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Article
Zahra Aminzare, Alan R. Kay
Animal cells regulate their volume by actively pumping sodium and potassium ions, preventing the osmotic influx of water from bursting the cell. We have extended the pump-leak equations that are used to characterize such systems to include impermeant extracellular molecules, cation–chloride co-transporters, and the energetics of ion transport.
Article
Garrett Elmore, Brooke M. Ahern, Nicholas M. McVay, Kyle W. Barker, Sarisha S. Lohano, Nemat Ali, Andrea Sebastian, Douglas A. Andres, Jonathan Satin, Bryana M. Levitan
RRAD is a constituent of the L-type calcium channel heteromultimeric complex. RRAD contributes to calcium channel modulation. Elmore, Ahern et al. show that the RRAD C-terminus confers membrane association concomitantly with the regulation of ICa,L modulation and in vivo heart function.
Methods and Approaches
Eduardo Ríos, Montserrat Samsó, Lourdes C. Figueroa, Carlo Manno, Eshwar R. Tammineni, Lucas Rios Giordano, Sheila Riazi
Artificial neural networks developed to quantify glycogen granules in EM images of human muscle find granular content that varies with cell region and is threefold lower than normal in patients susceptible to malignant hyperthermia, a condition with chronically elevated cytoplasmic [Ca2+].
Article
Magdalena N. Wojciechowski, Chaseley E. McKenzie, Andrew Hung, Alibek Kuanyshbek, Ming S. Soh, Christopher A. Reid, Ian C. Forster
Wojciechowlski et al. used voltage clamp fluorometry to probe the S4 helix movement in the voltage-sensing domain of the sea urchin HCN channel expressed in Xenopus oocytes. They found that when labeled with either ALEXA-488 or MTS-TAMRA, each fluorophore reported different components of S4 movement.
Article
Meyer B. Jackson, Chung-Wei Chiang, Jinbo Cheng
The impact of fusion pores on synaptic release is difficult to discern. Through analysis of miniature excitatory synaptic currents, Jackson et al. revealed a correlation between amplitude and rise-time. Modeling indicated this correlation results from the interplay between vesicle size and fusion pore flux.
Article
Mie Gangi, Takuma Maruyama, Toshiyuki Ishii, Makoto Kaneda
ON and OFF signals in the retina are processed via parallel pathways. Gangi et al. reveal that regulation of starburst amacrine cells, which are crucial for motion detection, is different between the ON and OFF pathways, despite their morphological mirror symmetry.
Article
Olle Rönnelid, Fredrik Elinder
In a screen of 10,000 compounds, Ronnelid and Elinder found that carboxyl-group–containing compounds are potent activators of voltage-gated potassium channels. They suggest that lipophilic and charged compounds electrostatically activate the channel by binding close to the channel’s voltage sensor.
Issue Cover
Current Issue
Volume 156,
Issue 7,
1 July 2024
Reviews & Opinions
Commentary
Joachim Nielsen
This Commentary discusses the implications of a recent JGP study demonstrating an AI model to quantify glycogen granules.
Research News
Ben Short
JGP study shows that hydrophobic residues in the S1 transmembrane domain modulate the voltage-sensor movements and enzymatic activity of voltage-sensing phosphatase.
Viewpoint
Jeffrey R. Holt, Robert Fettiplace, Ulrich Müller
In this Viewpoint, Holt, Fettiplace, and Müller weigh the evidence supporting a role for PIEZO and TMC channels in mechanosensory transduction in inner ear hair cells.

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