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Chiara Galloni, Davide Carra, Jasmine V.G. Abella, Svend Kjær, Pavithra Singaravelu, David J. Barry, Naoko Kogata, Christophe Guérin, Laurent Blanchoin, Michael Way
Galloni, Carra, et al. demonstrate that Arp3B isoform–specific Arp2/3 complexes generate branched actin networks with faster disassembly kinetics. This increased turnover is due to oxidation of Met293 of Arp3B by the methionine monooxygenase MICAL2, which is recruited to the branched actin network by coronin 1C.
Article
Artem K. Velichko, Natalia Ovsyannikova, Nadezhda V. Petrova, Artem V. Luzhin, Maria Vorobjeva, Alexey S. Gavrikov, Alexander S. Mishin, Igor I. Kireev, Sergey V. Razin, Omar L. Kantidze
Although replication stress response has been extensively studied, almost nothing is known about the replication stress response in nucleoli. Velichko et al. have studied the molecular mechanisms involved in protecting the cell from replication stress induced in rDNA (nucleolus) of the higher eukaryotes.
Article
Anne Pipathsouk, Rachel M. Brunetti, Jason P. Town, Brian R. Graziano, Artù Breuer, Patrina A. Pellett, Kyle Marchuk, Ngoc-Han T. Tran, Matthew F. Krummel, Dimitrios Stamou, Orion D. Weiner
The local rules that control cell shape and movement are not understood. Here, Pipathsouk et al. discover a novel nanoscale organization of a key actin regulator that could explain how cellular protrusions expand and self-straighten and how transcellular holes are repaired.
Article
Gabriele Marcianò, Midori Ishii, Olga O. Nerusheva, Bungo Akiyoshi
Kinetoplastids are evolutionarily divergent eukaryotes that have an unconventional set of kinetochore proteins. Marcianò et al. show that KKT2 and KKT3 play important roles in kinetochore assembly in Trypanosoma brucei. Centromere localization of these proteins is mediated by the unique centromere localization domain.
Article
Yun Quan, Stephen M. Hinshaw, Pang-Che Wang, Stephen C. Harrison, Huilin Zhou
SUMO homeostasis promotes error-free chromosome segregation. Quan et al. report the structure of a targeting peptide of the Ulp2 desumoylase bound to yeast Ctf3/CENP-I. Disrupting the interaction produces hyper-sumoylated kinetochores, demonstrating the existence of a conserved and dedicated pathway for the regulation of kinetochore sumoylation.
Report
Xi Yang, Lucas Reist, Dominic A. Chomchai, Liang Chen, Felichi Mae Arines, Ming Li
Yang et al. applied a microfluidics-based imaging method to resolve a controversy regarding how ubiquitinated lysosome membrane proteins are sorted into the lumen for degradation. ESCRTs, but not intralumenal fragments, are responsible for the sorting.
Report
Ruth A. Houseright, Veronika Miskolci, Oscar Mulvaney, Valeriu Bortnov, Deane F. Mosher, Julie Rindy, David A. Bennin, Anna Huttenlocher
This study shows that MYDGF regulates neutrophil behavior in response to tissue damage but not microbial cues. The findings suggest that MYDGF promotes wound healing in larval zebrafish by providing a brake on neutrophil inflammation.

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Current Issue
Volume 220,
Issue 6,
June 7, 2021
Reviews & Opinions
Review
Thomas C. Südhof
Thomas Südhof discusses the cell-biological principles underlying the assembly of specific synaptic connections with defined properties that control neural circuits.
Spotlight
Kaela S. Singleton, Victor Faundez
In this issue, Bowman et al. describe an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-safe to recognize sorting signals in VAMP7, a membrane protein required for fusion to melanosomes. Their observations define one of the first examples of distributed robustness in membrane traffic mechanisms.
Spotlight
Santosh Phuyal, Hesso Farhan
Phuyal and Farhan discuss works from Shomron et al. and Weigel et al. that provide exciting new insight to the debate about the nature of ER-to-Golgi carriers.

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