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Farideh Sabeh, Xiao-Yan Li, Adam W. Olson, Elliot Botvinick, Abhishek Kurup, Luis E. Gimenez, Jung-Sun Cho, Stephen J. Weiss
Dermal fibroblasts actively remodel pericellular type I collagen during early postnatal development. Sabeh et al. demonstrate that the membrane-anchored matrix metalloproteinase, Mmp14, serves as a requisite cell-survival factor by hydrolyzing collagen and activating β1 integrin, thereby suppressing aberrant activation of a TGF-β1/JNK-dependent apoptosis program in vivo.
Article
Weijing Yao, Yingcong Chen, Yi Zhang, Shu Zhong, Miaojuan Ye, Yuting Chen, Siyu Fan, Miao Ye, Huan Yang, Yixing Li, Choufei Wu, Mingzhu Fan, Shan Feng, Zhaoxiang He, Long Zhou, Liqin Zhang, Yigang Wang, Wei Liu, Jingjing Tong, Du Feng, Cong Yi
Snf1/AMPK-mediated Atg1/ULK1 activation is crucial for glucose starvation–induced autophagy. However, the activation mechanism remains poorly defined. Yao et al. demonstrate that Ca2+ is a critical signal linking environmental sensing to autophagy initiation by triggering Atg11–Bmh1/2–Snf1 complex assembly, which governs Atg1 activation upon glucose starvation.
Article
Min Zhu, Han Xu, Yulei Jin, Xiaoxu Kong, Bingkuan Xu, Yinghui Liu, Haijia Yu
Zhu et al. reveal that Synaptotagmin 1 (Syt1) forms condensate to interact with negatively charged lipid bilayers and recruit SNARE complexes and complexin. Syt1 undergoes a liquid-to-gel-like phase transition in condensates, reflecting the oligomerization of Syt1, which is blocked or reversed by Ca2+.
Article
Jonathan T. Vu, Katherine U. Tavasoli, Connor J. Sheedy, Soham P. Chowdhury, Lori Mandjikian, Julien Bacal, Meghan A. Morrissey, Chris D. Richardson, Brooke M. Gardner
The E3 ligase RNF146 regulates peroxisomal-protein import by preventing the PARsylation of peroxisomal proteins by the poly-ADP ribose polymerases TNKS and TNKS2. Highlighting the specialization of cell-wide regulatory mechanisms at organelles, peroxisomal recruitment of TNKS/2 reorients TNKS/2 activity away from components of the Wnt/β-catenin pathway.
Article
Wendy M. McKimpson, Sophia Spiegel, Maria Mukhanova, Michael Kraakman, Wen Du, Takumi Kitamoto, Junjie Yu, Zhaobin Deng, Utpal Pajvani, Domenico Accili
Calorie restriction increases lifespan. It is unclear how calorie restriction alters gastrointestinal cell composition. This study finds that calorie restriction promotes gastric endocrine cell differentiation through active Notch signaling and that the transcription factor FOXO1 regulates this process.
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Xiao Li, Rico Gamuyao, Ming-Lun Wu, Woo Jung Cho, Sharon V. King, R.A. Petersen, Daniel R. Stabley, Caleb Lindow, Leslie K. Climer, Abbas Shirinifard, Francesca Ferrara, Robert E. Throm, Camenzind G. Robinson, Yiwang Zhou, Alexandre F. Carisey, Alison G. Tebo, Chi-Lun Chang
Li and Gamuyao et al. engineer a synthetic lipid droplet (LD)-targeting motif and develop a tool kit that detects contact sites between LDs and other organelles. This method utilizes a reversible, split fluorescence protein (splitFAST) that enables the investigation of dynamic organelle interactions under various metabolic conditions in living cells.
Article
David Salvador-Garcia, Li Jin, Andrew Hensley, Mert Gölcük, Emmanuel Gallaud, Sami Chaaban, Fillip Port, Alessio Vagnoni, Vicente José Planelles-Herrero, Mark A. McClintock, Emmanuel Derivery, Andrew P. Carter, Régis Giet, Mert Gür, Ahmet Yildiz, Simon L. Bullock
Salvador-Garcia and colleagues combine Drosophila genetics, biochemistry, and biophysics to dissect the functions of the dynein motor. They reveal organismal effects of human disease-associated mutations and provide evidence for a non-canonical role for dynein in anaphase progression that involves it operating in a specific load regime.
Issue Cover
Current Issue
Volume 223,
Issue 7,
1 July 2024
Reviews & Opinions
Spotlight
Christophe Leterrier
The slender shape of axons makes them uniquely susceptible to mechanical stress. Leterrier discusses new work from Wang and colleagues finding that transient actomyosin beading protects axons by limiting the spread of damaging calcium waves.
Viewpoint
Vivek Malhotra
Vivek Malhotra discusses our emerging understanding of the roles of COPII in mediating the export of diverse cargoes from the ER.
Viewpoint
Adam Zweifach
Zweifach explains how to calculate how many cells to analyze per sample to achieve reasonable statistical power in microscopy experiments.

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