Skip to Main Content

Advertisement

Skip Nav Destination
Newest Articles
Communication
Saffie Mohran, Timothy S. McMillen, Christian Mandrycky, An-Yue Tu, Kristina B. Kooiker, Wenjing Qian, Stephanie Neys, Brayan Osegueda, Farid Moussavi-Harami, Thomas C. Irving, Michael Regnier, Weikang Ma
Mohran et al. show that calcium has a direct effect on thick filament activation in myocardium rather than an indirect effect due to calcium-mediated crosstalk between the thick and thin filaments. Their findings should be considered in developing future drug candidates to treat heart diseases.
Article
Helmuth A. Sanchez, Lina Kraujaliene, Vytas K. Verselis
Two connexins, Cx26 and Cx30, are expressed in the cochlea and play vital roles in hearing. Sanchez et al. identified a sequence difference in their E1 domains that differentially affects their abilities to operate as hemichannnels and function in transmembrane signaling.
Article
Lina Kraujaliene, Tadas Kraujalis, Mindaugas Snipas, Vytas K. Verselis
Kraujaliene et al. used modeling and dye uptake/transfer studies to show that an Ala/Glu difference in the E1 domains of Cx26 and Cx30 can account for their differential permeabilities to anionic permeants. The permeability profiles are conserved in gap junction channels and hemichannel configurations.
Hypothesis | Excitation–Contraction Coupling
D. George Stephenson
Using a mathematical model, Stephenson tests the hypothesis that the characteristic response to Ca2+ of RyR channels is key not only for the Ca2+ release mechanism in cardiac muscle and other tissues, but also for the DHPR-dependent Ca2+ release in skeletal muscles.
Methods and Approaches | Pain Focus
Taylor M. Mott, Grace C. Wulffraat, Alex J. Eddins, Ryan A. Mehl, Eric N. Senning
Mott et al. evaluate two click-chemistry protein labeling tools based on genetic code expansion technology and circularly permutated Halotag, respectively, for their utility in TRPV1 cell surface expression studies.
Article
Kristina Kooiker, Qing-Fen Gan, Ming Yu, Na Sa, Saffie Mohran, Yuanhua Cheng, Galina Flint, Stephanie Neys, Chengqian Gao, Devin Nissen, Tim McMillen, Anthony Asencio, Weikang Ma, Thomas C. Irving, Farid Moussavi-Harami, Michael Regnier
Kooiker et al. investigate the mechanisms of a novel cardiac myosin inhibitor that depends on the presence of a myosin regulatory light chain (RLC-1). They show that RLC-1 destabilizes myosin interactions to inhibit force and accelerate kinetics in cardiac muscle.
Article | Voltage-Gated Na Channels
Rita de Cássia Collaço, Filip Van Petegem, Frank Bosmans
The ω-grammotoxin-SIA peptide (GrTx-SIA) was originally found in tarantula venom and shown to inhibit voltage-gated Ca2+ channels. Here, Collaço et al. report that GrTx-SIA can also potently inhibit voltage-gated Na+ channel currents, with NaV1.6 being the most susceptible subtype.
Issue Cover
Current Issue
Volume 156,
Issue 9,
2 September 2024
Reviews & Opinions
Research News
Ben Short
This JGP study reveals that in addition to voltage-gated Ca2+ and K+ channels, ω-grammotoxin-SIA also inhibits voltage-gated Na+ channel currents.
Tutorial
Eduardo Rios
This tutorial provides the ideas and information needed to understand, at a basic level, the application of convolutional neural networks to analyze images in biology and traces a path to adopting the available applications of machine learning to biology research.
Commentary
Cherrie H.T. Kong, Eef Dries
Rad is an emerging key Cav1.2 modulator. In the present issue of JGP, Elmore, Ahern et al. examine how the Rad C-terminus affects its subcellular distribution and Cav1.2 regulation.

Most Read

Advertisement

Special Collections

Special Collections

Highlighting recent articles addressing a wide range of biophysical questions.

View Collections >

Close Modal

or Create an Account

Close Modal
Close Modal