Journal of Cell Biology (JCB) | Rockefeller University Press

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Cell cycle and division

Lebedev… Zanin: Anillin inhibits RhoA during unilateral furrowing.
Cilia

Deraniyagala...Gaertig: Periodic cortical patterning in Tetrahymena.
Trafficking

Ennis...Ye: NEMF facilitates atypical ERAD in TAQC.

New Articles

Article

| June 20 2025

Moonjung Jung, Jungwoo Kim, Yeji Park, Isaac Ilyashov, Fan Yang, Haruna B. Choijilsuren, Danielle Keahi, Jordan A. Durmaz, Habin Bea, Audrey M. Goldfarb, Mia D. Stein, Claudia Wong, Ryan R. White, Sunandini Sridhar, Raymond Noonan, Tom F. Wiley, Thomas S. Carroll, Francis P. Lach, Sangmoo Jeong, Ileana C. Miranda, Agata Smogorzewska

Jung and Kim et al. show that combined ALDH9A1 and FANCD2 deficiency leads to genomic instability, decreased cell survival, and tumorigenesis. Loss of ATP13A3, a polyamine transporter, rescues cellular growth, implicating aminoaldehydes in the creation of DNA damage, which necessitates repair by the Fanconi anemia pathway.

Article

| June 12 2025

NPC plasticity revealed by pan-ExM

Kimberly J. Morgan, Emma Carley, Alyssa N. Coyne, Jeffrey D. Rothstein, C. Patrick Lusk, Megan C. King

Morgan et al. demonstrate that pan-expansion microscopy is an exceptional tool for probing the molecular composition and structural plasticity of individual NPCs: they reveal LINC complex–dependent NPC diameter biases across the nuclear surface and changing nucleoporin positions in an ALS model.

Article

| June 12 2025

Arc controls MyoII through Crb

Ji Hoon Kim, Rika Maruyama, Kwon Kim, Devin A. Vertrees, Parama Paul, Kyla Britson, Nathaniel R. Laughner, Deborah J. Andrew

Kim et al. report on Arc, a large PDZ domain–containing cell membrane–associated protein that controls Drosophila salivary gland architecture. Arc facilitates apical membrane delivery of Crumbs; in turn, Crumbs limits accumulation and activity of non-muscle myosin II to regulate the number of salivary gland cells that internalize at a given time.

Report

| June 11 2025

LKB1 regulates retinal ganglion cell migration

Robert D. Mackin, Ritika V. Bhalla, Viktor Akhanov, Qudrat T. Abdulwahab, Courtney A. Burger, Melanie A. Samuel

This study reveals that the kinase LKB1 is crucial for migration and nuclear positioning of specialized type of RGCs called F-RGCs. Its absence leads to misplacement, altered morphology, and increased cell death, highlighting that different RGC types can use distinct migration programs.

Article

| June 09 2025

CNTD1 is critical for meiosis in female mice

Anna J. Wood, Rania M. Ahmed, Leah E. Simon, Rachel A. Bradley, Stephen Gray, Ian D. Wolff, Paula E. Cohen

Studies described in this manuscript show that cyclin N-terminal domain containing 1 (CNTD1) is a critical regulator of crossover formation during prophase I of meiosis in females. Loss of CNTD1 results in severe depletion of oocytes at birth leading to loss of the ovarian reserve.

Article

| June 09 2025

Metabolism and invasiveness in micrometastases

Michalis Gounis, America V. Campos, Engy Shokry, Louise Mitchell, Ruhi Deshmukh, Emmanuel Dornier, Nicholas Rooney, Sandeep Dhayade, Luis Pardo, Madeleine Moore, David Novo, Jenna Mowat, Craig Jamieson, Emily Kay, Sara Zanivan, Nikki R. Paul, Claire Mitchell, Colin Nixon, Iain Macpherson, Saverio Tardito, David Sumpton, Karen Blyth, Jim C. Norman, Cassie J. Clarke

Breast cancer cells isolated from lung micrometastases have altered metabolism, which influences extracellular vesicle production to generate invasive microenvironments.

Article

| June 05 2025

TPRN bundles F-actin at stereocilia pivots

Inna A. Belyantseva, Chang Liu, Abigail K. Dragich, Takushi Miyoshi, Sayaka Inagaki, Ayesha Imtiaz, Risa Tona, Karen Sofia Zuluaga-Osorio, Shadan Hadi, Elizabeth Wilson, Eva Morozko, Rafal Olszewski, Rizwan Yousaf, Yuliya Sokolova, Gavin P. Riordan, S. Andrew Aston, Atteeq U. Rehman, Cristina Fenollar Ferrer, Jan Wisniewski, Shoujun Gu, Gowri Nayak, Richard J. Goodyear, Jinan Li, Jocelyn F. Krey, Talah Wafa, Rabia Faridi, Samuel Mawuli Adadey, Meghan Drummond, Benjamin Perrin, Dennis C. Winkler, Matthew F. Starost, Hui Cheng, Tracy Fitzgerald, Guy P. Richardson, Lijin Dong, Peter G. Barr-Gillespie, Michael Hoa, Gregory I. Frolenkov, Thomas B. Friedman, Bo Zhao

Belyantseva and Liu report that taperin encircles and stabilizes F-actin at auditory hair cell stereocilia bases and bundles F-actin. Taperin deficiency causes stereocilia disassembly, rootlet breakage at pivots, and other abnormalities culminating in deafness. Thus, taperin bundles F-actin to maintain rootlet integrity and lifelong hearing.

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Current Issue

Volume 224,

Issue 6,

2 June 2025

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Reviews & Opinions

Spotlight

| June 18 2025

Plasma membrane repair by annexins and calpains

Sabina Elmi, Jesper Nylandsted

Sabina Elmi and Jesper Nylandsted highlight work by Williams and colleagues that provides new insight into the role of annexins in the repair of plasma membrane lesions.

Spotlight

| June 12 2025

Ciliary residence of FGFR2

Raman Kaushik, Raj K. Ladher

Kaushik and Ladher discuss recent work from Nita and colleagues, describing how FGFR2 localization at primary cilia affects FGFR signalling and highlighting the role of the cilium in a disease-related context.

Review

| June 10 2025