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Newest Articles
Dong Chen, Zhiliang Duan, Wenhua Zhou, Weiwei Zou, Shengwei Jin, Dezhou Li, Xinyu Chen, Yongchao Zhou, Lan Yang, Yanjun Zhang, Sujan Shresta, Jinsheng Wen
Chen et al. show that Japanese encephalitis virus (JEV)–elicited CD8+ T cells and antibodies play protective and pathogenic roles in Zika virus–infected wild-type C57BL/6 mice, respectively, and JEV-elicited CD8+ T cells abrogate anti-JEV antibody–mediated enhancement of Zika virus infection in mice.
Shih-Ying Wu, Fei Xing, Sambad Sharma, Kerui Wu, Abhishek Tyagi, Yin Liu, Dan Zhao, Ravindra Pramod Deshpande, Yusuke Shiozawa, Tamjeed Ahmed, Wei Zhang, Michael Chan, Jimmy Ruiz, Thomas W. Lycan, Andrew Dothard, Kounosuke Watabe
Wu et al. show that nicotine promotes brain metastasis of lung cancer by skewing polarity of M2 microglia and suppressing their phagocytic ability and show that this process is blocked by the natural compound parthenolide.
Teresa Manzo, Boone M. Prentice, Kristin G. Anderson, Ayush Raman, Aislyn Schalck, Gabriela S. Codreanu, Carina B. Nava Lauson, Silvia Tiberti, Andrea Raimondi, Marissa A. Jones, Michelle Reyzer, Breanna M. Bates, Jeffrey M. Spraggins, Nathan H. Patterson, John A. McLean, Kunal Rai, Carlo Tacchetti, Sara Tucci, Jennifer A. Wargo, Simona Rodighiero, Karen Clise-Dwyer, Stacy D. Sherrod, Michael Kim, Nicholas E. Navin, Richard M. Caprioli, Philip D. Greenberg, Giulio Draetta, Luigi Nezi
Metabolic constrains induce transcriptional deregulation of CD8+ T cells in pancreatic tumor microenvironment, driving progressive dysfunction. Here, metabolic reprogramming through enforced very-long-chain acyl-CoA dehydrogenase expression enhances intratumor T cells survival and persistence, overcoming a major hurdle to immunotherapy for PDA.
Kevin P. Meng, Fatemeh S. Majedi, Timothy J. Thauland, Manish J. Butte
Meng et al. identify YAP as a mechanosensor in T cells that suppresses metabolism and effector activity in mechanically soft tissues and accentuates in stiff ones.
Marcin Bączyk, Najwa Ouali Alami, Nicolas Delestrée, Clémence Martinot, Linyun Tang, Barbara Commisso, David Bayer, Nicolas Doisne, Wayne Frankel, Marin Manuel, Francesco Roselli, Daniel Zytnicki, Daniel Zytnicki
This study demonstrates that, in a mouse model of ALS, excitatory synapses on spinal motoneurons are disrupted. Activation of the cAMP/PKA pathway reverts the functional and structural synaptic deficits and ameliorates disease markers by increasing motoneuron firing.
Brief Definitive Report
Dan Wu, Chi Kin Wong, Jonathan M. Han, Paul C. Orban, Qing Huang, Jana Gillies, Majid Mojibian, William T. Gibson, Megan K. Levings
Insulin receptor deletion in T regs improves metabolic outcomes in models of diet- and age-induced obesity and hyperinsulinemia. Direct effects of hyperinsulinemia on T regs is a previously unknown mechanism controlling T reg function in metabolic syndrome.
Qingxin Zhou, Meihua Lin, Xing Feng, Fei Ma, Yuekun Zhu, Xing Liu, Chao Qu, Hong Sui, Bei Sun, Anlong Zhu, Heng Zhang, He Huang, Zhi Gao, Yongxiang Zhao, Jiangyun Sun, Yuxian Bai, Junfei Jin, Xuehui Hong, Chang Zou, Zhiyong Zhang
Zhou et al. characterize a critical role of CLK3 on purine metabolism in cholangiocarcinoma (CCA). Overexpressed or mutated CLK3 promotes CCA progression in vitro and in vivo. Therefore, CLK3 may serve as a biomarker and potential drug target for CCA.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 6,
June 1, 2020
Reviews & Opinions
Carolina Magdalen Greco, Paolo Sassone-Corsi
Personalized medicine and circadian rhythms: Opportunities for modern society
Luc Van Kaer, Sebastian Joyce
The Hippo signaling pathway controls the maturation and effector differentiation of iNKT cells.
Santosha A. Vardhana, Jedd D. Wolchok
This Perspective explores the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offers suggestions to both understand and therapeutically modulate anti-COVID immunity.

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