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Jessica Laiman, Yen-Jung Hsu, Julie Loh, Wei-Chun Tang, Mei-Chun Chuang, Hui-Kang Liu, Wei-Shun Yang, Bi-Chang Chen, Lee-Ming Chuang, Yi-Cheng Chang, Ya-Wen Liu
Laiman et al. discover that GSK3α, but not GSK3β, phosphorylates dynamin-2 to unleash the Bin1 inhibition and promotes GLUT4 endocytosis in skeletal muscle. Importantly, pharmacological inhibition of GSK3α improves insulin sensitivity and glucose tolerance in diet-induced diabetic mice, highlighting GSK3α as a therapeutic target for metabolic disorders.
Jonathan Pacheco, Anna C. Cassidy, James P. Zewe, Rachel C. Wills, Gerald R.V. Hammond
Pacheco et al. demonstrate that unbound PI(4,5)P2 diffusion in the PM is rapid and is not slowed by the majority of PI(4,5)P2-dependent PM complexes found there, such as clathrin-coated structures and focal adhesions.
Clotilde Huet-Calderwood, Felix E. Rivera-Molina, Derek K. Toomre, David A. Calderwood
Combining live TIRF microscopy and fluorescently tagged fibronectin, the authors show that fibronectin secretion by fibroblasts occurs preferentially at leading edge protrusions stabilized by mature focal adhesions and that fibronectin deposition requires both intact microtubules and myosin II contractility.
Ana Milas, Jorge de-Carvalho, Ivo A. Telley
Milas et al. use mechanical and optical perturbation to show the requirement of cell–cell contact between somatic follicle cells and the oocyte in the Drosophila egg chamber for maintaining Par protein polarity and posterior oskar mRNA localization.
Zhentai Huang, Chi-Wei Chen, Raquel Buj, Naveen Kumar Tangudu, Richard S. Fang, Kelly E. Leon, Erika S. Dahl, Erika L. Varner, Eliana von Krusenstiern, Aidan R. Cole, Nathaniel W. Snyder, Katherine M. Aird
Huang and Chen et al. find that inhibition of ATM in cancer cells induces uptake of branched-chain amino acids via macropinocytosis. This work also reveals that macropinocytosis is a metabolic vulnerability of cancer cells treated with ATM inhibitors.
Alexandria P. Lassetter, Megan M. Corty, Romina Barria, Amy E. Sheehan, Jo Q. Hill, Sue A. Aicher, A. Nicole Fox, Marc R. Freeman
Axon maintenance is critical to sustaining a functional nervous system as animals age. Glia contribute to axon maintenance, but precisely how is not well characterized. This work identifies a battery of glial genes that regulate axon support. These genes provide insight into in vivo mechanisms of axon maintenance and may help explain how glial dysfunction leads to neurodegeneration.
Nicolas G. Brukman, Kohdai P. Nakajima, Clari Valansi, Kateryna Flyak, Xiaohui Li, Tetsuya Higashiyama, Benjamin Podbilewicz
Egg–sperm fusion is the climax of fertilization. In vertebrates, the molecules that directly mediate egg–sperm merger and how this process occurs have been the holy grail of fertilization. Here, Brukman, Nakajima et al. demonstrate that the docking protein IZUMO1 from mouse can merge mammalian cells.

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Current Issue
Volume 221,
Issue 11,
7 November 2022
Reviews & Opinions
People & Ideas
Lucia Morgado-Palacin
Sachihiro Matsunaga studies the nuclear structure and chromatin dynamics of plants.
Kristin Eckel-Mahan
Kristin Eckel-Mahan previews work from Sánchez-Ramírez and Ung et al. that elucidates how NAD+ metabolism modulates the early stages of adipogenic differentiation whereas SIRT1’s effects are limited to terminal stages.
Rachel L. Babcock, Kevin Pruitt
Babcock and Pruitt preview work from Kang et al. describing how LLPS of Dishevelled promotes assembly of Wnt signalosome condensates while also disrupting the β-catenin destruction complex.

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