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Nicoletta Savalli, Marina Angelini, Federica Steccanella, Julian Wier, Fenfen Wu, Marbella Quinonez, Marino DiFranco, Alan Neely, Stephen C. Cannon, Riccardo Olcese
Savalli et al. reveal the early molecular events preceding skeletal muscle contraction by optically tracking the conformational changes of each of the four CaV1.1 voltage-sensing domains, which govern the voltage-dependent activation of both CaV1.1 and RYR1 channels.
Article
Fenfen Wu, Marbella Quinonez, Stephen C. Cannon
Known mutations in CaV1.1 in hypokalemic periodic paralysis (HypoPP) occur at arginine residues of the voltage sensor domain and cause an anomalous inward gating pore current. By studying several HypoPP mutations, Wu et al. show that the magnitude of these gating pore currents is mutation specific.
Article
Zeshan P. Sheikh, Matthias Wulf, Søren Friis, Mike Althaus, Timothy Lynagh, Stephan A. Pless
Despite high similarity in sequence and structure, epithelial sodium channels display at least 50-fold higher sodium selectivity than acid-sensing ion channels. Here, Sheikh et al. show that sodium selectivity is likely achieved by different mechanisms in these related channels.
Article | Mechanotransduction by Membrane Proteins
Maryline Beurg, Jong-Hoon Nam, Robert Fettiplace
Beurg et al. report that the conductance of cochlear hair cell mechanotransducer channels inferred from single-channel events is larger than using noise analysis, which underestimates size due to filtering of fast openings. The difference leads to a first estimate of the channel activation time constant.
Article
Jacob M. Kemp, Dominic G. Whittaker, Ravichandra Venkateshappa, ZhaoKai Pang, Raj Johal, Valentine Sergeev, Glen F. Tibbits, Gary R. Mirams, Thomas W. Claydon
Kemp et al. show that the hERG channel activator RPR260243 restores the repolarizing current of a mutant variant of the channel associated with LQTS2 with little effect on its resurgent current. This drug represents a therapeutic opportunity for the treatment of arrhythmia associated with LQTS2.
Article
Ida Björkgren, Sarah Mendoza, Dong Hwa Chung, Monika Haoui, Natalie True Petersen, Polina V. Lishko
Here, Björkgren et al. use whole-cell patch-clamp to show that the potassium channel Kir7.1 is stimulated by progesterone in the choroid plexus epithelium, as well as in other tissues in which Kir7.1 is present, and that the effect is specific to this steroid hormone.
Article
Jing Li, Rong Shen, Ahmed Rohaim, Ramon Mendoza Uriarte, Mikolai Fajer, Eduardo Perozo, Benoît Roux
Li et al. carry out molecular dynamics simulations of the K+ channels Shaker and KcsA to test whether a structural constriction of the non-conductive selectivity filter is a universal mechanism of C-type inactivation in K+ channels.

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Issue Cover
Current Issue
Volume 153,
Issue 9,
September 6, 2021
Reviews & Opinions
Tutorial
Eric J. Hustedt, Richard A. Stein, Hassane S. Mchaourab
DEER spectroscopy can be used to investigate the conformational equilibria of proteins. In this tutorial, we illustrate the rigorous global analysis of DEER data to quantitively analyze these equilibria to determine the populations of distinct intermediates under varying biochemical conditions.
Commentary
Roberto Márquez
Abderemane-Ali et al. investigated the mechanisms underlying self-resistance in poison dart frogs and poison birds.
Research News
Ben Short
JGP modeling study suggests that selectivity filter constriction is a plausible mechanism for C-type inactivation of the Shaker voltage-gated potassium channel.

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