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Elena B. Riel, Björn C. Jürs, Sönke Cordeiro, Marianne Musinszki, Marcus Schewe, Thomas Baukrowitz
Riel et al. screened K+ channels of the K2P family for sensitivity to polyanionic lipids, such as PIP2 and oleoyl-CoA. They show that these lipids activate or inhibit individual channels with different affinity and establish them as potential effectors to regulate channel activity.
Bastiaan J.D. Boukens, William Joyce, Ditte Lind Kristensen, Ingeborg Hooijkaas, Aldo Jongejan, Tobias Wang, Bjarke Jensen
Boukens and colleagues show that changes in ventricular repolarization in the ectothermic ball python are modulated by the sympathetic nervous system and not directly by changes in temperature. Their work shows that regulation of this process is conserved between pythons and mammals.
Communication | Excitation–Contraction Coupling
Lan Wei-LaPierre, Linda Groom, Robert T. Dirksen
This communication investigates the effect of extracellular BTP2 on electrically evoked Ca2+ release in intact skeletal muscle fibers. The results demonstrate that acute exposure to 10 μM BTP2 does not significantly affect the magnitude or kinetics of electrically evoked Ca2+ release.
Article | Mechanotransduction by Membrane Proteins
Jonathan R.M. Millet, Luis O. Romero, Jungsoo Lee, Briar Bell, Valeria Vásquez
Millet et al. show that the C. elegans orthologue of the PIEZO family, PEZO-1, is a mechanosensitive ion channel involved in food sensation and in regulating pharyngeal function in the nematode.
Zhuyuan Chen, Sheng Lin, Tianze Xie, Jin-Ming Lin, Cecilia M. Canessa
Chen et al. computationally model the open conformation of the hASIC1a channel to predict that mutations that eliminate channel selectivity cause a widening of the GAS belt. Their findings implicate the GAS belt diameter in channel kinetics and ion selectivity.
Hind Albadrani, T. Ammar, Michael Bader, Jean-Marc Renaud
Albadrani et al. studied the potential of angiotensin 1–7 to prevent the atrophy that normally ensues muscle denervation. Increasing angiotensin 1–7 levels do not prevent muscle mass loss in denervated muscles but maintain normalized tetanic force to cross-sectional area and membrane excitability for up to 28 d.
Catherine E. Morris, Joshua J. Wheeler, Béla Joos
Morris et al. use a computational model of Pump-Leak/Donnan ion homeostasis to suggest that the Donnan dominated steady-state of skeletal muscle fibers underpins their longevity in the face of the structural and metabolic injuries incurred with Duchenne muscular dystrophy.

Related Articles from Rockefeller University Press

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Current Issue
Volume 154,
Issue 1,
January 3, 2022
Reviews & Opinions
Research News
Ben Short
JGP study on python snakes reveals that the regulation of ventricular repolarization by the sympathetic nervous system is evolutionarily conserved.
Alex Lewalle, Kenneth S. Campbell, Stuart G. Campbell, Gregory N. Milburn, Steven A. Niederer
Lewalle et al. review differences in skinned and intact muscle preparations.
Michiel Helmes, Bradley M. Palmer
Helmes and Palmer review research by Kobirumaki-Shimozawa et al.

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