Skip to Main Content

Advertisement

Skip Nav Destination
New Articles
Report
Yung-Li Chen, Alisha N. Jones, Amy Crawford, Michael Sattler, Andreas Ettinger, Maria-Elena Torres-Padilla
Centromeric DNA regions are highly diverse and evolve rapidly. Chen et al. investigate how the correct balance of centromeric transcripts from mouse stem cells affects chromatin recruitment of CENPC and propose a model where structural RNA features, rather than sequence motifs, are key for RNA–protein interactions.
Report
Akshay Hegde, Subhasri Ghosh, Akhil SHP Ananthan, Sunny Kataria, Abhik Dutta, Srilekha Prabhu, Sneha Uday Khedkar, Anupam Dutta, Colin Jamora
Hegde et al. report that extracellular Caspase-1 functions as a chemotactic factor. This work solves the long-standing question of the cue(s) that coax the migration of HFSCs into the epidermis during the wound healing response and inflammatory skin conditions.
Article
Meng Li, Yali Hou, Yuzheng Zhou, Zhenni Yang, Hongyu Zhao, Tao Jian, Qianxi Yu, Fuxing Zeng, Xiaotian Liu, Zheng Zhang, Yan G. Zhao
Li et al. reveal that liquid–liquid phase separation of host fragile X–related (FXR) family proteins drives clustering of replication organelles of SARS-CoV-2 via specific interaction with viral nonstructural protein Nsp3. FXRs further recruit translation machinery to facilitate viral protein translation for efficient viral replication.
Tools
Hannes Maib, Petia Adarska, Robert Hunton, James H. Vines, David Strutt, Francesca Bottanelli, David H. Murray
Maib et al. present a toolbox of recombinant biosensors for the multiplex and super-resolution detection of phosphoinositides, a small family of signaling lipids. Detection of these crucial lipids in fixed cells and tissues will enable researchers to address key outstanding questions in cell biology.
Article
Mariska S. Simpson, Heidi De Luca, Sarah Cauthorn, Phi Luong, Namrata D. Udeshi, Tanya Svinkina, Stefanie S. Schmieder, Steven A. Carr, Michael J. Grey, Wayne I. Lencer
How the ER stress sensor IRE1α detects misfolded proteins to activate the unfolded protein response is not fully defined. Simpson et al. find that IRE1α binds a metastable structural motif in cholera toxin and other proteins that activate the UPR with implications for how binding may be linked to IRE1α activation.
Article
Margaret S. Robinson, Robin Antrobus, Anneri Sanger, Alexandra K. Davies, David C. Gershlick
Robinson et al. investigate AP-1 function using complementary approaches on cells coexpressing tagged AP-1 and cargo proteins. Their results support a model in which AP-1 is recruited onto post-Golgi carriers and early/recycling endosomes, where it retrieves selected proteins back to the TGN.
Article
Jack Houston, Clémence Vissotsky, Amar Deep, Hiroyuki Hakozaki, Enice Crews, Karen Oegema, Kevin D. Corbett, Pablo Lara-Gonzalez, Taekyung Kim, Arshad Desai
Houston et al. show that in C. elegans, BUB-1–BUB-3 kinetochore localization requires recognition of phosphorylated “TF” motifs in KNL-1 by the TPR domain of BUB-1. BUB-3 binding to phosphorylated “MELT” motifs in KNL-1 cooperates with the TPR to rapidly increase complex localization during mitotic entry.
Issue Cover
Current Issue
Volume 223,
Issue 4,
1 April 2024
Reviews & Opinions
Spotlight
Shiori Sekine, Yusuke Sekine
Shiori Sekine and Yusuke Sekine discuss work by Krakowczyk et al., which discovered a new quality control mechanism in human cells that eliminates stalled proteins in the mitochondrial TOM translocase.
Review
Gui-Jing Xiong, Zu-Hang Sheng
Xiong and Sheng review recent advances in presynaptic mechanisms of neurodevelopmental disorders by focusing on impaired axonal transport of presynaptic cargos.
Viewpoint
Michael Sebbagh, Martin A. Schwartz
Sebbagh and Schwartz discuss new research indicating that the nectin/afadin complex is the major force transmitting structure in mature intestinal epithelial adherens junctions.

Most Popular

Advertisement

Special Collections

Special Collections

Annual collection of our most exciting papers.

View Collections >
Close Modal

or Create an Account

Close Modal
Close Modal