Journal of Experimental Medicine (JEM) | Rockefeller University Press

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Mechanisms and Models of Cancer 2022 Update.
Anorectic actions of antimigraine drugs.
Meningeal lymphatic drainage in mice and humans.

JEM seeks a talented individual to join our editorial team as a Scientific Editor or Senior Editor.

RUP seeks a talented individual to join JEM and JGP editorial teams as a Scientific Editor.

Newest Articles

Brief Definitive Report

| August 16 2022

SARS-CoV-2–specific nasal resident T cells

Joey Ming Er Lim, Anthony Tanoto Tan, Nina Le Bert, Shou Kit Hang, Jenny Guek Hong Low, Antonio Bertoletti

Virus-specific T cells in the nasal cavity might provide an immediate layer of protection against SARS-CoV-2. This study detected SARS-CoV-2–specific nasal-resident T cells in vaccinees only after infection, highlighting the significance of nasal challenge in the formation of antiviral immunity at the site of infection.

Article

| August 16 2022

Sebum–propionate–IL-33 axis in atopic dermatitis

Zhuoqiong Qiu, Zhenlai Zhu, Xiaochun Liu, Baichao Chen, Huibin Yin, Chaoying Gu, Xiaokai Fang, Ronghui Zhu, Tianze Yu, Wenli Mi, Hong Zhou, Yufeng Zhou, Xu Yao, Wei Li

This study demonstrates that a dysregulated sebum–microbial metabolite–IL-33 axis is involved in the pathogenesis of atopic dermatitis, possibly by playing an initiating role in the induction of skin inflammation.

Article

| August 10 2022

Hypogammaglobulinemia and ASD upon PAX5 deficiency

Fabian M.P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A.S.H. Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D. Katsikis, Joyce H.G. Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I. De Zeeuw, Aleksandra Badura, Meinrad Busslinger

A mouse model carrying biallelic Pax5 mutations identified in a patient with hypogammaglobulinemia and autism spectrum disorder shows a B cell developmental arrest and autistic-like behavior caused by abnormal development of the cerebellum and loss of ventral midbrain GABAergic neurons.

Technical Advances and Resources

| August 08 2022

Zebrafish ETPs, pre-B cells revealed by scRNA-seq

Sara A. Rubin, Chloé S. Baron, Cecilia Pessoa Rodrigues, Madeleine Duran, Alexandra F. Corbin, Song P. Yang, Cole Trapnell, Leonard I. Zon

Single-cell RNA sequencing of zebrafish hematopoiesis provides new insights into zebrafish B- and T-cell development and cellular diversity within the primary lymphoid organs (kidney marrow and thymus). This work advances the current understanding of zebrafish immunology and will facilitate future genetic and developmental studies.

Brief Definitive Report

| August 08 2022

Helminth-dependent reprogramming of intestinal stem cells

Danielle Karo-Atar, Shaida Ouladan, Tanvi Javkar, Loick Joumier, Macy K. Matheson, Sydney Merritt, Susan Westfall, Annie Rochette, Maria E. Gentile, Ghislaine Fontes, Gregory J. Fonseca, Marc Parisien, Luda Diatchenko, Jakob von Moltke, Mohan Malleshaiah, Alex Gregorieff, Irah L. King

Karo-Atar et al. demonstrate direct regulation of the intestinal stem cell compartment by an enteric helminth, resulting in expansion of fetal-like stem cells and inhibition of secretory cells. They establish how a helminth parasite co-opts a tissue development program to counter type 2 immune-mediated expulsion.

Brief Definitive Report

| August 08 2022

IgM antibodies built from SARS-CoV-2 immune memory

Malika Hale, Jason Netland, Yu Chen, Christopher D. Thouvenel, Katherine Nabel Smith, Lucille M. Rich, Elizabeth R. Vanderwall, Marcos C. Miranda, Julie Eggenberger, Linhui Hao, Michael J. Watson, Charles C. Mundorff, Lauren B. Rodda, Neil P. King, Miklos Guttman, Michael Gale, Jr, Jonathan Abraham, Jason S. Debley, Marion Pepper, David J. Rawlings

Using monoclonal antibodies built from SARS-CoV-2–specific memory B cells, Hale et al. demonstrate that IgM antibodies outperform IgG in neutralization assays against mutated variants. The authors suggest that IgM antibodies may be useful therapeutically, and that IgM memory B cells may be underappreciated protectors against rapidly evolving pathogens.

Technical Advances and Resources

| August 08 2022

DNA methylation marker in murine ILCs

Michael Beckstette, Chia-Wen Lu, Susanne Herppich, Elia C. Diem, Anna Ntalli, Aaron Ochel, Friederike Kruse, Beate Pietzsch, Katrin Neumann, Jochen Huehn, Stefan Floess, Matthias Lochner

In this study, the authors perform a genome-wide methylation analysis to define epigenetic signatures for murine ILCs and to assess similarities and differences to CD4⁺ T cells. Models of IL-33–mediated inflammatory challenge reveal tissue-specific epigenetic changes within ILC2 signature regions.

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