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Sérgio Simões, Gerald Lerchbaumer, Milena Pellikka, Paraskevi Giannatou, Thomas Lam, Dohyun Kim, Jessica Yu, David ter Stal, Kenana Al Kakouni, Rodrigo Fernandez-Gonzalez, Ulrich Tepass
Most forms of cancer involve a step where cells move out of an epithelial layer, a step that requires the loss of the apical domain of epithelial cells. We show how this loss of polarity is regulated at multiple levels by key polarity proteins.
Ákos Farkas, Henning Urlaub, Katherine E. Bohnsack, Blanche Schwappach
Farkas et al. identify monotopic hairpin proteins as novel clients of the guided entry of tail-anchored proteins (GET) pathway. They demonstrate that high efficiency GET pathway–mediated ER targeting of the budding yeast hairpin protein Erg1, a key enzyme of sterol synthesis, becomes essential under conditions requiring increased Erg1 biogenetic flux.
Tanveer Ahmad, Detlef Vullhorst, Rituparna Chaudhuri, Carlos M. Guardia, Nisha Chaudhary, Irina Karavanova, Juan S. Bonifacino, Andres Buonanno
Ahmad and colleagues report that presynaptic accumulation of NRG3 involves multiple processes that include release of the EGF-containing domain from the TGN following BACE1 cleavage, transcytosis from somatodendritic to axonal plasma membranes, and selective retention at glutamatergic terminals through trans-synaptic interactions with postsynaptic ErbB4 receptors.
Leiling Shi, Youli Jian, Meijiao Li, Tianchao Hao, Chonglin Yang, Xiaochen Wang
The machinery and cellular mechanisms involved in multivesicular body (MVB) biogenesis are not fully understood. Shi et al. reveal that the F-actin crosslinker FLN-2/filamin acts as a bridging molecule that docks MVB on the actin cytoskeleton to facilitate MVB biogenesis.
Areej Abu Rmaileh, Balakrishnan Solaimuthu, Anees Khatib, Shirel Lavi, Mayur Tanna, Arata Hayashi, Michal Ben Yosef, Michal Lichtenstein, Nir Pillar, Yoav D. Shaul
Abu Rmaileh et al. demonstrate that the axon guidance adaptor protein DPYSL2 is essential for promoting breast cancer cell migration. Specifically, this adaptor protein interacts with JAK1 to regulate STAT3 signaling and subsequently vimentin expression.
Jesus Vega-Lugo, Bruno da Rocha-Azevedo, Aparajita Dasgupta, Khuloud Jaqaman
Vega-Lugo, da Rocha-Azevedo et al. analyze three-color microscopy images to determine whether the colocalization between two molecular entities is influenced by their colocalization with a third entity, providing evidence for cooperativity or competition between molecular interactions and for their enhancement or suppression at subcellular locations.
Mingming Ji, Meng Li, Long Sun, Hongyu Zhao, Ying Li, Lulu Zhou, Zhenni Yang, Xin Zhao, Wenyan Qu, Hanbing Xue, Ze Zheng, Yiming Li, Hongyu Deng, Yan G. Zhao
Ji et al. show that the autophagy proteins VMP1 and TMEM41B are required for β-coronavirus infection, and they function at different steps during DMV biogenesis. TMEM41B is involved in nsp3/4 binding and ER zippering, while VMP1 is essential for bending the paired ER into DMVs.

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Current Issue
Volume 221,
Issue 5,
2 May 2022
Reviews & Opinions
Stephen W.G. Tait
Tait discusses optogenetic methods developed by Shkarina et al. that engage different forms of regulated cell death.
Ebrahim Eskandari, Connie J. Eaves
Eskandari and Eaves review evidence of caspase-3-regulated protein quality, proliferation, differentiation, and tumorigenic activity in viable cells.
Susan E. Logue, Adrienne M. Gorman, Afshin Samali
Logue, Gorman, and Samali highlight a study by Guttman and colleagues (2022. J. Cell Biol. that shows exogenous antigen peptides imported into the ER can activate the ER stress sensor IRE1α, attenuating cross-presentation by dendritic cells.

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