Phosphoinositides, rare membrane lipids, mediate powerful second messenger signals to ion channels, endocytosis, and exocytosis, and specify organelle identity. Jensen et al. summarize 20 yr of biophysical research whose key message is that pools of phosphoinositides turn over remarkably quickly to regulate rapid physiological responses.

Commentary highlighting valuable mechanistic insights provided by Klipp and Bankston on ASIC3 regulation by lipids.

Voltage activation, but not channel opening, is required for RY785 to access the central cavity of Kv2 channels, where it promotes voltage sensor deactivation to trap itself in place.