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Nan Xin, Jenni Durieux, Chunxia Yang, Suzanne Wolff, Hyun-Eui Kim, Andrew Dillin
UPRmt increases mitochondrial quality control proteins and induces longevity. But how do the rescuing proteins enter mitochondria, as UPRmt is initiated with dampened mitochondrial import? The study by Xin et al. shows that enhanced mitochondrial import mediates UPRmt-induced lifespan extension upon UPRmt activation.
Article
Yaqian Zhang, Xing Hong, Shasha Hua, Kai Jiang
Zhang et al. reconstitute branching microtubule nucleation using native and recombinant human augmin–γ-TuRC complex and highlight the importance of the adaptor protein NEDD1 and CDK1/PLK1-mediated phosphorylation in this process. This study also unravels a novel augmin’s oligomerization-dependent mechanism for γ-TuRC activation.
Article
Xianghong Wang, Xinxin Li, Junkai Wang, Jiabin Wang, Can Hu, Jia Zeng, Anbing Shi, Long Lin
Unconventional protein secretion (UPS) mediates protein exocytosis without entering the ER-Golgi secretory route. Here, Wang et al. report SMGL-1 acts as a guanine nucleotide exchange factor for RAB-8 to facilitate apical UPS of integral proteins in Caenorhabditiselegans intestinal epithelia.
Article
Sérgio Simões, Gerald Lerchbaumer, Milena Pellikka, Paraskevi Giannatou, Thomas Lam, Dohyun Kim, Jessica Yu, David ter Stal, Kenana Al Kakouni, Rodrigo Fernandez-Gonzalez, Ulrich Tepass
Most forms of cancer involve a step where cells move out of an epithelial layer, a step that requires the loss of the apical domain of epithelial cells. We show how this loss of polarity is regulated at multiple levels by key polarity proteins.
Article
Ákos Farkas, Henning Urlaub, Katherine E. Bohnsack, Blanche Schwappach
Farkas et al. identify monotopic hairpin proteins as novel clients of the guided entry of tail-anchored proteins (GET) pathway. They demonstrate that high efficiency GET pathway–mediated ER targeting of the budding yeast hairpin protein Erg1, a key enzyme of sterol synthesis, becomes essential under conditions requiring increased Erg1 biogenetic flux.
Article
Tanveer Ahmad, Detlef Vullhorst, Rituparna Chaudhuri, Carlos M. Guardia, Nisha Chaudhary, Irina Karavanova, Juan S. Bonifacino, Andres Buonanno
Ahmad and colleagues report that presynaptic accumulation of NRG3 involves multiple processes that include release of the EGF-containing domain from the TGN following BACE1 cleavage, transcytosis from somatodendritic to axonal plasma membranes, and selective retention at glutamatergic terminals through trans-synaptic interactions with postsynaptic ErbB4 receptors.
Report
Leiling Shi, Youli Jian, Meijiao Li, Tianchao Hao, Chonglin Yang, Xiaochen Wang
The machinery and cellular mechanisms involved in multivesicular body (MVB) biogenesis are not fully understood. Shi et al. reveal that the F-actin crosslinker FLN-2/filamin acts as a bridging molecule that docks MVB on the actin cytoskeleton to facilitate MVB biogenesis.

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Issue Cover
Current Issue
Volume 221,
Issue 5,
2 May 2022
Reviews & Opinions
People & Ideas
Lucia Morgado-Palacin
Sara Wickström combines biophysics, next-generation sequencing, and basic cell biology to investigate how cellular forces regulate the fate and position of stem cells within epithelial tissues.
Spotlight
Stephen W.G. Tait
Tait discusses optogenetic methods developed by Shkarina et al. that engage different forms of regulated cell death.
Review
Ebrahim Eskandari, Connie J. Eaves
Eskandari and Eaves review evidence of caspase-3-regulated protein quality, proliferation, differentiation, and tumorigenic activity in viable cells.

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