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Jonathan Loi, Xiaofei Qu, Aussie Suzuki
Loi et al. introduce 3D-Speckler, a powerful and high-throughput image analysis software with a user-friendly interface that offers semi-automated, multi-dimensional measurements and corrections of fluorescent particles including 2D/3D size, localization with nanometer accuracy, and intensity for routine microscope calibration and quantitative analyses of biological structures.
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Maarten P. Bebelman, Matthew J. Bovyn, Carlotta M. Mayer, Julien Delpierre, Ronald Naumann, Nuno P. Martins, Alf Honigmann, Yannis Kalaidzidis, Pierre A. Haas, Marino Zerial
Bebelman and Bovyn et al. demonstrate that apical bulkheads, connections between the apical membranes of opposing hepatocytes, are load-bearing mechanical elements that contribute to the ability of bile canaliculi to withstand elevated luminal pressure.
Article
Yuanjiao Du, Weiping Chang, Lei Gao, Lin Deng, Wei-Ke Ji
Du et al. show that Tex2, a potential lipid transporter on the tubular endoplasmic reticulum, is recruited to late endosomes/lysosomes by endosome-resident phosphatidylinositol 4-phosphatases TMEM55 to regulate the lipid compositions, trafficking, and the functions of lysosomes.
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Konstanty Cieslinski, Yu-Le Wu, Lisa Nechyporenko, Sarah Janice Hörner, Duccio Conti, Michal Skruzny, Jonas Ries
Cieslinski and Wu et al. employ super-resolution microscopy to obtain a comprehensive model of the kinetochore structure in budding yeast. By measuring precise positions and stoichiometries, they could resolve the arrangement of the major kinetochore subunits when under attachment tension during metaphase.
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David Virant, Ilijana Vojnovic, Jannik Winkelmeier, Marc Endesfelder, Bartosz Turkowyd, David Lando, Ulrike Endesfelder
Virant et al. build an in situ model of the Schizosaccharomyces pombe kinetochore by determining inter-protein distances and copy numbers. Next to confirming its conserved nature known from in vitro data, they point out S. pombe specifics, e.g., within DASHc and the inner kinetochore structure.
Article
Adi Y. Berman, Michal Wieczorek, Amol Aher, Paul Dominic B. Olinares, Brian T. Chait, Tarun M. Kapoor
Berman et al. examine the capping activity of the γ-TuRC. Using in vitro and cellular assays, they characterize how the γ-TuRC's nucleotide-independent capping activity regulates microtubule dynamics and how it contributes to microtubule formation during cell division.
Article
Rafael Krämer, Neele Wolterhoff, Milos Galic, Sebastian Rumpf
Neurite pruning, a critical neuronal circuit specification mechanism, often involves neurite abscission by unknown mechanisms. In Drosophila sensory neurons, pruning dendrites first become mechanically fragile, and severing occurs through morphogenetic tissue movements that exert mechanical forces on the destabilized dendrites, thus establishing mechanical force as a mechanism during neurite pruning.

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Current Issue
Volume 222,
Issue 1,
2 January 2023
Reviews & Opinions
In Memoriam
Gregg Wildenberg, Deborah J. Mariner, Panos Z. Anastasiadis, Micheal A. Davis, Renee Ireton, Huapeng Yu, Andrew L. Smith, Sarah Kurley, Juliet M. Daniel, Agnes Roczniak-Ferguson, Xiaobo Xia, Meredith Brown, Manish Tripathi, Molly Seale, Robert Carnahan, Whitney Smalley-Freed, Michael Dohn
Albert (Al) B. Reynolds, professor of cancer biology, Vanderbilt School of Medicine, died unexpectedly, and far too soon, at his home in Nashville, TN, at the age of 66 on November 3, 2022. Al earned a bachelor of arts from Kenyon College and a doctor of philosophy (PhD) from University of Virginia. He began his career at ...
People & Ideas
Lucia Morgado-Palacin
Chii Jou Chan investigates how tissue mechanics and fluid pressure regulate mammalian development, with a special focus on folliculogenesis and oocyte quality control.
Spotlight
Catherine G. Galbraith
Catherine Galbraith previews a Tools study from Gallusser and colleagues which describes a new pipeline for training a convolutional neural aimed at rapid automated detection of intracellular structures in volume electron microscopy images.

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