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Kellen J. Cavagnero et al.
Cavagnero et al. use single-cell transcriptomics to identify dermal immune acting fibroblast (IAF) subsets that communicate with neutrophils during type 17 inflammation. Fibroblast-specific deletion of Il17ra in mice and analysis of human skin following anti–IL-17 demonstrate that such CXCL12+ IAFs play an important role in neutrophil recruitment.
Article
Rina Matsuda et al.
Monocytes restrict Yersinia infection within intestinal pyogranulomas. Here, we report that monocyte-intrinsic TNF signaling drives the production of IL-1 that signals non-hematopoietic cells to control intestinal Yersinia infection within pyogranulomas.
Brief Definitive Report
Mariah Hassert et al.
Lung resident memory CD8+ T cells (TRM) control heterosubtypic influenza infection and potentially cancer. We show that thorax-targeted irradiation depletes lung TRM and diminishes protection, but spares circulating memory CD8+ T cells that can be boosted to regenerate lung TRM.
Brief Definitive Report
Cuifeng Li et al.
This study illuminates that TRPV2 augments B cell activation and function through membrane depolarization and cytoskeletal remodeling. Consequently, TRPV2 is implicated in antibody responses and SLE. The study underscores the indispensable role of TRPV2 in immune regulation and potential therapeutic interventions.
Article
Lei Wang et al.
The study introduces a new immunotherapy for treating melanoma and other cancers by developing a PROTAC that degrades NR4A1, an intracellular nuclear factor that plays a crucial role in immune suppression.
Article
Zhen Qin et al.
TCR signaling (signal 1) induces STAT3 phosphorylation through Lck/Fyn and, synergistically with cytokine signal (signal 3), induces optimal STAT3 phosphorylation to drive TH17 cell differentiation. Selective inhibition of TCR stimulation–induced STAT3 phosphorylation significantly inhibits TH17 differentiation and ameliorates TH17 cell–related autoimmune diseases.
Brief Definitive Report
Kaiyi Zhang et al.
Shedding of infected enterocytes into the gut lumen is a hallmark of the adult mucosal antimicrobial response. In contrast, enterocyte shedding is rare in the neonatal intestine. Instead, we observe internalization and degradation of infected enterocytes by neighboring epithelial cells.
Issue Cover
Current Issue
Volume 221,
Issue 2,
5 February 2024
Reviews & Opinions
People & Ideas
Lucie Van Emmenis
Rita Colwell is a Distinguished University Professor at the University of Maryland at College Park and at Johns Hopkins University Bloomberg School of Public Health, and president of the Rosalind Franklin Society. She has authored or co-authored 20 books and more than 800 scientific publications, and throughout her career has focused on improving health outcomes across the world and highlighting the impacts of infectious diseases in drinking/bathing water. We recently spoke to Rita about her career and her thoughts about the future for women in science.
Review
Maurice Reimann et al.
Cellular senescence is a stress-inducible terminal cell-cycle arrest program with far-reaching pathophysiologic implications. This Review summarizes the evidence that senescent cells need to actively maintain their arrest machinery and discusses the consequences if these epigenome-remodeled cells resume proliferation in a “post-senescent” condition.
Insights
Melanie Lancien, Mathias Lichterfeld
Kufera et al. demonstrate that proliferative growth of cells infected with genome-intact HIV-1 is not limitless; rather, these cells seem to be at least partially refractory to TCR stimulation.

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