Skip to Main Content

Advertisement

Skip Nav Destination
Newest Articles
Article
Maarten M. Steinz, Nicole Beard, Emily Shorter, Johanna T. Lanner
Ca2+ release via the ryanodine receptor 1 (RyR1) is essential for skeletal muscle contraction. Here, Steinz et al. combine targeted mass spectrometry and single-channel recordings to elucidate how the stable oxidative posttranslational modifications 3-nitrotyrosine (3-NT) and malondialdehyde adducts (MDA) affect RyR1 channel gating.
Communication
Arnaldo Mercado-Perez, Jeric P. Hernandez, Yaroslav Fedyshyn, Anthony J. Treichel, Vikram Joshi, Kimberlee Kossick, Kalpana R. Betageri, Gianrico Farrugia, Brooke Druliner, Arthur Beyder
The mechanically gated ion channel Piezo2 initiates signaling molecule release in gastrointestinal epithelial mechanoreceptors. Mercado-Perez et al. demonstrate that some Piezo2 clusters in these cells interact with E-cadherin and actin cytoskeleton at the lateral wall.
Article
Kyle D. Berger, David M. MacLean
Hi1a, a bilobed peptide isolated from spider venom, reduces ischemic cell death by inhibiting ASIC1a channels. Berger and MacLean show that each domain of Hi1a binds to the same site on ASIC1a subunits, accounting for this peptide’s unusual functional effects.
Communication
Olga Chernyshkova, Natalia Erofeeva, Darya Meshalkina, Anna Balykina, Stepan Gambaryan, Michael Belyakov, Michael Firsov
Cyclic AMP levels can be increased in the rod outer segment by 30–60% within the first second of light exposure before returning to baseline levels. Chernyshkova et al. show that a short increase in cAMP results in PKA activation and that proteins ∼70 kDa are the major targets of the phospho-PKA substrate antibody.
Article | Voltage-Gated Na Channels
Dmytro V. Vasylyev, Peng Zhao, Betsy R. Schulman, Stephen G. Waxman
Vasylyev et al. show that the Na+ channel Nav1.8 amplifies DRG neuron excitability close to the activation potential threshold, while Nav1.7 acts closer to resting potential. Their findings suggest that full inhibition of Nav1.8 may not be required for the relief of pain due to DRG neuron hyperexcitability.
Article | Contractile Function
Andrew F. Mead, Neil B. Wood, Shane R. Nelson, Bradley M. Palmer, Lin Yang, Samantha Beck Previs, Angela Ploysangngam, Guy G. Kennedy, Jennifer F. McAdow, Sarah M. Tremble, Marcus A. Zimmermann, Marilyn J. Cipolla, Alicia M. Ebert, Aaron N. Johnson, Christina A. Gurnett, Michael J. Previs, David M. Warshaw
Myosin-binding protein H (MyBP-H) is an understudied paralog of the muscle regulator myosin-binding protein C (MyBP-C). Mead et al. reveal that MyBP-H is highly expressed in the muscles of prenatal rats and larval zebrafish and that MyBP-H impacts sarcomere function despite lacking key regulatory domains.
Article
Helmuth A. Sanchez, Lina Kraujaliene, Vytas K. Verselis
Two connexins, Cx26 and Cx30, are expressed in the cochlea and play vital roles in hearing. Sanchez et al. identified a sequence difference in their E1 domains that differentially affects their abilities to operate as hemichannnels and function in transmembrane signaling.
Issue Cover
Current Issue
Volume 156,
Issue 11,
4 November 2024
Reviews & Opinions
Commentary
David Y. Barefield
After decades of obscurity, we are finally gaining mechanistic insight into the function of myosin-binding protein-H in skeletal muscle regulation.
Commentary
Eve Marder
The knowledge in our brains, not in our phones, is necessary for creative thinking and the pursuit of truth.
Research News
Ben Short
Two JGP studies reveal how small differences in a pore-lining region alter both the gap junction and hemichannel function of connexin26 and connexin30.

Most Read

Advertisement

Special Collections

Special Collections

Highlighting recent articles addressing a wide range of biophysical questions.

View Collections >

Close Modal

or Create an Account

Close Modal
Close Modal