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Daniel D. Bisinski, Inês Gomes Castro, Muriel Mari, Stefan Walter, Florian Fröhlich, Maya Schuldiner, Ayelén González Montoro
Membrane contact sites allow organelles to communicate with each other. Bisinski et al. show that Cvm1 is a novel component of three different contacts involving the yeast lysosome-like vacuole. These contacts both control and are regulated by the levels of sphingolipids in the cell.
Article
Antonios Georgantzoglou, Hugo Poplimont, Hazel A. Walker, Tim Lämmermann, Milka Sarris
Previous studies of chemotaxis have focused on protrusions and in vitro models. Georgantzoglou et al. show that protrusive structures in neutrophils only drive a first exploratory stage in vivo, while a second stage of actin flows and contractility is required for the ultimate motion response.
Article
Ani Michaud, Marcin Leda, Zachary T. Swider, Songeun Kim, Jiaye He, Jennifer Landino, Jenna R. Valley, Jan Huisken, Andrew B. Goryachev, George von Dassow, William M. Bement
Michaud et al. identify Ect2 and RGA-3/4 as core components of the cortical excitability circuit associated with cytokinesis. Additionally, they demonstrate that the immature Xenopus oocyte is a powerful model for characterizing excitable dynamics.
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Brian G. Coon, Sushma Timalsina, Matteo Astone, Zhen W. Zhuang, Jennifer Fang, Jinah Han, Jurgen Themen, Minhwan Chung, Young Joo Yang-Klingler, Mukesh Jain, Karen K. Hirschi, Ai Yamamato, Louis-Eric Trudeau, Massimo Santoro, Martin A. Schwartz
Coon et al. identify an anti-inflammatory signaling pathway mediated by laminar shear stress stimulation of endothelial cells, whereby mitochondrial signaling and the adaptor protein, p62, promote ERK5 activation and enhance KLF2 expression. This accounts for relatively high KLF2 expression in laminar shear stimulated conditions compared to disturbed shear stimulation.
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Alba Zuidema, Paul Atherton, Maaike Kreft, Liesbeth Hoekman, Onno B. Bleijerveld, Nagarjuna Nagaraj, Nanpeng Chen, Reinhard Fässler, Arnoud Sonnenberg
Zuidema et al. demonstrate that Tyr-635 phosphorylation of PEAK1 regulates cell migration through association with Tensin3 and localization of PEAK1 in focal adhesions.
Article
Liying Wang, Chao Liu, Bo Yang, Haotian Zhang, Jian Jiao, Ruidan Zhang, Shujun Liu, Sai Xiao, Yinghong Chen, Bo Liu, Yanjie Ma, Xuefeng Duan, Yueshuai Guo, Mengmeng Guo, Bingbing Wu, Xiangdong Wang, Xingxu Huang, Haitao Yang, Yaoting Gui, Min Fang, Luo Zhang, Shuguang Duo, Xuejiang Guo, Wei Li
Wang et al. report that the SARS-CoV-2 ORF10 promotes IFT46 degradation via stimulating CUL2ZYG11B activity, thereby impairing both cilia biogenesis and maintenance. The study provides a pathological mechanism connecting COVID-19 symptoms with cilia dysfunction.
Article
Rebecca Harris, Ming Yang, Christina Schmidt, Chloe Royet, Sarbjit Singh, Amarnath Natarajan, May Morris, Christian Frezza, Heike Laman
Fbxo7 has dual roles, ubiquitining proteins and activating the kinase Cdk6. The authors show both Fbxo7 functions converge on phosphofructokinase (PFKP), a gatekeeper of glycolysis, inhibiting its function. Fbxo7 deficiency increases glycolysis and reduces T cell activation and viability, demonstrating its important role in regulating metabolism.

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Current Issue
Volume 221,
Issue 6,
6 June 2022
Reviews & Opinions
People & Ideas
Lucia Morgado-Palacin
Sara Cuylen-Haering studies the molecular mechanisms driving phase separation of chromosomes and other cellular organelles, with a special focus on biological surfactants.
Spotlight
Emir Bora Akmeriç, Holger Gerhardt
Akmeriç and Gerhardt highlight work from Coon et al., which shows that sustained laminar shear stress regulates Klf2 expression in endothelial cells via mitochondrial remodelling and mitophagy.
Spotlight
Jeanne C. Stachowiak
Jeanne Stachowiak highlights work from Cail and colleagues, which demonstrates that clathrin’s primary function is stabilizing membrane curvature during vesicle formation rather than scaffold recruitment.

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