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Frederik J. Verweij, Maarten P. Bebelman, Anna E. George, Mickael Couty, Anaïs Bécot, Roberta Palmulli, Xavier Heiligenstein, Julia Sirés-Campos, Graça Raposo, Dirk Michiel Pegtel, Guillaume van Niel
Exosomes are derived from endosomal compartments with an ill-defined molecular identity and whose trafficking steps to secretion are poorly understood. Using advanced imaging approaches, the authors identified these compartments as pre-lysosomal endosomes that require dynamic membrane contact sites with the endoplasmic reticulum to induce a prosecretory cascade of small-GTPases.
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Fabrizia Bonacina, Annalisa Moregola, Monika Svecla, David Coe, Patrizia Uboldi, Sara Fraire, Simona Beretta, Giangiacomo Beretta, Fabio Pellegatta, Alberico Luigi Catapano, Federica M. Marelli-Berg, Giuseppe Danilo Norata
Increased cholesterol uptake by the LDLR contributes to the immunometabolic response of activated CD8+ T cells through the modulation of lysosome–mTORC1 axis. This finding paves the way for cell-selective targeting of the LDLR to boost CD8-dependent immune response.
Article
Hui Jing Lim, Jacinta M. Wubben, Cristian Pinero Garcia, Sebastian Cruz-Gomez, Jieru Deng, Jeffrey Y.W. Mak, Abderrahman Hachani, Regan J. Anderson, Gavin F. Painter, Jesse Goyette, Shanika L. Amarasinghe, Matthew E. Ritchie, Antoine Roquilly, David P. Fairlie, Katharina Gaus, Jamie Rossjohn, Jose A. Villadangos, Hamish E.G. McWilliam
Lim et al. investigate the internalization mechanism of the antigen presenting molecule, MR1. Recognition of a conserved atypical motif in MR1’s cytoplasmic tail by AP2 defines the endocytosis rate and duration of MR1–metabolite cell surface display, functioning as the “off” switch for MR1 presentation.
Article
Yan-Xia Liu, Wei-Yue Sun, Bin Xue, Rui-Kai Zhang, Wen-Juan Li, Xixian Xie, Zhen-Chuan Fan
ARL3 mutations disrupt protein import into cilia causing Joubert syndrome (JBTS). Using Chlamydomonas, Liu et al. show that ARL3 recruits the BBSome to pass the transition zone for ciliary retrieval, providing a mechanistic explanation for why JBTS phenotypically overlaps with Bardet-Biedl syndrome.
Article
Kamilla M.E. Laidlaw, Grant Calder, Chris MacDonald
Laidlaw et al. show nutrient transporters rapidly internalize to an early endosome population. Substrate withdrawal triggers endosomal recycling of transporters from endosomes back to the surface in a pathway that relies on ubiquitination of the ESCRT protein Ist1 and the associated factors Cdc48 and Npl4.
Article
Ceniz Zihni, Anastasios Georgiadis, Conor M. Ramsden, Elena Sanchez-Heras, Alexis J. Haas, Britta Nommiste, Olha Semenyuk, James W.B. Bainbridge, Peter J. Coffey, Alexander J. Smith, Robin R. Ali, Maria S. Balda, Karl Matter
Phagocytosis by different cell types is essential for tissue homeostasis and function. This study identifies a Cdc42-based dual effector signaling mechanism that drives actomyosin remodeling and, thereby, internalization of phagocytic ligands in retinal pigment epithelial cells.
Article
Sean Rogers, Long Gui, Anastasiia Kovalenko, Valeria Zoni, Maxime Carpentier, Kamran Ramji, Kalthoum Ben Mbarek, Amelie Bacle, Patrick Fuchs, Pablo Campomanes, Evan Reetz, Natalie Ortiz Speer, Emma Reynolds, Abdou Rachid Thiam, Stefano Vanni, Daniela Nicastro, W. Mike Henne
Lipid droplets (LDs) can exhibit liquid crystalline sterol-esters in vivo, but the mechanisms governing this are unclear. Rogers et al. describe how yeast glucose restriction drives triglyceride lipolysis that promotes liquid crystalline phase transitions within LDs. They also investigate how these phase transitions alter the LD proteome.

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Current Issue
Volume 221,
Issue 9,
5 September 2022
Reviews & Opinions
Spotlight
André Barros-Carvalho, Eurico Morais-de-Sá
André Barros-Carvalho and Eurico Morais-de-Sá highlight work from Calvi and colleagues that demonstrates a role for PP1 in establishing embryo polarity via regulation of PAR-2 localization.
Spotlight
Elise Marsan, Eric J. Huang
Marsan and Huang discuss work from Chhetri et al. demonstrating that mutant huntingtin interferes with XK surface recycling and reduces divalent ion transport across the membrane.
Spotlight
Zheng Wang, Hong Zhang
Wang and Zhang preview work from the Mizushima lab showing that NCOA4 mediates formation of ferritin condensates that are destined for degradation by macroautophagy and microautophagy.

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