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Article
Chae Won Kim et al.
A high-salt diet increases Bacteroides abundance and intestinal propionate, activating the HIF-1α–TGF-β1 axis and promoting glioma invasion. This study reveals new insights into how gut microbiota and their metabolites contribute to glioma development and progression.
Article
Fanghui Zhang et al.
Zhang et al. demonstrate that the expression of a mutated CARMIL2 protein in CD28-deficient mice induces most of the developmental and functional consequences known to result from CD28 costimulation and in turn triggers potent tumor-specific T cell responses resistant to PD-1 and CTLA-4 blockade.
Article
Maryam Vaseghi-Shanjani et al.
Vaseghi-Shanjani et al. report the first human disease caused by a genetic alteration in ThPOK, establishing ThPOK as essential for human T cell development and the regulation of fibrosis. They link ThPOK dysfunction to immune dysregulation, T cell defects, and fibrosis.
Technical Advances and Resources
Endi K. Santosa et al.
Our findings reveal a divergent transcriptomic and epigenetic landscape between conventional and inflationary memory responses in spleen and liver during latent infection, while these molecular programs converge early in salivary glands, highlighting how the dynamics of memory CD8+ T cell responses are distinct between tissues.
Article
Flavia T.T. Antunes et al.
The manuscript reports on patient with a USP5 mutation that gives rise to insensitivity to pain. The patient’s pathology is phenocopied in a knock-in mouse model and appears to be due to a dominant-negative loss of function of deubiquitinase activity.
Brief Definitive Report
Ana Cardoso et al.
Cardoso et al. show that DNGR-1–deficient pre-cDCs display cell-intrinsic alterations in their ability to colonize peripheral organs. Their findings highlight an unexpected role for innate immune receptors in regulating cDCpoiesis.
Article
Jing Xu et al.
T cell exhaustion limits antiviral response. Targeting BCOR and ZC3H12A potently enhances the stemness and functionality of CD8 T cells in chronic viral infections, reversing T cell exhaustion and improving antiviral immunity.
Journal of Experimental Medicine Cover Image for Volume 222, Issue 5
Current Issue
Volume 222,
Issue 5,
5 May 2025
Reviews & Opinions
Insights
Feiya Ou, Kenneth M. Murphy
Sun et al. highlight eTACs as a key component in the group of RORγt+ antigen-presenting cells acting in the induction of RORγt+ pTregs specific to food antigens, while implicating DCs in the generation of RORγt pTregs.
People & Ideas
Lucie Van Emmenis
Laura Mackay is a professor and Immunology Theme Leader at the Doherty Institute at the University of Melbourne. Her lab investigates memory T cells, including their development, the role tissue-resident memory T cells play in cancer, autoimmune diseases, and barrier immunity, as well as ways in which these cells may be used therapeutically to treat various pathologies.
Review
Hanover C. Matz, Ali H. Ellebedy
Influenza virus remains a public health burden for which recommendations encourage annual vaccination. However, some studies have suggested repeat annual vaccination may have negative effects on influenza virus immunity. This review analyzes immunological mechanisms that may result in reduced effectiveness of annual influenza virus vaccines.

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