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Guest editors are Anne Carlson and Zhaozhu Qiu, with JGP Associate Editor Joe Mindell. Learn more.
Nav fast inactivation metaphors.
Cardiac alterations in Obscn KO mice.
iFGF14 loss increases pyramidal neuron excitability.

JGP and the Society of General Physiologists have a close and long-standing collaborative relationship.

Newest Articles

Article | Contractile Function

| July 07 2025

Single-molecule imaging of porcine and human β-cardiac myofibrils

Matvey Pilagov, Sonette Steczina, Ateeqa Naim, Michael Regnier, Michael A. Geeves, Neil M. Kad

Single-molecule imaging provides a high spatial resolution of fluorescent ATP binding to myosin within cardiac myofibrils. This is used to determine how cMyBP-C affects the reserve of cardiac myosins used to modulate force. Here, we study PKA phosphorylation and a haploinsufficiency-causing mutation from human tissue.

Article

| June 18 2025

Danicamtiv and omecamtiv mecarbil comparison

Joshua B. Holmes, Julian E. Stelzer

Danicamtiv and omecamtiv mecarbil are second- and first-generation myotropic sarcomere activators intended to treat patients with heart failure with reduced ejection fraction. This study directly compares the in vivo cardiac mechanisms to assess whether danicamtiv has improved upon the shortcomings of omecamtiv mecarbil.

Article

| June 10 2025

Molecular dynamics of disease-causing GJC2 mutants

David Gong, Jennifer L. Orthmann-Murphy, Deepak Kumar, Gabriel D. Dungan, Ayman W. El-Hattab, Nicoline Schiess, Yun L. Luo, Mona M. Freidin, Charles K. Abrams

Gong et al. present two novel, disease-causing genetic variants of connexin 47. In vitro assays and MD simulations of these mutant proteins reveal unique mechanisms that relate connexin 47 mutations to severities of Pelizaeus–Merzbacher-like disease 1.

Article

| May 30 2025

BK β subunit–mediated pore block

Yu Zhou, Xiao-Ming Xia, Christopher J. Lingle

The role of BK S6 residues R329K330K331 and E321/E324 in β subunit–mediated inactivation is probed. WT R329K330K331 hinders inactivation in closed states, while RKK mutations stabilize inactivated states even under conditions where channels are otherwise closed. E321/E324 mutations do not permit closed-state inactivation.

Article | Contractile Function

| May 14 2025

Cardiac alterations in Obscn KO mice

Josè Manuel Pioner, Enrico Pierantozzi, Raffaele Coppini, Egidio Maria Rubino, Valentina Biasci, Giulia Vitale, Annunziatina Laurino, Lorenzo Santini, Marina Scardigli, Davide Randazzo, Camilla Olianti, Matteo Serano, Daniela Rossi, Chiara Tesi, Elisabetta Cerbai, Stephan Lange, Carlo Reggiani, Leonardo Sacconi, Corrado Poggesi, Cecilia Ferrantini, Vincenzo Sorrentino

Obscurin deletion in mice is linked to compensated dilated cardiomyopathy, reduced sarcoplasmic reticulum volume, T-tubule alterations, altered E-C coupling, impaired response to inotropic agents, and increased propensity to arrhythmias.

Article | Contractile Function

| May 09 2025

Glycerol storage increases passive stiffness of muscle

Seong-Won Han, Justin Kolb, Gerrie P. Farman, Jochen Gohlke, Henk L. Granzier

To store and preserve muscle function, glycerol is often used, but its effect on passive properties is unclear. Muscles stored in glycerol showed increased passive stress that persisted after thin filament removal, indicating a titin-specific mechanism. Glycerol storage should be avoided in passive stiffness studies.

Article | Voltage-Gated Na Channels

| May 05 2025

iFGF14 loss increases pyramidal neuron excitability

Joseph L. Ransdell, Yarimar Carrasquillo, Marie K. Bosch, Rebecca L. Mellor, David M. Ornitz, Jeanne M. Nerbonne

FGF14 encodes a sodium channel accessory subunit. Mutations in Fgf14 are linked to spinocerebellar ataxia type 27. Fgf14 deletion in mouse Purkinje neurons causes reduced excitability. We show here that targeted Fgf14 deletion in mouse CA1 pyramidal neurons causes increased firing, revealing cell-type specific effects.

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Current Issue

Volume 157,

Issue 4,

7 July 2025

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Reviews & Opinions

Research News | Contractile Function

| June 18 2025

Trouble in store for muscle fibers

Ben Short

JGP study reveals that glycerol storage increases the titin-based stiffness of muscle fibers, suggesting that this commonly used method should be avoided by researchers interested in the passive properties of muscle.

Viewpoint | Voltage-Gated Na Channels

| June 03 2025

Nav fast inactivation metaphors

Peter Hull, Angelika Lampert

Metaphors shape how we communicate and understand science, from genetic blueprints to molecular gates. This article explores their role in the sodium channel fast inactivation mechanism.

Review | Voltage-Gated Na Channels

| April 28 2025

Na_V1.8 as a pain target for Journalvx

John N. Wood, Nieng Yan, Jian Huang, Jing Zhao, Armen Akopian, James J. Cox, C. Geoffrey Woods, Mohammed A. Nassar

The development of analgesic drugs targeting sodium channels Na_V1.7 and Na_V1.8 is described. FDA approval of the Na_V1.8 antagonist suzetrigine presages an exciting new era in analgesic treatment with the drug alone, or in combination with other types of analgesic.

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Special Collections

Biophysics 2024

Highlighting recent articles addressing a wide range of biophysical questions.

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Guest editors are Anne Carlson and Zhaozhu Qiu, with JGP Associate Editor Joe Mindell. Learn more.

Nav fast inactivation metaphors.

Cardiac alterations in Obscn KO mice.

iFGF14 loss increases pyramidal neuron excitability.

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Special Collections

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