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Article | Excitation–Contraction Coupling
Anna V. Maltsev, Michael D. Stern, Victor A. Maltsev
The present numerical modeling study shows that disorder in locations of Ca release units in cardiac pacemaker cells has substantial functional impact by creating release clusters, similar to Poisson clumping, and opportunity of Ca release to propagate within the clusters.
Gustavo Frindt, Joel R. Meyerson, Alexandra Satty, Joseph M. Scandura, Lawrence G. Palmer
Epithelial Na+ channels are major regulators of fluid volumes and ultimately blood pressure in terrestrial vertebrates. We found that the amounts of protein comprising these channels in the kidneys and colons of rats and mice exceed what is required to explain the transport of Na+ by these tissues. This excess may facilitate regulation of the channels.
Article | Excitation–Contraction Coupling
Maricela García-Castañeda, Antonio Michelucci, Nan Zhao, Sundeep Malik, Robert T. Dirksen
Postdevelopmental, muscle-specific ablation of Orai1 in mdx mice abolishes excessive constitutive and store-operated Ca2+ entry, improves muscular dystrophy pathology, and promotes sarcolemmal integrity, thus demonstrating an important role of enhanced Orai1-mediated Ca2+ entry in exacerbating the dystrophic phenotype.
Article | Channels and Transporters in Immunity
Liwei Wang, Lucile Noyer, Yin-Hu Wang, Anthony Y. Tao, Wenyi Li, Jingjie Zhu, Pedro Saavedra, Syed T. Hoda, Jun Yang, Stefan Feske
Ca2+ release–activated Ca2+ (CRAC) channels mediate store-operated Ca2+ entry (SOCE) in many nonexcitable cells. In contrast to the CRAC channel subunit ORAI1, its homologue ORAI3 is dispensable for SOCE in lymphocytes and macrophages and not essential for immune cell function.
Communication | Mechanotransduction by Membrane Proteins
Yiechang Lin, Amanda Buyan, Ben Corry
Piezo2 is a membrane protein that activates in response to mechanical signals and plays key roles in humans. Lipids in the membrane such as cholesterol and phosphoinositides modulate Piezo2’s function. We used computational simulations of Piezo2 in a realistic mammalian membrane to investigate how lipids interact with Piezo2.
Miriam K. Bell, Maven V. Holst, Christopher T. Lee, Padmini Rangamani
The authors develop a stochastic model for calcium influx in dendritic spines in idealized and realistic geometries. Using this model, they show that spine morphology alters calcium transients and synaptic weight updates.
Communication | Mechanotransduction by Membrane Proteins
John Smith Del Rosario, Matthew Gabrielle, Yevgen Yudin, Tibor Rohacs
Del Rosario and Gabrielle et al. show that TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels both in heterologous systems and in dorsal root ganglion neurons. TMEM120A does not inhibit PIEZO1 and TREK1 channel activity and its expression alone does not lead to appearance of mechanically activated currents.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 154,
Issue 8,
1 August 2022
Reviews & Opinions
Review | Excitation–Contraction Coupling
Carlo Reggiani, Lorenzo Marcucci
In skeletal muscle fibers, mitochondria calcium uptake is relevant for metabolic activation, trophic regulation, and apoptosis. It is still debated whether mitochondria can modulate cytosolic calcium transients and contractile performance. Here, we discuss evidence in favor or against this possibility.
Research News
Ben Short
JGP study identifies a novel peptide in scorpion venom that inhibits KV1.2 and KV1.3 channels and could form the basis for new treatments for autoimmune diseases.
Viewpoint | Excitation–Contraction Coupling
Samantha C. Salvage, Christopher L.-H. Huang, James A. Fraser, Angela F. Dulhunty
The promiscuity of flecainide underscores its antiarrhythmic efficacy in CPVT: this paper presents a discussion of its mechanisms of action on the cardiac ryanodine receptor (RyR2) and other cardiac excitation–contraction coupling proteins.

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