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Article | Excitation–Contraction Coupling
Parisa Asghari, David R.L. Scriven, Saba Shahrasebi, Hector H. Valdivia, Katherina M. Alsina, Carmen R. Valdivia, J. Alberto Navarro-Garcia, Xander H.T. Wehrens, Edwin D.W. Moore
Asghari et al. analyzed a series of RyR2 phosphorylation mutants, all of which altered the structure of the dyad and its response to the β-agonist isoproterenol. Their results suggest a direct link between the phosphorylation state of the channel tetramer and the microarchitecture of the dyad.
Article
Ricardo A. Galli, Tamara C. Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T. Hwee, Fady I. Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M. de Winter, Coen A.C. Ottenheijm
Acute and long-term treatment with tirasemtiv, a fast troponin skeletal muscle activator, improves skeletal and respiratory muscle function in a mouse model for nemaline myopathy type 3, caused by a p.Asp286Cys variant in ACTA1.
Article
David Fedida, Daniel Sastre, Ying Dou, Maartje Westhoff, Jodene Eldstrom
Fedida et al. use experimental data and Markov model simulations of IKs kinetics to demonstrate the superiority of allosteric over sequential models in understanding the effects of the number of active voltage sensors on channel activation.
Article
Rachael M. Lucero, Kemal Demirer, Trevor Justin Yeh, Randy B. Stockbridge
Lucero et al. characterize the binding and transport of metformin metabolites by bacterial SMR transporters. Their findings provide insight into the mechanism of the SMRGdx subtype and into the co-opting of existing microbial transporters to manage new selective pressures.
Communication
Baharak Mehrdel, Carlos A. Villalba-Galea
Mehrdel and Villalba-Galea found that removing the charge of residue R198 in the human KV7.2, a critical regulator of electrical excitability, caused a dramatic increase in pH sensitivity on the activity of this channel, with a more robust effect on deactivation.
Hypothesis
Lorena Carmina Hernández-Espinosa, Rolando Hernández-Muñoz
The mechanisms governing the release of hepatic enzymes are largely unknown. It is hypothesized that hemodynamic changes, exerting mechanotransducing actions on the liver endothelium, play a crucial role in stimulating the release of enzymes from the intact liver.
Article
Tytus Bernas, John Seo, Zachary T. Wilson, Bi-hua Tan, Isabelle Deschenes, Christiane Carter, Jinze Liu, Gea-Ny Tseng
Bernas et al. show that persistent PKA activation increases INa by directing NaV1.5 to the myocyte surface, activating CREB1, upregulating EB1, and reorganizing microtubules. Their study suggests that persistent PKA activation may protect impulse propagation in a chronically stressed heart.
Issue Cover
Current Issue
Volume 156,
Issue 2,
5 February 2024
Reviews & Opinions
Research News
Ben Short
JGP study shows that members of the SMRGdx subtype can export the degradation products of metformin, helping bacteria adapt to high environmental levels of the commonly prescribed diabetes medication.
Commentary
Shimon Schuldiner
The study by Lucero et al. sheds light on the remarkable capabilities of bacterial transporters to adapt to new selective pressures. Their findings provide insight into the mechanism of a subtype of SMR transporters.
Research News
Ben Short
JGP study suggests that, by altering microtubule dynamics, persistent PKA activation promotes the delivery of Nav1.5 channels to intercalated discs.

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