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Article | Voltage-Gated Na Channels
Dmytro V. Vasylyev, Peng Zhao, Betsy R. Schulman, Stephen G. Waxman
Vasylyev et al. show that the Na+ channel Nav1.8 amplifies DRG neuron excitability close to the activation potential threshold, while Nav1.7 acts closer to resting potential. Their findings suggest that full inhibition of Nav1.8 may not be required for the relief of pain due to DRG neuron hyperexcitability.
Article | Contractile Function
Andrew F. Mead, Neil B. Wood, Shane R. Nelson, Bradley M. Palmer, Lin Yang, Samantha Beck Previs, Angela Ploysangngam, Guy G. Kennedy, Jennifer F. McAdow, Sarah M. Tremble, Marcus A. Zimmermann, Marilyn J. Cipolla, Alicia M. Ebert, Aaron N. Johnson, Christina A. Gurnett, Michael J. Previs, David M. Warshaw
Myosin-binding protein H (MyBP-H) is an understudied paralog of the muscle regulator myosin-binding protein C (MyBP-C). Mead et al. reveal that MyBP-H is highly expressed in the muscles of prenatal rats and larval zebrafish and that MyBP-H impacts sarcomere function despite lacking key regulatory domains.
Article
Lina Kraujaliene, Tadas Kraujalis, Mindaugas Snipas, Vytas K. Verselis
Kraujaliene et al. used modeling and dye uptake/transfer studies to show that an Ala/Glu difference in the E1 domains of Cx26 and Cx30 can account for their differential permeabilities to anionic permeants. The permeability profiles are conserved in gap junction channels and hemichannel configurations.
Communication
Saffie Mohran, Timothy S. McMillen, Christian Mandrycky, An-Yue Tu, Kristina B. Kooiker, Wenjing Qian, Stephanie Neys, Brayan Osegueda, Farid Moussavi-Harami, Thomas C. Irving, Michael Regnier, Weikang Ma
Mohran et al. show that calcium has a direct effect on thick filament activation in myocardium rather than an indirect effect due to calcium-mediated crosstalk between the thick and thin filaments. Their findings should be considered in developing future drug candidates to treat heart diseases.
Article
Helmuth A. Sanchez, Lina Kraujaliene, Vytas K. Verselis
Two connexins, Cx26 and Cx30, are expressed in the cochlea and play vital roles in hearing. Sanchez et al. identified a sequence difference in their E1 domains that differentially affects their abilities to operate as hemichannnels and function in transmembrane signaling.
Hypothesis | Excitation–Contraction Coupling
D. George Stephenson
Using a mathematical model, Stephenson tests the hypothesis that the characteristic response to Ca2+ of RyR channels is key not only for the Ca2+ release mechanism in cardiac muscle and other tissues, but also for the DHPR-dependent Ca2+ release in skeletal muscles.
Methods and Approaches | Pain Focus
Taylor M. Mott, Grace C. Wulffraat, Alex J. Eddins, Ryan A. Mehl, Eric N. Senning
Mott et al. evaluate two click-chemistry protein labeling tools based on genetic code expansion technology and circularly permutated Halotag, respectively, for their utility in TRPV1 cell surface expression studies.
Issue Cover
Current Issue
Volume 156,
Issue 10,
7 October 2024
Reviews & Opinions
Viewpoint
Thiago F. A. França, José Maria Monserrat
The advent of large language models and their indiscriminate use to speed up the production of papers threatens to worsen the already dysfunctional state of the scientific literature and its publishing industry.
Research News
Ben Short
This JGP study reveals that in addition to voltage-gated Ca2+ and K+ channels, ω-grammotoxin-SIA also inhibits voltage-gated Na+ channel currents.
Tutorial
Eduardo Rios
This tutorial provides the ideas and information needed to understand, at a basic level, the application of convolutional neural networks to analyze images in biology and traces a path to adopting the available applications of machine learning to biology research.

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