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2025: The Year in Experimental Medicine
Our annual Best of JEM series highlights research in basic immunology, immunotherapy and tumor immunology, inborn errors of immunity, neurodegeneration, and inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward and we are pleased to present some of the most exciting studies published over the last 12 months.
We would like to use this opportunity to thank our authors, reviewers, and reader for your interest and continued support for JEM. We hope you enjoy reading this collection, and we invite you to follow JEM on Bluesky at @jem.org. We are also on X/Twitter at @JExpMed. To learn more about JEM or to submit your research, please visit our Instructions for Authors or reach out to our team of editors. Sign up to receive future special collections here.
Article
Volodymyr Stetsenko; Daniel P. Gail; Scott M. Reba; Vinicius G. Suzart; Robert Schauner; Avinaash K. Sandhu; Alessandro Sette; Mohammad Haj Dezfulian; Cecilia S. Lindestam Arlehamn; Stephen M. Carpenter
Brief Definitive Report
Qing Chang; Li Ma; Ziying Lin; Yang Shu; Pao-Fen Ko; Matthew Blumberg; Jian-Fu Chen
Article
Kevin Wilhelmsen; Aditi Deshpande; Sarah Tronnes; Maitriyee Mahanta; Matthew Banicki; Mary Cochran; Samantha Cowdin; Kristen Fortney; George Hartman; Robert E. Hughes; Rusty Montgomery; Claudia P. Portillo; Paul Rubin; Taiz Salazar; Yan Wang; Shijun Yan; Barry A. Morgan; Assem Duisembekova; Romane Riou; Michael Marleaux; Inga V. Hochheiser; Hannes Buthmann; Dominic Ferber; Jane Torp; Wei Wang; Melanie Cranston; Chloe M. McKee; Thea J. Mawhinney; Emma C. McKay; Fehime K. Eroglu; Jasmin Kümmerle-Deschner; Alexander N.R. Weber; Bénédicte F. Py; Matthias Geyer; Rebecca C. Coll
Article
Marjon Wouters; Lisa Ehlers; Wout Van Eynde; Meltem Ece Kars; Selket Delafontaine; Verena Kienapfel; Mariia Dzhus; Rik Schrijvers; Petra De Haes; Sofie Struyf; Giorgia Bucciol; Yuval Itan; Alexandre Bolze; Arnout Voet; Anneleen Hombrouck; Leen Moens; Benson Ogunjimi; Isabelle Meyts
Article
Jonathan R. McDaniel; William N. Voss; Georgina Bowyer; Scott A. Rush; Alexandra J. Spencer; Duncan Bellamy; Marta Ulaszewska; Jule Goike; Scott Gregory; C. Richter King; Jason S. McLellan; Adrian V.S. Hill; George Georgiou; Katie J. Ewer; Gregory C. Ippolito
Article
Xiaoyun Li; Sofie Hedlund Møller; Jaeoh Park; Yu-Ming Chuang; Pei-Chun Hsueh; Tzu-Hsuan Chang; Kung-Chi Kao; Hector Gallart-Ayala; Yi-Hao Wang; Jhan-Jie Peng; Alessio Bevilacqua; Yi-Ru Yu; Zhiyu Li; Yann Kieffer; Domitille Peigney; Hugo Croizer; Yingxi Xu; Alfred Zippelius; Isabel C. Lopez-Mejia; Lluis Fajas; Fatima Mechta-Grigoriou; Julijana Ivanisevic; Zhengtao Xiao; Ming-Chih Ho; Ying-Chun Shen; Ping-Chih Ho
Article
Ahmed Kabil; Natalia Nayyar; Chengxi Xu; Julyanne Brassard; Lesley A. Hill; Samuel B. Shin; Sameeksha Chopra; Bernard Lo; Yicong Li; Mya Bal; Marine Theret; Fabio M.V. Rossi; T. Michael Underhill; Michael R. Hughes; Kelly M. McNagny
Article
