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Akshay Hegde, Subhasri Ghosh, Akhil SHP Ananthan, Sunny Kataria, Abhik Dutta, Srilekha Prabhu, Sneha Uday Khedkar, Anupam Dutta, Colin Jamora
Hegde et al. report that extracellular Caspase-1 functions as a chemotactic factor. This work solves the long-standing question of the cue(s) that coax the migration of HFSCs into the epidermis during the wound healing response and inflammatory skin conditions.
Article
Meng Li, Yali Hou, Yuzheng Zhou, Zhenni Yang, Hongyu Zhao, Tao Jian, Qianxi Yu, Fuxing Zeng, Xiaotian Liu, Zheng Zhang, Yan G. Zhao
Li et al. reveal that liquid–liquid phase separation of host fragile X–related (FXR) family proteins drives clustering of replication organelles of SARS-CoV-2 via specific interaction with viral nonstructural protein Nsp3. FXRs further recruit translation machinery to facilitate viral protein translation for efficient viral replication.
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Jack Houston, Clémence Vissotsky, Amar Deep, Hiroyuki Hakozaki, Enice Crews, Karen Oegema, Kevin D. Corbett, Pablo Lara-Gonzalez, Taekyung Kim, Arshad Desai
Houston et al. show that in C. elegans, BUB-1–BUB-3 kinetochore localization requires recognition of phosphorylated “TF” motifs in KNL-1 by the TPR domain of BUB-1. BUB-3 binding to phosphorylated “MELT” motifs in KNL-1 cooperates with the TPR to rapidly increase complex localization during mitotic entry.
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Hannes Maib, Petia Adarska, Robert Hunton, James H. Vines, David Strutt, Francesca Bottanelli, David H. Murray
Maib et al. present a toolbox of recombinant biosensors for the multiplex and super-resolution detection of phosphoinositides, a small family of signaling lipids. Detection of these crucial lipids in fixed cells and tissues will enable researchers to address key outstanding questions in cell biology.
Article
Mariska S. Simpson, Heidi De Luca, Sarah Cauthorn, Phi Luong, Namrata D. Udeshi, Tanya Svinkina, Stefanie S. Schmieder, Steven A. Carr, Michael J. Grey, Wayne I. Lencer
How the ER stress sensor IRE1α detects misfolded proteins to activate the unfolded protein response is not fully defined. Simpson et al. find that IRE1α binds a metastable structural motif in cholera toxin and other proteins that activate the UPR with implications for how binding may be linked to IRE1α activation.
Article
Margaret S. Robinson, Robin Antrobus, Anneri Sanger, Alexandra K. Davies, David C. Gershlick
Robinson et al. investigate AP-1 function using complementary approaches on cells coexpressing tagged AP-1 and cargo proteins. Their results support a model in which AP-1 is recruited onto post-Golgi carriers and early/recycling endosomes, where it retrieves selected proteins back to the TGN.
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Verena Baumann, Sonja Achleitner, Susanna Tulli, Martina Schuschnig, Lara Klune, Sascha Martens
Baumann, Achleitner, and Tulli et al. dissect Faa1 function and recruitment during autophagy. They discover that Faa1 is directly recruited to membranes via a positive patch on the protein surface. This is a prerequisite for Faa1’s enzymatic activity sustaining autophagosome biogenesis.
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Current Issue
Volume 223,
Issue 4,
1 April 2024
Reviews & Opinions
Review
Gui-Jing Xiong, Zu-Hang Sheng
Xiong and Sheng review recent advances in presynaptic mechanisms of neurodevelopmental disorders by focusing on impaired axonal transport of presynaptic cargos.
Viewpoint
Michael Sebbagh, Martin A. Schwartz
Sebbagh and Schwartz discuss new research indicating that the nectin/afadin complex is the major force transmitting structure in mature intestinal epithelial adherens junctions.
Spotlight
Kota Saito, Miharu Maeda
Saito and Maeda discuss work by Yang et al. showing that all four p24 subfamilies are required for secretion and their interactions with Tango1 are vital for a stable ER–Golgi interface.

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