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Fang Chen, Bing Yan, Jie Ren, Rui Lyu, Yanfang Wu, Yuting Guo, Dong Li, Hong Zhang, Junjie Hu
How lipid droplets are formed is largely unclear. Chen et al. show that FIT2 recruits ER tubule-forming proteins and septin cytoskeletons to facilitate nascent LD formation by providing membrane curvature and bulging scaffold.
Elena A. May, Marian Kalocsay, Inès Galtier D’Auriac, Patrick S. Schuster, Steven P. Gygi, Maxence V. Nachury, David U. Mick
May et al. combine proximity labeling with quantitative mass spectrometry to profile the proteome of primary cilia in cells responding to Hedgehog. They identify signaling factors that undergo dynamic ciliary enrichment and uncover an unanticipated regulation of ciliary cAMP signaling.
Harinath Doodhi, Taciana Kasciukovic, Lesley Clayton, Tomoyuki U. Tanaka
Doodhi et al. reconstitute the yeast kinetochore–microtubule interface in vitro and compare the relative strength of distinct kinetochore–microtubule interaction modes. Their results suggest how Aurora B kinase promotes the exchange of kinetochore–microtubule interactions to eliminate aberrant interactions and establish chromosome biorientation.
Alexandre T. Vessoni, Tianpeng Zhang, Annabel Quinet, Ho-Chang Jeong, Michael Munroe, Matthew Wood, Enzo Tedone, Alessandro Vindigni, Jerry W. Shay, Roger A. Greenberg, Luis F.Z. Batista
Vessoni et al. demonstrate telomere shortening leads to a unique DDR response in human pluripotent stem cells. Unlike terminally differentiated cells, telomere shortening induces formation of single-stranded DNA telomere overhangs in hPSCs, which activate ATR signaling and lead to mitotic catastrophe and p53-dependent cell death.
Yumiko Oshima, Etienne Cartier, Liron Boyman, Nicolas Verhoeven, Brian M. Polster, Weiliang Huang, Maureen Kane, W. Jonathan Lederer, Mariusz Karbowski
Oshima et al. report that in the absence of Parkin activity, cells adapt to mitochondrial proteotoxicity through a Drp1-mediated mechanism that includes the severing of the OMM and IMM ubiquitination, followed by recruitment of autophagy machinery to the ubiquitinated IMM proteins.
Olga Shomron, Inbar Nevo-Yassaf, Tamar Aviad, Yakey Yaffe, Eitan Erez Zahavi, Anna Dukhovny, Eran Perlson, Ilya Brodsky, Adva Yeheskel, Metsada Pasmanik-Chor, Anna Mironov, Galina V. Beznoussenko, Alexander A. Mironov, Ella H. Sklan, George H. Patterson, Yoji Yonemura, Mara Sannai, Christoph Kaether, Koret Hirschberg
Live-cell microscopy reveals a novel mode of function for COPII: COPII binds the membrane at the boundary between the ER and ER exit sites, where it executes cargo sorting and concentration into ERES and does not coat cargo exporting containers.
Yanling Yan, Shuai Liu, Can Hu, Chaoyi Xie, Linyue Zhao, Shimin Wang, Wenjuan Zhang, Zihang Cheng, Jinghu Gao, Xin Fu, Zhenrong Yang, Xianghong Wang, Jing Zhang, Long Lin, Anbing Shi
Yan et al. identify C. elegans RTKN-1 as a novel endocytic recycling regulator that impedes UNC-60A/cofilin-mediated endosomal actin disassembly. Further evidence indicates that the self-binding capacity of RTKN-1 is indispensable for this functionality and SDPN-1/Syndapin acts to direct the proper residency of RTKN-1 in recycling endosomes.

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Current Issue
Volume 220,
Issue 4,
April 5, 2021
Reviews & Opinions
Hellyeh Hamidi, Johanna Ivaska
Hamidi and Ivaska preview work from the Korolchuk laboratory describing focal adhesions as hubs mediating growth factor signaling via mTORC1 and amino acid input into the cell.
Christopher G. Burd
Christopher G. Burd discusses recent studies that implicate the GRASP65 and GRASP55 proteins in organizing stacks of Golgi cisternae into a ribbon.
Guillaume Romet-Lemonne, Antoine Jégou
Romet-Lemonne and Jégou discuss recent evidence that actin filaments can both grow and shrink in elongation-promoting conditions.

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