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Newest Articles
Alejandra Cely-Ortiz, Juan I. Felice, Leandro A. Díaz-Zegarra, Carlos A. Valverde, Marilén Federico, Julieta Palomeque, Xander H.T. Wehrens, Evangelia G. Kranias, Ernesto A. Aiello, Elena C. Lascano, Jorge A. Negroni, Alicia Mattiazzi
The present work shows that SR Ca2+ load and RYR2 Ca2+ sensitivity are major determinants of Ca2+ release restitution (CRR) after each heartbeat. Mathematical modeling led us to speculate that the velocity of SR Ca2+ refilling might regulate CRR independently of SR Ca2+ content.
Vladimir V. Cherny, Boris Musset, Deri Morgan, Sarah Thomas, Susan M.E. Smith, Thomas E. DeCoursey
The voltage-gated proton channel (HV1) resembles the voltage sensors of other channels, but its movement during channel opening remains controversial. Cherny et al. establish open and closed gating configurations of HV1 by analyzing the interactions of Zn2+ with an introduced histidine residue.
Jiali Wang, Kaiqi Zhang, Puja Goyal, Christof Grewer
K+ binding to mammalian glutamate transporters is essential for the import and release of glutamate into cells. Using MD simulations and site-directed mutagenesis, Wang et al. identify two K+ binding sites in the transporter EAAC1, one of which appears to catalyze the relocation step of the transport cycle.
Maria A. Neginskaya, Jasiel O. Strubbe, Giuseppe F. Amodeo, Benjamin A. West, Shoshana Yakar, Jason N. Bazil, Evgeny V. Pavlov
Stress increases the permeability of the mitochondrial inner membrane by activating permeability transition pores (PTPs), likely composed of ATP synthase or the adenine nucleotide translocator. By measuring water flux during calcium-activated mitochondrial swelling, Neginskaya et al. estimate that if these proteins are involved in PTP, only a small fraction becomes transformed into the pore on a single mitochondrion.
Antonio Michelucci, Simona Boncompagni, Laura Pietrangelo, Takahiro Takano, Feliciano Protasi, Robert T. Dirksen, Robert T. Dirksen
Mice lacking calsequestrin-1 have reduced levels of releasable Ca2+ in the sarcoplasmic reticulum of their skeletal muscles. Michelucci et al. reveal that this is compensated by constitutive assembly of STIM1 and Orai1 into Ca2+ entry units, promoting both constitutive and store-operated Ca2+ entry.
Kathiresan Natarajan, Nuriya Mukhtasimova, Jeremías Corradi, Matías Lasala, Cecilia Bouzat, Steven M. Sine
The α7 nicotinic acetylcholine receptor (nAChR) is highly abundant in the brain but is frequently located at extra-synaptic regions where the concentration of ACh is low. Natarajan et al. reveal that at low ACh concentrations, calcium potentiates α7 channel opening by binding to a novel structural motif.
Alessandro Porro, Anna Binda, Matteo Pisoni, Chiara Donadoni, Ilaria Rivolta, Andrea Saponaro
The gating of neuronal HCN channels is modulated by the competitive binding of cAMP and TRIP8b, a brain-specific protein that also controls channel trafficking. Porro et al. identify a rational mutation in HCN channels that affects binding of TRIP8b, without altering cAMP affinity or TRIP8b-dependent trafficking. The mutation represents a valuable tool to investigate HCN channels in vivo.

Related Articles from Rockefeller University Press

Current Issue
Volume 152,
Issue 9,
September 7, 2020
Reviews & Opinions
Jasmine A. Nirody, Itay Budin, Padmini Rangamani
This review outlines a holistic framework for studying ATP synthase and emphasizes the importance of considering interactions with the lipid environment in shaping the function and evolutionary history of membrane proteins.
H. Peter Larsson
Cherny and coworkers use zinc ion as a probe to identify different conformational states of voltage-gated proton (Hv1) channels.
Anthony Auerbach
Agonist actions at transition states can explain the observation that different pathways are taken for acetylcholine receptor desensitization and recovery.

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