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Jun Zhou, Yasamin Dabiri, Rodrigo A. Gama-Brambila, Shahrouz Ghafoory, Mukaddes Altinbay, Arianeb Mehrabi, Mohammad Golriz, Biljana Blagojevic, Stefanie Reuter, Kang Han, Anna Seidel, Ivan Đikić, Stefan Wölfl, Xinlai Cheng
R-SMAD stability is essential for TGF-β signaling. In this study, Zhou and Dabiri et al. describe a new role of the tumor suppressor pVHL as an E3 ligase for R-SMAD ubiquitination, implicating the potential interaction between oxygen sensing and TGF-β signaling in human cells and Drosophila tissue development.
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Satoshi Uchino, Yuma Ito, Yuko Sato, Tetsuya Handa, Yasuyuki Ohkawa, Makio Tokunaga, Hiroshi Kimura
Uchino et al. have developed a genetically encoded probe to specifically detect the Ser2-phosphorylated, elongating form of RNA polymerase II in living cells. Ser2-phosphorylated RNA polymerase foci exhibit more dynamic motion than chromatin replication domains and p300-enriched foci.
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Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, Junya Hasegawa, Tomohiko Taguchi, Junko Sasaki, Hiroyuki Arai, Takehiko Sasaki, Michihiro Igarashi, Fubito Nakatsu
ORP10 localizes in a PI4P-dependent manner at ER–endosome membrane contact sites tethered by ORP9 and VAP, where it mediates countertransport of PI4P and PS. This in turn supplies endosomes with PS, thereby promoting EHD1 recruitment and endosome fission.
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Jan van der Beek, Cecilia de Heus, Nalan Liv, Judith Klumperman
Van der Beek et al. introduce a quantitative CLEM method using fluorescence to label electron microscopy images by overlay. By comparing the ultrastructural distributions of the endosomal regulators Rab5, Rab7, EEA1, APPL1, and PI(3)P, they reveal distinct endosomal subpopulations and an unexpected localization of EEA1 to late endosomes.
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Anabella Aguilera, Federico Berdun, Carlos Bartoli, Charlotte Steelheart, Matías Alegre, Hülya Bayir, Yulia Y. Tyurina, Valerian E. Kagan, Graciela Salerno, Gabriela Pagnussat, María Victoria Martin
Aguilera et al. show that ferroptosis, an oxidative and iron-dependent form of regulated cell death, plays an important role in the cyanobacterium Synechocystis sp. PCC 6803 in response to heat stress.
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Daniel Crosby, Melissa R. Mikolaj, Sarah B. Nyenhuis, Samantha Bryce, Jenny E. Hinshaw, Tina H. Lee
Human atlastin GTPases are assumed to catalyze ER membrane fusion, but their fusion activity has not previously been reconstituted. Crosby et al. show that purified atlastin1 and atlastin2 are capable of fusion catalysis and that each is negatively regulated by a variable C-terminal extension.
Article
Hui-Chia Yu-Kemp, Rachel A. Szymanski, Daniel B. Cortes, Nicole C. Gadda, Madeline L. Lillich, Amy S. Maddox, Mark Peifer
Yu-Kemp et al. explore mechanisms that epithelial cells use to assemble supramolecular actomyosin structures at E-Cadherin–based cell–cell junctions. They find that individual actin assembly pathways are not essential. Instead, microscopy and pharmacologic inhibition suggest that micron-scale supramolecular myosin arrays help bundle actin at mature junctions.

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Current Issue
Volume 220,
Issue 11,
November 1, 2021
Reviews & Opinions
Spotlight
Ira Milosevic, Michael A. Cousin
Milosevic and Cousin discuss recent work from Peng et al. showing bidirectional phosphorylation-dependent control of two discrete synaptic vesicle endocytosis modes via calcineurin and Minibrain kinase.
Spotlight
Adele L. Marston
Marston discusses work from the Wozniak laboratory showing that mitotic phosphorylation triggers a wave of SUMOylation at the nuclear envelope to re-establish chromatin tethers in late mitosis.
Spotlight
Indrayani Waghmare, Andrea Page-McCaw
Waghmare and Page-McCaw highlight work from Hu et al. that describes a mechanism by which convergence and extension of the mesoderm and endoderm is regulated non–cell-autonomously.

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