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Sungjin Ryu, Donghee Ko, Byungho Shin, Kunsoo Rhee
Ryu et al. investigate a delivery mechanism of centriolar satellites in cilia formation. They propose that intercentriolar/rootletin fibers are used as docking sites for centriolar satellites near the centrosome based on the specific interaction of CROCC/rootletin, the main component of intercentriolar fiber, with PCM1, a scaffold of centriolar satellites.
Article
Qiaoni Shi, Fei Huang, Yalong Wang, Huidong Liu, Haiteng Deng, Ye-Guang Chen
Shi et al. demonstrate that in the presence of ligand, the TGF-β type I receptor interacts with and phosphorylates HER2 at Ser779 to enhance HER2 activity, leading to AKT and ERK activation and thus promoting mammary gland development and breast cancer progression.
Report
Alexander D. Fellows, Michaela Bruntraeger, Thomas Burgold, Andrew R. Bassett, Andrew P. Carter
Fellows et al. report that individual dynein motors can move the entire axon length during retrograde transport. They find factors LIS1 and NDEL1, needed for transport initiation, also move with cargos. In the anterograde direction, dynein and its cofactor dynactin are transported separately, keeping them apart until required.
Article
Ksenia Trofimov, Regina Gratz, Rumen Ivanov, Yvonne Stahl, Petra Bauer, Tzvetina Brumbarova
The bHLH transcription factor FIT controls iron acquisition and growth in plants. FIT undergoes light-induced, reversible condensation and localizes to nuclear bodies (NBs), likely via liquid–liquid phase separation. FIT engages in protein complex, preferentially in NBs. FIT NBs are related to splicing and light signaling.
Report
Yamini Ravichandran, Jan Hänisch, Kerren Murray, Vanessa Roca, Florent Dingli, Damarys Loew, Valentin Sabatet, Batiste Boëda, Theresia E. Stradal, Sandrine Etienne-Manneville
Using primary astrocytes and neural precursors, which naturally express both CDC42 isoforms, the authors show that the short carboxy-terminal sequence, which distinguishes the two isoforms, dictates different cell functions by influencing the protein intracellular localization.
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Andrea Scelfo, Viviana Barra, Nezar Abdennur, George Spracklin, Florence Busato, Catalina Salinas-Luypaert, Elena Bonaiti, Guillaume Velasco, Frédéric Bonhomme, Anna Chipont, Andréa E. Tijhuis, Diana C.J. Spierings, Coralie Guérin, Paola Arimondo, Claire Francastel, Floris Foijer, Jӧrg Tost, Leonid Mirny, Daniele Fachinetti
Scelfo et al. present an inducible, rapid, and reversible DNMT1 depletion cell system allowing DNA methylation modulation. They unveil a cooperative DNMT1 and DNMT3B activity in maintaining methylation, heterochromatin, chromatin compartmentalization, and cell fitness. Overall, this system offers temporal resolution for exploring the role of DNAme dysfunction in human disease.
Article
Leonie F. Schrӧder, Wesley Peng, Ge Gao, Yvette C. Wong, Michael Schwake, Dimitri Krainc
Using live-cell microscopy, we find that loss of VPS13C in human neurons disrupts lysosomal morphology and dynamics with increased inter-lysosomal tethers, leading to impaired lysosomal motility and defective lysosomal function as well as a decreased phospho-Rab10-mediated lysosomal stress response.
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Current Issue
Volume 223,
Issue 2,
5 February 2024
Reviews & Opinions
Spotlight
Noah J. Gurley, Mark Peifer
Gurley and Peifer highlight work from Quintanilla et al. that reveals how the local biophysical environment regulates assembly of myosin filaments.
In Memoriam
Mark Peifer, Alexander R. Dunn
In October 2023, cell biology lost one of its brightest stars, Bill Weis, gone too soon at the age of 64. Bill was a masterful biochemist and structural biologist who made landmark contributions to a remarkable number of fields, most notably cell–cell adhesion, Wnt signaling, and signaling by G-protein coupled receptors.
Spotlight
Anne Fassl, Piotr Sicinski
Fassl and Sicinski highlight work from Pang and colleagues that shows that the RNA-binding protein PC4 modulates cyclin D1 levels in cancer cells by regulating mRNA stability.

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