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Special Issue: Cardiac, Skeletal, and Smooth Muscle Excitation–Contraction Coupling

Read new work on a broad range of relevant mechanisms, in all types and sources of muscle.
Piezo1 affects cholesterol during brain development.
Myosin ELC1sa decelerates actin gliding.
Call for Papers: Myofilament Function 2022.
Call for Papers: Ion Channels in Context.

RUP seeks a talented individual to join JEM and JGP editorial teams as a Scientific Editor.

JGP and the Society of General Physiologists have a close and long-standing collaborative relationship.

Newest Articles

Article

| September 27 2022

Altered channel gating by Ca_V1.2 mutations

Moradeke A. Bamgboye, Kevin G. Herold, Daiana C.O. Vieira, Maria K. Traficante, Philippa J. Rogers, Manu Ben-Johny, Ivy E. Dick

Human mutations in Ca_V1.2 underlie life-threatening arrhythmias and neurodevelopmental disorders. Through in-depth biophysical analysis, this study identifies divergent mechanistic alterations linked to Ca_V1.2 channelopathies and reveals an association between changes in channel function and patient phenotypes.

Article | Excitation–Contraction Coupling

| September 23 2022

Subsynaptic IP₃R1s at the NMJ

Pompeo Volpe, Alessandra Bosutti, Alessandra Nori, Riccardo Filadi, Gaia Gherardi, Gabor Trautmann, Sandra Furlan, Gabriele Massaria, Marina Sciancalepore, Aram Megighian, Paola Caccin, Annalisa Bernareggi, Michele Salanova, Roberta Sacchetto, Dorianna Sandonà, Paola Pizzo, Paola Lorenzon

The present study reports on a novel effect of denervation at the neuromuscular junction level. It shows that the absence of nerve causes a reduction in the subsynaptic type 1 inositol 1,4,5-trisphosphate-stained region likely involved in the stabilization of the endplate.

Article | Mechanotransduction by Membrane Proteins

| September 07 2022

Piezo1 affects cholesterol biosynthesis during brain development

Jamison L. Nourse, Vivian M. Leung, Hamid Abuwarda, Elizabeth L. Evans, Esmeralda Izquierdo-Ortiz, Alan T. Ly, Nguyen Truong, Samantha Smith, Harsh Bhavsar, Gabriella Bertaccini, Edwin S. Monuki, Mitradas M. Panicker, Medha M. Pathak

PIEZO1, a mechanically gated ion channel, transduces mechanical cues in neural stem cells. Here, we show the impact of Piezo1 knockout on neural development in vivo and find that cholesterol biosynthesis and lipid membrane composition are regulated by Piezo1.

Article

| September 02 2022

Myosin ELC1sa decelerates actin gliding

Jennifer Osten, Maral Mohebbi, Petra Uta, Faramarz Matinmehr, Tianbang Wang, Theresia Kraft, Mamta Amrute-Nayak, Tim Scholz

Compared to the “ventricular” essential myosin light chain MLC1sb/v, the longer and more positively charged MLC1sa present in slow-twitch M. soleus fibers decelerates actin filament gliding on β-myosin molecules presumably by a decreased dissociation rate from actin filaments.

Article

| August 24 2022

Studying the latch state at the molecular level

Megan Jean Hammell, Linda Kachmar, Zsombor Balassy, Gijs IJpma, Anne-Marie Lauzon

Using a novel assay chamber to inject myosin light chain phosphatase during laser trap measurements, tonic smooth muscle force maintenance is observed at the myosin molecular level, marking an important step toward elucidating the underlying mechanisms of the latch state.

Article | Excitation–Contraction Coupling

| August 09 2022

Ca²⁺ release propagation controls heart pacemaking

Anna V. Maltsev, Michael D. Stern, Victor A. Maltsev

The present numerical modeling study shows that disorder in locations of Ca release units in cardiac pacemaker cells has substantial functional impact by creating release clusters, similar to Poisson clumping, and opportunity of Ca release to propagate within the clusters.

Article | Excitation–Contraction Coupling

| August 08 2022

Orai1 ablation reduces dystrophy

Maricela García-Castañeda, Antonio Michelucci, Nan Zhao, Sundeep Malik, Robert T. Dirksen

Postdevelopmental, muscle-specific ablation of Orai1 in mdx mice abolishes excessive constitutive and store-operated Ca²⁺ entry, improves muscular dystrophy pathology, and promotes sarcolemmal integrity, thus demonstrating an important role of enhanced Orai1-mediated Ca²⁺ entry in exacerbating the dystrophic phenotype.

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Volume 154,

Issue 10,

3 October 2022

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Reviews & Opinions

Viewpoint

| September 01 2022

Na and K balance

Lawrence G. Palmer

The kidneys regulate transport of Na⁺ and K⁺ in complex ways to maintain the overall economies of both ions simultaneously.

Editorial | Excitation–Contraction Coupling

| August 19 2022

EC coupling in muscle

Robert T. Dirksen, David A. Eisner, Eduardo Ríos, Karin R. Sipido

The term “excitation–contraction (EC) coupling” was introduced by Alexander Sandow ( Sandow, 1952 ) as “the entire sequence of reactions—excitation, inward acting link, and activation of contraction”—in skeletal muscle. It is evidence of Sandow’s foresight that 70 years later, a large community of researchers still ...

Review | Excitation–Contraction Coupling

| August 18 2022

Calcium homeostasis and congenital myopathies

Daniela Rossi, Maria Rosaria Catallo, Enrico Pierantozzi, Vincenzo Sorrentino

This review provides an up-to-date overview of current knowledge on myopathies caused by mutations in proteins participating in excitation–contraction coupling and store-operated Ca²⁺ entry mechanisms in skeletal muscle.

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Special Collections

Biophysics 2022

A special collection highlighting recent articles addressing a wide range of biophysical questions

View Collections

Read new work on a broad range of relevant mechanisms, in all types and sources of muscle.

Piezo1 affects cholesterol during brain development.

Myosin ELC1sa decelerates actin gliding.

Call for Papers: Myofilament Function 2022.

Call for Papers: Ion Channels in Context.

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