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Article
Yichen Liu, Francisco Bezanilla
In this work, Liu and Bezanilla describe a voltage-gated sodium channel mutant that removes fast inactivation while the fast inactivation particle, the IFM motif, remains bound. This work indicates that fast inactivation requires further conformational changes in addition to IFM motif binding.
Methods and Approaches
Allison L. Germann, Spencer R. Pierce, Joe Henry Steinbach, Gustav Akk
In macroscopic electrophysiological experiments, the maximal probability of being active (PA,max) is typically determined by comparing the response to a saturating concentration of the test agonist to the response to a reference agonist. Germann et al. present an approach to estimate PA,max at subsaturating concentrations of test agonist.
Article
Miaomiao He, Lonnie P. Wollmuth
At synapses, NMDA receptors (NMDAR) convert presynaptically released glutamate into a synaptic signal. Here, He and Wollmuth define the impact of various environmental factors and GluN2 subunit composition on the efficiency of rapid glutamate-induced channel opening.
Hypothesis
Vidya Murthy, Josh E. Baker
Murthy and Baker propose a stochastic two-state thermodynamic model of muscle contraction that provides a novel interpretation of muscle mechanics and chemistry, in which the entropy of an ensemble of molecules contributes to the energetics and mechanics of the contractile system.
Article
Joseph F.S. Davies, Andrew Daab, Nicholas Massouh, Corey Kirkland, Bernadette Strongitharm, Andrew Leech, Marta Farré, Gavin H. Thomas, Christopher Mulligan
Bacterial TAXI-TRAP transporters are widespread but poorly understood. Davies et al. characterize a TAXI from Vibrio cholerae, revealing its glutamate specificity, binding determinants, and unusual membrane component. As glutamate is a key metabolite in pathogens, glutamate transporters are potential therapeutic targets.
Communication
Mathilde Dubois, Florian Pallot, Maxime Gouin-Gravezat, Doria Boulghobra, Florence Coste, Guillaume Walther, Gregory Meyer, Isabelle Bornard, Cyril Reboul
The activation of DRP1 during ischemia-reperfusion results in mitochondrial fragmentation, which is known to be a key trigger of cardiac injuries. Dubois et al. evaluate whether preconditioning with exercise training can limit the activation of DRP1 and excessive mitochondrial fragmentation during myocardial ischemia-reperfusion.
Article
Maarten M. Steinz, Nicole Beard, Emily Shorter, Johanna T. Lanner
Ca2+ release via the ryanodine receptor 1 (RyR1) is essential for skeletal muscle contraction. Here, Steinz et al. combine targeted mass spectrometry and single-channel recordings to elucidate how the stable oxidative posttranslational modifications 3-nitrotyrosine (3-NT) and malondialdehyde adducts (MDA) affect RyR1 channel gating.
Issue Cover
Current Issue
Volume 156,
Issue 12,
2 December 2024
Reviews & Opinions
Research News
Ben Short
JGP study reveals that oxidative stress can induce stable posttranslational modifications of RyR1 that increase the channel’s open probability and could therefore disrupt muscle contractility.
Commentary
David Y. Barefield
After decades of obscurity, we are finally gaining mechanistic insight into the function of myosin-binding protein-H in skeletal muscle regulation.
Commentary
Eve Marder
The knowledge in our brains, not in our phones, is necessary for creative thinking and the pursuit of truth.

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