Skip to Main Content

Advertisement

Skip Nav Destination
New Articles
Article
Amanda Guerreiro, Filipe De Sousa, Nicolas Liaudet, Daria Ivanova, Anja Eskat, Patrick Meraldi
Guerreiro et al. show that loss of the primary microcephaly gene WDR62 in human cells mislocalizes the microtubule-severing enzyme katanin from mitotic spindle poles. This mislocalization reduces microtubule minus-end depolymerization, slowing poleward microtubule flux and promoting asynchronous chromosome segregation in anaphase.
Article
Junjie Huang, Zhuobi Liang, Cuirong Guan, Shasha Hua, Kai Jiang
Huang et al. reveal that the microcephaly-related protein WDR62 possesses an intrinsic affinity for curved microtubules and regulates spindle dynamics by functioning as an adaptor protein between its recruiting factor TPX2/Aurora A and the effector katanin.
Article
Dharmendra Puri, Keerthana Ponniah, Kasturi Biswas, Atrayee Basu, Swagata Dey, Erik A. Lundquist, Anindya Ghosh-Roy
Puri et al. demonstrate that the Kinesin-13 family microtubule catastrophe factor is a critical determinant of neuronal microtubule dynamics and polarity. This work provides a mechanistic link between Wnt signaling and Kinesin-13 in establishing microtubule polarity in touch neurons of C. elegans.
Article
Christopher L. Sander, Avery E. Sears, Antonio F.M. Pinto, Elliot H. Choi, Shirin Kahremany, Fangyuan Gao, David Salom, Hui Jin, Els Pardon, Susie Suh, Zhiqian Dong, Jan Steyaert, Alan Saghatelian, Dorota Skowronska-Krawczyk, Philip D. Kiser, Krzysztof Palczewski
Sander et al. have parsed the lipid composition of native-source photoreceptor disks and found large differences in fatty acid unsaturation and chain length between the center and rim regions. They selectively copurified membrane proteins and lipids from each region in SMALPs using nanobodies and antibodies.
Article
Vivek K. Gupta, Sungmin Nam, Donghyun Yim, Jaclyn Camuglia, Judy Lisette Martin, Erin Nicole Sanders, Lucy Erin O’Brien, Adam C. Martin, Taeyoon Kim, Ovijit Chaudhuri
Gupta et al. investigate forces generated during cell division in confining epithelial monolayers. In addition to finding that cells generate forces during mitotic rounding, they find that cells generate protrusive forces along the division axis that drive elongation and outward forces that facilitate postdivision spreading.
Article
Mezmur D. Belew, Emilie Chien, Matthew Wong, W. Matthew Michael
Belew et al. report that C. elegans primordial germ cells become transcriptionally repressed if embryos hatch without nutrients. They also describe a novel pathway whereby condensin II and TOP-2 regulate heterochromatin to compact the germline genome to globally repress transcription.
Article
Arun A. Chandrakumar, Étienne Coyaud, Christopher B. Marshall, Mitsuhiko Ikura, Brian Raught, Robert Rottapel
Chandrakumar et al. reveal that lumen formation in epithelial cells is regulated by ADP-ribosylation and ubiquitylation. Tankyrase inhibits its substrates SH3BP5 and SH3BP5L, which are Rab11a guanine nucleotide exchange factors, while the E3 ligase RNF146 promotes Rab11a activity by degrading Tankyrase during lumenogenesis.

Related Articles from Rockefeller University Press

Issue Cover
Current Issue
Volume 220,
Issue 6,
June 7, 2021
Reviews & Opinions
Review
Isha Ralhan, Chi-Lun Chang, Jennifer Lippincott-Schwartz, Maria S. Ioannou
Ralhan et al. review the emerging role of lipid droplets in the nervous system in development, aging, and disease.
Spotlight
Jennifer J. Kohler
Kohler highlights work from Yoo and Mitchison that reveals that O-GlcNAcylation of the nuclear pore complex accelerates nucleocytoplasmic trafficking in both directions.
Spotlight
Yvette W.H. Koh, Jennifer L. Stow
Koh and Stow highlight work from Yang et al. describing Leep1, a novel regulator of protrusions and macropinocytosis in Dictyostelium.

Most Popular

Advertisement

Tweets by @JCellBiol

Special Collections

Special Collections

We are delighted to present this collection of cutting-edge research published over the past year in the Journal of Cell Biology.

View Collections
Close Modal

or Create an Account

Close Modal
Close Modal