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Bobby White, Zhenyi Wang, Matthew Dean, Johanna Michl, Natalia Nieora, Sarah Flannery, Iolanda Vendrell, Roman Fischer, Alzbeta Hulikova, Pawel Swietach
This study shows that the combination of hypoxia and acidosis, common in tumors, produces only transient activation of HIF-1α activity due to its autophagic degradation. Consequently, key HIF targets are not induced, helping prevent excessive acidification by fermentation. This pH-hypoxia interplay has implications for cancer diagnostics, treatment, and experimental design.
Article
Moonjung Jung, Jungwoo Kim, Yeji Park, Isaac Ilyashov, Fan Yang, Haruna B. Choijilsuren, Danielle Keahi, Jordan A. Durmaz, Habin Bea, Audrey M. Goldfarb, Mia D. Stein, Claudia Wong, Ryan R. White, Sunandini Sridhar, Raymond Noonan, Tom F. Wiley, Thomas S. Carroll, Francis P. Lach, Sangmoo Jeong, Ileana C. Miranda, Agata Smogorzewska
Jung and Kim et al. show that combined ALDH9A1 and FANCD2 deficiency leads to genomic instability, decreased cell survival, and tumorigenesis. Loss of ATP13A3, a polyamine transporter, rescues cellular growth, implicating aminoaldehydes in the creation of DNA damage, which necessitates repair by the Fanconi anemia pathway.
Article
Kimberly J. Morgan, Emma Carley, Alyssa N. Coyne, Jeffrey D. Rothstein, C. Patrick Lusk, Megan C. King
Morgan et al. demonstrate that pan-expansion microscopy is an exceptional tool for probing the molecular composition and structural plasticity of individual NPCs: they reveal LINC complex–dependent NPC diameter biases across the nuclear surface and changing nucleoporin positions in an ALS model.
Article
Ji Hoon Kim, Rika Maruyama, Kwon Kim, Devin A. Vertrees, Parama Paul, Kyla Britson, Nathaniel R. Laughner, Deborah J. Andrew
Kim et al. report on Arc, a large PDZ domain–containing cell membrane–associated protein that controls Drosophila salivary gland architecture. Arc facilitates apical membrane delivery of Crumbs; in turn, Crumbs limits accumulation and activity of non-muscle myosin II to regulate the number of salivary gland cells that internalize at a given time.
Report
Robert D. Mackin, Ritika V. Bhalla, Viktor Akhanov, Qudrat T. Abdulwahab, Courtney A. Burger, Melanie A. Samuel
This study reveals that the kinase LKB1 is crucial for migration and nuclear positioning of specialized type of RGCs called F-RGCs. Its absence leads to misplacement, altered morphology, and increased cell death, highlighting that different RGC types can use distinct migration programs.
Article
Anna J. Wood, Rania M. Ahmed, Leah E. Simon, Rachel A. Bradley, Stephen Gray, Ian D. Wolff, Paula E. Cohen
Studies described in this manuscript show that cyclin N-terminal domain containing 1 (CNTD1) is a critical regulator of crossover formation during prophase I of meiosis in females. Loss of CNTD1 results in severe depletion of oocytes at birth leading to loss of the ovarian reserve.
Article
Michalis Gounis, America V. Campos, Engy Shokry, Louise Mitchell, Ruhi Deshmukh, Emmanuel Dornier, Nicholas Rooney, Sandeep Dhayade, Luis Pardo, Madeleine Moore, David Novo, Jenna Mowat, Craig Jamieson, Emily Kay, Sara Zanivan, Nikki R. Paul, Claire Mitchell, Colin Nixon, Iain Macpherson, Saverio Tardito, David Sumpton, Karen Blyth, Jim C. Norman, Cassie J. Clarke
Breast cancer cells isolated from lung micrometastases have altered metabolism, which influences extracellular vesicle production to generate invasive microenvironments.
Journal of Cell Biology Cover Image for Volume 224, Issue 6
Current Issue
Volume 224,
Issue 6,
2 June 2025
Reviews & Opinions
Spotlight
Sabina Elmi, Jesper Nylandsted
Sabina Elmi and Jesper Nylandsted highlight work by Williams and colleagues that provides new insight into the role of annexins in the repair of plasma membrane lesions.
Spotlight
Raman Kaushik, Raj K. Ladher
Kaushik and Ladher discuss recent work from Nita and colleagues, describing how FGFR2 localization at primary cilia affects FGFR signalling and highlighting the role of the cilium in a disease-related context.
Review
Tatsuya Hirano
Hirano reviews mitotic genome folding with an emphasis on the mechanistic aspects of condensins, topoisomerase II, and histones.

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