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Michael J. Rynkiewicz, Matthew C. Childers, Olga E. Karpicheva, Michael Regnier, Michael A. Geeves, William Lehman
Molecular simulations by Rynkiewicz and Lehman indicate that tropomyosin repositions on thin filament actin as myosin transitions from pre-powerstroke to post-powerstroke conformation. Charge repulsion between polar residues on myosin’s Loop-4 and on individual tropomyosin pseudorepeats is shown to facilitate tropomyosin movement.
Article
Anaïs Bertaud, Thierry Cens, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Lisa Soussi, Claudine Ménard, Akelsso Kadala, Claude Collet, Sébastien Dutertre, Patrick Bois, Pascal Gosselin-Badaroudine, Jean-Baptiste Thibaud, Julien Roussel, Michel Vignes, Mohamed Chahine, Pierre Charnet
Bertaud et al. characterize CaV4, a honeybee voltage-gated Ca2+ channel with high sequence homology to Na+ channels, but with a distinct permeation, voltage- and cation-dependent inactivation, and pharmacology from Na+ channels. Their study highlights the unique properties of this new class of voltage-gated Ca2+ channels.
Article
Sofia Benucci, Alexis Ruiz, Martina Franchini, Lucia Ruggiero, Dario Zoppi, Rebecca Sitsapesan, Chris Lindsay, Pawel Pelczar, Laura Pietrangelo, Feliciano Protasi, Susan Treves, Francesco Zorzato
Benucci et al. characterize a new mouse model carrying a mutation in RyR1 identified in a severely affected child. Their model reveals that homozygosity for this pathophysiologically relevant mutation functionally impacts muscle function and alters calcium homeostasis.
Article | Excitation–Contraction Coupling
Parisa Asghari, David R.L. Scriven, Saba Shahrasebi, Hector H. Valdivia, Katherina M. Alsina, Carmen R. Valdivia, J. Alberto Navarro-Garcia, Xander H.T. Wehrens, Edwin D.W. Moore
Asghari et al. analyzed a series of RyR2 phosphorylation mutants, all of which altered the structure of the dyad and its response to the β-agonist isoproterenol. Their results suggest a direct link between the phosphorylation state of the channel tetramer and the microarchitecture of the dyad.
Article
Ricardo A. Galli, Tamara C. Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T. Hwee, Fady I. Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M. de Winter, Coen A.C. Ottenheijm
Acute and long-term treatment with tirasemtiv, a fast troponin skeletal muscle activator, improves skeletal and respiratory muscle function in a mouse model for nemaline myopathy type 3, caused by a p.Asp286Cys variant in ACTA1.
Article
David Fedida, Daniel Sastre, Ying Dou, Maartje Westhoff, Jodene Eldstrom
Fedida et al. use experimental data and Markov model simulations of IKs kinetics to demonstrate the superiority of allosteric over sequential models in understanding the effects of the number of active voltage sensors on channel activation.
Article
Rachael M. Lucero, Kemal Demirer, Trevor Justin Yeh, Randy B. Stockbridge
Lucero et al. characterize the binding and transport of metformin metabolites by bacterial SMR transporters. Their findings provide insight into the mechanism of the SMRGdx subtype and into the co-opting of existing microbial transporters to manage new selective pressures.
Issue Cover
Current Issue
Volume 156,
Issue 4,
1 April 2024
Reviews & Opinions
Research News
Ben Short
JGP study indicates that β-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers in cardiomyocytes.
Research News
Ben Short
JGP study shows that members of the SMRGdx subtype can export the degradation products of metformin, helping bacteria adapt to high environmental levels of the commonly prescribed diabetes medication.
Commentary
Shimon Schuldiner
The study by Lucero et al. sheds light on the remarkable capabilities of bacterial transporters to adapt to new selective pressures. Their findings provide insight into the mechanism of a subtype of SMR transporters.

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