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Heather J. Faust et al.
Type I IFN signaling contributes to arthritis pathogenesis in obesity through activation and expansion of CD8 T cells in visceral adipose tissue and synovium. Deletion of IFNAR1 in T cells reduces arthritis severity in obese mice.
Brief Definitive Report
Aneesha Dasgupta et al.
Cachexia is a devastating cancer comorbidity that impacts numerous cancer outcomes, including therapeutic efficacy, quality of life, and overall survival. This work describes a novel metabolic pathway/target with clinical implications for the treatment of cachectic pancreatic cancer patients.
Article
Xin Geng et al.
TLOs are LN-like structures that are observed in certain inflammatory diseases. Geng et al. demonstrate that S1PR1 activity in the lymphatic vasculature is necessary to prevent TLO formation in the terminal ileum.
Article
Jorden I. Lane et al.
Lane et al. discover that the lymphatic vasculature is functionally and transcriptionally distinct along the gut. Duodenal lymphatic vessels appear optimized for dietary lipid uptake. Duodenal helminths compromise this property, providing an alternative explanation for worm-induced resistance to weight gain.
Brief Definitive Report
Kun Peng et al.
Current mRNA vaccines have either limited efficacy or severe toxicity. This study highlights that next-generation mRNA vaccines encoding membrane-tethered cytokine adjuvants can generate potent pre-effector cells, offering effective tumor control with reduced toxicity.
Article
Riem Gawish et al.
In this study, Gawish et al. show that RNA editing of the actin cross-linker FLNA is similarly regulated in mice and humans and that the targeted induction of edited FLNAR in myeloid cells governs resistance to DSS-induced colitis, revealing its potential in IBD therapy.
Article
Ramona Rica et al.
Rica et al. demonstrate that HDAC1 promotes an open chromatin state at effector-like signature gene loci in exhausted T cell progenitors and thereby primes cell fate specification toward effector-like exhausted T cells, which is essential for controlling viral load during chronic infection.
Journal of Experimental Medicine Cover Image for Volume 222, Issue 7
Current Issue
Volume 222,
Issue 7,
7 July 2025
Reviews & Opinions
Insights
Lawrence P. Kane
In this issue of JEM, Malissen and colleagues report that a gain-of-function mutation in CARMIL2, previously identified in patients, is sufficient to replace the contribution of CD28 to NF-κB activation and downstream effects in T cells, including in the setting of an anti-tumor response.
Review | Cancer Focus
Chuangyu Wen et al.
This review highlights how YTHDF proteins regulate tumor responses to radiotherapy by modulating DNA repair and the immune microenvironment and discusses their potential as therapeutic targets to enhance the efficacy of radiotherapy and immunotherapy in cancer treatment.
Review
Natalia Reglero-Real et al.
This review explores how aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic inflammation. The authors highlight key molecular changes and propose therapeutic strategies targeting vascular aging to mitigate age-related inflammatory diseases.

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