Chae Won Kim; Hyun-Jin Kim; In Kang; Keun Bon Ku; Yumin Kim; Jang Hyun Park; Juhee Lim; Byeong Hoon Kang; Won Hyung Park; Jeongwoo La; Sungwoo Chang; Inju Hwang; Minji Kim; Stephen Ahn; Heung Kyu Lee
Article
Åsa Johansson; Mahadevan Venkita Subramani; Bahtiyar Yilmaz; Elisabeth E.L. Nyström; Elena Layunta; Liisa Arike; Felix Sommer; Philip Rosenstiel; Lars Vereecke; Louise Mannerås-Holm; Andy Wullaert; Thaher Pelaseyed; Malin E.V. Johansson; George M.H. Birchenough
Article
Im-Hong Sun; Anita E. Qualls; Han S. Yin; Jiaxi Wang; Matthew P. Arvedson; Joe Germino; Nolan K. Horner; Sheng Zhong; Juan Du; Martin Valdearcos; Vasilis Ntranos; Richard M. Locksley; Roberto R. Ricardo-Gonzalez; James M. Gardner
Article
Sirimuvva Tadepalli; Derek R. Clements; Hayley M. Raquer-McKay; Anja Lüdtke; Sanjana Saravanan; David Seong; Lorraine Vitek; Christopher M. Richards; Jan E. Carette; Matthias Mack; Andres Gottfried-Blackmore; Edward E. Graves; Juliana Idoyaga
Article
Kevin Groen; Roger Kuratli; Jannik Enkelmann; Sonja Fernbach; Pedro D. Wendel-Garcia; Willy I. Staiger; Marylène Lejeune; Esther Sauras-Colón; Ferran Roche-Campo; Paraskevas Filippidis; Andri Rauch; Swiss HIV Cohort Study; Alexandra Trkola; Huldrych F. Günthard; Roger D. Kouyos; Silvio D. Brugger; Benjamin G. Hale
Article
Benjamin J. Broomfield; Chin Wee Tan; Raymond Z. Qin; Hanna Abberger; Brigette C. Duckworth; Carolina Alvarado; Lennard Dalit; Chee Leng Lee; Rekha Shandre Mugan; Zihnil A.I. Mazrad; Hiromi Muramatsu; Liana Mackiewicz; Bailey E. Williams; Jinjin Chen; Asuka Takanashi; Stewart Fabb; Marc Pellegrini; Kelly L. Rogers; Woohyun J. Moon; Colin W. Pouton; Melissa J. Davis; Stephen L. Nutt; Norbert Pardi; Verena C. Wimmer; Joanna R. Groom
Brief Definitive Report
Hannah Peckham; Anna Radziszewska; Justyna Sikora; Nina M. de Gruijter; Restuadi Restuadi; Melissa Kartawinata; Lucia Martin-Gutierrez; George A. Robinson; Claire T. Deakin; Lucy R. Wedderburn; Elizabeth C. Jury; Gary Butler; Emma S. Chambers; Elizabeth C. Rosser; Coziana Ciurtin
Article
Qing Wang; Francesco Boccalatte; Jason Xu; Giovanni Gambi; Bettina Nadorp; Fatema Akter; Carea Mullin; Ashley F. Melnick; Elizabeth Choe; Anna C. McCarter; Nicole A. Jerome; Siyi Chen; Karena Lin; Sarah Khan; Rohan Kodgule; Jonathan H. Sussman; Petri Pölönen; Javier Rodriguez-Hernaez; Sonali Narang; Kleopatra Avrampou; Bryan King; Aristotelis Tsirigos; Russell J.H. Ryan; Charles G. Mullighan; David T. Teachey; Kai Tan; Iannis Aifantis; Mark Y. Chiang
Brief Definitive Report
Amir Ferry; Kianoosh M. Mempel; Alexander Monell; Miguel Reina-Campos; Nicole E. Scharping; Maximilian Heeg; Kennidy K. Takehara; Shiruyeh Schokrpur; Ning Kuo; Robert Saddawi-Konefka; J. Silvio Gutkind; Ananda W. Goldrath
Technical Advances and Resources
Márcia Mesquita Peixoto; Francisca Soares-da-Silva; Valentin Bonnet; Yanping Zhou; Gustave Ronteix; Rita Faria Santos; Marie-Pierre Mailhe; Gonçalo Nogueira; Xing Feng; João Pedro Pereira; Emanuele Azzoni; Giorgio Anselmi; Marella F.T.R. de Bruijn; Archibald Perkins; Charles N. Baroud; Perpétua Pinto-do-Ó; Ana Cumano
