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Robert C. Klipp, Megan M. Cullinan, John R. Bankston
The integral membrane protein stomatin inhibits the gating of acid-sensing ion channels by an unknown mechanism. Klipp et al. suggest that stomatin binds to the C-terminus of ASIC3 and stabilizes the desensitized state via an interaction with the channels’ first transmembrane domain.
Christopher H. Thompson, Roy Ben-Shalom, Kevin J. Bender, Alfred L. George, Jr.
Early-onset epileptic encephalopathy (EOEE) is associated with variants in the SCN2A gene encoding the voltage-gated sodium channel NaV1.2. Thompson et al. reveal that several of these variants have a greater effect on channel function and neuronal excitability when present in neonatal splice isoforms.
Norianne T. Ingram, Alapakkam P. Sampath, Gordon L. Fain
Ingram et al. identify and characterize the membrane conductance properties of mouse cone photoreceptors, including the light-dependent conductance in the outer segment and voltage-dependent and Ca2+-activated conductances in the cone inner segment, which shape the voltage response to light.
Methods and Approaches
Lejie Zhang, Mei Zhang, Karl Bellve, Kevin E. Fogarty, Maite A. Castro, Sebastian Brauchi, William R. Kobertz
Zhang et al. derivatize wheat germ agglutinin with small-molecule fluorescent pH sensors to visualize proton fluxes over the extracellular surfaces of transfected cells and primary cardiomyocytes and neuron–astrocyte cocultures.
Kevin M. Tylock, David S. Auerbach, Zhen Zhi Tang, Charles A. Thornton, Robert T. Dirksen
The expression of expanded CUG-repeat RNAs in myotonic dystrophy type 1 patients is associated with cardiac electrophysiological defects and an elevated risk of sudden cardiac death. Tylock et al. reveal that expression of these RNAs in the murine heart results in prolonged QRS and corrected QT-intervals due to alterations in sodium and potassium channel activity.
Timothy Lynagh, Emelie Flood, Céline Boiteux, Zeshan Pervez Sheikh, Toby W. Allen, Stephan A. Pless
Neuronal ASIC channels mediate excitatory sodium currents in response to extracellular acidification. Lynagh et al. reveal the essential roles of pore-lining glutamates in ion conduction and selectivity for ASIC1a- and ASIC2a-containing channels.
María Queralt-Martín, Lucie Bergdoll, Oscar Teijido, Nabill Munshi, Daniel Jacobs, Adam J. Kuszak, Olga Protchenko, Simona Reina, Andrea Magrì, Vito De Pinto, Sergey M. Bezrukov, Jeff Abramson, Tatiana K. Rostovtseva
Mammalian isoforms of mitochondrial VDAC have unique functional roles in vivo, but they all share similar β-barrel pore structures. Queralt-Martín et al. provide the first mechanistic insights into VDAC’s isoform-specific function by showing that VDAC3 exhibits unique properties when interacting with cytosolic proteins α-synuclein and tubulin.

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Volume 152,
Issue 2,
February 3, 2020
Reviews & Opinions
Erhu Cao
Cao synthesizes data from TRP channel structures that have resulted from the “resolution revolution” in cryo-EM.
Research News
Ben Short
JGP study suggests that varying the head group of polyunsaturated fatty acids could enable personalized treatments for long QT syndrome.
Donald W. Hilgemann
Ion transporters can be strongly regulated by autoinhibitory reactions that depend on ion binding within their transport sites.

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