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Keisuke Mochida, Toshifumi Otani, Yuto Katsumata, Hiromi Kirisako, Chika Kakuta, Tetsuya Kotani, Hitoshi Nakatogawa
Mochida et al. find that the autophagy receptor Atg39 links the outer and inner nuclear membranes via two distinct membrane-binding regions. Autophagosome formation-coupled Atg39 condensation causes local nuclear envelope protrusion, leading to sequestration of a small piece of the nucleus into the autophagosome.
Article
Luis Daniel Ríos-Barrera, Maria Leptin
Drosophila tracheal terminal cells form subcellular tubes by invaginating their apical plasma membrane. Ríos-Barrera and Leptin show that late endosomes guide subcellular tube elongation toward the direction of cell growth by promoting F-actin organization between the tip of the subcellular tube and the advancing tip of the cell.
Article
Kazuhisa Kinoshita, Yuko Tsubota, Shoji Tane, Yuuki Aizawa, Ryota Sakata, Kozo Takeuchi, Keishi Shintomi, Tomoko Nishiyama, Tatsuya Hirano
Kinoshita et al. address the role of condensin I in chromosome assembly and identify two classes of mutations that cause hyper- and hypocompaction phenotypes in Xenopus egg extracts. The study reveals that a loop extrusion–independent mechanism also contributes to chromosome assembly and shaping.
Article
Gregory C. Addicks, Hongbo Zhang, Dongryeol Ryu, Goutham Vasam, Alexander E. Green, Philip L. Marshall, Sonia Patel, Baeki E. Kang, Doyoun Kim, Elena Katsyuba, Evan G. Williams, Jean-Marc Renaud, Johan Auwerx, Keir J. Menzies
Addicks et al. identify a role for protein acetylation in the regulation of muscle integrity by linking GCN5 acetyltransferase activity to the expression of dystrophin and other genes important for muscle structure. They find that this occurs through GCN5-directed acetylation of the transcriptional repressor YY1.
Article
Adam N. Keen, Luke A. Payne, Vedanta Mehta, Alistair Rice, Lisa J. Simpson, Kar Lai Pang, Armando del Rio Hernandez, John S. Reader, Ellie Tzima
Keen et al. discover a new role for eIF6, a protein classically known for its role in protein synthesis, in mechanotransduction, and the cellular response to force. These data provide a novel paradigm for how the cytoskeletal and translational machineries are linked.
Tools
Michelle E. Maxson, Yazan M. Abbas, Jing Ze Wu, Jonathan D. Plumb, Sergio Grinstein, John L. Rubinstein
SidK is introduced as a highly specific probe to visualize and quantify the proton-pumping vacuolar H+ATPases (V-ATPases) of mammalian cells and yeast.
Article
Suzan Kors, Christian Hacker, Chloe Bolton, Renate Maier, Lena Reimann, Emily J.A. Kitchener, Bettina Warscheid, Joseph L. Costello, Michael Schrader
Kors et al. reveal that peroxisome–ER associations via the ACBD5-VAPB tether are regulated by phosphorylation and GSK3β in mammalian cells. Phosphorylation sites in the FFAT-like motif of ACBD5 affect the binding to VAPB—and thus peroxisome–ER contact sites—differently.

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Current Issue
Volume 221,
Issue 1,
January 3, 2022
Reviews & Opinions
People & Ideas
Lucia Morgado-Palacin
Elda Grabocka investigates the role of stress granules in obesity and cancer.
Spotlight
Darren Graham Samuel Wilson, Thomas Iskratsch
Wilson and Iskratsch highlight work from the Tzima laboratory that reveals a noncanonical role for eIF6 in the regulation of focal adhesion formation and mechanotransduction.
Spotlight
Klemens Rottner, Theresia E.B. Stradal
Rottner and Stradal discuss new work from the Weiner laboratory unveiling that WASP integrates substrate topology, cell polarity, and migration in immune cells.

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