Terez Shea-Donohue is the program director of the Division of Digestive Diseases and Nutrition at the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health. As a program director, Terez supports basic and translational research related to neurogastroenterology, gastrointestinal (GI), and GI epithelial barrier function.

Folkert et al. define an “iron-rich” subset of tumor-associated macrophages (iTAMs). The metabolism of heme leads to the degradation of the transcriptional repressor Bach1 and shapes the transcriptional profile of iTAMs. The endothelin receptor B in iTAMs signals tumor-supportive functions.

This review describes the current state of understanding of how RNA processing is dysregulated in cancer (including alterations in RNA splicing, capping, polyadenylation, and decay) and how this knowledge is being harnessed for therapeutic intent.