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Ming-Chao Zhong, Yan Lu, Jin Qian, Yingzi Zhu, Lingli Dong, Astrid Zahn, Javier M. Di Noia, Danielle Karo-Atar, Irah L. King, André Veillette
Zhong et al. show that the SLAM family of receptors is critical for T cell–dependent humoral immunity due to its ability to enhance expression of pro-survival effectors such as Bcl-2 and BCR in germinal center B cells.
Article
Raud Razzaghi, Shreya Agarwal, Nikita Kotlov, Olga Plotnikova, Krystle Nomie, Da Wei Huang, George W. Wright, Grace A. Smith, Moyi Li, Katsuyoshi Takata, Maryam Yamadi, Chen Yao, John J. O’Shea, James D. Phelan, Stefania Pittaluga, David W. Scott, Jagan R. Muppidi
The role of Fas in germinal center (GC) homeostasis is controversial. Razzaghi et al. show that Fas is a strong cell-intrinsic regulator of the GC and that its loss defines an aggressive subtype of GC-derived lymphoma.
Brief Definitive Report
Tamara S. Rodrigues, Keyla S.G. de Sá, Adriene Y. Ishimoto, Amanda Becerra, Samuel Oliveira, Leticia Almeida, Augusto V. Gonçalves, Debora B. Perucello, Warrison A. Andrade, Ricardo Castro, Flavio P. Veras, Juliana E. Toller-Kawahisa, Daniele C. Nascimento, Mikhael H.F. de Lima, Camila M.S. Silva, Diego B. Caetite, Ronaldo B. Martins, Italo A. Castro, Marjorie C. Pontelli, Fabio C. de Barros, Natália B. do Amaral, Marcela C. Giannini, Letícia P. Bonjorno, Maria Isabel F. Lopes, Rodrigo C. Santana, Fernando C. Vilar, Maria Auxiliadora-Martins, Rodrigo Luppino-Assad, Sergio C.L. de Almeida, Fabiola R. de Oliveira, Sabrina S. Batah, Li Siyuan, Maira N. Benatti, Thiago M. Cunha, José C. Alves-Filho, Fernando Q. Cunha, Larissa D. Cunha, Fabiani G. Frantz, Tiana Kohlsdorf, Alexandre T. Fabro et al.
This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients. Activation of inflammasomes in moderate and severe cases of COVID-19 contributes to the exacerbated inflammatory response, impacting disease progression and clinical outcome.
Brief Definitive Report
Wakako Kuribayashi, Motohiko Oshima, Naoki Itokawa, Shuhei Koide, Yaeko Nakajima-Takagi, Masayuki Yamashita, Satoshi Yamazaki, Bahityar Rahmutulla, Fumihito Miura, Takashi Ito, Atsushi Kaneda, Atsushi Iwama
Kuribayashi et al. demonstrate that the engraftment of aged hematopoietic stem cells into intact young niche largely rejuvenates their transcriptional profile but does not restore their function, highlighting a key role for age-associated cell-intrinsic defects in HSC aging.
Brief Definitive Report
Atar Lev, Yu Nee Lee, Guangping Sun, Enas Hallumi, Amos J. Simon, Keren S. Zrihen, Shiran Levy, Tal Beit Halevi, Maria Papazian, Neta Shwartz, Ido Somekh, Sarina Levy-Mendelovich, Baruch Wolach, Ronit Gavrieli, Helly Vernitsky, Ortal Barel, Elisheva Javasky, Tali Stauber, Chi A. Ma, Yuan Zhang, Ninette Amariglio, Gideon Rechavi, Ayal Hendel, Deborah Yablonski, Joshua D. Milner, Raz Somech
SLP76 is a key molecule involved in the T cell signaling pathway; therefore, SLP76 deficiency can lead to a severe type of immunodeficiency. By reporting on a patient with germline mutation in SLP76, deficiency in this gene is linked, for the first time, to a human disease.
Article
Katharina Richard, Kurt H. Piepenbrink, Kari Ann Shirey, Archana Gopalakrishnan, Shreeram Nallar, Daniel J. Prantner, Darren J. Perkins, Wendy Lai, Alexandra Vlk, Vladimir Y. Toshchakov, Chiguang Feng, Rachel Fanaroff, Andrei E. Medvedev, Jorge C.G. Blanco, Stefanie N. Vogel
We developed mice expressing Tlr4 SNPs homologous to those expressed in humans and associated with infectious and inflammatory diseases. Cellular and molecular analyses of TLR4 signaling in wild-type vs. TLR4-SNP mice revealed novel mechanisms of LPS hyporesponsiveness and altered disease susceptibility.
Article
Alexandra Schäfer, Frauke Muecksch, Julio C.C. Lorenzi, Sarah R. Leist, Melissa Cipolla, Stylianos Bournazos, Fabian Schmidt, Rachel M. Maison, Anna Gazumyan, David R. Martinez, Ralph S. Baric, Davide F. Robbiani, Theodora Hatziioannou, Jeffrey V. Ravetch, Paul D. Bieniasz, Richard A. Bowen, Michel C. Nussenzweig, Timothy P. Sheahan
Human monoclonal antibody potency in vitro does not uniformly correlate with its in vivo neutralization of SARS-CoV-2. Antibody Fc-effector function is important for in vivo neutralization, and antibody combinations show superior efficacy compared with single antibodies.

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Current Issue
Volume 217,
Issue 11,
November 2, 2020
Reviews & Opinions
Found in Translation
Tamara Laskowski, Katayoun Rezvani
Tamara Laskowski and Katayoun Rezvani discuss the recent advances of adoptive cell therapy in cancer.
Insights
Jeremy F. Brooks, Julie Zikherman
The pathways involved in the persistence of memory B cells are largely unknown. In this issue, two groups (Müller-Winkler et al. and Lau et al.) take complementary approaches to identify an essential role for BAFFR in the survival of memory B cells.
Insights
Megan Bywater, Steven W. Lane
Arsenic trioxide in combination with IFNα is able to deplete MPN stem cells, leading to reduced transplantation and even long-term treatment-free remission in disease control.

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