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Article
Biljana Ermanoska, Jonathan Baets, Avital A. Rodal
Neurons and muscles must maintain structural contact despite mechanical strain. Ermanoska et al. identify a presynaptic actomyosin core at Drosophila neuromuscular junctions that coordinates with integrin adhesion receptors to sense and respond to tension changes, preserving neuron–muscle mechanical continuity.
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Vanessa Teixeira, Kashish Singh, José B. Gama, Matilde Moreira, Ricardo Celestino, Ana Xavier Carvalho, Paulo S. Pereira, Carla M.C. Abreu, Tiago J. Dantas, Andrew P. Carter, Reto Gassmann
Teixeira et al. identify the onconeural antigen CDR2 as an ER-localized adaptor for the microtubule-based motor cytoplasmic dynein-1 and show that CDR2 contributes to ER organization through its interaction with the integral ER membrane protein kinectin.
Tools
Milena Pasolli, Joyce C.M. Meiring, James P. Conboy, Gijsje H. Koenderink, Anna Akhmanova
Pasolli, Meiring et al. describe tools to acutely relocate vimentin intermediate filaments by inducibly coupling them to microtubule motors. Rapid perinuclear clustering of vimentin had no strong effects on microtubules or actin but was accompanied by redistribution of mitochondria and endoplasmic reticulum sheets, and reduced cell stiffness.
Article
Astrid G. Petzoldt, Marc J. F. Escher, Oriane Turrel, Niclas Gimber, Ina M. Schedina, Sophie Walter, Torsten W.B. Götz, Marta Maglione, David Toppe, Tanja Matkovic-Rachid, Alexander Neumann, Janine Lützkendorf, Jan Schmoranzer, Martin Lehmann, Jörg Großhans, Stephan J. Sigrist
The authors identify the conserved unconventional class XV myosin, Myo15, an actin motor, as a novel regulator of presynaptic assembly and remodeling in Drosophila. They find Myo15 to be essential for presynaptic functional homeostatic plasticity and memory consolidation.
Article
Sunyoung Hwang, William Russo, Jaylah Cormier, Jillian Johnson, Sara Martin, Marica Rosaria Ippolito, Sara Cordone, Rui Li, Lihua Julie Zhu, Stefano Santaguida, Eduardo M. Torres
Lipid synthesis supports membrane growth and organelle biogenesis. Hwang et al. show that synthesis of sphingolipids, mainly long-chain bases, is essential to increasing nuclear membranes during cell division. Failure to make sphingolipids in human cells causes abnormal nuclear morphology and genomic instability.
Report
Helena Cantwell, Hieu Nguyen, Arminja N. Kettenbach, Rebecca Heald
Cantwell et al. utilize Ciona and Xenopus systems to uncover conserved differential CK2 regulation of the RanGTP pathway of spindle assembly in meiosis and mitosis, contributing to the rapid, dramatic change in spindle morphology seen at the meiosis-to-mitosis transition in very early embryogenesis.
Article
Antonios Chronopoulos, Ivan Chavez, Chandra Kaladhar Vemula, Nikhil Mittal, Vic Zamloot, Yuanzhong Pan, Sangyoon J. Han, JinSeok Park
The PAX3-FOXO1 fusion gene suppresses TGFβ signaling and cell–ECM interactions by stimulating nitric oxide synthesis in fusion-positive rhabdomyosarcoma. This finding reveals that the subtype-defining molecule promotes anchorage independence and may contribute to distinct clinical behavior of rhabdomyosarcoma subtypes, suggesting subtype-specific therapies in this pediatric sarcoma.
Journal of Cell Biology Cover Image for Volume 224, Issue 7
Current Issue
Volume 224,
Issue 7,
7 July 2025
Reviews & Opinions
Spotlight
Sabina Elmi, Jesper Nylandsted
Sabina Elmi and Jesper Nylandsted highlight work by Williams and colleagues that provides new insight into the role of annexins in the repair of plasma membrane lesions.
Spotlight
Raman Kaushik, Raj K. Ladher
Kaushik and Ladher discuss recent work from Nita and colleagues, describing how FGFR2 localization at primary cilia affects FGFR signalling and highlighting the role of the cilium in a disease-related context.
Review
Tatsuya Hirano
Hirano reviews mitotic genome folding with an emphasis on the mechanistic aspects of condensins, topoisomerase II, and histones.

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