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Communication | Myofilament Function 2022
Christopher T.A. Lewis, Lee Tabrizian, Joachim Nielsen, Jenni Laitila, Thomas N. Beck, Mathilde S. Olsen, Marija M. Ognjanovic, Per Aagaard, Rune Hokken, Simon Laugesen, Arthur Ingersen, Jesper L. Andersen, Casper Soendenbroe, Jørn W. Helge, Flemming Dela, Steen Larsen, Ronni E. Sahl, Tue Rømer, Mikkel T. Hansen, Jacob Frandsen, Charlotte Suetta, Julien Ochala
Lewis et al. investigate how training status influences relaxed myosin conformations known to play a role in skeletal muscle metabolism. Their findings indicate that individuals with moderate activity levels have a shift in the relaxed conformations of their type II myosin molecules, lowering the basal ATP consumption.
Article
Tibor G. Szanto, Ferenc Papp, Florina Zakany, Zoltan Varga, Carol Deutsch, Gyorgy Panyi
Szanto et al. provide data that support the idea that rearrangement of S6, including its rotation, may mediate the communication between the activation gate and the inactivation gate controlling slow inactivation in KV channels.
Communication
Rua’a Al-Aqtash, Maxwell S. Ross, Daniel M. Collier
Histone proteins are known to be elevated in circulation where they contribute to vascular dysfunction. However, many details regarding the mechanism of action are unknown. Here, the authors show that P2XR7 channel current is activated by extracellularly applied histone proteins in a heterologous expression system.
Article
Mauricio A. Lillo, Manuel Muñoz, Paula Rhana, Kelli Gaul-Muller, Jonathan Quan, Natalia Shirokova, Lai-Hua Xie, Luis Fernando Santana, Diego Fraidenraich, Jorge E. Contreras
This work demonstrates that the opening of lateralize cardiac connexin-43 hemichannels, in the absence of a cardiac pathology, is still sufficient to alter cardiac membrane excitability and promote arrhythmias upon β-adrenergic cardiac stress.
Article
Guanxing Chen, Qin Li, Timothy I. Webb, Mark A. Hollywood, Jiusheng Yan
The intracellular C-terminal positively charged regions of the γ subunits play important roles in BK channel modulation. This work identifies positively charged peptides as BK channel modulators and reveals a role for the Ca2+-bowl site in BK channel modulation by positively charged peptides and the auxiliary γ subunits.
Article | Myofilament Function 2022
Sukriti Dewan, Namthip Witayavanitkul, Mohit Kumar, Beth J. Mayer, Lauren Betancourt, Olivier Cazorla, Pieter P. de Tombe
Diastolic dysfunction was induced in guinea pigs by pressure overload. We found myofilament dysfunction that included depressed force development, reduced tension-dependent ATP consumption rate, prolonged Ktr, and prolonged myofibril relaxation in the absence of a change in myosin isoform composition. Blunted cross-bridge cycle kinetics may be an important contributor to diastolic heart failure.
Communication | Mechanotransduction by Membrane Proteins
Swetha E. Murthy
Characterization of stretch-activated currents from dorsal root ganglion neurons reveals heterogeneity at the single-channel conductance level and suggests that in addition to PIEZO2, at least two other mechanically activated ion channels are expressed in somatosensory neurons.
Issue Cover
Current Issue
Volume 155,
Issue 5,
1 May 2023
Reviews & Opinions
Commentary | Myofilament Function 2022
Wout J. Claassen, Coen A.C. Ottenheijm
Recent papers by Nelson et al. and Pilagov et al. provide important new information on the ever-expanding role of myosin heads in the regulation of contraction.
Research News
Ben Short
JGP study reveals that the membrane lipid PI(4,5)P2 alters the activity of NaV1.4 channels by modulating their gating behavior.
Commentary
Miaomiao He, Lonnie P. Wollmuth
Glycine-gated NMDA receptors contribute to brain functions and disorders. Rouzbeh et al. shed light on their odd pharmacology.

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