation by competitively consuming GTP, consequently fostering tumor immune evasion.
Brief Definitive Report
Hannah Peckham et al.
Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in individuals with an XX chromosomal background.
Article
Evi Duthoo et al.
Homozygous ATRIP splice variants are identified in patients with microcephalic primordial dwarfism and immunodeficiency, highlighting ATRIP’s essential role in the replication stress response, chromosomal stability, and immune cell viability and proliferation, providing insights into the molecular basis of these complex conditions.
Issue Cover
Current Issue
Volume 222,
Issue 3,
3 March 2025
Reviews & Opinions
Perspective
Kerry L. Hilligan et al.
This review summarizes evidence that both the mycobacterial-specific and off-target nonspecific effects of BCG immunization require the interplay of innate and adaptive responses and proposes that elucidating this interaction should be a major approach in developing more effective TB vaccines.
Insights
Kevin Coughlin, Jr., Ledong Wan
In this issue of JEM, Krishnamoorthy et al. identify the loss of the splicing factor RBM10 as a driver of metastasis in thyroid cancer through the regulation of RNA splicing. The synthetic lethal interaction between NF-κB and RBM10 loss reveals a potential therapeutic vulnerability.
Insights
Pierre A. Coulombe
In this issue, Bergson et al. report on variants in HMCN1 that co-segregate with and account for variations in disease severity in individuals suffering from epidermolysis bullosa simplex. Their findings help explain the clinical heterogeneity observed in this rare skin disorder and related conditions.

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