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Swagatika Paul, Shireen A. Sarraf, Ki Hong Nam, Leila Zavar, Nicole DeFoor, Sahitya Ranjan Biswas, Lauren E. Fritsch, Tomer M. Yaron, Jared L. Johnson, Emily M. Huntsman, Lewis C. Cantley, Alban Ordureau, Alicia M. Pickrell
Paul et al. demonstrate that NAP1/AZI2 is a cell cycle protein that activates TBK1 during mitosis and regulates key mitotic and cytokinetic proteins to ensure accurate cell division.
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Rebecca A. Jones, Brandon Trejo, Parijat Sil, Katherine A. Little, H. Amalia Pasolli, Bradley Joyce, Eszter Posfai, Danelle Devenport
Jones et al. describe a new mouse model for live visualization of the basement membrane (BM) in which endogenous type IV collagen is fluorescently labeled. Live imaging BM dynamics during skin development reveals that epidermal progenitors remain attached to and deform the BM during division, rather than lose adhesion as generally thought.
Article
Jumpei Omi, Taiga Kato, Yohei Yoshihama, Koki Sawada, Nozomu Kono, Junken Aoki
Omi et al. identify phosphatidylserine (PS) synthesis as a key metabolic vulnerability in B cell receptor (BCR)-positive B cell lymphomas. Inhibition of PS synthesis causes an imbalanced phospholipid metabolism via membrane contact-based lipid transfer machinery, leading to aberrant BCR hyperactivation and ultimately cell death.
Article
Bekir Altas, Hong-Jun Rhee, Anes Ju, Hugo Cruces Solís, Samir Karaca, Jan Winchenbach, Oykum Kaplan-Arabaci, Manuela Schwark, Mateusz C. Ambrozkiewicz, ChungKu Lee, Lena Spieth, Georg L. Wieser, Viduth K. Chaugule, Irina Majoul, Mohamed A. Hassan, Rashi Goel, Sonja M. Wojcik, Noriko Koganezawa, Kenji Hanamura, Daniela Rotin, Andrea Pichler, Miso Mitkovski, Livia de Hoz, Alexandros Poulopoulos, Henning Urlaub, Olaf Jahn, Gesine Saher, Nils Brose, JeongSeop Rhee, Hiroshi Kawabe
Altas et al. demonstrate that astrocytic ion channel proteostasis coordinated by an E3 ubiquitin ligase Nedd4-2 is of particular importance for the maintenance of neuronal network activity.
Article
Xinxin Li, Bowen Liu, Yue Wen, Jiabin Wang, Yusong R. Guo, Anbing Shi, Long Lin
Some integral membrane proteins can reach the plasma membrane in a Golgi-bypassing manner, a process also known as type IV UcPS. Here, Li et al. report that RAB-8– and RAB-11–positive endosomes are utilized as intermediate carriers in the unconventional apical protein transport.
Article
Christopher R. Mahone, Isaac P. Payne, Zhixin Lyu, Joshua W. McCausland, Jordan M. Barrows, Jie Xiao, Xinxing Yang, Erin D. Goley
Mahone et al. use genetic, biochemical, and single-molecule imaging approaches to define a signaling pathway that coordinates chromosome segregation with progression of constriction during cell division in the bacterium Caulobacter crescentus. This pathway ensures genome integrity during the division process.
Article
Ruoxi Wang, Jiaxiang Li, Yuqi Tian, Yating Sun, Yu Zhang, Mengfei Liu, Ruirui Zhang, Li Zhao, Qian Li, Xiaoqian Meng, Jun Zhou, Jinmin Gao
Wang et al. explore the dynamic behaviors of two chromosome axis–associated proteins, LAB-1 and LAB-2, during meiotic prophase in Caenorhabditis elegans, revealing that their recruitment senses axis differentiation. Both proteins have phase separation capacities, which may promote the establishment of distinct chromosome subdomains required for accurate chromosome segregation.
Issue Cover
Current Issue
Volume 222,
Issue 12,
4 December 2023
Reviews & Opinions
In Memoriam
Neville Cobbe, Francesca Di Cara, Allan C. Spradling, Sharron Vass
Margarete M.S. Heck, professor of cell biology and genetics, University of Edinburgh, died peacefully at home amid her loving family under a blue moon on August 30, 2023, after a long journey with ovarian cancer.
Review
Qian Lyu, Qingchao Li, Jun Zhou, Huijie Zhao
Lyu et al. summarize the current knowledge of multiciliogenesis by which the respiratory tract, brain ventricles, and reproductive tracts of vertebrates form multiple motile cilia for tissue homeostasis.
Spotlight
Paulina Podszywalow-Bartnicka, Karla M. Neugebauer
Podszywalow-Bartnicka and Neugebauer preview a study from the Stoecklin lab, which shows that nuclear speckles are reorganized under stress in order to facilitate efficient splicing of immediate early genes (IEGs).

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