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Newest Articles
Qiuyuan Yin, Youli Jian, Meng Xu, Xiahe Huang, Niya Wang, Zhifang Liu, Qian Li, Jinglin Li, Hejiang Zhou, Lin Xu, Yingchun Wang, Chonglin Yang
How lysosomes change their numbers for cell division is unknown. Yin et al. reveal that lysosome numbers increase in the S and G2/M phases in the cell cycle and the cyclin-dependent kinases CDK4/6 regulate lysosome biogenesis through TFEB/TFE3.
Mitsutoshi Nakamura, Jeffrey M. Verboon, Clara L. Prentiss, Susan M. Parkhurst
The centralspindlin complex, comprising Tumbleweed RhoGAP and kinesin-like Pavarotti proteins, associates with microtubules during cytokinesis. Nakamura et al. show that Pavarotti has centralspindlin complex–independent functions, binds directly to actin, and regulates actin dynamics during cell wound repair and oogenesis.
Yanmei Qi, Jie Liu, Joshua Chao, Peter A. Greer, Shaohua Li
The tumor suppressor PTEN is essential for epithelial morphogenesis. Qi et al. identify Abi1, a core adaptor protein in the WAVE regulatory complex, as a new PTEN substrate. PTEN dephosphorylates Abi1 and causes Abi1 degradation through calpains and thus down-regulates the WAVE regulatory complex to induce epithelial differentiation and polarization.
Isaac S. Chan, Hildur Knútsdóttir, Gayathri Ramakrishnan, Veena Padmanaban, Manisha Warrier, Juan Carlos Ramirez, Matthew Dunworth, Hao Zhang, Elizabeth M. Jaffee, Joel S. Bader, Andrew Josef Ewald
Chan et al. show that natural killer (NK) cells can be reprogrammed by breast cancer cells to promote metastasis. Reprogramming can be blocked by targeting NK cell inhibitory receptors TIGIT or KLRG1 or inhibiting DNA methyltransferases, which suggests new approaches to prevent or treat metastasis.
Keyu Chen, Rui Yang, Rui Yang, Yubing Li, Jin Chuan Zhou, Mingjie Zhang
Chen et al. identified a bipartite motif from the 440-kD giant ankyrin-B, which bundles and avidly binds to microtubules in vitro. They further demonstrated that giant ankyrin-B suppresses axon collateral branching and prevents microtubule invasion of nascent axon branches through direct interaction with microtubules.
Gilles Moulay, Jeanne Lainé, Mégane Lemaître, Masayuki Nakamori, Ichizo Nishino, Ghislaine Caillol, Kamel Mamchaoui, Laura Julien, Florent Dingli, Damarys Loew, Marc Bitoun, Christophe Leterrier, Denis Furling, Denis Furling, Stéphane Vassilopoulos, Stéphane Vassilopoulos
A single alternatively spliced exon in the CLTC gene contributes to clathrin coat organization. This event participates in the plasticity from clathrin-coated pits to plaques, structures that are essential for muscle fiber function and maintenance.
Yu-Yang Jiang, Wolfgang Maier, Uzoamaka N. Chukka, Michael Choromanski, Chinkyu Lee, Ewa Joachimiak, Dorota Wloga, Wayland Yeung, Natarajan Kannan, Joseph Frankel, Jacek Gaertig
Jiang and colleagues investigate how locations of sites of organelle assembly are determined during cell division in the ciliate Tetrahymena thermophila. They find that correct placement of new organelles involves antagonistic influences of a cyclin E and a Hippo/Mst kinase.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 7,
July 6, 2020
Reviews & Opinions
Jack Houston, Pablo Lara-Gonzalez, Arshad Desai
Houston et al. synthesize recent work analyzing Mad1–cyclin B1 complex function in mitosis.
Michelle Grace Acoba, Nanami Senoo, Steven M. Claypool
In this review, Acoba et al. discuss the surprisingly complicated mechanisms, regulation, and functions of mitochondrial membrane building.
Nobuo N. Noda, Zheng Wang, Hong Zhang
Zhang and colleagues summarize phase separation and transition in the assembly of autophagosome formation sites and triage of protein condensates for degradation.

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