Skip to Main Content

Advertisement

Skip Nav Destination
New Articles
Article
Thibault Legal, Mireya Parra, Maxwell Tong, Corbin S. Black, Ewa Joachimiak, Melissa Valente-Paterno, Karl Lechtreck, Jacek Gaertig, Khanh Huy Bui
Legal et al. use cryo-electron tomography to study the tips of motile cilia. They reveal novel structural features of the central pair, expand on the functional role of CEP104/FAP256, and identify potential new proteins that are important for the stability of the ciliary tip.
Article
Alba Yurani Torres, Maddalena Nano, Joseph P. Campanale, Sierra Deak, Denise J. Montell
Drosophila border cells are an excellent model to study fundamental cell behaviors. Torres et al show that elevated and localized Src activity in border cells induces cannibalism of neighboring cells by aberrantly activating phagocytosis with implications for the role of Src in cancer progression.
Article
Nisha R. Pawar, Marguerite S. Buzza, Nadire Duru, Amando A. Strong, Toni M. Antalis
Metastatic spread of ovarian cancer is associated with multicellular spheroids shed from the primary tumor into the peritoneal cavity. Pawar et al. show that overactive matriptase activates a PAR-2/PI3K/Akt/MMP9 signaling axis to enhance spheroid dissemination and metastasis.
Report
Enrica Pellegrino, Beren Aylan, Claudio Bussi, Antony Fearns, Elliott M. Bernard, Natalia Athanasiadi, Pierre Santucci, Laure Botella, Maximiliano G. Gutierrez
Pellegrino et al. show that Mtb infection triggers an increase in the number of peroxisomes and peroxisomal ROS in human macrophages. Macrophages lacking peroxisomes are unable to restrict Mtb infection due to a decreased source of ROS, uncovering a new role for peroxisomes in the host response.
Article
Hope E. Burks, Jenny L. Pokorny, Jennifer L. Koetsier, Quinn R. Roth-Carter, Christopher R. Arnette, Pedram Gerami, John T. Seykora, Jodi L. Johnson, Ziyou Ren, Kathleen J. Green
Melanoma cells exist in a bidirectional communication unit with lesional keratinocytes. In this niche, melanoma cells hijack keratinocyte signaling, causing them to produce promigratory chemokines through the downregulation of keratinocyte desmosomal cadherin Dsg1, leading to increased migration in vitro and an associated epidermal spread in vivo.
Article
Xuli Qi, Youhong Liu, Yuchong Peng, Yuxin Fu, Yongming Fu, Linglong Yin, Xiong Li
Qi et al. report a novel UHRF1 function as a nuclear protein catalyzing EG5 polyubiquitination for proper spindle architecture and faithful genomic transmission, which is independent of its roles in epigenetics and DNA damage repair. These findings reveal a previously unknown mechanism of UHRF1 controlling mitotic spindle architecture and chromosome behavior.
Article
Christabel Xin Tan, Dhanesh Sivadasan Bindu, Evelyn J. Hardin, Kristina Sakers, Ryan Baumert, Juan J. Ramirez, Justin T. Savage, Cagla Eroglu
Tan et al. show that δ-catenin, previously thought to be neuron specific, is expressed by astrocytes and required both in astrocytes and neurons to control astrocyte morphogenesis. Furthermore, they provide evidence demonstrating how the cadherin–δ-catenin adhesion complex controls astrocyte morphology in a layer-specific manner.
Issue Cover
Current Issue
Volume 222,
Issue 9,
4 September 2023
Reviews & Opinions
Spotlight
Monica Sharma, Andrey S. Shaw
Activated T cells boost ribosome production to meet their enormous protein synthesis demands. Sharma and Shaw discuss work from Zhou et al. showing the protein DCAF13 mediates nucleolar expansion in this setting.
Spotlight
Arisa Ikeda, Miho Iijima, Hiromi Sesaki
Ikeda et al. highlight work from Su and colleagues that describes the mechanism by which NME3 and phosphatidic acid promote mitochondrial tethering prior to fusion.
Spotlight
Wen Lu, Vladimir I. Gelfand
Lu and Gelfand preview work from Song et al., which reveals a role for the microtubule-binding protein DCX-EMAP in the 3D organization of mechanosensory organelles of Drosophila.

Most Popular

Advertisement

Special Collections

Special Collections

We are delighted to present this collection of cutting-edge research published over the past year in the Journal of Cell Biology.

View Collections
Close Modal

or Create an Account

Close Modal
Close Modal