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Phillip Scott, Ana Curinha, Colin Gliech, Andrew J. Holland
Scott et al. show with ultrastructure expansion microscopy that self-phosphorylation is a major driver of the spatial patterning of PLK4 at the centriole and plays a critical role in selecting a single centriole duplication site.
Article
Anna-Katharina Pfitzner, Henry Zivkovic, César Bernat-Silvestre, Matt West, Tanner Peltier, Frédéric Humbert, Greg Odorizzi, Aurélien Roux
Pfitzner, Zivkovic, et al. characterize a novel membrane-bound ESCRT-III copolymer initiated by Vps60. They show that Vps60-based copolymers are in vitro spatially and biochemically distinct from classical Snf7-based ESCRT-III filaments. Different behavior of both ESCRT-III filaments in cells furthermore suggests potential diverse functions in vivo.
Article
Thibault Legal, Mireya Parra, Maxwell Tong, Corbin S. Black, Ewa Joachimiak, Melissa Valente-Paterno, Karl Lechtreck, Jacek Gaertig, Khanh Huy Bui
Legal et al. use cryo-electron tomography to study the tips of motile cilia. They reveal novel structural features of the central pair, expand on the functional role of CEP104/FAP256, and identify potential new proteins that are important for the stability of the ciliary tip.
Article
Alba Yurani Torres, Maddalena Nano, Joseph P. Campanale, Sierra Deak, Denise J. Montell
Drosophila border cells are an excellent model to study fundamental cell behaviors. Torres et al show that elevated and localized Src activity in border cells induces cannibalism of neighboring cells by aberrantly activating phagocytosis with implications for the role of Src in cancer progression.
Article
Nisha R. Pawar, Marguerite S. Buzza, Nadire Duru, Amando A. Strong, Toni M. Antalis
Metastatic spread of ovarian cancer is associated with multicellular spheroids shed from the primary tumor into the peritoneal cavity. Pawar et al. show that overactive matriptase activates a PAR-2/PI3K/Akt/MMP9 signaling axis to enhance spheroid dissemination and metastasis.
Report
Enrica Pellegrino, Beren Aylan, Claudio Bussi, Antony Fearns, Elliott M. Bernard, Natalia Athanasiadi, Pierre Santucci, Laure Botella, Maximiliano G. Gutierrez
Pellegrino et al. show that Mtb infection triggers an increase in the number of peroxisomes and peroxisomal ROS in human macrophages. Macrophages lacking peroxisomes are unable to restrict Mtb infection due to a decreased source of ROS, uncovering a new role for peroxisomes in the host response.
Article
Hope E. Burks, Jenny L. Pokorny, Jennifer L. Koetsier, Quinn R. Roth-Carter, Christopher R. Arnette, Pedram Gerami, John T. Seykora, Jodi L. Johnson, Ziyou Ren, Kathleen J. Green
Melanoma cells exist in a bidirectional communication unit with lesional keratinocytes. In this niche, melanoma cells hijack keratinocyte signaling, causing them to produce promigratory chemokines through the downregulation of keratinocyte desmosomal cadherin Dsg1, leading to increased migration in vitro and an associated epidermal spread in vivo.
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Current Issue
Volume 222,
Issue 9,
4 September 2023
Reviews & Opinions
Review
Muhammad U. Anwar, F. Gisou van der Goot
S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. Anwar and van der Goot discuss the complexity and disease implications of this highly regulated reversible lipidation.
Spotlight
Monica Sharma, Andrey S. Shaw
Activated T cells boost ribosome production to meet their enormous protein synthesis demands. Sharma and Shaw discuss work from Zhou et al. showing the protein DCAF13 mediates nucleolar expansion in this setting.
Spotlight
Arisa Ikeda, Miho Iijima, Hiromi Sesaki
Ikeda et al. highlight work from Su and colleagues that describes the mechanism by which NME3 and phosphatidic acid promote mitochondrial tethering prior to fusion.

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