Skip to Main Content

Advertisement

Skip Nav Destination
New Articles
Tools
Jeffrey Y. Lee, Dalia S. Gala, Maria Kiourlappou, Julia Olivares-Abril, Jana Joha, Joshua S. Titlow, Rita O. Teodoro, Ilan Davis
Lee and Gala et al. meta-analyzed studies identifying mRNAs localized to cytoplasmic projections of various mammalian glial cells, which they showed are strong predictors of localized RNA in Drosophila and are associated with neurological diseases. They found some are essential for synapse formation in adjacent neurons.
Article
Alexandre Thomas, Patrick Meraldi
Human culture cells are thought to divide symmetrically. This study reveals that centrosome age breaks via the kinase Plk1 the symmetry of spindle size through a differential microtubule nucleation capacity. This asymmetry leads to asymmetric cell divisions giving rise to daughter cells of unequal sizes.
Article
Neil J. Ball, Sujan Ghimire, Gautier Follain, Ada O. Pajari, Diana Wurzinger, Monika Vaitkevičiūtė, Alana R. Cowell, Bence Berki, Johanna Ivaska, Ilkka Paatero, Benjamin T. Goult, Guillaume Jacquemet
Ball and Ghimire et al. identified that the actin-bundling protein TLNRD1 is an integral component of the CCM complex, specifically binding to CCM2. The TLNRD1–CCM2 interaction is pivotal for maintaining endothelial barrier integrity, offering new insights into CCM-related diseases.
Article
Marcus A. Harrell, Ziyi Liu, Bethany F. Campbell, Olivia Chinsen, Tian Hong, Maitreyi Das
Cdc42 regulates growth in most eukaryotes and must be cyclically activated and inactivated at sites of growth. We show that endocytosis allows inactivated sites to regain activity by removing the negative feedback (Pak1 kinase) from cell ends.
Article
Claire L. Riggs, Nancy Kedersha, Misheel Amarsanaa, Safiyah Noor Zubair, Pavel Ivanov, Paul Anderson
Riggs et al. characterize the RNA binding protein Ubiquitin Associated Protein 2-Like (UBAP2L) and its role in stress-responsive biomolecular condensates, stress granules and p-bodies. They find that UBAP2L contributes to PB biogenesis and SG–PB interactions, in addition to SG formation.
Article
Min-Chi Yeh, Ning-Hsiang Hsu, Hao-Yu Chu, Cheng-Han Yang, Pang-Hung Hsu, Chi-Chi Chou, Jing-Ting Shie, Wei-Ming Lee, Meng-Chiao Ho, Kai-Yin Lo
Yeh et al. have revealed the molecular mechanism by which the ribosomal protein uL14 is protected by its dedicated chaperone and the methyltransferase. This dual protection system sequentially delivers uL14, ensuring its quality and safety from the cytoplasm until its incorporation into the pre-60S ribosome.
Article
Kieop Park, Aastha Garde, Siddharthan B. Thendral, Adam W.J. Soh, Qiuyi Chi, David R. Sherwood
Invasive cells form large, specialized protrusions to break through basement membrane (BM) matrix barriers. Park et al. reveal a crucial requirement for de novo lipid synthesis and a dynamic polarizing prenylation system to rapidly construct invasive protrusions that breach BMs.
Issue Cover
Current Issue
Volume 223,
Issue 7,
1 July 2024
Reviews & Opinions
Spotlight
Christophe Leterrier
The slender shape of axons makes them uniquely susceptible to mechanical stress. Leterrier discusses new work from Wang and colleagues finding that transient actomyosin beading protects axons by limiting the spread of damaging calcium waves.
Viewpoint
Vivek Malhotra
Vivek Malhotra discusses our emerging understanding of the roles of COPII in mediating the export of diverse cargoes from the ER.
Viewpoint
Adam Zweifach
Zweifach explains how to calculate how many cells to analyze per sample to achieve reasonable statistical power in microscopy experiments.

Most Popular

Advertisement

Special Collections

Special Collections

Annual collection of our most exciting papers.

View Collections >
Close Modal

or Create an Account

Close Modal
Close Modal