Journal of General Physiology (JGP) | Rockefeller University Press

Call for papers:

What’s Hot in Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function and Disease
A journal committed to an inclusive, globally representative community. Learn about publishing in JGP.
Modeling drug actions in ocular surface epithelia.
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Guest Editors are Angelika Lampert, Hugues Abriel, and Rajesh Khanna, with JGP Associate Editors Teresa Giraldez and Jeanne Nerbonne. Learn more.
Call for Papers: Membrane Excitability and Reproductive Biology.

JGP and the Society of General Physiologists have a close and long-standing collaborative relationship.

Newest Articles

Article | Ion Channels in Health and Disease

| August 10 2026

A TMEM63B channelopathy passes ions and lipids

Augustus J. Lowry, Pengfei Liang, Maria A. Gonzalez Torres, Huanghe Yang

Lowry et al. show that the disease-associated TMEM63B I475del variant uniquely promotes both mechanosensitive ion channel gain of function and acquired lipid scramblase activity. Their findings reveal graded hydrophobic gate destabilization as a mechanism for variant-specific TMEM63B channelopathies and suggest new directions for targeted therapeutic strategies to treat TMEM63B channelopathy.

Communication | Ion Channels in Health and Disease

| August 06 2026

Gain-of-function mutations in TASK channelopathies

Kate M. Crowther, Thibault R.H. Jouen-Tachoire, Peter Proks, Peter Rory Hall, Emma L. Veale, Janina Sörmann, Karin E.J. Rödström, Thomas Müller, Saskia B. Wortmann, Nina Barisic, Natalie Hauser, Vincenzo Salpietro, RaeLynn Forsyth, Linford Williams, Nora Derrabi, Carlos A. Bacino, Jill A. Rosenfeld, Henry Houlden, Simon Newstead, Caroline F. Wright, James Fasham, Alistair A. Mathie, Reza Maroofian, Stephen J. Tucker

In this study, Crowther and colleagues report new disease-causing variants in the TASK-1 and TASK-3 potassium channels responsible for two different neurodevelopmental disorders. They also examine the structural and functional properties of these variants and examine their effects when incorporated into heteromeric TASK-1/TASK-3 channels.

Article | Ion Channels in Health and Disease

| August 06 2026

Cholesterol reorganizes slide helix of KirBac1.1

Arpan Bysack, H. Raghuraman

Bysack and Raghuraman show specific lipid–protein interactions mediate the cholesterol-induced reorganization of the slide helix in membranes during cholesterol-dependent regulation of KirBac1.1. Importantly, they hypothesize that the slide helix movement might function as a lipid-sensitive “conformational-switch” controlling KirBac1.1 gating.

Article | Voltage-Gated Na Channels 2026

| August 06 2026

Aconitine and bulleyaconitine in sodium channel

Boris S. Zhorov

Sodium channel antagonist bulleyaconitine and agonist aconitine bind in the pore-domain fenestration I/II and stabilize the open activation gate. Aconitine transiently chelates passing sodium ions, while protonated bulleyaconitine blocks the permeation.

Article

| July 21 2026

Allosteric activation of calcium release in muscle

Eduardo Rios, Gonzalo Pizarro

The contraction of skeletal muscles is turned on by Ca²⁺ released from the cellular store by RyR channels in a quasi-crystalline array, half of which only have contacts with neighbor RyRs. Rios and Pizarro’s model assumes these channels to be controlled allosterically by their neighbors and matches quantitatively observations of Ca²⁺ release gathered over decades.

Article

| July 20 2026

Nanoscale electrophysiology

Madeleine R. Howell, Rosalind J. Xu, Adam E. Cohen

Bioelectrical signaling is important in many small structures, such as bacteria, viruses, and intracellular vesicles. The dynamics in small structures are strongly affected by stochastic gating of single ion channels. Howell et al. provide a framework for predicting and interpreting bioelectrical dynamics in small structures.

Article

| July 07 2026

Reconstructing Paramecium graded excitability

Takashi Tominaga, Yoko Tominaga

We developed a kinetic framework for the major membrane-current components in Paramecium. The framework integrates late-component, leak, and inward Ca²⁺ currents, including Ca²⁺-dependent inactivation and slow recovery. It reproduces graded membrane responses under the present recording conditions.

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Current Issue

Volume 158,

Issue 4,

6 July 2026

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Commentary

| August 12 2026

The mitochondrial swelling channel

Elizabeth A. Jonas, Eleanora Margulis, Ava Yu, Nelli Mnatsakanyan

Akosah et al. highlight the multifaceted nature of mitochondrial swelling, and its relationship to membrane potential changes, to mitochondrial permeability, and to activation of the mitochondrial permeability transition pore. This study reinforces the need to use direct and comprehensive approaches to evaluate mitochondrial physiology.

Research News

| August 11 2026

ATP1A1 variants spring a leak

Ben Short

JGP study identifies passive “leak” currents as a likely common mechanism underlying hypomagnesemia with treatment-resistant seizures in patients with certain mutations in the Na⁺, K⁺-ATPase α1 subunit.

Commentary

| July 30 2026

Modelling couplons

Werner Melzer

Couplons are large multi-protein clusters consisting of Ca_V1.1 and RyR1 channels that connect SR and transverse tubulus in skeletal muscle cells and permit voltage-controlled Ca²⁺ release. Rios and Pizarro (2026) simulate allosteric interactions within the couplon using Markov chain modelling to successfully describe many characteristics of whole-cell and microdomain Ca²⁺ signals.

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Special Collections

Neuroscience 2025

Highlighting recent articles addressing a wide variety of neuroscience research.

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What’s Hot in Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function and Disease

A journal committed to an inclusive, globally representative community. Learn about publishing in JGP.

Modeling drug actions in ocular surface epithelia.

Guest Editors are Angelika Lampert, Hugues Abriel, and Rajesh Khanna, with JGP Associate Editors Teresa Giraldez and Jeanne Nerbonne. Learn more.

Call for Papers: Membrane Excitability and Reproductive Biology.

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