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Laura-Marie Winterstein, Kerri Kukovetz, Ulf-Peter Hansen, Indra Schroeder, James L. Van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh
Winterstein et al. use the natural diversity of small viral K+ channels to address the impact of phospholipid bilayer composition on channel function. Single-channel recordings reveal a stimulating effect of anionic phospholipids on channel conductance and protein-specific effects on gating.
Article
Richard K. Brizendine, Murali Anuganti, Christine R. Cremo
Brizendine et al. directly visualized quantum dot–labeled myosin heads and rods in vitro to understand the flexibility of the S2 subdomain. Their results confirm theoretical predictions about the range of motion of S2 and its effect on the relative movement of myosin on actin in vitro.
Article
Marco Caremani, Luca Fusi, Marco Linari, Massimo Reconditi, Gabriella Piazzesi, Thomas C. Irving, Theyencheri Narayanan, Malcolm Irving, Vincenzo Lombardi, Elisabetta Brunello
Caremani et al. use x-ray diffraction and interference to characterize the structure of thick filaments in relaxed demembranated and intact resting mammalian muscle, revealing two closely spaced axial periodicities as well as structural changes that occur when filament activation is mimicked by cooling below near-physiological temperature.
Article
Maxime Lorenzini, Sophie Burel, Adrien Lesage, Emily Wagner, Camille Charrière, Pierre-Marie Chevillard, Bérangère Evrard, Dan Maloney, Kiersten M. Ruff, Rohit V. Pappu, Stefan Wagner, Jeanne M. Nerbonne, Jonathan R. Silva, R. Reid Townsend, Lars S. Maier, Céline Marionneau
Lorenzini et al. describe the native phosphorylation sites of NaV1.5 channels in mouse left ventricles. By analyzing expression and function of phosphosilent and phosphomimetic mutants, they identify phosphorylation hot spots regulating channel cell surface expression and gating.
Article
Jose Millet, Yuriana Aguilar-Sanchez, Dmytro Kornyeyev, Maedeh Bazmi, Diego Fainstein, Julio A. Copello, Ariel L. Escobar
Ca2+ alternans can lead to T-wave alternans, a highly arrhythmogenic phenomenon. Through a thermodynamic analysis of the molecular mechanisms involved in generating Ca2+ alternans, Millet et al. concluded that Ca2+ alternans are produced by an incomplete replenishment of SR Ca2+ during tachycardia.
Article
Pengfei Liang, Huanghe Yang
Liang and Yang show that the activity of TMEM16F, a scramblase and ion channel, is regulated by intracellular pH in a Ca2+-dependent manner. The effects of pH in TMEM16F activity stem from competition between protons and Ca2+ for the main Ca2+-binding residues in the channel.
Article
Jochen Gohlke, Paola Tonino, Johan Lindqvist, John E. Smith, III, Henk Granzier
Gohlke et al. compare the structure of the sarcomeric protein nebulin across 53 species. They uncover an association between the number of nebulin structural repeats and animal body size that has implications for muscle mechanics.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 153,
Issue 1,
January 4, 2021
Reviews & Opinions
Research News
Ben Short
JGP study reveals that insufficient reuptake of calcium into the sarcoplasmic reticulum underlies arrhythmogenic variations in cardiac calcium transients.
Research News
Ben Short
JGP study describes method to trace the real-time movements of individual membrane proteins in live tissue slices.
Review
Sara Nathan, Sandra B. Gabelli, Jesse B. Yoder, Lakshmi Srinivasan, Richard W. Aldrich, Gordon F. Tomaselli, Manu Ben-Johny, L. Mario Amzel
In this review, Nathan et al. discuss recent structural insights into the regulation of the Na+ channels NaV1.5 and NaV1.4, facilitated by the combination of cryo-EM and x-ray crystallography data.

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