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Isabell Schneider, Marta de Ruijter-Villani, M. Julius Hossain, Tom A.E. Stout, Jan Ellenberg
Schneider and de Ruijter-Villani et al. demonstrate that two spindles assemble around the parental genomes in bovine zygotes even though, like human zygotes, they inherit centrioles from the sperm. The two independent microtubule arrays form by self-organization with only loosely connected centrosomes.
Article
Daisuke Nanba, Fujio Toki, Kyosuke Asakawa, Hiroyuki Matsumura, Ken Shiraishi, Koji Sayama, Kyoichi Matsuzaki, Hiroshi Toki, Emi K. Nishimura
Nanba et al. demonstrate that the age-dependent decline of EGFR signaling impairs epidermal stem cell motility and reepithelialization through COL17A1 proteolysis. The resulting alteration of epidermal stem cell dynamics is involved in the decline of skin regenerative capacity with aging.
Article
Carolyn M. Kelly, Laura J. Byrnes, Niharika Neela, Holger Sondermann, John P. O’Donnell
Kelly et al. identify the hypervariable region of atlastins as a partially structured segment that in human atlastin-1 contributes to membrane tethering efficiency and is a site for distinct phosphorylation events, suggesting a mode of regulation by post-translational modification of the enzyme in cells.
Article
Emir Bozkurt, Heiko Düssmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H.M. Prehn
Bozkurt et al. find that besides activating apoptosis, TRAIL signaling induces entosis in colon cancer cells through TRAIL receptors and structural presence but not catalytic activity of caspase-8. Moreover, they provide evidence for an association of TRAIL signaling, cell-in-cell structures, and clinical outcome in CRC.
Article
Sachin Surve, Simon C. Watkins, Alexander Sorkin
Ras GTPases are key membrane-associated elements of the EGFR-MAPK signaling pathway. Surve et al. demonstrate that endogenous KRAS and NRAS are predominantly localized to the plasma membrane and its tubular shaped protrusions and show that a small pool of surface EGFRs sustain signaling along the RAS-MAPK pathway, whereas internalized EGFRs do not significantly contribute to MAPK activity.
Article
Leslie A. Sepaniac, Whitney Martin, Louise A. Dionne, Timothy M. Stearns, Laura G. Reinholdt, Jason Stumpff
Kif18a mutant mice produce micronuclei following segregation of unaligned chromosomes but do not spontaneously form tumors. KIF18A KO cells form stable micronuclear envelopes around lagging chromosomes located near the spindle pole and outside the midzone. These data suggest stable micronuclei may not actively promote tumorigenesis.
Article
Chen Chen, Yoshiaki Yamanaka, Koji Ueda, Peiying Li, Tamami Miyagi, Yuichiro Harada, Sayaka Tezuka, Satoshi Narumi, Masahiro Sugimoto, Masahiko Kuroda, Yuhei Hayamizu, Kohsuke Kanekura
Chen et al. provide a novel insight on how poly(PR) dipeptides from C9orf72 gene exert cytotoxicity. The alternate distribution of Arg facilitates multivalent protein–protein interactions with proteins harboring acidic motifs and disturbs their functions through entrapment in the phase-separated droplets.

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Current Issue
Volume 220,
Issue 9,
September 6, 2021
Reviews & Opinions
People & Ideas
Lucia Morgado-Palacin
Ye Tian investigates how mitochondrial stress signaling pathways regulate longevity using C. elegans as a model system.
Spotlight
Claudiu Andrei Cozmescu, Paul Gissen
Cozmescu and Gissen highlight work from Belicova et al., which shows that the hepatocyte apical membrane produces Rab35-dependent extensions important for bile canaliculi formation.
Spotlight
Yeojin Lee, Lei Ding
Lee and Ding highlight work from Hao et al. describing that membrane-bound stem cell factor synergizes with VCAM-1 to induce polarized protrusions that regulate adhesion in hematopoietic stem cells.

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