Journal of General Physiology (JGP) | Rockefeller University Press

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You are invited to submit papers on the topic of the Society of General Physiologists 76th Annual Meeting.
Physiology of Pain Detection and Processing Collection 2023.
Authors can now publish in JGP free of charge or pay a fee to make their articles immediately Open Access.
Turning on TMEM16A in the Xenopus laevis fast block to polyspermy.

JGP and the Society of General Physiologists have a close and long-standing collaborative relationship.

Newest Articles

Article

| September 27 2023

Calcium sensitivity of skeletal muscle thick filament

Marco Caremani, Luca Fusi, Massimo Reconditi, Gabriella Piazzesi, Theyencheri Narayanan, Malcolm Irving, Vincenzo Lombardi, Marco Linari, Elisabetta Brunello

Thick filament structure in skeletal muscle is more sensitive to calcium than isometric force, with a higher cooperativity. A novel thick filament structure in which myosin motors take up a longer axial periodicity is formed at partial calcium activation.

Article | Excitation–Contraction Coupling

| September 26 2023

TRIC characteristics and effects on RyR2

Jianshu Hu, Elisa Venturi, Charalampos Sigalas, Takashi Murayama, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan

Hu et al. demonstrate that, independent of other countercurrents, TRIC-A and TRIC-B differentially modulate RyR2 gating. Results also suggest that TRIC-A and TRIC-B are permeable to both K⁺ and Cl⁻, thus enabling them to provide adaptable countercurrents for many cell types.

Hypothesis

| September 20 2023

Dihydropyridines in L-type Ca²⁺ channel

Denis B. Tikhonov, Boris S. Zhorov

Computational models based on different cryo-EM structures of ligand-bound calcium and sodium channels suggest that dihydropyridine antagonists stabilize entirely α-helical conformation of the pore-lining helix S6_IV, whereas agonists promote channel opening by stabilizing π-bulged helix S6_IV.

Article

| September 20 2023

Calcium binding and permeation in TRPV channels

Chunhong Liu, Lingfeng Xue, Chen Song

Using a recently developed multisite ion model, Liu et al. conducted molecular dynamics simulations to study the Ca²⁺ binding and permeation in TRPV channels. The ion binding strength and number of binding sites within the selectivity filter are found to be key factors determining the permeation patterns and probably ion selectivity.

Article | Excitation–Contraction Coupling

| September 20 2023

Visualizing and analyzing RyR2 tetramer arrays

David R.L. Scriven, Anne Berit Johnsen, Parisa Asghari, Keng C. Chou, Edwin D.W. Moore

We show that isoproterenol applied to rat ventricular myocytes produced symmetrical increases in the size of ryanodine receptor clusters, a decrease in fragmentation, and the coalescence of smaller clusters. Additionally, receptors were found in irregularly arranged arrays resembling those seen by electron tomography.

Communication

| September 20 2023

Circadian rhythm in KCNMA1 channelopathy mice models

Ria L. Dinsdale, Cooper E. Roache, Andrea L. Meredith

KCNMA1 regulates circadian rhythm in animals, and mutations in this potassium channel are associated with human neuromotor disease. Dinsdale et al. evaluated circadian clock function in three mouse models harboring KCNMA1 mutations associated with human channelopathies and found clock-controlled behavioral deficits without primary rhythm ablation.

Article

| September 19 2023

Cooperative activation of force in mammalian myocardium

Jitandrakumar R. Patel, Kayla J.V. Park, Aidan S. Bradshaw, Tuan Phan, Daniel P. Fitzsimons

The Fitzsimons lab examines the activation dependence of contractile kinetics in mouse and swine hearts. Their findings demonstrate that the cooperative mechanisms underlying contraction differ in the hearts of small and large mammals and yield insights into normal heart function.

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Current Issue

Volume 155,

Issue 10,

2 October 2023

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Reviews & Opinions

Research News

| September 13 2023

The fast block to polyspermy breaks with convention

Ben Short

JGP study reveals that conventional PLC activation pathways are not required for the fertilization-induced depolarization of Xenopus eggs that prevents the entry of additional sperm.

Perspective

| August 25 2023

The physical basis of osmosis

Gerald S. Manning, Alan R. Kay

It is surprising that osmosis, a phenomenon so central to biology, has been cloaked in misunderstanding for so long. The authors show that the most plausible account for what drives water fluxes is one put forward by Peter Debye in 1923, where the repulsion of solute molecules from the semipermeable membrane generates a pressure drop, which draws water from a chamber with low solute concentration to one that is high.

Research News

| August 16 2023

Kv12 channels flick the switch

Ben Short

JGP study shows that Kv12-encoded K⁺ currents reduce the repetitive firing rates of SCN neurons at night, thereby regulating daily oscillations in the master circadian pacemaker.

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Special Collections

Biophysics 2022

A special collection highlighting recent articles addressing a wide range of biophysical questions

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You are invited to submit papers on the topic of the Society of General Physiologists 76th Annual Meeting.

Physiology of Pain Detection and Processing Collection 2023.

Authors can now publish in JGP free of charge or pay a fee to make their articles immediately Open Access.

Turning on TMEM16A in the Xenopus laevis fast block to polyspermy.

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