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Brief Definitive Report
Stephan Culemann et al.
The authors show that the anti-inflammatory effects of clodronate liposomes do not result from the depletion of mononuclear phagocytes but from a functional stunning of polymorphonuclear neutrophils. These findings necessitate a critical revision of the current literature on the role of monocytes and macrophages in inflammation.
Article
Garrett R. Overcast et al.
This study characterizes the dual role of IL-1R signaling in IECs during C. rodentium infection and DSS-induced colitis. IEC-intrinsic IL-1R signaling enhances IL-22–induced AMPs for protection but contributes to damage-induced inflammation through induction of chemokines and ROS genes.
Article
Alev Baysoy et al.
This work provides a compendium of early transcriptional responses to “common-gamma-chain” cytokines across all major immunocyte lineages of the mouse.
Brief Definitive Report
Ying Liu et al.
The mechanism of Ca2+ release from ER in resting cells was unclear. Liu et al. demonstrate that VMP1 is required for ER Ca2+ release in resting cells, and VMP1 deficiency in T cells leads to ER Ca2+ overload and massive apoptosis.
Article
Chong Zuo et al.
Stromal desmoplasia drives local proliferation of TAMs and induces their immunosuppressive ability through altering p21 expression. These changes in p21 in TAMs also potentially render tumors more sensitive to CD40 agonist therapy.
Brief Definitive Report
Kavita Rawat et al.
Both DCs and monocytes capture antigen for presentation to lymph node T cells. Here, Rawat et al. show that DCs use the chemokine receptor CCR7, while monocytes follow chemokines secreted by migratory DCs to reach the nodes and control immunity.
Article
Tina Nguyen et al.
Detailed analysis of patients with APDS2 and a novel mouse model of Pik3r1 LOF reveals multiple cellular defects, some of which are unique to APDS2 and not seen in APDS1. This is associated with unique signaling changes caused by Pik3r1 LOF.

Related Articles from Rockefeller University Press

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Current Issue
Volume 220,
Issue 3,
6 March 2023
Reviews & Opinions
Insights
Elvira Mass
Not only macrophages, but also neutrophils, are a main target of clodronate. In this issue of JEM, Culemann et al. demonstrate that anti-inflammatory effects of clodronate liposomes are driven via stunning of polymorphonuclear neutrophils and not solely through depletion of macrophages.
People & Ideas
Lucie Van Emmenis
Soyon Hong is a group leader at the UK Dementia Research Institute at UCL. Her lab is interested in investigating how cell types work together to maintain brain function, and how these interactions are dysregulated during neurodegenerative disease states such as Alzheimer’s disease.
Insights
Samuel W. Du, Krzysztof Palczewski
CRISPR/Cas9 genome editing techniques have the potential to treat previously untreatable inherited genetic disorders of vision by correcting mutations that cause these afflictions. Using a prime editor, Qin et al. restored visual functions in a mouse model (rd10) of retinitis pigmentosa.

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