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Sudeshna Roy Chowdhury, Chumki Bhattacharjee, Jason C. Casler, Bhawik Kumar Jain, Benjamin S. Glick, Dibyendu Bhattacharyya
ER arrival sites (ERAS) that capture retrograde Golgi-to-ER COPI vesicles have not been well characterized. Roy Chowdhury et al. use the budding yeast Pichia pastoris to show that ERAS are physically and functionally linked to ER exit sites (ERES).
Article
Shuangxi Li, Aiguo Tian, Shuang Li, Yuhong Han, Bing Wang, Jin Jiang
Stem cell activity has to be regulated throughout adult life to maintain tissue homeostasis. Li et al. find that the membrane-associated kinase Gilgamesh (Gish/CK1γ) restricts JNK signaling and Drosophila intestinal stem cell proliferation by phosphorylating and destabilizing Rho1.
Article
Eisuke Itakura, Momoka Chiba, Takeshi Murata, Akira Matsuura
Itakura et al. identify a protein quality control system for aberrant extracellular proteins, including misfolded proteins and amyloid β. This extracellular proteostasis pathway involves the cell-surface heparan sulfate receptor, which mediates internalization of aberrant extracellular proteins in complex with an extracellular chaperone.
Tools
James P. Zewe, April M. Miller, Sahana Sangappa, Rachel C. Wills, Brady D. Goulden, Gerald R.V. Hammond
Zewe et al. develop approaches to map the subcellular distribution of the major phospholipid, phosphatidylinositol (PI), revealing that the lipid is present in most membranes except for plasma membrane, where it is found mainly as PI4P and PI(4,5)P2.
Tools
Joshua G. Pemberton, Yeun Ju Kim, Jana Humpolickova, Andrea Eisenreichova, Nivedita Sengupta, Daniel J. Toth, Evzen Boura, Tamas Balla
Pemberton et al. characterize a molecular toolbox for the visualization and manipulation of phosphatidylinositol (PI) within intact cells. Results using these approaches define the steady-state distribution of PI across subcellular membrane compartments and provide new insights into the relationship between PI availability and polyphosphoinositide turnover.
Article
Linda Viol, Shoji Hata, Ana Pastor-Peidro, Annett Neuner, Florian Murke, Patrick Wuchter, Anthony D. Ho, Bernd Giebel, Gislene Pereira
Viol et al. show that the conserved Never-in-mitosis-A–related kinase-2 (Nek2) removes distal appendage components from the mother centriole prior to mitosis in every cell cycle. These findings suggest that Nek2 prevents cilia maintenance during mitosis via distal appendage regulation.
Article
Gisela Cairo, Anne M. MacKenzie, Soni Lacefield
Cairo et al. show that in S. cerevisiae meiosis, spindle checkpoint proteins Bub1 and Bub3 have a critical role in preventing chromosome missegregation and setting the normal duration of anaphase I and II onset by regulating the kinetochore-localization of Ipl1 and PP1.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 2,
February 3, 2020
Reviews & Opinions
Review
Fred D. Mast, Richard A. Rachubinski, John D. Aitchison
Mast et al. review peroxisome biogenesis, interorganellar contacts, and the connections and shared molecular players acting in the formation of peroxisomes and lipid droplets at the ER.
Spotlight
Pablo Sánchez-Martín, Masaaki Komatsu
Sánchez-Martín and Komatsu preview work from Itakura and colleagues that describes a mechanism that mediates degradation of misfolded extracellular proteins.
Spotlight
Guillaume Drin
Drin highlights works from Pemberton et al. and Zewe et al. describing new tools to visualize PI inside cells and clarify how polyphosphoinositides are generated.

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