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Tsukasa Makino, Ryo Kanada, Teppei Mori, Ken-ichi Miyazono, Yuta Komori, Haruaki Yanagisawa, Shoji Takada, Masaru Tanokura, Masahide Kikkawa, Michio Tomishige
Kinesin-1 alternately moves its two motor domains (heads) to walk along the microtubule. Makino et al. demonstrate that the detached head cannot rebind to the rear binding site because of an intolerable increase in tension, thus ensuring forward stepping after ATP binding.
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Mao Mao, Yoshihiro Ishikawa, Cassandre Labelle-Dumais, Xiaowei Wang, Yien-Ming Kuo, Uma B. Gaffney, Megan E. Smith, Carlie N. Abdala, Matthew D. Lebedev, William J. Paradee, Douglas B. Gould
This work introduces a novel and innovative tagged Col4a1 mouse model for studies of basement membrane dynamics. The authors elucidate important details of COL4A1 turnover in cerebral vasculature and demonstrate that Col4a1 heterozygous deletion is better tolerated than missense mutations.
Article
Martina Gregori, Gustavo J.S. Pereira, Robert Allen, Nicholas West, Kai-Yin Chau, Xinjiang Cai, Matthew P. Bostock, Stephen R. Bolsover, Marco Keller, Chiao-Yin Lee, Si Hang Lei, Kirsten Harvey, Franz Bracher, Christian Grimm, Gaiti Hasan, Matthew E. Gegg, Anthony H.V. Schapira, Sean T. Sweeney, Sandip Patel
Death of dopaminergic neurons in the brain is a hallmark of Parkinson’s disease. Gregori and colleagues show that deviant calcium signals in familial disease models caused by mutations in LRRK2 can be reversed by targeting lysosomal TPC2 channels and that TPC2 mimics disease effects in vivo.
Article
Peng Huang, Guanghan Chen, Zhiwen Zhu, Shimin Wang, Zhe Chen, Yongping Chai, Wei Li, Guangshuo Ou
Peng Huang et al. find that the ciliary kinesin OSM-3 exhibits an extended, active conformation at the ciliary base and middle segments. Their results indicate the NEK family kinases and PP2A phosphatase collaborate through a phosphorylation-mediated mechanism to regulate the regional motility of ciliary kinesin.
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Amanda Ennis, Lihui Wang, Yue Xu, Layla Saidi, Xiaorong Wang, Clinton Yu, Sijung Yun, Lan Huang, Yihong Ye
Mammalian cells eliminate nascent chains stalled during co-translational protein translocation by activating a ribosome UFMylation-dependent TAQC process at the ER. Our study establishes a role for NEMF-mediated CAT tailing in TAQC, targeting defective nascent chains for degradation via an unconventional ERAD mechanism.
Article
Alexandru Nita, Sara P. Abraham, Eman R. Elrefaay, Bohumil Fafilek, Eliska Cizkova, Vlad Constantin Ursachi, Iva Gudernova, Adolf Koudelka, Pooja Dudeja, Tomas Gregor, Zuzana Feketova, Gustavo Rico, Katerina Svozilova, Canan Celiker, Aleksandra A. Czyrek, Tomas Barta, Lukas Trantirek, Antoni Wiedlocha, Pavel Krejci, Michaela Bosakova
Nita et al. show that the FGFR2 localizes to primary cilia of the developing mouse tissues and in vitro cells; they identify the molecular mechanism of this action, and show its critical function in FGFR2 signaling.
Article
Mikhail Lebedev, Fung-Yi Chan, Elisabeth Rackles, Jennifer Bellessem, Tamara Mikeladze-Dvali, Ana Xavier Carvalho, Esther Zanin
The authors show that anillin mediates unilateral cytokinesis by blocking the effector binding site of active RhoA. The interaction between active RhoA and anillin is strengthened by anillin’s disordered linker region and is differentially controlled at the slow and fast ingressing sides of the contractile ring.
Journal of Cell Biology Cover Image for Volume 224, Issue 4
Current Issue
Volume 224,
Issue 4,
7 April 2025
Reviews & Opinions
Spotlight
Yu Sun, Terytty Yang Li
Yu Sun and Terytty Yang Li preview work from Li and colleagues, which describes a role for TMBIM-2 in the regulation of Ca2+ oscillations and coordinating the neuronal-to-intestinal mitochondrial UPR.
Review
Hiroki Shibuya
Shibuya reviews meiotic chromosome movements, highlighting telomere and nuclear membrane modifications crucial for accurate sexual reproduction.
Spotlight
Sarah E. Sandkuhler, Samuel J. Mackenzie
Sandkuhler and Mackenzie discuss the potential impact of protein-level discovery for individuals with TANGO2 deficiency disorder, a rare neurometabolic condition.

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