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Newest Articles
Article
Joseph L. Dynes, Andriy V. Yeromin, Michael D. Cahalan
The authors use a fluorescent genetically encoded Ca2+ indicator, GCaMP6f, fused to Orai1 to visualize Ca2+ influx through store-operated Orai1 channels. Combined with whole-cell recording of transfected human cells, this reporter reveals heterogeneity of channel activation and kinetics in STIM1-Orai1 puncta within the same cell.
Article
Pietro Ridone, Elvis Pandzic, Massimo Vassalli, Charles D. Cox, Alexander Macmillan, Philip A. Gottlieb, Boris Martinac
The essential mammalian mechanosensitive channel PIEZO1 organizes in the plasma membrane into nanometric clusters that depend on the integrity of cholesterol domains to rapidly detect applied force and especially inactivate synchronously, the most commonly altered feature of PIEZO1 in pathology.
Article
Colin H. Peters, Abeline R. Watkins, Olivia L. Poirier, Peter C. Ruben
Inheritable and de novo variants of voltage-gated sodium channels that lead to sudden cardiac death can affect several different aspects of channel function, making pharmaceutical treatment difficult. Peters et al. show that the E1784K mutant in Nav1.5 alters channel function through two distinct and separable mechanisms.
Article
Felix Neumaier, Serdar Alpdogan, Jürgen Hescheler, Toni Schneider
Neumaier et al. reveal that Zn2+ effects on Cav2.3 channels are complex, can be either inhibitory or stimulatory, and may persist for several minutes after cessation of the Zn2+ signal. A Markov model is developed that can account for Cav2.3 channel currents in the absence and presence of physiological Zn2+ concentrations.
Article
Morag K. Mansley, Christian Niklas, Regina Nacken, Kathrin Mandery, Hartmut Glaeser, Martin F. Fromm, Christoph Korbmacher, Marko Bertog
In murine cortical collecting duct cells, prostaglandin E2 (PGE2) stimulates transepithelial sodium transport mediated by the epithelial sodium channel (ENaC). PGE2 is synthesized and secreted by the cells and acts on basolateral prostaglandin E receptor type 4 (EP4).
Article
Tibor G. Szanto, Florina Zakany, Ferenc Papp, Zoltan Varga, Carol J. Deutsch, Gyorgy Panyi
Szanto et al. propose a new gating scheme to explain how the Shaker family of voltage-gated potassium channels are inactivated at negative membrane potentials and how these channels recover from this state.
Article
Kotaro Oyama, Kotaro Oyama, Mizuho Gotoh, Yuji Hosaka, Tomoko G. Oyama, Aya Kubonoya, Yuma Suzuki, Tomomi Arai, Seiichi Tsukamoto, Yuki Kawamura, Hideki Itoh, Seine A. Shintani, Toshiko Yamazawa, Mitsumasa Taguchi, Shin’ichi Ishiwata, Norio Fukuda
Living cells convert the hydrolytic energy of ATP to heat during various biochemical reactions. Oyama et al. show that thermogenesis increases temperature on the order of 1°C only proximal to the heat source, but not on a global basis in either non-excitable or excitable cells.

Related Articles from Rockefeller University Press

Current Issue
Volume 152,
Issue 6,
June 1, 2020
Reviews & Opinions
Commentary
Eric Accili
In the current issue of JGP, Lamothe and Kurata explore the functional relationship between the Kv1.2 potassium channel, with Kvβ1.2 bound to the interior aspect of the channel, and Slc7a5, a component of the neutral amino acid transporter LAT1.
Commentary
Valerie Abigail Nirenberg, Ofer Yifrach
Closing the cycle of Kv channel slow inactivation gating.
Commentary
Robert S. Balaban
Large changes in energy metabolism are associated with minimal alterations in surface temperature of isolated mammalian cells.

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