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Article | Voltage-Gated Na Channels
Rita de Cássia Collaço, Filip Van Petegem, Frank Bosmans
The ω-grammotoxin-SIA peptide (GrTx-SIA) was originally found in tarantula venom and shown to inhibit voltage-gated Ca2+ channels. Here, Collaço et al. report that GrTx-SIA can also potently inhibit voltage-gated Na+ channel currents, with NaV1.6 being the most susceptible subtype.
Article
Man Si, Ahmad Darvish, Kelsey Paulhus, Praveen Kumar, Kathryn A. Hamilton, Edward Glasscock
Si et al. use electrophysiology to show that genetic or pharmacological ablation of Kv1.1 K+ channel subunits reduces the firing rate of the heart’s sinoatrial node in mice. They attribute this decrease to impaired outward K+ currents resulting in prolonged action potentials. These findings identify Kv1.1 as a novel regulator of cardiac pacemaking.
Article
Zahra Aminzare, Alan R. Kay
Animal cells regulate their volume by actively pumping sodium and potassium ions, preventing the osmotic influx of water from bursting the cell. We have extended the pump-leak equations that are used to characterize such systems to include impermeant extracellular molecules, cation–chloride co-transporters, and the energetics of ion transport.
Article
Garrett Elmore, Brooke M. Ahern, Nicholas M. McVay, Kyle W. Barker, Sarisha S. Lohano, Nemat Ali, Andrea Sebastian, Douglas A. Andres, Jonathan Satin, Bryana M. Levitan
RRAD is a constituent of the L-type calcium channel heteromultimeric complex. RRAD contributes to calcium channel modulation. Elmore, Ahern et al. show that the RRAD C-terminus confers membrane association concomitantly with the regulation of ICa,L modulation and in vivo heart function.
Methods and Approaches
Eduardo Ríos, Montserrat Samsó, Lourdes C. Figueroa, Carlo Manno, Eshwar R. Tammineni, Lucas Rios Giordano, Sheila Riazi
Artificial neural networks developed to quantify glycogen granules in EM images of human muscle find granular content that varies with cell region and is threefold lower than normal in patients susceptible to malignant hyperthermia, a condition with chronically elevated cytoplasmic [Ca2+].
Article
Magdalena N. Wojciechowski, Chaseley E. McKenzie, Andrew Hung, Alibek Kuanyshbek, Ming S. Soh, Christopher A. Reid, Ian C. Forster
Wojciechowlski et al. used voltage clamp fluorometry to probe the S4 helix movement in the voltage-sensing domain of the sea urchin HCN channel expressed in Xenopus oocytes. They found that when labeled with either ALEXA-488 or MTS-TAMRA, each fluorophore reported different components of S4 movement.
Article
Meyer B. Jackson, Chung-Wei Chiang, Jinbo Cheng
The impact of fusion pores on synaptic release is difficult to discern. Through analysis of miniature excitatory synaptic currents, Jackson et al. revealed a correlation between amplitude and rise-time. Modeling indicated this correlation results from the interplay between vesicle size and fusion pore flux.
Issue Cover
Current Issue
Volume 156,
Issue 7,
1 July 2024
Reviews & Opinions
Review | Pain Focus
Cheyanne M. Lewis, Theanne N. Griffith
Lewis and Griffith review developments in ion channels of cold transduction and transmission.
Commentary
Joachim Nielsen
This Commentary discusses the implications of a recent JGP study demonstrating an AI model to quantify glycogen granules.
Research News
Ben Short
JGP study shows that hydrophobic residues in the S1 transmembrane domain modulate the voltage-sensor movements and enzymatic activity of voltage-sensing phosphatase.

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