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Robert C. Klipp, John R. Bankston
Arachidonic acid (AA) is a known modulator of ASICs. Klipp and Bankston examine the structural requirements for ASIC modulation by a number of lipids related to AA. Negatively charged head groups are stronger potentiators and may interact with an arginine in TM1 near the outer leaflet of the plasma membrane.
Klaus Benndorf, Thomas Eick, Christian Sattler, Ralf Schmauder, Eckhard Schulz
Benndorf et al. present a strategy to analyze the functionality of heteromeric ligand-gated ion channels by combining subunit concatenation, mutagenesis, and extensive global fit strategies with intimately coupled Markov models.
Article | Excitation–Contraction Coupling
Jian-Bin Xue, Almudena Val-Blasco, Moran Davoodi, Susana Gómez, Yael Yaniv, Jean-Pierre Benitah, Ana María Gómez
Xue et al. show that alteration of the Ca2+ clock by a mechanism involving CaMKII hypoactivation contributes to depression of the intrinsic pacemaker function of the sinoatrial node (SAN) in a mouse model of heart failure.
Krishna D. Reddy, Didar Ciftci, Amanda J. Scopelliti, Olga Boudker
GltPh is a model glutamate transporter with a kinetic heterogeneity of transport. Reddy et al. show that substrate binding is heterogeneous and suggest that subtle structural differences distinguish transporter subpopulations with different dynamic properties.
Article | Excitation–Contraction Coupling
Nagomi Kurebayashi, Takashi Murayama, Ryosaku Ota, Junji Suzuki, Kazunori Kanemaru, Takuya Kobayashi, Seiko Ohno, Minoru Horie, Masamitsu Iino, Fumiyoshi Yamashita, Takashi Sakurai
CPVT-linked RYR2 mutations are prone to induce spontaneous Ca2+ release from the ER, which is associated with arrhythmias. Kurebayashi et al. used experiments and simulations to explore the mechanisms relating cytosolic Ca2+-dependent activity by RYR2 mutations and spontaneous Ca2+ release.
Matthew James Marquis, Jon T. Sack
Marquis and Sack show that the use-dependent inhibition of Kv2.1 by RY785 is consistent with gated access to a cavity within the channel that traps RY785. While voltage activation is required for access to the blocking site, channel opening itself is not required for access.
Article | Channels and Transporters in Immunity
Dominique Tandl, Tim Sponagel, Dalia Alansary, Sebastian Fuck, Timo Smit, Stephanie Hehlgans, Burkhard Jakob, Claudia Fournier, Barbara A. Niemeyer, Franz Rödel, Bastian Roth, Anna Moroni, Gerhard Thiel
The authors expose T lymphocytes to x-ray doses relevant in tumor therapy. This triggers an immune response via activation of store-operated Ca2+ entry.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 154,
Issue 5,
2 May 2022
Reviews & Opinions
Jill B. Jensen, Bjoern H. Falkenburger, Eamonn J. Dickson, Lizbeth de la Cruz, Gucan Dai, Jongyun Myeong, Seung-Ryoung Jung, Martin Kruse, Oscar Vivas, Byung-Chang Suh, Bertil Hille
Phosphoinositides, rare membrane lipids, mediate powerful second messenger signals to ion channels, endocytosis, and exocytosis, and specify organelle identity. Jensen et al. summarize 20 yr of biophysical research whose key message is that pools of phosphoinositides turn over remarkably quickly to regulate rapid physiological responses.
Sara I. Liin
Commentary highlighting valuable mechanistic insights provided by Klipp and Bankston on ASIC3 regulation by lipids.
Research News
Ben Short
Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place.

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