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Longfei Chen, David A. Christian, Joshua A. Kochanowsky, Anthony T. Phan, Joseph T. Clark, Shuai Wang, Corbett Berry, Jung Oh, Xiaoguang Chen, David S. Roos, Daniel P. Beiting, Anita A. Koshy, Christopher A. Hunter
The ability of T. gondii to promote a STAT3- and STAT6-dependent M2 phenotype in macrophages by injecting the virulence factor ROP16 in cis and trans subsequently limits the magnitude of the parasite-specific T cell response.
Miao Liu, Yuanyuan Wang, Chuanzhen Yang, Yuxia Ruan, Changsen Bai, Qiaoyun Chu, Yanfen Cui, Ceshi Chen, Guoguang Ying, Binghui Li
Liu et al. build up an electron balance model for central carbon metabolism in cancer cells and reveal that simultaneous inhibitions of proline biosynthesis and lipogenesis can block cancer cell growth under hypoxia and in vivo tumor progress.
Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh-Keller, Marc Bajenoff, Michael H. Sieweke, Søren Kragh Moestrup, Nathalie Auphan-Anezin, Toby Lawrence
Etzerodt et al. identify a unique subset of CD163+ Tim4+ tissue-resident macrophages in omentum that are maintained independently of bone marrow–derived monocytes and have a specific role in the metastatic spread of ovarian cancer cells.
Lan Kang, Xiang Zhang, Liangliang Ji, Tiantian Kou, Sinead M. Smith, Baohong Zhao, Xiaohuan Guo, Inés Pineda-Torra, Li Wu, Xiaoyu Hu
Transcription factor RBP-J in intestinal macrophages dynamically controls antibacterial immunity by interfacing with T cells and ILCs. Macrophage-intrinsic RBP-J supports intestinal Th17 cell responses via IL-6 production, whereas RBP-J deficiency unexpectedly reveals a compensatory role for ILC3 late during infection.
Aude-Hélène Capietto, Aude-Hélène Capietto, Suchit Jhunjhunwala, Samuel B. Pollock, Patrick Lupardus, Jim Wong, Lena Hänsch, James Cevallos, Yajun Chestnut, Ajay Fernandez, Nicolas Lounsbury, Tamaki Nozawa, Manmeet Singh, Zhiyuan Fan, Cecile C. de la Cruz, Qui T. Phung, Lucia Taraborrelli, Benjamin Haley, Jennie R. Lill, Ira Mellman, Richard Bourgon, Lélia Delamarre
Cancer mutations create neoantigens that are of great interest for immunotherapy, but their accurate identification remains a challenge. Capietto et al. show that mutation position is an important determinant for immunogenicity, and incorporating this feature into prediction algorithms improves their identification.
Wei Liu, Yonju Ha, Fan Xia, Shuang Zhu, Yi Li, Shuizhen Shi, Fang C. Mei, Kevin Merkley, Gianmarco Vizzeri, Massoud Motamedi, Xiaodong Cheng, Hua Liu, Wenbo Zhang
This study shows that the cAMP/Epac1 pathway plays a critical role in retinal neurodegeneration via CaMKII activation in mouse models of ocular hypertension and suggests that Epac1 is a therapeutic target for neuroprotection in glaucoma.
Brief Definitive Report
Adam J. Byrne, Joseph E. Powell, Brendan J. O’Sullivan, Patricia P. Ogger, Ashley Hoffland, James Cook, Katie L. Bonner, Richard J. Hewitt, Simone Wolf, Poonam Ghai, Simone A. Walker, Samuel W. Lukowski, Philip L. Molyneaux, Sejal Saglani, Daniel C. Chambers, Toby M. Maher, Clare M. Lloyd
We characterized monocyte/macrophage populations from infants to older adults and lineage traced these cells using sex-mismatched lung transplant recipients. Classical monocytes peak in adulthood and decline in older adults. Importantly, our data show that after transplant, donor human airway macrophages (AMs) are readily replaced by recipient-derived monocytes.

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