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Welcome to Journal of Human Immunity!

Journal of Human Immunity (JHI) is a joint venture between the International Alliance for Primary Immunodeficiency Societies (IAPIDS) and Rockefeller University Press (RUP). JHI publishes papers that provide novel insights into the physiology and pathology of human immunity through the study of genetic defects and their phenocopies, including the study of leukocytes and other cells. The journal focuses on human inborn errors of immunity, encompassing conditions as diverse as infection, autoimmunity, autoinflammation, malignancy, and allergy. Human inborn errors of immunity include monogenic disorders with complete (Mendelian traits) or incomplete (non-Mendelian) penetrance. The journal welcomes other types of genetic basis (e.g., digenic) if causality is genetically unquestionable or if the immunological mechanism is documented (or both). Single patient and single kindred genetic studies are welcome, as are small and large series of patients. We will publish descriptions of new genotypes, immunological phenotypes, and clinical phenotypes, which may result from hitherto understudied ancestries or environments. The journal also welcomes other papers, if they are clearly relevant to human inborn errors of immunity. Submissions will open soon!

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Current Issue
Volume 1,
Issue 1,
5 May 2025
Reviews & Opinions
Editorial
Jean-Laurent Casanova
Human immunity is often insufficient against infectious agents and sometimes over-reactive to innocuous components of the environment or the human body. Genetic, immunological, and clinical studies of inborn errors of immunity—where responses are either too weak or too strong—offer unprecedented insights into the physiology and pathology of host defense. This is the focus of the Journal of Human Immunity.

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JHI is a partnership between the International Alliance for Primary Immunodeficiency Societies (IAPIDS) and Rockefeller University Press (RUP) and is the official journal of IAPIDS and its member societies. Learn more about the origins of JHI.

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