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Article | Myofilament Function 2022
Matthew H. Doran, Michael J. Rynkiewicz, Elumalai Pavadai, Skylar M.L. Bodt, David Rasicci, Jeffrey R. Moore, Christopher M. Yengo, Esther Bullitt, William Lehman
The muscle regulatory protein tropomyosin relocates on thin filaments as the myosin motor binds to and releases from actin. We show that amino acid side chains at the tip of the myosin motor are critical for optimal tropomyosin repositioning.
Article | Excitation–Contraction Coupling
Mathilde Chivet, Maximilian McCluskey, Anne Sophie Nicot, Julie Brocard, Mathilde Beaufils, Diane Giovannini, Benoit Giannesini, Brice Poreau, Jacques Brocard, Sandrine Humbert, Frédéric Saudou, Julien Fauré, Isabelle Marty
The Huntingtin protein, well known for its involvement in the neurodegenerative Huntington’s disease, is also expressed in skeletal muscle. The work presented here is dedicated to a better understanding of its function in skeletal muscle through the development and characterization of KO models.
Matvey Pilagov, Laurens W.H.J. Heling, Jonathan Walklate, Michael A. Geeves, Neil M. Kad
Control of muscle contraction is still not understood. Here, we image fluorescently tagged ATP with single-molecule precision to reveal the activity of individual myosins in different sarcomeric locations. We show how treatment with PKA and the FDA-approved drug mavacamten affects relaxed myofibrils.
Savyon Mazgaoker, Ido Weiser-Bitoun, Inbar Brosh, Ofer Binah, Yael Yaniv
The automaticity of human-induced pluripotent stem cell–derived cardiomyocytes is regulated by a coupled-clock system of the Ca2+ and membrane clocks. We found that the coupled-clock system is regulated by local Ca2+ releases and cAMP/PKA-dependent coupling of the Ca2+ clock to the membrane clock.
Vilius Kurauskas, Marco Tonelli, Katherine Henzler-Wildman
The dominant models explaining potassium channel gating often invoke widening and narrowing of the helix bundle crossing. This paper shows that a closely related channel, NaK, is not gated by this mechanism as the helix bundle crossing in the nonconducting channel is already open.
Merouann Kassa, Jonathan Bradley, Abdelali Jalil, Isabel Llano
Optical activation of channel rhodopsin is used to increase neuronal activity. In cerebellar interneurons, it actually leads to a biphasic activation/inhibition sequence. In these cells, activation of KCa1.1 channels contributes to the post-stimulus inhibition.
Methods and Approaches
Takashi Murayama, Nagomi Kurebayashi, Takuro Numaga-Tomita, Takuya Kobayashi, Satoru Okazaki, Kyosuke Yamashiro, Tsutomu Nakada, Shuichi Mori, Ryosuke Ishida, Hiroyuki Kagechika, Mitsuhiko Yamada, Takashi Sakurai
Mutations in essential components for depolarization-induced Ca2+ release (DICR) are implicated into various skeletal muscle diseases. Murayama et al. establish a reconstituted DICR platform in nonmuscle cells for validation of disease-causing mutations and drug discovery.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 154,
Issue 12,
5 December 2022
Reviews & Opinions
Review | Channels and Transporters in Immunity
Jing Feng, Zili Xie, Hongzhen Hu
This Review discusses ion channel expression and function in immune cells, residential non-immune cells and neuroimmune interactions in the gut, and how ion channels contribute to the maintenance of intestinal immune homeostasis and generation of autoimmune disorders under pathological conditions.
Camden M. Driggers, Show-Ling Shyng
Driggers and Shyng present a comprehensive review of recent advances in cryo-EM structures of KATP channels and the insights from these structures on the mechanisms of channel gating and pharmacology.
Commentary | Myofilament Function 2022
Raúl Padrón, Debabrata Dutta, Roger Craig
The two heads of myosin II interact with each other and with the proximal part of the myosin tail, forming the interacting-heads motif (IHM). The IHM is normally thought of as a single, unique structure, but there are several variants, with important energetic and pathophysiological consequences.

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