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Konstanty Cieslinski, Yu-Le Wu, Lisa Nechyporenko, Sarah Janice Hörner, Duccio Conti, Michal Skruzny, Jonas Ries
Cieslinski and Wu et al. employ super-resolution microscopy to obtain a comprehensive model of the kinetochore structure in budding yeast. By measuring precise positions and stoichiometries, they could resolve the arrangement of the major kinetochore subunits when under attachment tension during metaphase.
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David Virant, Ilijana Vojnovic, Jannik Winkelmeier, Marc Endesfelder, Bartosz Turkowyd, David Lando, Ulrike Endesfelder
Virant et al. build an in situ model of the Schizosaccharomyces pombe kinetochore by determining inter-protein distances and copy numbers. Next to confirming its conserved nature known from in vitro data, they point out S. pombe specifics, e.g., within DASHc and the inner kinetochore structure.
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Yuanjiao Du, Weiping Chang, Lei Gao, Lin Deng, Wei-Ke Ji
Du et al. show that Tex2, a potential lipid transporter on the tubular endoplasmic reticulum, is recruited to late endosomes/lysosomes by endosome-resident phosphatidylinositol 4-phosphatases TMEM55 to regulate the lipid compositions, trafficking, and the functions of lysosomes.
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Adi Y. Berman, Michal Wieczorek, Amol Aher, Paul Dominic B. Olinares, Brian T. Chait, Tarun M. Kapoor
Berman et al. examine the capping activity of the γ-TuRC. Using in vitro and cellular assays, they characterize how the γ-TuRC's nucleotide-independent capping activity regulates microtubule dynamics and how it contributes to microtubule formation during cell division.
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Rafael Krämer, Neele Wolterhoff, Milos Galic, Sebastian Rumpf
Neurite pruning, a critical neuronal circuit specification mechanism, often involves neurite abscission by unknown mechanisms. In Drosophila sensory neurons, pruning dendrites first become mechanically fragile, and severing occurs through morphogenetic tissue movements that exert mechanical forces on the destabilized dendrites, thus establishing mechanical force as a mechanism during neurite pruning.
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Minou Djannatian, Swathi Radha, Ulrich Weikert, Shima Safaiyan, Christoph Wrede, Cassandra Deichsel, Georg Kislinger, Agata Rhomberg, Torben Ruhwedel, Douglas S. Campbell, Tjakko van Ham, Bettina Schmid, Jan Hegermann, Wiebke Möbius, Martina Schifferer, Mikael Simons
Djannatian et al. show by ultrastructural analysis of mouse optic nerves and in vivo imaging of zebrafish spinal cords that developmental myelination is an error-prone process and microglia contribute to the removal of aberrant structures. This may be an important mechanism to generate properly functioning myelin.
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Celina Eckfeld, Benjamin Schoeps, Daniel Häußler, Julian Frädrich, Felix Bayerl, Jan Philipp Böttcher, Percy Knolle, Simone Heisz, Olga Prokopchuk, Hans Hauner, Enkhtsetseg Munkhbaatar, Ihsan Ekin Demir, Chris D. Hermann, Achim Krüger
The authors identified a new mechanism of monocyte activation that is mediated by the interaction of TIMP-1 with APP. Furthermore, they provide evidence for a TIMP-1-mediated proinflammatory activation of human monocytes in clinical cancer samples.

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Volume 222,
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2 January 2023
Reviews & Opinions
In Memoriam
Gregg Wildenberg, Deborah J. Mariner, Panos Z. Anastasiadis, Micheal A. Davis, Renee Ireton, Huapeng Yu, Andrew L. Smith, Sarah Kurley, Juliet M. Daniel, Agnes Roczniak-Ferguson, Xiaobo Xia, Meredith Brown, Manish Tripathi, Molly Seale, Robert Carnahan, Whitney Smalley-Freed, Michael Dohn
Albert (Al) B. Reynolds, professor of cancer biology, Vanderbilt School of Medicine, died unexpectedly, and far too soon, at his home in Nashville, TN, at the age of 66 on November 3, 2022. Al earned a bachelor of arts from Kenyon College and a doctor of philosophy (PhD) from University of Virginia. He began his career at ...
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Catherine G. Galbraith
Catherine Galbraith previews a Tools study from Gallusser and colleagues which describes a new pipeline for training a convolutional neural aimed at rapid automated detection of intracellular structures in volume electron microscopy images.
People & Ideas
Lucia Morgado-Palacin
Chii Jou Chan investigates how tissue mechanics and fluid pressure regulate mammalian development, with a special focus on folliculogenesis and oocyte quality control.

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