Journal of General Physiology (JGP) | Rockefeller University Press

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You are invited to submit papers on the topic of the Society of General Physiologists 76th Annual Meeting.
Authors can now publish in JGP free of charge or pay a fee to make their articles immediately Open Access.
Cryopreservation preserves integrity of porcine myocardium.
Different species, different gap junctions.

JGP and the Society of General Physiologists have a close and long-standing collaborative relationship.

Newest Articles

Hypothesis

| September 20 2023

Dihydropyridines in L-type Ca²⁺ channel

Denis B. Tikhonov, Boris S. Zhorov

Computational models based on different cryo-EM structures of ligand-bound calcium and sodium channels suggest that dihydropyridine antagonists stabilize entirely α-helical conformation of the pore-lining helix S6_IV, whereas agonists promote channel opening by stabilizing π-bulged helix S6_IV.

Article

| September 20 2023

Calcium binding and permeation in TRPV channels

Chunhong Liu, Lingfeng Xue, Chen Song

Using a recently developed multisite ion model, Liu et al. conducted molecular dynamics simulations to study the Ca²⁺ binding and permeation in TRPV channels. The ion binding strength and number of binding sites within the selectivity filter are found to be key factors determining the permeation patterns and probably ion selectivity.

Article | Excitation–Contraction Coupling

| September 20 2023

Visualizing and analyzing RyR2 tetramer arrays

David R.L. Scriven, Anne Berit Johnsen, Parisa Asghari, Keng C. Chou, Edwin D.W. Moore

We show that isoproterenol applied to rat ventricular myocytes produced symmetrical increases in the size of ryanodine receptor clusters, a decrease in fragmentation, and the coalescence of smaller clusters. Additionally, receptors were found in irregularly arranged arrays resembling those seen by electron tomography.

Communication

| September 20 2023

Circadian rhythm in KCNMA1 channelopathy mice models

Ria L. Dinsdale, Cooper E. Roache, Andrea L. Meredith

KCNMA1 regulates circadian rhythm in animals, and mutations in this potassium channel are associated with human neuromotor disease. Dinsdale et al. evaluated circadian clock function in three mouse models harboring KCNMA1 mutations associated with human channelopathies and found clock-controlled behavioral deficits without primary rhythm ablation.

Article

| September 19 2023

Cooperative activation of force in mammalian myocardium

Jitandrakumar R. Patel, Kayla J.V. Park, Aidan S. Bradshaw, Tuan Phan, Daniel P. Fitzsimons

The Fitzsimons lab examines the activation dependence of contractile kinetics in mouse and swine hearts. Their findings demonstrate that the cooperative mechanisms underlying contraction differ in the hearts of small and large mammals and yield insights into normal heart function.

Article

| September 13 2023

Local coupling of ANO1, Ca_V1.2, and IP₃R in PASMCs

Elizabeth J. Akin, Joydeep Aoun, Connor Jimenez, Katie Mayne, Julius Baeck, Michael D. Young, Brennan Sullivan, Kenton M. Sanders, Sean M. Ward, Simon Bulley, Jonathan H. Jaggar, Scott Earley, Iain A. Greenwood, Normand Leblanc

This study examined how structural microdomains comprising the Ca²⁺-activated Cl⁻ channel encoded by Tmem16a or Anoctamin-1 (ANO1) interact with voltage-gated Ca²⁺ channel Ca_V1.2 in the plasma membrane and how Ca²⁺ release from IP₃ receptors in the sarcoplasmic reticulum drive intracellular Ca²⁺ waves and force production of pulmonary artery smooth muscle cells in response to the vasoconstrictor agonist serotonin.

Article

| September 01 2023

Functional effects of replating hPSC-CMs

Felix Osten, Natalie Weber, Meike Wendland, Tim Holler, Birgit Piep, Simon Kröhn, Jana Teske, Alea K. Bodenschatz, Santoshi Biswanath Devadas, Kaja S. Menge, Shambhabi Chatterjee, Kristin Schwanke, Maike Kosanke, Judith Montag, Thomas Thum, Robert Zweigerdt, Theresia Kraft, Bogdan Iorga, Joachim D. Meissner

Osten et al. describe rapid changes in myosin heavy chain isoform expression, contractile function, and calcium transients after enzymatic detachment and replating of human stem cell–derived cardiomyocytes (CMs). These changes may alter mechanosensation and need to be considered when replating CMs in the context of functional measurements.

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Current Issue

Volume 155,

Issue 9,

4 September 2023

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Reviews & Opinions

Research News

| September 13 2023

The fast block to polyspermy breaks with convention

Ben Short

JGP study reveals that conventional PLC activation pathways are not required for the fertilization-induced depolarization of Xenopus eggs that prevents the entry of additional sperm.

Perspective

| August 25 2023

The physical basis of osmosis

Gerald S. Manning, Alan R. Kay

It is surprising that osmosis, a phenomenon so central to biology, has been cloaked in misunderstanding for so long. The authors show that the most plausible account for what drives water fluxes is one put forward by Peter Debye in 1923, where the repulsion of solute molecules from the semipermeable membrane generates a pressure drop, which draws water from a chamber with low solute concentration to one that is high.

Research News

| August 16 2023

Kv12 channels flick the switch

Ben Short

JGP study shows that Kv12-encoded K⁺ currents reduce the repetitive firing rates of SCN neurons at night, thereby regulating daily oscillations in the master circadian pacemaker.

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Special Collections

Biophysics 2022

A special collection highlighting recent articles addressing a wide range of biophysical questions

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You are invited to submit papers on the topic of the Society of General Physiologists 76th Annual Meeting.

Authors can now publish in JGP free of charge or pay a fee to make their articles immediately Open Access.

Cryopreservation preserves integrity of porcine myocardium.

Different species, different gap junctions.

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Special Collections

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