Journal of General Physiology | Rockefeller University Press

RUP response to COVID-19 crisis

All articles temporarily free to read. Learn about the steps we're taking and find COVID-19 relevant content.
Call for Papers: Myofilament Function

Submit your research by September 30, 2020 to be considered for a special issue edited by Christine Cremo, Henk Granzier, and Richard L. Moss. Learn more
Quickly see whether citations provide supporting or disputing evidence for the cited claim directly in the article metrics section. Learn more
Cholesterol organization of Piezo1 channel clusters
Activation Gate Controls Inactivation

JGP staff members are working remotely in line with New York City’s efforts to contain COVID-19. While our offices are physically closed, editorial and publication operations continue. JGP staff can be reached via email and phone, as we tend to our family, friends and community. Thank you for your patience and understanding.

Our pilot partnership with Society of General Physiologists offers a $500 discount to members on our $2,000 publication fee. Learn more about SGP membership.

Newest Articles

Article

| July 23 2020

Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor

Kathiresan Natarajan, Nuriya Mukhtasimova, Jeremías Corradi, Matías Lasala, Cecilia Bouzat, Steven M. Sine

The α7 nicotinic acetylcholine receptor (nAChR) is highly abundant in the brain but is frequently located at extra-synaptic regions where the concentration of ACh is low. Natarajan et al. reveal that at low ACh concentrations, calcium potentiates α7 channel opening by binding to a novel structural motif.

Article

| July 07 2020

A rational mutation to investigate HCN channels in vivo

Alessandro Porro, Anna Binda, Matteo Pisoni, Chiara Donadoni, Ilaria Rivolta, Andrea Saponaro

The gating of neuronal HCN channels is modulated by the competitive binding of cAMP and TRIP8b, a brain-specific protein that also controls channel trafficking. Porro et al. identify a rational mutation in HCN channels that affects binding of TRIP8b, without altering cAMP affinity or TRIP8b-dependent trafficking. The mutation represents a valuable tool to investigate HCN channels in vivo.

Article

| June 26 2020

Functional heterogeneity in STIM1-Orai1 puncta

Joseph L. Dynes, Andriy V. Yeromin, Michael D. Cahalan

The authors use a fluorescent genetically encoded Ca2+ indicator, GCaMP6f, fused to Orai1 to visualize Ca2+ influx through store-operated Orai1 channels. Combined with whole-cell recording of transfected human cells, this reporter reveals heterogeneity of channel activation and kinetics in STIM1-Orai1 puncta within the same cell.

Article

| June 24 2020

Cholesterol organization of Piezo1 channel clusters

Pietro Ridone, Elvis Pandzic, Massimo Vassalli, Charles D. Cox, Alexander Macmillan, Philip A. Gottlieb, Boris Martinac

The essential mammalian mechanosensitive channel PIEZO1 organizes in the plasma membrane into nanometric clusters that depend on the integrity of cholesterol domains to rapidly detect applied force and especially inactivate synchronously, the most commonly altered feature of PIEZO1 in pathology.

Article

| June 22 2020

The E1784K mutant in Nav1.5 disrupts inactivation through two mechanisms

Colin H. Peters, Abeline R. Watkins, Olivia L. Poirier, Peter C. Ruben

Inheritable and de novo variants of voltage-gated sodium channels that lead to sudden cardiac death can affect several different aspects of channel function, making pharmaceutical treatment difficult. Peters et al. show that the E1784K mutant in Nav1.5 alters channel function through two distinct and separable mechanisms.

Article

| June 19 2020

Complex Zn 2+ effects on Ca v 2.3 channel function

Felix Neumaier, Serdar Alpdogan, Jürgen Hescheler, Toni Schneider

Neumaier et al. reveal that Zn2+ effects on Cav2.3 channels are complex, can be either inhibitory or stimulatory, and may persist for several minutes after cessation of the Zn2+ signal. A Markov model is developed that can account for Cav2.3 channel currents in the absence and presence of physiological Zn2+ concentrations.

Article

| May 22 2020

ENaC stimulation by prostaglandin E 2

Morag K. Mansley, Christian Niklas, Regina Nacken, Kathrin Mandery, Hartmut Glaeser, Martin F. Fromm, Christoph Korbmacher, Marko Bertog

In murine cortical collecting duct cells, prostaglandin E2 (PGE2) stimulates transepithelial sodium transport mediated by the epithelial sodium channel (ENaC). PGE2 is synthesized and secreted by the cells and acts on basolateral prostaglandin E receptor type 4 (EP4).

Browse All >

Related Articles from Rockefeller University Press

Current Issue

Volume 152,

Issue 8,

August 3, 2020

View This Issue

Submit Your Research

Manage Email Alerts

Reviews & Opinions

Viewpoint

| July 28 2020

SNAP25, exocytosis, fusion pore, dynamic acceptor complex

Ronald W. Holz, Mary A. Bittner

The domain in SNAP25 that links its two SNARE motifs plays important roles in fusion pore formation, secretion kinetics, and the formation of a dynamic plasma membrane SNAP25/syntaxin “acceptor” complex for the v-SNARE synaptobrevin.

Research News

| July 15 2020

Cholesterol helps PIEZO1 use the force

Ben Short

JGP study shows that disruption of membrane cholesterol alters the organization and activity of mechanosensitive PIEZO1 channels.

Commentary

| June 24 2020

An ion channel in the company of a transporter

Eric Accili

In the current issue of JGP, Lamothe and Kurata explore the functional relationship between the Kv1.2 potassium channel, with Kvβ1.2 bound to the interior aspect of the channel, and Slc7a5, a component of the neutral amino acid transporter LAT1.

Browse All

Special Collections

Ion Channel Structure and Function

A special collection of reviews curated from recent issues of JGP

View Collections

All articles temporarily free to read. Learn about the steps we're taking and find COVID-19 relevant content.

Submit your research by September 30, 2020 to be considered for a special issue edited by Christine Cremo, Henk Granzier, and Richard L. Moss. Learn more

Quickly see whether citations provide supporting or disputing evidence for the cited claim directly in the article metrics section. Learn more

Cholesterol organization of Piezo1 channel clusters

Activation Gate Controls Inactivation

Related Articles from Rockefeller University Press

Most Read

Special Collections

This Feature Is Available To Subscribers Only