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Brief Definitive Report
Siddharth Krishnan, Kelly Wemyss, Ian E. Prise, Flora A. McClure, Conor O’Boyle, Hayley M. Bridgeman, Tovah N. Shaw, John R. Grainger, Joanne E. Konkel
Krishnan et al. outline a novel pathway of myeloid cell development in healthy gingiva. They identify HSPCs in noninflamed gingiva tissue, which support the generation of a proportion of the innate immune cells that police this barrier site.
Article
Celia Rupérez, Gemma Ferrer-Curriu, Aina Cervera-Barea, Laura Florit, Mariona Guitart-Mampel, Gloria Garrabou, Mònica Zamora, Fàtima Crispi, Joaquim Fernandez-Solà, Josep Lupón, Antoni Bayes-Genis, Francesc Villarroya, Anna Planavila
Rupérez et al. report the discovery of the protein Metrnβ as a new cardiokine with cardioprotective actions. They established that the heart produces Metrnβ, which in turn protects against cardiac hypertrophy. Metrnβ is also a new prognostic biomarker in heart failure patients.
Brief Definitive Report
Daria Kveštak, Vanda Juranić Lisnić, Berislav Lisnić, Jelena Tomac, Mijo Golemac, Ilija Brizić, Daniela Indenbirken, Maja Cokarić Brdovčak, Giovanni Bernardini, Fran Krstanović, Carmen Rožmanić, Adam Grundhoff, Astrid Krmpotić, William J. Britt, Stipan Jonjić
Using a mouse model of congenital cytomegalovirus infection, evidence is provided for a pathogenic role of NK and ILC1 cells in the brain. Although brain-infiltrating innate immune cells fail to control infection, they orchestrate pathological inflammatory responses that lead to altered cerebellar development.
Article
Alessia Balestrini, Victory Joseph, Michelle Dourado, Rebecca M. Reese, Shannon D. Shields, Lionel Rougé, Daniel D. Bravo, Tania Chernov-Rogan, Cary D. Austin, Huifen Chen, Lan Wang, Elisia Villemure, Daniel G.M. Shore, Vishal A. Verma, Baihua Hu, Yong Chen, Laurie Leong, Chris Bjornson, Kathy Hötzel, Alvin Gogineni, Wyne P. Lee, Eric Suto, Xiumin Wu, John Liu, Juan Zhang, Vineela Gandham, Jianyong Wang, Jian Payandeh, Claudio Ciferri, Alberto Estevez, Christopher P. Arthur, Jens Kortmann, Ryan L. Wong, Jose E. Heredia, Jonas Doerr, Min Jung, Jason A. Vander Heiden, Merone Roose-Girma, Lucinda Tam, Kai H. Barck et al.
Balestrini et al. show the identification of a TRPA1 inhibitor that suppresses airway smooth muscle contraction, inflammation, edema, and cough in preclinical models and show target engagement in humans, demonstrating that pharmacologic inhibition of TRPA1 is a promising therapy for asthma.
Article
Zheng-jun Gao, Wen-ping Li, Xin-tao Mao, Tao Huang, Hao-li Wang, Yi-ning Li, Bao-qin Liu, Jiang-yan Zhong, Chai Renjie, Jin Jin, Yi-yuan Li
DNA methylation plays a critical role in innate immune response, but the underlying mechanisms have not been clarified. The authors found a single-nucleotide methylation controls IFN-I induction and antiviral immunity via regulating IRF3 recruitment both in human and mouse.
Article
Ommar Omarjee, Anne-Laure Mathieu, Gaëlle Quiniou, Marion Moreews, Michelle Ainouze, Cécile Frachette, Isabelle Melki, Cécile Dumaine, Mathieu Gerfaud-Valentin, Agnès Duquesne, Tilmann Kallinich, Eda Tahir Turanli, Christophe Malcus, Sébastien Viel, Rémi Pescarmona, Sophie Georgin-Lavialle, Yvan Jamilloux, Jean-Paul Larbre, Guillaume Sarrabay, Flora Magnotti, Gillian I. Rice, Francoise Bleicher, Jonathan Reboulet, Samir Merabet, Thomas Henry, Yanick J. Crow, Mathias Faure, Thierry Walzer, Alexandre Belot
Juvenile arthritis represents the most common rheumatic manifestation in children. LACC1 deficiency has been identified as a monogenic cause of juvenile arthritis. In this issue, Omarjee et al. demonstrate a new role of LACC1 in autophagy and metabolism in macrophages.
Brief Definitive Report
Nutthakarn Suwankitwat, Stephen Libby, H. Denny Liggitt, Alan Avalos, Alanna Ruddell, Jason W. Rosch, Heon Park, Brian M. Iritani
Mutations in the actin-regulatory protein Hem-1 result in primary immunodeficiency disease in humans. Using murine models, Suwankitwat et al. show that myeloid-specific Hem-1 is essential for the development of alveolar macrophages and protection against influenza A virus and Streptococcus pneumoniae.

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