Journal of General Physiology (JGP) | Rockefeller University Press

Skip Nav Destination

Submit your best papers:

Guest editors are Anne Carlson and Zhaozhu Qiu, with JGP Associate Editor Joe Mindell. Learn more.
K+ Dependencies of Periodic Paralysis.
Store Overload Induced Ca2+ Release.

JGP and the Society of General Physiologists have a close and long-standing collaborative relationship.

Newest Articles

Article | Contractile Function

| May 14 2025

Josè Manuel Pioner, Enrico Pierantozzi, Raffaele Coppini, Egidio Maria Rubino, Valentina Biasci, Giulia Vitale, Annunziatina Laurino, Lorenzo Santini, Marina Scardigli, Davide Randazzo, Camilla Olianti, Matteo Serano, Daniela Rossi, Chiara Tesi, Elisabetta Cerbai, Stephan Lange, Carlo Reggiani, Leonardo Sacconi, Corrado Poggesi, Cecilia Ferrantini, Vincenzo Sorrentino

Obscurin deletion in mice is linked to compensated dilated cardiomyopathy, reduced sarcoplasmic reticulum volume, T-tubule alterations, altered E-C coupling, impaired response to inotropic agents, and increased propensity to arrhythmias.

Article | Contractile Function

| May 09 2025

Glycerol storage increases passive stiffness of muscle

Seong-Won Han, Justin Kolb, Gerrie P. Farman, Jochen Gohlke, Henk L. Granzier

To store and preserve muscle function, glycerol is often used, but its effect on passive properties is unclear. Muscles stored in glycerol showed increased passive stress that persisted after thin filament removal, indicating a titin-specific mechanism. Glycerol storage should be avoided in passive stiffness studies.

Article | Voltage-Gated Na Channels

| May 05 2025

iFGF14 loss increases pyramidal neuron excitability

Joseph L. Ransdell, Yarimar Carrasquillo, Marie K. Bosch, Rebecca L. Mellor, David M. Ornitz, Jeanne M. Nerbonne

FGF14 encodes a sodium channel accessory subunit. Mutations in Fgf14 are linked to spinocerebellar ataxia type 27. Fgf14 deletion in mouse Purkinje neurons causes reduced excitability. We show here that targeted Fgf14 deletion in mouse CA1 pyramidal neurons causes increased firing, revealing cell-type specific effects.

Article | Contractile Function

| April 24 2025

Effects of decreasing Lmod2 affinity for Tpm1.1

Eduardo Sánchez Díaz, Brayan Osegueda, Svetlana Minakhina, Nickolas Starks, Stefanie Novak, Dmitri Tolkatchev, Carol C. Gregorio, Alla S. Kostyukova, Garry E. Smith, Jr

In cardiac muscle, leiomodin-2 and tropomodulin-1 compete for binding thin filaments to control their length. We showed that mutations that lower leiomodin-2’s affinity for tropomyosin weaken its ability to displace tropomodulin-1. This highlights the critical role of the tropomyosin-binding site in the competition.

Article | Voltage-Gated Na Channels

| March 26 2025

State-dependent Nav1.8 channel inhibition

Sooyeon Jo, Akie Fujita, Tomás Osorno, Robert G. Stewart, Patric M. Vaelli, Bruce P. Bean

Jo et al. use the Nav1.8 inhibitors suzetrigine, A-887826, and LTGO-33 to show differences in the kinetics with which the compounds unbind from depolarized channels and rebind to resting state channels, explaining reverse use dependence under physiological conditions seen with A-887826 but not suzetrigine or LTGO-33.

Article | Contractile Function

| March 24 2025

Regulation of loaded sarcomere shortening

Kerry S. McDonald, Theodore J. Kalogeris, Adam B. Veteto, Daniel J. Davis, Laurin M. Hanft

McDonald et al. use permeabilized rodent left ventricular cardiac myocytes to study power generation during the ejection phase of the cardiac cycle. They show that cardiac myosin binding protein-C regulates sarcomere-loaded shortening, especially at high loads, seemingly, by modulating cross-bridge availability.

Article

| March 18 2025

Functional diversity of ctenophore K⁺ channels

Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan, Timothy Jegla

Comb jellies are the oldest animal lineage and are missing six of our eight voltage-gated K⁺ channel lineages. We show here that they independently evolved a functionally diverse suite of voltage-gated K⁺ channels from a single ancestral Shaker family lineage.

Browse All >

Current Issue

Volume 157,

Issue 3,

5 May 2025

View This Issue

Submit Your Research

Manage Email Alerts

Reviews & Opinions

Review | Voltage-Gated Na Channels

| April 28 2025

Na_V1.8 as a pain target for Journalvx

John N. Wood, Nieng Yan, Jian Huang, Jing Zhao, Armen Akopian, James J. Cox, C. Geoffrey Woods, Mohammed A. Nassar

The development of analgesic drugs targeting sodium channels Na_V1.7 and Na_V1.8 is described. FDA approval of the Na_V1.8 antagonist suzetrigine presages an exciting new era in analgesic treatment with the drug alone, or in combination with other types of analgesic.

Research News

| April 16 2025

A realistic look at rod synapses

Ben Short

In a new JGP study, anatomically realistic simulations reveal how the complex architecture of rod synapses influences glutamate dynamics and postsynaptic responses.

Commentary

| March 19 2025

Potassium channel evolution

Lawrence Salkoff

Studies of potassium channel evolution from the Jegla group contribute valuable insights into the evolution of complexity in electrical signaling and the conservation and repurposing of key molecular components throughout evolutionary history.

Browse All

Special Collections

Biophysics 2024

Highlighting recent articles addressing a wide range of biophysical questions.

View Collections >

Guest editors are Anne Carlson and Zhaozhu Qiu, with JGP Associate Editor Joe Mindell. Learn more.

K+ Dependencies of Periodic Paralysis.

Store Overload Induced Ca2+ Release.

Most Read

Special Collections

This Feature Is Available To Subscribers Only