Journal of General Physiology | Rockefeller University Press

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Submit your research by September 30, 2020 to be considered for a special issue edited by Christine Cremo, Henk Granzier, and Richard L. Moss. Learn more
Depressive effect of low Ca2+ in HyperKPP muscles
MthK Polyamine Block
Data and model reveal two pathways for voltage sensing in outer hair cells

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Newest Articles

Article

| July 07 2020

A rational mutation to investigate HCN channels in vivo

Alessandro Porro, Anna Binda, Matteo Pisoni, Chiara Donadoni, Ilaria Rivolta, Andrea Saponaro

The gating of neuronal HCN channels is modulated by the competitive binding of cAMP and TRIP8b, a brain-specific protein that also controls channel trafficking. Porro et al. identify a rational mutation in HCN channels that affects binding of TRIP8b, without altering cAMP affinity or TRIP8b-dependent trafficking. The mutation represents a valuable tool to investigate HCN channels in vivo.

Article

| June 26 2020

Functional heterogeneity in STIM1-Orai1 puncta

Joseph L. Dynes, Andriy V. Yeromin, Michael D. Cahalan

The authors use a fluorescent genetically encoded Ca2+ indicator, GCaMP6f, fused to Orai1 to visualize Ca2+ influx through store-operated Orai1 channels. Combined with whole-cell recording of transfected human cells, this reporter reveals heterogeneity of channel activation and kinetics in STIM1-Orai1 puncta within the same cell.

Article

| June 24 2020

Cholesterol organization of Piezo1 channel clusters

Pietro Ridone, Elvis Pandzic, Massimo Vassalli, Charles D. Cox, Alexander Macmillan, Philip A. Gottlieb, Boris Martinac

The essential mammalian mechanosensitive channel PIEZO1 organizes in the plasma membrane into nanometric clusters that depend on the integrity of cholesterol domains to rapidly detect applied force and especially inactivate synchronously, the most commonly altered feature of PIEZO1 in pathology.

Article

| June 22 2020

The E1784K mutant in Nav1.5 disrupts inactivation through two mechanisms

Colin H. Peters, Abeline R. Watkins, Olivia L. Poirier, Peter C. Ruben

Inheritable and de novo variants of voltage-gated sodium channels that lead to sudden cardiac death can affect several different aspects of channel function, making pharmaceutical treatment difficult. Peters et al. show that the E1784K mutant in Nav1.5 alters channel function through two distinct and separable mechanisms.

Article

| June 19 2020

Complex Zn 2+ effects on Ca v 2.3 channel function

Felix Neumaier, Serdar Alpdogan, Jürgen Hescheler, Toni Schneider

Neumaier et al. reveal that Zn2+ effects on Cav2.3 channels are complex, can be either inhibitory or stimulatory, and may persist for several minutes after cessation of the Zn2+ signal. A Markov model is developed that can account for Cav2.3 channel currents in the absence and presence of physiological Zn2+ concentrations.

Article

| May 22 2020

ENaC stimulation by prostaglandin E 2

Morag K. Mansley, Christian Niklas, Regina Nacken, Kathrin Mandery, Hartmut Glaeser, Martin F. Fromm, Christoph Korbmacher, Marko Bertog

In murine cortical collecting duct cells, prostaglandin E2 (PGE2) stimulates transepithelial sodium transport mediated by the epithelial sodium channel (ENaC). PGE2 is synthesized and secreted by the cells and acts on basolateral prostaglandin E receptor type 4 (EP4).

Article

| May 22 2020

Activation gate controls inactivation

Tibor G. Szanto, Florina Zakany, Ferenc Papp, Zoltan Varga, Carol J. Deutsch, Gyorgy Panyi

Szanto et al. propose a new gating scheme to explain how the Shaker family of voltage-gated potassium channels are inactivated at negative membrane potentials and how these channels recover from this state.

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All articles temporarily free to read. Learn about the steps we're taking and find COVID-19 relevant content.

Submit your research by September 30, 2020 to be considered for a special issue edited by Christine Cremo, Henk Granzier, and Richard L. Moss. Learn more

Depressive effect of low Ca2+ in HyperKPP muscles

MthK Polyamine Block

Data and model reveal two pathways for voltage sensing in outer hair cells

Related Articles from Rockefeller University Press

Special Collections

All articles temporarily free to read. Learn about the steps we're taking and find COVID-19 relevant content.

Submit your research by September 30, 2020 to be considered for a special issue edited by Christine Cremo, Henk Granzier, and Richard L. Moss. Learn more

Depressive effect of low Ca2+ in HyperKPP muscles

MthK Polyamine Block

Data and model reveal two pathways for voltage sensing in outer hair cells

Related Articles from Rockefeller University Press

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