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PIP2 driven motions in Kir2 channels.
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Guest Editors are Angelika Lampert, Hugues Abriel, and Rajesh Khanna, with JGP Associate Editors Teresa Giraldez and Jeanne Nerbonne. Learn more.
Submit your best papers:

Guest editors are Anne Carlson and Zhaozhu Qiu, with JGP Associate Editor Joe Mindell. Learn more.
Submit your best papers

Guest editors are Jelena Baranovic, Osama Harraz, Conor McClenaghan, and Lejla Zubcevic, with JGP Associate Editors Chris Lingle and Jeanne Nerbonne. Learn more.
Taxonomy and evolution of the NALCN channelosome.

JGP and the Society of General Physiologists have a close and long-standing collaborative relationship.

Newest Articles

Article

| December 03 2025

Novel binding mode for NMDA receptor modulators

James S. Lotti, Jed T. Syrenne, Avery J. Benton, Ahmad Al-Mousawi, Lauren E. Cornelison, Christopher J. Trolinder, Feng Yi, Zhucheng Zhang, Cindee K. Yates-Hansen, Levi J. McClelland, James Bosco, Andrew R. Rau, Rasmus P. Clausen, Kasper B. Hansen

This study describes a novel negative allosteric modulator that engages previously unexplored structural determinants in an allosteric binding site between NMDA receptor subunits, enabling new opportunities for structure-based design of subtype-selective NMDA receptor modulators.

Article

| December 02 2025

Distinct properties of Na_v1.5 CTD missense mutants

Akshay Sharma, Christopher Marra, Nomon Mohammad, Vasilisa Iatckova, Lillian Lawrence, Mitchell Goldfarb

The CTD of voltage-gated sodium channels influences many properties of the channel. Here, Akshay Sharma et al. show the differential effects of CTD missense mutations of cardiac sodium channel activation, inactivation, persistent current, and accessory protein modulation and suggest the structural bases for these mutational effects.

Article

| November 25 2025

Coassembly of β2 and β3a subunits in BK channels

Yu Zhou, Vivian Gonzalez-Perez, Xiao-Ming Xia, Gopal S. Kallure, Sandipan Chowdhury, Christopher J. Lingle

Zhou et al. ask whether distinct β subunit isoforms coassemble in BK channel complexes or segregate into different complexes. Taking advantage of differences in β2- and β3a-mediated inactivation, macroscopic currents, single channels, and biochemical tests unambiguously show that ternary β2:β3:α subunit ternary complexes form, consistent with a trinomial model of random mixing of β subunits.

Article | Contractile Function

| November 19 2025

MYBPHL truncating variants

Alejandro Alvarez-Arce, Geena E. Fritzmann, Hope V. Burnham, Kelly N. Araujo, Alexandra Peña, Lucas M. Wittenkeller, Hannah E. Cizauskas, David Y. Barefield

Premature stop variants in myosin-binding protein H-like prevent sarcomere incorporation of the translated protein regardless of the location of the premature stop along the protein. Overexpression of truncating variants causes contractile defects in neonatal rat cardiomyocytes.

Methods and Approaches

| November 18 2025

Light control of PIP₂ binding of ion channels

Junxian Zhou, Rizki Tsari Andriani, Natsuki Mizutani, Kohei Yamamoto, Daisuke Yoshioka, Akira Kawanabe, Takafumi Kawai, Yoshifumi Okochi, Yasushi Okamura

Zhou et al. introduce a novel optogenetic approach to control ion channel activity using a photocaged lysine. Combined with VSP, the method provides new insights into PI(4,5)P₂-dependent ion channels and offers a promising tool for in-depth analysis of PI(4,5)P₂-regulated ion transport proteins.

Article

| November 11 2025

Lack of Ca entry in activated zebrafish muscle

Francisco Jaque-Fernandez, Léa Demesmay, Romane Idoux, Christine Berthier, Vincent Jacquemond, Bruno Allard

Jaque-Fernandez et al. show that depolarization of zebrafish skeletal muscle fibers evokes a Mn²⁺ quenching signal that does not result from store-operated Ca²⁺ entry but from a displacement of Mn²⁺ accumulated on intracellular Ca²⁺ buffers by the increase in intracellular Ca²⁺.

Article

| November 05 2025

Ca_V1.2–VSD II remodeling by the β subunit

Daniela De Giorgis, Guido Mellado, Jose Antonio Garate, Alan Neely

Combining voltage-clamp fluorometry, kinetic modeling, and molecular dynamics simulation, we show that the auxiliary β-subunit remodels only voltage sensor II and its allosteric contribution to channel opening upon the translocation of two charges before reaching full activation.

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Current Issue

Volume 157,

Issue 6,

3 November 2025

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Reviews & Opinions

Commentary

| December 03 2025

A new subtype-selective NMDAR inhibitor

Hiro Furukawa

Lotti et al. report a new subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition.

Research News

| October 22 2025

The origins of oscillations

Ben Short

JGP study explains why mice lacking TRPM1 exhibit oscillatory firing of their retinal ganglion cells, and suggests that the same mechanism causes similar oscillations in other outer retinal diseases.

Editorial | Voltage-Gated Na Channels

| October 10 2025

Editorial for the special issue on Voltage-Gated Sodium Channels in JGP

Hugues Abriel, Angelika Lampert

Researchers worldwide are advancing our understanding of voltage-gated sodium channels, exploring their mechanisms, disease relevance, and potential as clinical targets in a rapidly evolving field. In this special issue, Abriel and Lampert bring together a collection of studies that exemplify the multidimensional progress in physiology, pharmacology, and structure-function analysis of voltage-gated sodium channels.

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Special Collections

Biophysics 2024

Highlighting recent articles addressing a wide range of biophysical questions.

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PIP2 driven motions in Kir2 channels.

Guest Editors are Angelika Lampert, Hugues Abriel, and Rajesh Khanna, with JGP Associate Editors Teresa Giraldez and Jeanne Nerbonne. Learn more.

Guest editors are Anne Carlson and Zhaozhu Qiu, with JGP Associate Editor Joe Mindell. Learn more.

Guest editors are Jelena Baranovic, Osama Harraz, Conor McClenaghan, and Lejla Zubcevic, with JGP Associate Editors Chris Lingle and Jeanne Nerbonne. Learn more.

Taxonomy and evolution of the NALCN channelosome.

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