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Luísa T. Ferreira, Bernardo Orr, Girish Rajendraprasad, António J. Pereira, Carolina Lemos, Joana T. Lima, Clàudia Guasch Boldú, Jorge G. Ferreira, Marin Barisic, Helder Maiato
Detyrosination is a frequent posttranslational modification of long-lived microtubules that inhibits microtubule depolymerase activity in vitro. Ferreira et al. combine manipulation of tubulin tyrosine ligase and carboxypeptidase (Vasohibins-SVBP) activities with state-of-the-art microscopy in human cells to show that α-tubulin detyrosination allows centromeric MCAK to discriminate between correct and incorrect kinetochore–microtubule attachments and ensure mitotic fidelity.
Article
Hua Deng, Limin Yang, Pei Wen, Huiyan Lei, Paul Blount, Duojia Pan
Deng et al. report an essential role for the spectrin-based membrane skeleton in specifying cell shape by transmitting intracellular actomyosin force to cell membrane. Their findings uncover an essential mechanism that couples cell shape, cortical tension, and Hippo signaling in tissue morphogenesis.
Article
Robert G. Abrisch, Samantha C. Gumbin, Brett Taylor Wisniewski, Laura L. Lackner, Gia K. Voeltz
Mitochondria form a network that is constantly remodeled by fission and fusion. Abrisch et al. show that fission and fusion machineries converge at ER membrane contact sites (MCSs) to provide a unified platform where fission and fusion are coordinated to balance mitochondrial dynamics and morphology.
Tools
Wilco Nijenhuis, Mariëlle M.P. van Grinsven, Lukas C. Kapitein
Nijenhuis et al. developed a robust optogenetic toolbox to reversibly reposition organelles in populations of cells with minimal adverse effects on endogenous transport. This work opens new opportunities to dissect intracellular transport and spatial cell biology.
Article
Nidhi Vishnoi, Karthigeyan Dhanasekeran, Madeleine Chalfant, Ivan Surovstev, Mustafa K. Khokha, C. Patrick Lusk
Nup188 is part of the nuclear pore complex scaffold that is specifically required for heart development. As shown by Vishnoi et al., Nup188 also moonlights as a centrosome protein by binding directly to Cep152 and contributing to centriole duplication.
Article
Sudeshna Roy Chowdhury, Chumki Bhattacharjee, Jason C. Casler, Bhawik Kumar Jain, Benjamin S. Glick, Dibyendu Bhattacharyya
ER arrival sites (ERAS) that capture retrograde Golgi-to-ER COPI vesicles have not been well characterized. Roy Chowdhury et al. use the budding yeast Pichia pastoris to show that ERAS are physically and functionally linked to ER exit sites (ERES).
Article
Shuangxi Li, Aiguo Tian, Shuang Li, Yuhong Han, Bing Wang, Jin Jiang
Stem cell activity has to be regulated throughout adult life to maintain tissue homeostasis. Li et al. find that the membrane-associated kinase Gilgamesh (Gish/CK1γ) restricts JNK signaling and Drosophila intestinal stem cell proliferation by phosphorylating and destabilizing Rho1.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 2,
February 3, 2020
Reviews & Opinions
Perspective
Robert G. Parton, Michael M. Kozlov, Nicholas Ariotti
Parton et al. discuss how the proteins of caveolae, and the architecture of the domain, can concentrate specific lipids in caveolae. They propose that disassembly of caveolae in response to cellular stressors releases specialized lipids to modulate signaling.
Review
Fred D. Mast, Richard A. Rachubinski, John D. Aitchison
Mast et al. review peroxisome biogenesis, interorganellar contacts, and the connections and shared molecular players acting in the formation of peroxisomes and lipid droplets at the ER.
Spotlight
Pablo Sánchez-Martín, Masaaki Komatsu
Sánchez-Martín and Komatsu preview work from Itakura and colleagues that describes a mechanism that mediates degradation of misfolded extracellular proteins.

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