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Call for Papers: Myofilament Function 2022.
Functional heterogeneity of glutamate transporters.
Splice-variants of Nav1.5 alter activation by distinct mechanisms.
X-ray triggered Ca2+ signaling in T cells.
Call for Papers: Ion Channels in Context.

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Newest Articles

Article

| May 18 2022

Lipid regulation of acid-sensing ion channels

Robert C. Klipp, John R. Bankston

Arachidonic acid (AA) is a known modulator of ASICs. Klipp and Bankston examine the structural requirements for ASIC modulation by a number of lipids related to AA. Negatively charged head groups are stronger potentiators and may interact with an arginine in TM1 near the outer leaflet of the plasma membrane.

Article

| April 29 2022

A strategy for determining the equilibrium constants for heteromeric ion channels in a complex model

Klaus Benndorf, Thomas Eick, Christian Sattler, Ralf Schmauder, Eckhard Schulz

Benndorf et al. present a strategy to analyze the functionality of heteromeric ligand-gated ion channels by combining subunit concatenation, mutagenesis, and extensive global fit strategies with intimately coupled Markov models.

Article | Excitation–Contraction Coupling

| April 22 2022

Heart failure reduces CaMKII activity in the pacemaker

Jian-Bin Xue, Almudena Val-Blasco, Moran Davoodi, Susana Gómez, Yael Yaniv, Jean-Pierre Benitah, Ana María Gómez

Xue et al. show that alteration of the Ca²⁺ clock by a mechanism involving CaMKII hypoactivation contributes to depression of the intrinsic pacemaker function of the sinoatrial node (SAN) in a mouse model of heart failure.

Article

| April 22 2022

Functional heterogeneity of glutamate transporters

Krishna D. Reddy, Didar Ciftci, Amanda J. Scopelliti, Olga Boudker

Glt_Ph is a model glutamate transporter with a kinetic heterogeneity of transport. Reddy et al. show that substrate binding is heterogeneous and suggest that subtle structural differences distinguish transporter subpopulations with different dynamic properties.

Article | Excitation–Contraction Coupling

| April 21 2022

Cytosolic control of ER Ca²⁺ by CPVT mutant RYR2s

Nagomi Kurebayashi, Takashi Murayama, Ryosaku Ota, Junji Suzuki, Kazunori Kanemaru, Takuya Kobayashi, Seiko Ohno, Minoru Horie, Masamitsu Iino, Fumiyoshi Yamashita, Takashi Sakurai

CPVT-linked RYR2 mutations are prone to induce spontaneous Ca²⁺ release from the ER, which is associated with arrhythmias. Kurebayashi et al. used experiments and simulations to explore the mechanisms relating cytosolic Ca²⁺-dependent activity by RYR2 mutations and spontaneous Ca²⁺ release.

Article

| April 18 2022

Inhibition of Kv2 Channels by RY785

Matthew James Marquis, Jon T. Sack

Marquis and Sack show that the use-dependent inhibition of Kv2.1 by RY785 is consistent with gated access to a cavity within the channel that traps RY785. While voltage activation is required for access to the blocking site, channel opening itself is not required for access.

Article | Channels and Transporters in Immunity

| April 13 2022

X-ray–triggered Ca²⁺ signaling in T cells

Dominique Tandl, Tim Sponagel, Dalia Alansary, Sebastian Fuck, Timo Smit, Stephanie Hehlgans, Burkhard Jakob, Claudia Fournier, Barbara A. Niemeyer, Franz Rödel, Bastian Roth, Anna Moroni, Gerhard Thiel

The authors expose T lymphocytes to x-ray doses relevant in tumor therapy. This triggers an immune response via activation of store-operated Ca²⁺ entry.

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Volume 154,

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Reviews & Opinions

Review | Mechanotransduction by Membrane Proteins

| May 20 2022

Piezo physics

Michael Young, Amanda H. Lewis, Jörg Grandl

Young et al. review and synthesize the mechanistic principles of forces and energies involved in Piezo ion channel mechanotransduction.

Review

| May 18 2022

Kinetics of phosphoinositide dynamics

Jill B. Jensen, Bjoern H. Falkenburger, Eamonn J. Dickson, Lizbeth de la Cruz, Gucan Dai, Jongyun Myeong, Seung-Ryoung Jung, Martin Kruse, Oscar Vivas, Byung-Chang Suh, Bertil Hille

Phosphoinositides, rare membrane lipids, mediate powerful second messenger signals to ion channels, endocytosis, and exocytosis, and specify organelle identity. Jensen et al. summarize 20 yr of biophysical research whose key message is that pools of phosphoinositides turn over remarkably quickly to regulate rapid physiological responses.

Commentary

| May 18 2022