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Article
Rong Shen, Benoît Roux, Eduardo Perozo
Shen et al. show that mutating countercharge residues in Ciona intestinalis voltage-sensing phosphatase result in the formation of a continuous water path through the voltage-sensing domain and the generation of omega currents. Their work reveals a novel role for voltage-sensor countercharges.
Article
Guilherme Henrique Souza Bomfim, Erna Mitaishvili, Paul P.M. Schnetkamp, Rodrigo S. Lacruz
Enamel-forming cells direct the transport of calcium out of the cell to help mineralize the enamel crystals. Sodium/calcium exchangers are proteins that efficiently extrude calcium. In enamel cells, NCKX proteins dominate this function explaining why patients with defective NCKX4 have enamel defects.
Article
Gregory W. Busey, Mohan C. Manjegowda, Tao Huang, Wesley H. Iobst, Shardul S. Naphade, Joel A. Kennedy, Catherine A. Doyle, Philip V. Seegren, Kevin R. Lynch, Bimal N. Desai
VPC01091.4 and AAL-149 are FTY720 analogs that inhibit TRPM7 without targeting S1P receptors and exert multimodal anti-inflammatory effects in vivo. In a mouse endotoxemia model, VPC01091.4 reduces inflammation and disease severity without impacting blood lymphocyte counts.
Article | Pain Focus
Goragot Wisedchaisri, Tamer M. Gamal El-Din, Natasha M. Powell, Ning Zheng, William A. Catterall
Mutations in the voltage-gated sodium channel NaV1.7 cause the chronic pain syndrome, inherited erythromelalgia. Structures of bacterial sodium channel NaVAb with these mutations revealed changes that would enhance the outward movement of the gating charges and lead to hyperexcitability underlying chronic pain.
Article
Klaus Benndorf, Eckhard Schulz
Benndorf and Schulz present a strategy to analyze the functionality of dimeric through pentameric ligand-gated ion channels by combining subunit concatenation, mutagenesis, and extensive global fit strategies with intimately coupled Markov models.
Communication
Shuya Ishii, Kotaro Oyama, Fuyu Kobirumaki-Shimozawa, Tomohiro Nakanishi, Naoya Nakahara, Madoka Suzuki, Shin’ichi Ishiwata, Norio Fukuda
Ishii et al. analyze the microheating-induced sliding movements of reconstituted thin filaments in an in vitro motility assay. They find that the temperature dependence of thin filament sliding is complementarily regulated by myosin and tropomyosin–troponin within the body temperature range.
Article
Scott D. Zawieja, Grace A. Pea, Sarah E. Broyhill, Advaya Patro, Karen H. Bromert, Min Li, Charles E. Norton, Jorge A. Castorena-Gonzalez, Edward J. Hancock, Christopher D. Bertram, Michael J. Davis
Pressure-dependent lymphatic pacemaking is regulated by the Ca2+-activated Cl channel, Anoctamin1. Zawieja et al. show that IP3R1-mediated Ca2+ release is the primary Ca2+ source driving Anoctamin1 activation during diastole to regulate pacemaking and contributes to lymphatic vessel tone.
Issue Cover
Current Issue
Volume 155,
Issue 11,
6 November 2023
Reviews & Opinions
Research News
Ben Short
JGP study reveals that the calcium sensitivity of thick filament structure in skeletal muscle is greater than that of force, offering new insights into the mechanisms of thick filament activation.
Commentary
Alf Månsson
Studies using isolated myosin and troponin–tropomyosin from either heart or skeletal muscle show new features of contractile regulation.
Research News
Ben Short
JGP study suggests that, by altering mechanosensitive signaling pathways, replating stem cell-derived cardiomyocytes changes myosin expression and contractile function.

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