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Article
Seth H. Weinberg
Sodium channels are organized in multiple pools with distinct biophysical properties and subcellular localization, but the role of these subpopulations is not well understood. Computational modeling predicts that intercalated disk-localized sodium channels with shifted steady-state activation and inactivation voltage dependence promote faster cardiac conduction.
Communication
Kafa Walweel, Nicole Beard, Dirk F. van Helden, Derek R. Laver
Dantrolene, an inhibitor of the cardiac calcium release channel (RyR2), is a lead compound for stabilizing overactive RyR2 in heart failure. We find that dantrolene inhibition requires RyR2 association with FKBP12.6, which in turn depends on RyR2 phosphorylation at S2808.
Article
William Lehman, Michael J. Rynkiewicz
Lehman and Rynkiewicz show that, in the absence of Ca2+, troponin-I causes tropomyosin to pivot over relatively fixed points on actin subunits, blocking myosin-head binding sites on actin and thereby causing muscle relaxation.
Communication | Myofilament Function 2022
Christopher T.A. Lewis, Lee Tabrizian, Joachim Nielsen, Jenni Laitila, Thomas N. Beck, Mathilde S. Olsen, Marija M. Ognjanovic, Per Aagaard, Rune Hokken, Simon Laugesen, Arthur Ingersen, Jesper L. Andersen, Casper Soendenbroe, Jørn W. Helge, Flemming Dela, Steen Larsen, Ronni E. Sahl, Tue Rømer, Mikkel T. Hansen, Jacob Frandsen, Charlotte Suetta, Julien Ochala
Lewis et al. investigate how training status influences relaxed myosin conformations known to play a role in skeletal muscle metabolism. Their findings indicate that individuals with moderate activity levels have a shift in the relaxed conformations of their type II myosin molecules, lowering the basal ATP consumption.
Article
Tibor G. Szanto, Ferenc Papp, Florina Zakany, Zoltan Varga, Carol Deutsch, Gyorgy Panyi
Szanto et al. provide data that support the idea that rearrangement of S6, including its rotation, may mediate the communication between the activation gate and the inactivation gate controlling slow inactivation in KV channels.
Communication
Rua’a Al-Aqtash, Maxwell S. Ross, Daniel M. Collier
Histone proteins are known to be elevated in circulation where they contribute to vascular dysfunction. However, many details regarding the mechanism of action are unknown. Here, the authors show that P2XR7 channel current is activated by extracellularly applied histone proteins in a heterologous expression system.
Article
Mauricio A. Lillo, Manuel Muñoz, Paula Rhana, Kelli Gaul-Muller, Jonathan Quan, Natalia Shirokova, Lai-Hua Xie, Luis Fernando Santana, Diego Fraidenraich, Jorge E. Contreras
This work demonstrates that the opening of lateralize cardiac connexin-43 hemichannels, in the absence of a cardiac pathology, is still sufficient to alter cardiac membrane excitability and promote arrhythmias upon β-adrenergic cardiac stress.
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Current Issue
Volume 155,
Issue 6,
5 June 2023
Reviews & Opinions
Research News
Ben Short
JGP study suggests that tropomyosin regulates the crossbridge cycle in muscle by pivoting around relatively fixed points on actin thin filaments.
Commentary | Myofilament Function 2022
Wout J. Claassen, Coen A.C. Ottenheijm
Recent papers by Nelson et al. and Pilagov et al. provide important new information on the ever-expanding role of myosin heads in the regulation of contraction.
Research News
Ben Short
JGP study reveals that the membrane lipid PI(4,5)P2 alters the activity of NaV1.4 channels by modulating their gating behavior.

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