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Newest Articles
Technical Advances and Resources
Tahereh Derakhshan, Sachin K. Samuchiwal, Nils Hallen, Lora G. Bankova, Joshua A. Boyce, Nora A. Barrett, K. Frank Austen, Daniel F. Dwyer
Mast cells (MCs) comprise two lineages that differ in tissue localization and ontologic origin. Derakhshan et al. define the transcriptomes of these lineages during airway inflammation, identifying distinct programs associated with each lineage and a role for TGF-β signaling in inducible MC development.
Technical Advances and Resources
Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, LuLin Jiang, Andrew P. Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E. Tanzi, Timothy Y. Huang, Huaxi Xu
Liu et al. compare epigenetic and expression profiles in isogenic ESC-derived human microglia-like cells (hMGLs) comprising Alzheimer’s disease (AD)–associated mutations. Using this model, convergent dysregulation at the APOE locus is observed with AD-associated mutations in SORL1 and TREM2.
Brief Definitive Report
Yulong Xu, Changning Wang, Hsiao-Ying Wey, Yingxia Liang, Zude Chen, Se Hoon Choi, Chongzhao Ran, Kevin D. Rynearson, Daniela R. Bernales, Robert E. Koegel, Stephanie A. Fiedler, Robin Striar, Steven L. Wagner, Rudolph E. Tanzi, Can Zhang
Alzheimer’s disease–related γ-secretase is a prime drug target whose brain regional expression and distribution remain largely unknown. This study describes the development of a molecular imaging probe to reveal γ-secretase in rodents and macaques with translational potentials in humans.
Article
Astrid Hagelkruys, Gerald Wirnsberger, Johannes Stadlmann, Miriam Wöhner, Marion Horrer, Bojan Vilagos, Gustav Jonsson, Melanie Kogler, Luigi Tortola, Maria Novatchkova, Peter Bönelt, David Hoffmann, Rubina Koglgruber, Ulrike Steffen, Georg Schett, Meinrad Busslinger, Andreas Bergthaler, Christoph Klein, Josef M. Penninger
Jagn1 deficiency results in alterations in the endoplasmic reticulum (ER) and Golgi apparatus of antibody-producing cells, reduced antibody secretion, and aberrant IgG N-glycosylation. The data uncover a key role for JAGN1 and ER stress in antibody glycosylation and humoral immunity in mice and humans.
Brief Definitive Report
Coraline Radermecker, Nancy Detrembleur, Julien Guiot, Etienne Cavalier, Monique Henket, Céline d’Emal, Céline Vanwinge, Didier Cataldo, Cécile Oury, Cécile Oury, Philippe Delvenne, Philippe Delvenne, Thomas Marichal, Thomas Marichal
Radermecker et al. report the presence of neutrophil extracellular traps (NETs) in fixed lung tissues from severe COVID-19 patients. NETs infiltrate the airway, interstitial, and vascular compartments, supporting the hypothesis that they may drive several aspects of COVID-19 lung pathology and represent therapeutic targets.
Brief Definitive Report
Flavio Protasio Veras, Marjorie Cornejo Pontelli, Camila Meirelles Silva, Juliana E. Toller-Kawahisa, Mikhael de Lima, Daniele Carvalho Nascimento, Ayda Henriques Schneider, Diego Caetité, Lucas Alves Tavares, Isadora M. Paiva, Roberta Rosales, David Colón, Ronaldo Martins, Italo Araujo Castro, Glaucia M. Almeida, Maria Isabel Fernandes Lopes, Maíra Nilson Benatti, Letícia Pastorelli Bonjorno, Marcela Cavichioli Giannini, Rodrigo Luppino-Assad, Sérgio Luna Almeida, Fernando Vilar, Rodrigo Santana, Valdes R. Bollela, Maria Auxiliadora-Martins, Marcos Borges, Carlos Henrique Miranda, Antônio Pazin-Filho, Luis Lamberti P. da Silva, Larissa Dias Cunha, Dario S. Zamboni, Felipe Dal-Pizzol, Luiz O. Leiria, Li Siyuan, Sabrina Batah, Alexandre Fabro, Thais Mauad, Marisa Dolhnikoff, Amaro Duarte-Neto, Paulo Saldiva et al.
The knowledge of COVID-19 pathophysiology is pivotal for the discovery of effective treatments. Here, we described that SARS-CoV-2 triggers the release of ACE2-depended neutrophil extracellular traps (NETs) that mediate lung pathology, supporting the use of NETs inhibitors for COVID-19 treatment.
Brief Definitive Report
Youenn Jouan, Antoine Guillon, Loïc Gonzalez, Yonatan Perez, Chloé Boisseau, Stephan Ehrmann, Marion Ferreira, Thomas Daix, Robin Jeannet, Bruno François, Pierre-François Dequin, Mustapha Si-Tahar, Thomas Baranek, Christophe Paget, Christophe Paget
This study reveals profound alteration in biology of blood unconventional T cells (MAIT, iNKT, and γδT) in severe COVID-19. Highly activated MAIT cells are found in abundance in the airways of mechanically ventilated patients. Activation levels of MAIT/iNKT cells at admission positively correlate with clinical improvement.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 9,
September 7, 2020
Reviews & Opinions
Review
Hao Guo, Sara A. Gibson, Jenny P.Y. Ting
An extensive crosstalk between host and intestinal microbiota contributes to the development and maturation of intestinal epithelium and immune system. This review details the interplay between nucleotide-binding domain leucine-rich repeat containing proteins (NLR, or NOD-like receptors) signaling to host-microbiota homeostasis.
Insights
William A. Muller
In this commentary on Hong et al., Bill Muller explains the significance of their findings as a mechanism for the non–cell autonomous pathogenesis of CCMs and the potential relevance of targeting ADAMTS5 therapeutically in this condition, for which the only current option is surgery.
Perspective
Ting Zhou, Tina Tianjiao Su, Tenny Mudianto, Jun Wang
COVID-19 may result from a hyperactive but asynchronized immune system causing a cacophony of severe tissue damage without optimal viral clearance and immunological resolution. A general strategy for COVID-19 treatment is to correct the immune dysregulation at the late stage of disease.

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