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Katie Linvill, Liam J. Russell, Timothy E. Vanderleest, Hui Miao, Yi Xie, J. Todd Blankenship, Dinah Loerke
In the early Drosophila embryo, germband extension requires positional switches of neighboring epithelial cells through remodeling of cell–cell junctions. Linvill et al. find that junctions systematically rotate from a horizontal towards a vertical orientation. During this process, rotating interfaces acquire myosin and newly initialized contractile identities, which allows for multiple rounds of intercalation.
Article
Saishree S. Iyer, Fangrui Chen, Funso E. Ogunmolu, Shoeib Moradi, Vladimir A. Volkov, Emma J. van Grinsven, Chris van Hoorn, Jingchao Wu, Nemo Andrea, Shasha Hua, Kai Jiang, Ioannis Vakonakis, Mia Potočnjak, Franz Herzog, Benoît Gigant, Nikita Gudimchuk, Kelly E. Stecker, Marileen Dogterom, Michel O. Steinmetz, Anna Akhmanova
Iyer et al. combine in vitro reconstitution assays with cryo-electron tomography, biophysical, and cell biological approaches to show that two centriolar proteins, CP110 and CPAP, exhibit antagonistic activities at microtubule plus ends. Together, they impart very slow but processive microtubule polymerization, and their interaction promotes robust centriole formation.
Article
Zhuobi Liang, Junjie Huang, Yong Wang, Shasha Hua, Kai Jiang
Liang et al. elucidate that TPX2 possesses α-helical repeats exhibiting opposite preferences for “extended” and “compacted” tubulin dimer spacing, with the C-terminal repeat group R8-9 being crucial for its function. They also highlight the synergy between TPX2 and HURP in stabilizing spindle microtubules.
Article
Amanda Bentley-DeSousa, Agnes Roczniak-Ferguson, Shawn M. Ferguson
LRRK2 is a kinase whose activity is linked to Parkinson’s disease. This study identifies a pathway that links LRRK2 activation to lysosome perturbations. This pathway involves the process known as CASM and culminates in an interaction between LRRK2 and GABARAP at the surface of lysosomes.
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Yasuyuki Iwasa, Sohtaroh Miyata, Takuya Tomita, Naoto Yokota, Maho Miyauchi, Ruka Mori, Shin Matsushita, Rigel Suzuki, Yasushi Saeki, Hiroyuki Kawahara
The accumulation of defective polypeptides is a significant cause of various diseases. The authors developed a probe that is specific for defective proteins, which allowed the isolation and visualization of as-yet-hypothetical existence of endogenous orphaned polypeptides as tangible entities.
Article
Yuou Wang, Alex Yemelyanov, Christopher D. Go, Sun K. Kim, Jeanne M. Quinn, Annette S. Flozak, Phuong M. Le, Shannon Liang, Anne-Claude Gingras, Mitsu Ikura, Noboru Ishiyama, Cara J. Gottardi
This paper shows how epithelial cell–cell junctions play a critical role in the fidelity of cell division, where persistent unfolding of the mechanosensitive cadherin complex and actin-binding component, alpha catenin, interferes with cytokinesis through excessive sequestration of the abscission factor, LZTS2.
Article
Andreas Brunner, Natalia Rosalía Morero, Wanlu Zhang, M. Julius Hossain, Marko Lampe, Hannah Pflaumer, Aliaksandr Halavatyi, Jan-Michael Peters, Kai S. Beckwith, Jan Ellenberg
Using quantitative and super-resolution microscopy of loop extruders and DNA, Brunner et al. show that the interphase Cohesins form chromatin loops in a sequential and hierarchical manner, which is conceptually very similar to Condensins generating DNA loops during mitosis.
Issue Cover
Current Issue
Volume 224,
Issue 1,
6 January 2025
Reviews & Opinions
Spotlight
Hannes E. Bülow
H.E. Bülow previews a study from Dhanya Cheerambathur and colleagues, which reveals that a kinetochore protein surprisingly regulates dendrite branching by modulating F-actin dynamics.
Spotlight
Xiaoliang Liu, Xuecai Ge
Liu and Ge highlight work from He et al. that elucidates a phosphorylation cascade that regulates axoneme polyglutamylation and primary cilia function via modulation of ciliary import of tubulin glutamylases.
Spotlight
Edward M.C. Courvan, Roy R. Parker
Cajal bodies are essential sites for the biogenesis of small nuclear and nucleolar ribonucleoproteins. In this issue, Courvan and Parker discuss new work from Neugebauer and colleagues that carefully profiles Cajal Body components and finds an unexpected role for 60S ribosomal proteins.

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