Skip to Main Content

Advertisement

Skip Nav Destination
Newest Articles
Article
Vamseedhar Rayaprolu, Heini M. Miettinen, William D. Baker, Victoria C. Young, Matthew Fisher, Gwendolyn Mueller, William O. Rankin, John T. Kelley, William J. Ratzan, Lee Min Leong, Joshua A. Davisson, Bradley J. Baker, Susy C. Kohout
Rayaprolu et al. investigated how hydrophobic residues impact the function of the voltage-sensing phosphatase. They mutated different positions in the S1 helix of the voltage-sensing domain and found more energy was needed for enzyme activation while less was needed to move the sensor.
Article
Sebastian Duno-Miranda, Shane R. Nelson, David V. Rasicci, Skylar M.L. Bodt, Joseph A. Cirilo, Jr, Duha Vang, Sivaraj Sivaramakrishnan, Christopher M. Yengo, David M. Warshaw
Duno-Miranda et al. investigate the E525K mutation in human β-cardiac myosin, a protein crucial for heart contraction, and its role in causing dilated cardiomyopathy (DCM). They demonstrate that the length of the myosin tail influences its self-inhibition and that the E525K mutation strengthens this effect, potentially reducing heart contractility in DCM.
Article
Noel Tewes, Beatrice Kubitzki, Flandrit Bytyqi, Nikola Metko, Sebastian Mach, Gerhard Thiel, Oliver Rauh
Tewes et al. use a simple K+ channel pore to examine filter gating. Voltage-dependent closings in pore-helix mutants can be explained by an elevated sensitivity to block by trace contaminations of Ba2+. This means that the dwell time of ions in the filter determines the closed times of the filter gate.
Article
Dana A. Page, Peter C. Ruben
HCN4 channels play an important role in cardiac action potential initiation in the sinoatrial node. In this study, Page and Ruben find that cannabidiol potentiates HCN4 channels independently of other activators (cAMP) and agonists (PIP2) via binding to a lipid-binding pocket at the C-terminus of the voltage sensor.
Article
Michael J. Rynkiewicz, Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman
Molecular simulations by Rynkiewicz and Lehman indicate that tropomyosin repositions on thin filament actin as myosin transitions from pre-powerstroke to post-powerstroke conformation. Charge repulsion between polar residues on myosin’s Loop-4 and on individual tropomyosin pseudorepeats is shown to facilitate tropomyosin movement.
Article
Anaïs Bertaud, Thierry Cens, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Lisa Soussi, Claudine Ménard, Akelsso Kadala, Claude Collet, Sébastien Dutertre, Patrick Bois, Pascal Gosselin-Badaroudine, Jean-Baptiste Thibaud, Julien Roussel, Michel Vignes, Mohamed Chahine, Pierre Charnet
Bertaud et al. characterize CaV4, a honeybee voltage-gated Ca2+ channel with high sequence homology to Na+ channels, but with a distinct permeation, voltage- and cation-dependent inactivation, and pharmacology from Na+ channels. Their study highlights the unique properties of this new class of voltage-gated Ca2+ channels.
Article
Sofia Benucci, Alexis Ruiz, Martina Franchini, Lucia Ruggiero, Dario Zoppi, Rebecca Sitsapesan, Chris Lindsay, Pawel Pelczar, Laura Pietrangelo, Feliciano Protasi, Susan Treves, Francesco Zorzato
Benucci et al. characterize a new mouse model carrying a mutation in RyR1 identified in a severely affected child. Their model reveals that homozygosity for this pathophysiologically relevant mutation functionally impacts muscle function and alters calcium homeostasis.
Issue Cover
Current Issue
Volume 156,
Issue 5,
6 May 2024
Reviews & Opinions
Viewpoint
Jeffrey R. Holt, Robert Fettiplace, Ulrich Müller
In this Viewpoint, Holt, Fettiplace, and Müller weigh the evidence supporting a role for PIEZO and TMC channels in mechanosensory transduction in inner ear hair cells.
Research News
Ben Short
JGP study shows that a mutation linked to dilated cardiomyopathy stabilizes β-cardiac myosin in its autoinhibited, super-relaxed state.
Research News
Ben Short
JGP study indicates that β-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers in cardiomyocytes.

Most Read

Advertisement

Special Collections

Special Collections

Highlighting recent articles addressing a wide range of biophysical questions.

View Collections >

Close Modal

or Create an Account

Close Modal
Close Modal