Stromal desmoplasia drives local proliferation of TAMs and induces their immunosuppressive ability through altering p21 expression. These changes in p21 in TAMs also potentially render tumors more sensitive to CD40 agonist therapy.

Both DCs and monocytes capture antigen for presentation to lymph node T cells. Here, Rawat et al. show that DCs use the chemokine receptor CCR7, while monocytes follow chemokines secreted by migratory DCs to reach the nodes and control immunity.

Detailed analysis of patients with APDS2 and a novel mouse model of Pik3r1 LOF reveals multiple cellular defects, some of which are unique to APDS2 and not seen in APDS1. This is associated with unique signaling changes caused by Pik3r1 LOF.

Billiet et al. identify the post-thymic progeny of the agonist-selected CD10⁺ PD-1⁺ precursors in humans based on shared characteristics of the T cell receptor repertoire and the transcriptome. This lineage represents a well-defined but heterogeneous, unconventional TCRαβ⁺ lineage mostly confined within the CD8⁺ Helios⁺ T cells.

Qin and colleagues develop a genome-editing tool characterized by the versatility of prime editors and unconstrained PAM requirement of SpRY. In vivo gene correction is successfully implemented in the mouse model of Pde6b-associated retinitis pigmentosa, leading to substantial functional rescue of vision.

Extracellular nucleases of the DNASE1 family are conserved in vertebrates, yet their physiological function remains unclear. This study shows that DNASE1 and its homolog DNASE1L3 jointly facilitate resistance to systemic infection with Staphylococcus aureus by digesting bacterial biofilms.

Abdulla et al. show that the LMO2 transcription factor, a key driver of human T-lymphoblastic leukemia, inhibits thymocyte competition in a transgenic mouse model and that this enables LMO2 to promote T-lymphoblastic leukemia.