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Joy Armistead, Julia Hatzold, Anna van Roye, Evelin Fahle, Matthias Hammerschmidt
Armistead et al. show that in a bilayered epithelium in vivo, apical cell extrusion of basal cells is achieved via their engulfment by surface cells. In zebrafish hai1a mutants, this constitutes a tumor-suppressive mechanism, revealing a double face of Matriptase.
Article
Szilárd Szikora, Tamás Gajdos, Tibor Novák, Dávid Farkas, István Földi, Peter Lenart, Miklós Erdélyi, József Mihály
Szikora et al. use superresolution microscopy to reveal muscle protein localizations at the nanoscale level. With this protein localization atlas and template-based protein structure modeling, they assemble refined I-band and H-zone models and provide new mechanistic insights into sarcomerogenesis.
Report
Chelsea Maniscalco, Allison E. Hall, Jeremy Nance
Maniscalco et al. show that primordial germ cells remodel by assembling a nonmitotic contractile ring. Ring formation requires the RhoGEF ECT-2 and its activator NOP-1 but not centralspindlin, which activates ECT-2 to position the cytokinetic contractile ring during mitosis.
Article
Paul Atherton, Franziska Lausecker, Alexandre Carisey, Andrew Gilmore, David Critchley, Igor Barsukov, Christoph Ballestrem
Talin and vinculin control mechanosensing by linking adhesion receptors to the contractile actin cytoskeleton. Using a mitochondrial targeting system, Atherton et al. elucidate mechanisms regulating conformational changes required for vinculin binding to talin. Such activation mechanisms are not required for either protein to interact with the adhesion regulatory protein paxillin.
Article
Hugo Girão, Naoyuki Okada, Tony A. Rodrigues, Alexandra O. Silva, Ana C. Figueiredo, Zaira Garcia, Tatiana Moutinho-Santos, Ikuko Hayashi, Jorge E. Azevedo, Sandra Macedo-Ribeiro, Helder Maiato
Girão et al. use structure-guided functional mutants of CLASP2 to show that recognition of growing microtubule plus-ends through EB–protein interaction and the ability to associate with curved microtubule protofilaments through TOG2 and TOG3 domains promote growth and stabilization of kinetochore–microtubules required for poleward flux.
Report
Jiah Kim, Neha Chivukula Venkata, Gabriela Andrea Hernandez Gonzalez, Nimish Khanna, Andrew S. Belmont
Many active genes position near nuclear speckles. Kim et al. show that Hsp70 speckle association correlates with increased nascent transcripts. Live-cell imaging shows that increases in nascent Hsp70 transcripts strictly follow speckle association (∼0–2 min), suggesting that speckle association amplifies gene expression.
Report
Carina Patrizia Derrer, Roberta Mancini, Pascal Vallotton, Sébastien Huet, Karsten Weis, Elisa Dultz
Derrer et al. show that the mRNA export factor Mex67 can perform its essential function when stably tethered to the nuclear pore complex.

Related Articles from Rockefeller University Press

Current Issue
Volume 218,
Issue 12,
December 2, 2019
Reviews & Opinions
Review
Kim Bich Nguyen, Stefani Spranger
Nguyen and Spranger discuss how signaling pathways within tumor cells establish tumor microenvironments that exclude tumor-reactive CD8+ T cells, leading to tumor-immune evasion.
Review
Christina G. Towers, Darya Wodetzki, Andrew Thorburn
Towers et al. review the complex roles of autophagy in cancer and how autophagy relates to mechanisms of cancer cell death and tumor immunology.
People & Ideas
Marie Anne O’Donnell
Lazarou investigates the relationship between mitochondria and autophagy.

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