Skip to Main Content

Advertisement

Skip Nav Destination
Newest Articles
Article
Marco Caremani, Luca Fusi, Massimo Reconditi, Gabriella Piazzesi, Theyencheri Narayanan, Malcolm Irving, Vincenzo Lombardi, Marco Linari, Elisabetta Brunello
Thick filament structure in skeletal muscle is more sensitive to calcium than isometric force, with a higher cooperativity. A novel thick filament structure in which myosin motors take up a longer axial periodicity is formed at partial calcium activation.
Article | Excitation–Contraction Coupling
Jianshu Hu, Elisa Venturi, Charalampos Sigalas, Takashi Murayama, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan
Hu et al. demonstrate that, independent of other countercurrents, TRIC-A and TRIC-B differentially modulate RyR2 gating. Results also suggest that TRIC-A and TRIC-B are permeable to both K+ and Cl, thus enabling them to provide adaptable countercurrents for many cell types.
Hypothesis
Denis B. Tikhonov, Boris S. Zhorov
Computational models based on different cryo-EM structures of ligand-bound calcium and sodium channels suggest that dihydropyridine antagonists stabilize entirely α-helical conformation of the pore-lining helix S6IV, whereas agonists promote channel opening by stabilizing π-bulged helix S6IV.
Article
Chunhong Liu, Lingfeng Xue, Chen Song
Using a recently developed multisite ion model, Liu et al. conducted molecular dynamics simulations to study the Ca2+ binding and permeation in TRPV channels. The ion binding strength and number of binding sites within the selectivity filter are found to be key factors determining the permeation patterns and probably ion selectivity.
Article | Excitation–Contraction Coupling
David R.L. Scriven, Anne Berit Johnsen, Parisa Asghari, Keng C. Chou, Edwin D.W. Moore
We show that isoproterenol applied to rat ventricular myocytes produced symmetrical increases in the size of ryanodine receptor clusters, a decrease in fragmentation, and the coalescence of smaller clusters. Additionally, receptors were found in irregularly arranged arrays resembling those seen by electron tomography.
Communication
Ria L. Dinsdale, Cooper E. Roache, Andrea L. Meredith
KCNMA1 regulates circadian rhythm in animals, and mutations in this potassium channel are associated with human neuromotor disease. Dinsdale et al. evaluated circadian clock function in three mouse models harboring KCNMA1 mutations associated with human channelopathies and found clock-controlled behavioral deficits without primary rhythm ablation.
Article
Jitandrakumar R. Patel, Kayla J.V. Park, Aidan S. Bradshaw, Tuan Phan, Daniel P. Fitzsimons
The Fitzsimons lab examines the activation dependence of contractile kinetics in mouse and swine hearts. Their findings demonstrate that the cooperative mechanisms underlying contraction differ in the hearts of small and large mammals and yield insights into normal heart function.
Issue Cover
Current Issue
Volume 155,
Issue 10,
2 October 2023
Reviews & Opinions
Research News
Ben Short
JGP study reveals that conventional PLC activation pathways are not required for the fertilization-induced depolarization of Xenopus eggs that prevents the entry of additional sperm.
Perspective
Gerald S. Manning, Alan R. Kay
It is surprising that osmosis, a phenomenon so central to biology, has been cloaked in misunderstanding for so long. The authors show that the most plausible account for what drives water fluxes is one put forward by Peter Debye in 1923, where the repulsion of solute molecules from the semipermeable membrane generates a pressure drop, which draws water from a chamber with low solute concentration to one that is high.
Research News
Ben Short
JGP study shows that Kv12-encoded K+ currents reduce the repetitive firing rates of SCN neurons at night, thereby regulating daily oscillations in the master circadian pacemaker.

Most Read

Advertisement

Special Collections

Special Collections

A special collection highlighting recent articles addressing a wide range of biophysical questions

View Collections

Close Modal

or Create an Account

Close Modal
Close Modal