Journal of Experimental Medicine (JEM) | Rockefeller University Press

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Watch our workshop featuring guest investigators, dive into a timeline of discoveries, and more.
Introducing CME Activities with JEM and Memorial Sloan Kettering Cancer Center
Targeting EYA2 Kills Glioblastoma Stem Cells
Human monoclonal GABAA receptor antibodies
Maternal microbiome impacts neonatal RSV response

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Newest Articles

Article

| December 02 2021

Microbiota–microglia–amyloid axis in AD mice

Hemraj B. Dodiya, Holly L. Lutz, Ian Q. Weigle, Priyam Patel, Julia Michalkiewicz, Carlos J. Roman-Santiago, Can Martin Zhang, Yingxia Liang, Abhinav Srinath, Xulun Zhang, Jessica Xia, Monica Olszewski, Xiaoqiong Zhang, Matthew John Schipma, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, Sangram S. Sisodia

Dodiya et al. characterize an APPPS1-21 mouse model of Aβ amyloidosis with an antibiotic-perturbed microbiome. Fecal transplantation approaches and microglial depletion studies are employed to establish the causality between the gut microbiota, microglia, Aβ, and neurodegeneration.

Article

| November 30 2021

Macrophage-derived GDF-15 in muscle regeneration

Andreas Patsalos, Laszlo Halasz, Miguel A. Medina-Serpas, Wilhelm K. Berger, Bence Daniel, Petros Tzerpos, Máté Kiss, Gergely Nagy, Cornelius Fischer, Zoltan Simandi, Tamas Varga, Laszlo Nagy

Regenerative inflammation in skeletal muscle drives macrophage specification via a regeneration-promoting program. A growth factor–expressing macrophage population develops, producing GDF-15 under the control of RXR and PPARγ. GDF-15 acts as an autocrine and paracrine factor coordinating myoblast proliferation and myeloid cell invasion and activity.

Article

| November 30 2021

3K3A-APC protects ischemic white matter

Mikko T. Huuskonen, Yaoming Wang, Angeliki Maria Nikolakopoulou, Axel Montagne, Zhonghua Dai, Divna Lazic, Abhay P. Sagare, Zhen Zhao, Jose A. Fernandez, John H. Griffin, Berislav V. Zlokovic

3K3A-APC has shown promise in human ischemic stroke. Present data support that 3K3A-APC could very well be the first therapeutic agent at our disposal to prevent and/or treat white matter strokes, a major cause of human disability, including cognitive dysfunction.

Article

| November 26 2021

WEE1 inhibition induces anti-tumor immunity

Ensong Guo, Rourou Xiao, Yifan Wu, Funian Lu, Chen Liu, Bin Yang, Xi Li, Yu Fu, Zizhuo Wang, Yuan Li, Yuhan Huang, Fuxia Li, Xue Wu, Lixin You, Tianyu Qin, Yiling Lu, Xiaoyuan Huang, Ding Ma, Gordon B. Mills, Chaoyang Sun, Gang Chen

WEE1 inhibition modulates the efficacy of cancer immunotherapy by regulating dsRNA and interferon responses, which increases recruitment of anti-tumor T cells with concurrent PD-L1 elevation. This study provides a rationale for combination strategies between WEE1 inhibitors and anti–PD-L1 therapies.

Article

| November 24 2021

The DCIR-NA2 in the immune and bone system

Tomonori Kaifu, Rikio Yabe, Takumi Maruhashi, Soo-Hyun Chung, Hiroaki Tateno, Noriyuki Fujikado, Jun Hirabayashi, Yoichiro Iwakura

Asialo-biantennary N-glycan is identified as a ligand for the inhibitory C-type lectin receptor DCIR, which is important for the homeostasis of the immune and bone system. The interaction between DCIR and asialo-biantennary N-glycans negatively regulates antigen presentation by DCs and osteoclastogenesis.

Brief Definitive Report

| November 24 2021

No fast PU.1 autoregulation in HSPCs in vitro

Nouraiz Ahmed, Martin Etzrodt, Philip Dettinger, Tobias Kull, Dirk Loeffler, Philipp S. Hoppe, James S. Chavez, Yang Zhang, Germán Camargo Ortega, Oliver Hilsenbeck, Hideaki Nakajima, Eric M. Pietras, Timm Schroeder

By manipulating and quantifying the dynamics of PU.1 protein expression in live differentiating adult HSPCs in vitro, Ahmed et al. report that PU.1 upregulation is not caused by fast direct autoregulation but occurs as a later consequence of hematopoietic differentiation.

Article

| November 23 2021

NR2F1 agonist induces cancer cell dormancy

Bassem D. Khalil, Roberto Sanchez, Tasrina Rahman, Carolina Rodriguez-Tirado, Stefan Moritsch, Alba Rodriguez Martinez, Brett Miles, Eduardo Farias, Mihaly Mezei, Ana Rita Nobre, Deepak Singh, Nupura Kale, Karl Christoph Sproll, Maria Soledad Sosa, Julio A. Aguirre-Ghiso

Computational screening identifies a novel agonist for NR2F1, a master activator of cancer cell dormancy. Agonist-mediated activation of NR2F1 induces a novel long-lived dormancy program with neural crest-like features and prevents disseminated squamous carcinoma cancer cell progression to overt metastasis.

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NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation

Snehlata Kumari ... Manolis Pasparakis | Life Sci. Alliance

TNFR1 was found to cause skin inflammation in mice with epidermal keratinocyte-specific ablation of IKK2 or of both the NF-kB subunits RelA and cRel by triggering RIPK1-dependent, RIPK3-MLKL–mediated necroptosis of keratinocytes.
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Current Issue

Volume 218,

Issue 11,

November 1, 2021

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Insights

| November 30 2021

Helminths make themselves at home

Elia D. Tait Wojno

Drurey et al. show that excretory/secretory products from the parasitic helminth Heligmosomoides polygyrus suppress the host-protective small intestinal epithelial response.

Viewpoint

| November 22 2021

Can repurposing drugs play a role in malaria control?

Roland A. Cooper, Laura Kirkman

Laura Kirkman and Roland Cooper discuss how repurposing drugs can play a role in controlling malaria.

Insights

| November 18 2021

Making memories with Bcl-6

Kaitlin A. Read, Kenneth J. Oestreich

Mutual antagonism between the transcriptional repressors Bcl-6 and Blimp-1 has been appreciated as a key mechanistic determinant of lymphoid differentiation programs. Now, in this issue of JEM, Ciucci et al. demonstrate that this relationship is central to the generation of T cell memory.

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Special Collections

The Year in Experimental Medicine

Our annual Best of JEM series, featuring articles that were of great interest to our readers..

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Watch our workshop featuring guest investigators, dive into a timeline of discoveries, and more.

Introducing CME Activities with JEM and Memorial Sloan Kettering Cancer Center

Targeting EYA2 Kills Glioblastoma Stem Cells

Human monoclonal GABAA receptor antibodies

Maternal microbiome impacts neonatal RSV response

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