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Andrea Scelfo, Viviana Barra, Nezar Abdennur, George Spracklin, Florence Busato, Catalina Salinas-Luypaert, Elena Bonaiti, Guillaume Velasco, Frédéric Bonhomme, Anna Chipont, Andréa E. Tijhuis, Diana C.J. Spierings, Coralie Guérin, Paola Arimondo, Claire Francastel, Floris Foijer, Jӧrg Tost, Leonid Mirny, Daniele Fachinetti
Scelfo et al. present an inducible, rapid, and reversible DNMT1 depletion cell system allowing DNA methylation modulation. They unveil a cooperative DNMT1 and DNMT3B activity in maintaining methylation, heterochromatin, chromatin compartmentalization, and cell fitness. Overall, this system offers temporal resolution for exploring the role of DNAme dysfunction in human disease.
Article
Leonie F. Schrӧder, Wesley Peng, Ge Gao, Yvette C. Wong, Michael Schwake, Dimitri Krainc
Using live-cell microscopy, we find that loss of VPS13C in human neurons disrupts lysosomal morphology and dynamics with increased inter-lysosomal tethers, leading to impaired lysosomal motility and defective lysosomal function as well as a decreased phospho-Rab10-mediated lysosomal stress response.
Article
Hideyuki Shimizu, Samira Hosseini-Alghaderi, Simon A. Woodcock, Martin Baron
Sorting of signaling receptors between membrane environments can regulate their activity. Shimizu et al. show that localization of Notch to alternative microdomains on the endosome switches between different mechanisms of activation, and lateral movement of Notch on the endosome membrane between these microdomains is regulated by Deltex and limited by differential roles of ESCRT-I and III complexes.
Article
Melissa A. Quintanilla, Hiral Patel, Huini Wu, Kem A. Sochacki, Shreya Chandrasekar, Matthew Akamatsu, Jeremy D. Rotty, Farida Korobova, James E. Bear, Justin W. Taraska, Patrick W. Oakes, Jordan R. Beach
Quintanilla et al. demonstrate that, in addition to known biochemical signaling pathways, myosin filament assembly is controlled by the local biophysical environment to enable contractile network assembly.
Article
Hiroki Inoue, Taku Kanda, Gakuto Hayashi, Ryota Munenaga, Masayuki Yoshida, Kana Hasegawa, Takuya Miyagawa, Yukiya Kurumada, Jumpei Hasegawa, Tomoyuki Wada, Motoi Horiuchi, Yasuhiro Yoshimatsu, Fumiko Itoh, Yuki Maemoto, Kohei Arasaki, Yuichi Wakana, Tetsuro Watabe, Hiromichi Matsushita, Hironori Harada, Mitsuo Tagaya
Inoue et al. demonstrate that the microtubule- and actin-binding protein MAP1B promotes invadopodia stabilization, invasion, and tumorigenesis in triple-negative breast cancer cells by preventing autophagic degradation of the pro-invasive protein Tks5 and propose the MAP1B–Tks5–cortactin axis as a potential therapeutic target for TNBC.
Article
Qimei Pan, Peng Luo, Kaishun Hu, Yuntan Qiu, Gaoyu Liu, Shijie Dai, Bokang Cui, Dong Yin, Chunmeng Shi
Pan et al. describe that the stability of cyclin D1 mRNA fluctuates throughout the cell cycle, controlled by PC4, a small RNA binding protein modified by cell cycle–dependent phosphorylation and ubiquitination. This regulation impacts cell cycle progression and tumorigenesis, suggesting PC4 as a promising therapeutic target for hepatocellular carcinoma treatment.
Article
Ian A. Windham, Alex E. Powers, Joey V. Ragusa, E. Diane Wallace, Maria Clara Zanellati, Victoria H. Williams, Colby H. Wagner, Kristen K. White, Sarah Cohen
Windham et al. discover that APOE in astrocytes can traffic to lipid droplets (LDs), where it modulates LD composition and size. Astrocytes expressing the Alzheimer’s risk variant APOE4 form large LDs with impaired turnover and increased peroxidation sensitivity.
Issue Cover
Current Issue
Volume 223,
Issue 2,
5 February 2024
Reviews & Opinions
Spotlight
Jinyi Chen, Mingxi Liu
Chen and Liu preview work from the Takemaru lab that describes how a Cby3/ciBAR1 complex controls positioning of the annulus in the sperm flagellum.
Review
Sookyung Kim, Theresa R. Ramalho, Cole M. Haynes
Kim et al. review how mitochondria-to-nuclear communication promotes proteostasis and immunity.
Spotlight
James E. Vince
TNF signaling does not result in cell death unless multiple inhibitory signals are overcome, which can be accomplished by simultaneous signaling through IFNγ. In this issue, Deng and colleagues dissect the mechanisms by which IFNγ signaling combines with TNF to mediate cell death through caspase-8, discussed by James E. Vince.

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