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Moradeke A. Bamgboye, Kevin G. Herold, Daiana C.O. Vieira, Maria K. Traficante, Philippa J. Rogers, Manu Ben-Johny, Ivy E. Dick
Human mutations in CaV1.2 underlie life-threatening arrhythmias and neurodevelopmental disorders. Through in-depth biophysical analysis, this study identifies divergent mechanistic alterations linked to CaV1.2 channelopathies and reveals an association between changes in channel function and patient phenotypes.
Article | Excitation–Contraction Coupling
Pompeo Volpe, Alessandra Bosutti, Alessandra Nori, Riccardo Filadi, Gaia Gherardi, Gabor Trautmann, Sandra Furlan, Gabriele Massaria, Marina Sciancalepore, Aram Megighian, Paola Caccin, Annalisa Bernareggi, Michele Salanova, Roberta Sacchetto, Dorianna Sandonà, Paola Pizzo, Paola Lorenzon
The present study reports on a novel effect of denervation at the neuromuscular junction level. It shows that the absence of nerve causes a reduction in the subsynaptic type 1 inositol 1,4,5-trisphosphate-stained region likely involved in the stabilization of the endplate.
Article | Mechanotransduction by Membrane Proteins
Jamison L. Nourse, Vivian M. Leung, Hamid Abuwarda, Elizabeth L. Evans, Esmeralda Izquierdo-Ortiz, Alan T. Ly, Nguyen Truong, Samantha Smith, Harsh Bhavsar, Gabriella Bertaccini, Edwin S. Monuki, Mitradas M. Panicker, Medha M. Pathak
PIEZO1, a mechanically gated ion channel, transduces mechanical cues in neural stem cells. Here, we show the impact of Piezo1 knockout on neural development in vivo and find that cholesterol biosynthesis and lipid membrane composition are regulated by Piezo1.
Article
Jennifer Osten, Maral Mohebbi, Petra Uta, Faramarz Matinmehr, Tianbang Wang, Theresia Kraft, Mamta Amrute-Nayak, Tim Scholz
Compared to the “ventricular” essential myosin light chain MLC1sb/v, the longer and more positively charged MLC1sa present in slow-twitch M. soleus fibers decelerates actin filament gliding on β-myosin molecules presumably by a decreased dissociation rate from actin filaments.
Article
Megan Jean Hammell, Linda Kachmar, Zsombor Balassy, Gijs IJpma, Anne-Marie Lauzon
Using a novel assay chamber to inject myosin light chain phosphatase during laser trap measurements, tonic smooth muscle force maintenance is observed at the myosin molecular level, marking an important step toward elucidating the underlying mechanisms of the latch state.
Article | Excitation–Contraction Coupling
Anna V. Maltsev, Michael D. Stern, Victor A. Maltsev
The present numerical modeling study shows that disorder in locations of Ca release units in cardiac pacemaker cells has substantial functional impact by creating release clusters, similar to Poisson clumping, and opportunity of Ca release to propagate within the clusters.
Article
Gustavo Frindt, Joel R. Meyerson, Alexandra Satty, Joseph M. Scandura, Lawrence G. Palmer
Epithelial Na+ channels are major regulators of fluid volumes and ultimately blood pressure in terrestrial vertebrates. We found that the amounts of protein comprising these channels in the kidneys and colons of rats and mice exceed what is required to explain the transport of Na+ by these tissues. This excess may facilitate regulation of the channels.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 154,
Issue 9,
5 September 2022
Reviews & Opinions
Viewpoint
Lawrence G. Palmer
The kidneys regulate transport of Na+ and K+ in complex ways to maintain the overall economies of both ions simultaneously.
Editorial | Excitation–Contraction Coupling
Robert T. Dirksen, David A. Eisner, Eduardo Ríos, Karin R. Sipido
The term “excitation–contraction (EC) coupling” was introduced by Alexander Sandow ( Sandow, 1952 ) as “the entire sequence of reactions—excitation, inward acting link, and activation of contraction”—in skeletal muscle. It is evidence of Sandow’s foresight that 70 years later, a large community of researchers still ...
Research News | Excitation–Contraction Coupling
Ben Short
JGP study reveals that adult zebrafish skeletal muscle fibers display the fastest kinetics of excitation–contraction coupling ever measured in vertebrate locomotor muscles.

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