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Article
Laura Mathä et al.
Mathä et al. report a resting CD127CD45RO+ ILC2 population in humans that exhibits features of memory cells. These memory ILC2s are present in the circulation and tissues of healthy individuals and patients with chronic type 2 inflammation.
Article
Jonathan J. Hodgins et al.
Cell-intrinsic PD-L1 signaling inhibits the type I interferon pathway in cancer cells via a mechanism that involves metabolic alterations. PD-L1 activity is triggered by a variety of stimuli, including PD-L1 antibodies, and ultimately increases the efficacy of oncolytic virus therapy.
Brief Definitive Report
Clémence David et al.
David et al. describe UNC93B1 missense substitutions causing systemic lupus erythematosus or chilblain lupus, inherited as either autosomal dominant or autosomal recessive traits. In vitro and ex vivo assays show that these variants confer differential hypermorphic TLR7 and TLR8 signaling.
Article
Kelsey A. Toth et al.
STAT3 gain-of-function syndrome causes early-onset autoimmunity and immune dysregulation in patients. Here, we report spontaneous and stimulus-driven skin disease in a mouse model associated with locally increased Th17 that is partially dependent on IL-22 signaling.
Article
Lingzi Hong et al.
Hong et al. report that IL-17/Act1 induces chemoresistance by modulating redox homeostasis through epitranscriptomic regulation of antioxidant RNA metabolism. Antisense oligonucleotide that specifically disrupts Act1’s binding to Wtap mRNA inhibits IL-17/Act1–WTAP-mediated antioxidant protein production, offering a potential therapeutic strategy for chemoresistance.
Article
Pooja Parameswaran et al.
The guard protein NLRP1 senses pathogen-encoded effector activities, but whether successful pathogens evade the consequences of NLRP1 activation is less clear. Parameswaran et al. demonstrate that HSV-1 inhibits the antiviral NLRP1 pathway via production of a viral E3 ubiquitin ligase.
Technical Advances and Resources
Michelle A. Tran et al.
Tran et al. use single-cell RNA-sequencing to discover diverse immune cell populations in bladder cancer patient urine that have highly similar gene expression programs to those in tumor.
Issue Cover
Current Issue
Volume 221,
Issue 6,
3 June 2024
Reviews & Opinions
People & Ideas
Lucie Van Emmenis
Linda-Gail Bekker is a professor, chief executive officer of the Desmond Tutu HIV Foundation, and director of the Desmond Tutu HIV Centre at the Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa. Her research interests include HIV treatment and prevention and tuberculosis, and she is active in developing community projects to promote education and research. We talked to Linda-Gail about her career, the importance of mentorship, and how rewarding it is to collaborate, mentor, and uplift other scientists.
Insights
Justin Taft, Dusan Bogunovic
In this issue, two studies report the analysis of seven patient variants combined with a comprehensive alanine screen and reveal that different regions of UNC93B1 selectively regulate different TLRs.
Viewpoint
Clarissa Campbell et al.
This year at JEM, we are highlighting women in science by sharing their stories and amplifying their voices. In this Viewpoint, we hear from a cross section of women, across multiple research fields, discussing their science and the process of setting up a lab as an independent researcher.

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