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Niklas Brake, Adamo S. Mancino, Yuhao Yan, Takushi Shimomura, Yoshihiro Kubo, Anmar Khadra, Derek Bowie
Combining electrophysiology and kinetic modeling, Brake et al. highlight the role of closed-state inactivation in the gating behavior of cardiac, skeletal muscle, and neuronal voltage-gated sodium channels.
Nicole E. Godellas, Claudio Grosman
Godellas and Grosman revisit the use of ligand-binding assays to study pentameric ligand-gated ion channels (pLGICs). They show that ligand-binding affinity is unaffected by binding-site occupancy and that changes to the transmembrane domain are unlikely to affect binding to the extracellular domain.
Robert C. Klipp, John R. Bankston
Arachidonic acid (AA) is a known modulator of ASICs. Klipp and Bankston examine the structural requirements for ASIC modulation by a number of lipids related to AA. Negatively charged head groups are stronger potentiators and may interact with an arginine in TM1 near the outer leaflet of the plasma membrane.
Klaus Benndorf, Thomas Eick, Christian Sattler, Ralf Schmauder, Eckhard Schulz
Benndorf et al. present a strategy to analyze the functionality of heteromeric ligand-gated ion channels by combining subunit concatenation, mutagenesis, and extensive global fit strategies with intimately coupled Markov models.
Article | Excitation–Contraction Coupling
Jian-Bin Xue, Almudena Val-Blasco, Moran Davoodi, Susana Gómez, Yael Yaniv, Jean-Pierre Benitah, Ana María Gómez
Xue et al. show that alteration of the Ca2+ clock by a mechanism involving CaMKII hypoactivation contributes to depression of the intrinsic pacemaker function of the sinoatrial node (SAN) in a mouse model of heart failure.
Krishna D. Reddy, Didar Ciftci, Amanda J. Scopelliti, Olga Boudker
GltPh is a model glutamate transporter with a kinetic heterogeneity of transport. Reddy et al. show that substrate binding is heterogeneous and suggest that subtle structural differences distinguish transporter subpopulations with different dynamic properties.
Article | Excitation–Contraction Coupling
Nagomi Kurebayashi, Takashi Murayama, Ryosaku Ota, Junji Suzuki, Kazunori Kanemaru, Takuya Kobayashi, Seiko Ohno, Minoru Horie, Masamitsu Iino, Fumiyoshi Yamashita, Takashi Sakurai
CPVT-linked RYR2 mutations are prone to induce spontaneous Ca2+ release from the ER, which is associated with arrhythmias. Kurebayashi et al. used experiments and simulations to explore the mechanisms relating cytosolic Ca2+-dependent activity by RYR2 mutations and spontaneous Ca2+ release.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 154,
Issue 5,
2 May 2022
Reviews & Opinions
Commentary | Excitation–Contraction Coupling
Naohiro Yamaguchi
It is controversial whether the cardiac type-2 ryanodine receptor harboring a catecholaminergic polymorphic ventricular tachycardia-associated point mutation is regulated by luminal or cytosolic Ca2+. This commentary discusses new findings supporting the cytosolic Ca2+-dependent regulation.
Review | Mechanotransduction by Membrane Proteins
Michael Young, Amanda H. Lewis, Jörg Grandl
Young et al. review and synthesize the mechanistic principles of forces and energies involved in Piezo ion channel mechanotransduction.
Jill B. Jensen, Bjoern H. Falkenburger, Eamonn J. Dickson, Lizbeth de la Cruz, Gucan Dai, Jongyun Myeong, Seung-Ryoung Jung, Martin Kruse, Oscar Vivas, Byung-Chang Suh, Bertil Hille
Phosphoinositides, rare membrane lipids, mediate powerful second messenger signals to ion channels, endocytosis, and exocytosis, and specify organelle identity. Jensen et al. summarize 20 yr of biophysical research whose key message is that pools of phosphoinositides turn over remarkably quickly to regulate rapid physiological responses.

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Mechanotransduction by Membrane Proteins
Physics of mechanotransduction by Piezo ion channels


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