Rainbow and Barrett-Jolley discuss Scala et al., who combined genetic and pharmacological approaches to demonstrate that Kir6.2/SUR2-containing K_ATP potassium ion channels are the functionally relevant isoform that modulate contractile behavior of fast-twitch muscle during fatigue.

JGP study shows that, in the absence of full-length dysferlin, its C2A domain alone can support normal Ca2⁺ signaling and sarcolemma repair, suggesting that it could be used in gene replacement therapies.

Schuldiner recounts the decades-long journey of VMAT research, bridging foundational bioenergetics with recent high-resolution structural breakthroughs. This retrospective highlights the role of serendipity and “optimistic ignorance” in discovery, providing a comprehensive framework for understanding the essential mechanisms of neurotransmitter storage and their significant therapeutic potential.