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Newest Articles
Article | Pain Focus
Phil Alexander Köster, Enrico Leipold, Jenny Tigerholm, Anna Maxion, Barbara Namer, Thomas Stiehl, Angelika Lampert
Köster et al. characterize eight sodium channel subtypes relevant to nociception and use a computer model to simulate the response of two types of nociceptive nerve fibers. Their results provide a better understanding of Nav1.7 and Nav1.9 and have implications for future mechanistic studies and disease modelling.
Article | Voltage-Gated Na Channels
Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li
Elhanafy et al. show that identical mutations at equivalent positions in VSDs of cardiac sodium channels can lead to diverse functional effects. Using molecular dynamics simulations, they uncover VSD-specific structural dynamics and gating-pore conformations that explain these differential impacts, advancing our understanding of sodium channelopathies.
Article | Voltage-Gated Na Channels
Elaine Tao, Ben Corry
Tao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the fenestrations and central cavity. These findings shed light on diverse ways drugs inhibit the channel, offering insights for improving therapeutic development for conditions like chronic pain, epilepsy, and cardiac arrhythmias.
Article
Sabrina I. Apel, Emily Schaffter, Nicholas Melisi, Matthew J. Gage
Apel et al. demonstrate that the calcium-binding protein S100A1 binds the N2A region of titin and that binding is regulated through calcium concentration and pH. Their work suggests that this interaction is a physiological sensor to regulate titin function in the muscle.
Methods and Approaches
Alessandra Picollo, Michael Pusch
Picollo and Pusch present ALLIN (Annotation of sequence aLignment and structuraL ProteIn visualizatioN), a web interface to generate an interactive HTML page for the simultaneous visualization of annotated protein sequences alignment and 3-D structures or homology models of the related proteins.
Article
Jonathan Schreiber, Ludivine Rotard, Yves Tourneur, Aude Lafoux, Christine Berthier, Bruno Allard, Corinne Huchet, Vincent Jacquemond
Defective Ca2+ signaling in muscle cells is thought to play a role in Duchenne muscular dystrophy. Schreiber et al. report that voltage-activated SR Ca2+ release is moderately depressed in muscle fibers isolated from a rat model that reproduces the human disease well.
Article
Smriti Gupta, Yu-Hsin Chiu, Mohan C. Manjegowda, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Gupta et al. show that Pannexin 1 (PANX1) channels can function as both hexamers and heptamers, but that heptameric PANX1 shows higher conductance, longer mean open times, and supports greater ATP release and dye uptake. Structurally distinct mechanisms underlie C-tail cleavage and receptor-mediated PANX1 activation.
Issue Cover
Current Issue
Volume 157,
Issue 1,
6 January 2025
Reviews & Opinions
Commentary | Voltage-Gated Na Channels
Christian Jorgensen
Elhanafy et al. used Molecular Dynamics simulations and electrophysiology to show how identical mutations in the volgage sending domain of sodium channels can yield differential functional effects.
Commentary | Voltage-Gated Na Channels
Tanadet Pipatpolkai
Tao and Corry (2025) used metadynamics, an enhanced sampling method to identify and classify Nav channel blockers.
Review
Elizabeth Murphy, David A. Eisner
The regulation of mitochondrial calcium and its role in regulating cell death.

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