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Anoop Kumar Yadav, Abhijeet S. Jadhav, Pawel M. Szczepanik, Paolo Fagherazzi, Ivo Kabelka, Robert Vácha, Jakub Svenda, Hana Polasek-Sedlackova
Yadav & Jadhav et al. present the design, synthesis, and validation of a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling and providing capabilities for efficient affinity capture of protein variants from live cells.
Article
Muziyue Wu, Raj Kumar Sadhu, Kirstin Meyer, Ziqi Tang, Paul Marchando, Derek N. Woolfson, Nir S. Gov, Orion D. Weiner
The WAVE complex is an actin nucleator that regulates sheet-like lamellipodial protrusions. M. Wu et al. find that the WAVE complex is a core and limiting component of a highly stereotyped membrane curvature-dependent linear array that could serve as a structural template for lamellipodial generation.
Article
Brigitte S. Naughton, Swapnil C. Devarkar, Vanessa Todorow, Sunanda Mallik, Stacey Oxendine, Sanjana Junnarkar, Yuan Ren, Julien Berro, Janine Kirstein, Yong Xiong, Christian Schlieker
Naughton et al. establish that the ER experiences forces in the piconewton range across the ER lumen and identify NOMO as a force-bearing transmembrane protein that is required for myogenesis.
Article
Biljana Ermanoska, Jonathan Baets, Avital A. Rodal
Neurons and muscles must maintain structural contact despite mechanical strain. Ermanoska et al. identify a presynaptic actomyosin core at Drosophila neuromuscular junctions that coordinates with integrin adhesion receptors to sense and respond to tension changes, preserving neuron–muscle mechanical continuity.
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Vanessa Teixeira, Kashish Singh, José B. Gama, Matilde Moreira, Ricardo Celestino, Ana Xavier Carvalho, Paulo S. Pereira, Carla M.C. Abreu, Tiago J. Dantas, Andrew P. Carter, Reto Gassmann
Teixeira et al. identify the onconeural antigen CDR2 as an ER-localized adaptor for the microtubule-based motor cytoplasmic dynein-1 and show that CDR2 contributes to ER organization through its interaction with the integral ER membrane protein kinectin.
Tools
Milena Pasolli, Joyce C.M. Meiring, James P. Conboy, Gijsje H. Koenderink, Anna Akhmanova
Pasolli, Meiring et al. describe tools to acutely relocate vimentin intermediate filaments by inducibly coupling them to microtubule motors. Rapid perinuclear clustering of vimentin had no strong effects on microtubules or actin but was accompanied by redistribution of mitochondria and endoplasmic reticulum sheets, and reduced cell stiffness.
Article
Astrid G. Petzoldt, Marc J. F. Escher, Oriane Turrel, Niclas Gimber, Ina M. Schedina, Sophie Walter, Torsten W.B. Götz, Marta Maglione, David Toppe, Tanja Matkovic-Rachid, Alexander Neumann, Janine Lützkendorf, Jan Schmoranzer, Martin Lehmann, Jörg Großhans, Stephan J. Sigrist
The authors identify the conserved unconventional class XV myosin, Myo15, an actin motor, as a novel regulator of presynaptic assembly and remodeling in Drosophila. They find Myo15 to be essential for presynaptic functional homeostatic plasticity and memory consolidation.
Journal of Cell Biology Cover Image for Volume 224, Issue 7
Current Issue
Volume 224,
Issue 7,
7 July 2025
Reviews & Opinions
Spotlight
Amanda M. Powell, Elizabeth T. Ables
Powell and Ables preview work from Ghosh et al., which reveals that ecdysone signaling reprograms epithelial follicle cells toward a phagocytic fate during late oogenesis.
Spotlight
Clémence Paumier, Cécile Sauvanet, Benoît Gigant
Paumier, Sauvanet, and Gigant highlight work from Muñoz-Hernández, Xu, and colleagues, which describes new insight into the means by which NEDD1 protein recruits the γ-TuRC to microtubule-organizing centers.
Spotlight
Sabina Elmi, Jesper Nylandsted
Sabina Elmi and Jesper Nylandsted highlight work by Williams and colleagues that provides new insight into the role of annexins in the repair of plasma membrane lesions.

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