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Yana Zhang, Yajun Wang, Beixue Gao, Yueqi Sun, Liang Cao, Samantha M. Genardi, Chyung-Ru Wang, HuaBin Li, Zhaolin Sun, Yanjie Yang, Deyu Fang
This study identifies USP22 as an essential regulator specifically for iNKT but not conventional T cell development. USP22 suppresses histone H2A monoubiquitination through its interaction with MED1 to partially control expression of genes required for iNKT cell development and differentiation.
Brief Definitive Report
Carlos Diaz-Salazar, Regina Bou-Puerto, Adriana M. Mujal, Colleen M. Lau, Madlaina von Hoesslin, Dietmar Zehn, Joseph C. Sun
Natural killer (NK) cells are critical for protection against viruses. Diaz-Salazar et al. show that adrenergic neurons modulate the adaptive NK cell response in a cell-intrinsic manner. This study identifies the nervous system as a novel axis through which antigen-specific NK cell responses are regulated.
Brief Definitive Report
Elisabeth Wieduwild, Mathilde J. Girard-Madoux, Linda Quatrini, Caroline Laprie, Lionel Chasson, Rafaëlle Rossignol, Claire Bernat, Sophie Guia, Sophie Ugolini
Stress hormones increase host susceptibility to viral infection. β2-adrenergic signals in nonhematopoietic cells downmodulate the proinflammatory antiviral natural killer cell response, which is necessary for efficient pathogen elimination. This modulation increases the severity of tissue lesions, decreasing resistance to infection.
Brief Definitive Report
Genki Okumura, Akiko Iguchi-Manaka, Rikito Murata, Yumi Yamashita-Kanemaru, Akira Shibuya, Kazuko Shibuya
This report demonstrated that soluble CD155 interferes with the DNAM-1–mediated antitumor immunity mediated by NK cells and promotes lung colonization of B16/BL6 melanoma cells.
Brief Definitive Report
Roberto R. Ricardo-Gonzalez, Christoph Schneider, Chang Liao, Jinwoo Lee, Hong-Erh Liang, Richard M. Locksley
Activated ILC2s can enter circulation after migratory helminth infection. Using fate-mapping, alarmin-specific knockouts, and methods to isolate tissue-specific perturbations, the authors demonstrate that ILC2 extrusion from tissues reflects activation of pathways specific to receptors on the resident ILC2 population.
Article
Ivan Ting Hin Fung, Poornima Sankar, Yuanyue Zhang, Lisa S. Robison, Xiuli Zhao, Shanti S. D’Souza, Abigail E. Salinero, Yue Wang, Jiang Qian, Marcy L. Kuentzel, Sridar V. Chittur, Sally Temple, Kristen L. Zuloaga, Qi Yang
Fung et al. show that group 2 innate lymphoid cells (ILC2) accumulate in the choroid plexus (CP) of the aged brain. These aging-associated CP-resident ILC2 exhibit unique functional and molecular properties, and their activation revitalizes the aged brain and alleviates aging-associated cognitive decline.
Article
Juan Tang, Juan Tang, Sha Tu, Guoxin Lin, Hui Guo, Chengkai Yan, Qingjun Liu, Ling Huang, Na Tang, Yizhi Xiao, R. Marshall Pope, Murugesan V.S. Rajaram, Amal O. Amer, Brian M. Ahmer, John S. Gunn, Daniel J. Wozniak, Lijian Tao, Vincenzo Coppola, Liwen Zhang, Wallace Y. Langdon, Jordi B. Torrelles, Stanley Lipkowitz, Jian Zhang
Hyper-activation of NLRP3 inflammasomes contributes to the development of endotoxemia, but the molecular mechanisms are poorly defined. Tang et al. demonstrate that sequential ubiquitination of NLRP3 is crucial to keep NLRP3 inflammasomes in check and limits endotoxemia.

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Volume 217,
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Reviews & Opinions
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Andrea D. Branch
Andrea D. Branch discusses the challenges of eliminating the burden of disease caused by HCV infection, despite the availability of curative antiviral treatments.
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Omentum-resident macrophages of embryonic origin facilitate ovarian cancer metastasis
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