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Usha Nair et al.
The diversity of coronaviruses renders neutralization breadth key for vaccine and monoclonal antibody development. Using immunoglobulin knock-in mice, Nair et al. rediversify germline and mature versions of the human anti-SARS-CoV-2 spike antibody CR3022 to obtain broadened reactivity against human and bat coronaviruses.
Article
Xiaoyun Li et al.
This paper uncovers an unexplored metabolic symbiosis between tumor cells, CAFs, and TAMs. The authors show how tumor-derived lipids can induce an IL-6–dependent increased glutamine synthesis pathway in CAFs, supporting CAFs ability to promote pro-tumorigenic TAMs.
Brief Definitive Report
Tomoyuki Iwata et al.
Monoallelic mutations, p.A116V and p.R126P, in MMD2 disturb fMLP-induced activation of Ras/ERK signaling and underlie the impairment of neutrophil chemotaxis, which leads to the development of the autosomal dominant form of aggressive periodontitis.
Article
Marie Ménard et al.
This study describes a Mycn-nGEMM for neuroblastoma. Murine and human neuroblastomas showed profound immunosuppression mediated by PD-L1–expressing, TAMs. Anti–PD-L1 immunotherapy depleted TAMs and inhibited tumor growth, demonstrating the potential for myeloid-targeted immunotherapies to overcome the immuno-inhibitory barriers.
Article
Kun Yang et al.
NGLY1 deficiency is an early-onset neurodegenerative disorder with no effective therapy. Here, we describe an inducible Ngly1 knockout mouse model, iNgly1−/−, that reveals pronounced loss of Purkinje cells in the cerebellum without neuroinflammation. Sting1 knockout or STING inhibitor VS-X4 significantly rescues iNgly1−/− disease in mice.
Article
Quin T. Waterbury et al.
During obesity, the bone marrow is dysregulated to overproduce myeloid cells that drive systemic inflammation. Neutrophil migration is a key mediator of this process, and targeting neutrophil movement during obesity or weight loss improves inflammatory and metabolic outcomes.
Brief Definitive Report
Hannah van Dijk et al.
Plasmodium falciparum circumsporozoite protein harbors conserved human T cell epitopes that may serve as targets for broad strain-transcending immunity. The findings offer guidance for the design of improved malaria vaccines.
Journal of Experimental Medicine Cover Image for Volume 222, Issue 7
Current Issue
Volume 222,
Issue 7,
7 July 2025
Reviews & Opinions
Insights
Samantha Mahfoud, Timothy P. Padera
Geng et al. show that LEC S1P/S1PR1 signaling plays a role in mesenteric TLS formation in the absence of subclinical inflammation and, importantly, is a key regulator of lymphatic valve development.
Insights
Aman Mangalmurti, John R. Lukens
Yang and colleagues provide an exhaustive study of a novel mouse model of NGLY1 deficiency, a devastating neurological disease, and implicate the cGAS-STING pathway in mediating key disease features which can be rescued using an orally administered STING antagonist.
Insights
Lawrence P. Kane
In this issue of JEM, Malissen and colleagues report that a gain-of-function mutation in CARMIL2, previously identified in patients, is sufficient to replace the contribution of CD28 to NF-κB activation and downstream effects in T cells, including in the setting of an anti-tumor response.

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