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Adam N. Keen, Luke A. Payne, Vedanta Mehta, Alistair Rice, Lisa J. Simpson, Kar Lai Pang, Armando del Rio Hernandez, John S. Reader, Ellie Tzima
Keen et al. discover a new role for eIF6, a protein classically known for its role in protein synthesis, in mechanotransduction, and the cellular response to force. These data provide a novel paradigm for how the cytoskeletal and translational machineries are linked.
Article
Gregory C. Addicks, Hongbo Zhang, Dongryeol Ryu, Goutham Vasam, Alexander E. Green, Philip L. Marshall, Sonia Patel, Baeki E. Kang, Doyoun Kim, Elena Katsyuba, Evan G. Williams, Jean-Marc Renaud, Johan Auwerx, Keir J. Menzies
Addicks et al. identify a role for protein acetylation in the regulation of muscle integrity by linking GCN5 acetyltransferase activity to the expression of dystrophin and other genes important for muscle structure. They find that this occurs through GCN5-directed acetylation of the transcriptional repressor YY1.
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Michelle E. Maxson, Yazan M. Abbas, Jing Ze Wu, Jonathan D. Plumb, Sergio Grinstein, John L. Rubinstein
SidK is introduced as a highly specific probe to visualize and quantify the proton-pumping vacuolar H+ATPases (V-ATPases) of mammalian cells and yeast.
Article
Suzan Kors, Christian Hacker, Chloe Bolton, Renate Maier, Lena Reimann, Emily J.A. Kitchener, Bettina Warscheid, Joseph L. Costello, Michael Schrader
Kors et al. reveal that peroxisome–ER associations via the ACBD5-VAPB tether are regulated by phosphorylation and GSK3β in mammalian cells. Phosphorylation sites in the FFAT-like motif of ACBD5 affect the binding to VAPB—and thus peroxisome–ER contact sites—differently.
Article
Badri Krishnan, Takaaki Yasuhara, Purva Rumde, Marcello Stanzione, Chenyue Lu, Hanjun Lee, Michael S. Lawrence, Lee Zou, Linda T. Nieman, Ioannis Sanidas, Nicholas J. Dyson
Krishnan et al. use FISH to show that specific forms of RB induce changes in the organization of euchromatin and heterochromatin domains. These changes are visible under the microscope, occur after cell cycle arrest, are separable from senescence, and represent an E2F-independent activity of RB.
Report
Alexandre Toulmay, Fawn B. Whittle, Jerry Yang, Xiaofei Bai, Jessica Diarra, Subhrajit Banerjee, Tim P. Levine, Andy Golden, William A. Prinz
Glycosylphosphatidylinositol (GPI) anchors attach many proteins to the extracellular surface of the plasma membrane. Anchor synthesis occurs in the ER and requires phosphatidylethanolamine (PE). Toulmay et al. show that tubelike lipid transport proteins bring PE to the ER to support GPI anchor production.
Report
Sophia M. Hirsch, Frances Edwards, Mimi Shirasu-Hiza, Julien Dumont, Julie C. Canman
Hirsch et al. found that genetic disruption of central spindle microtubule assembly in C. elegans embryos does not block cytokinesis or midbody assembly. These central spindle–independent midbodies appeared to form from astral microtubules, bundled by contractile ring constriction.

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Current Issue
Volume 221,
Issue 1,
January 3, 2022
Reviews & Opinions
Spotlight
Ahmet Höke
Ahmet Höke previews work from Li and colleagues that shows that the axonal degeneration induced by the chemotherapy agent paclitaxel is mediated by Sarm1-dependent cADPR signaling and calcium flux.
Review
Bryony Braschi, Heymut Omran, George B. Witman, Gregory J. Pazour, K. Kevin Pfister, Elspeth A. Bruford, Stephen M. King
In this review, Braschi et al. provide an updated consensus nomenclature for components of dynein motors and their assembly factors.
Spotlight
Hilary A. Coller
Coller highlights work from Argüello-Miranda et al. that reveals that yeast devoid of nutrients can enter into quiescence outside of the G1/GO phase in the cell cycle.

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