Journal of Cell Biology (JCB) | Rockefeller University Press

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The Year in Cell Biology: 2023

Explore our annual collection of the most exciting JCB papers.
Cilia

Chatzifrangkeskou…Skourides: JNK is involved in ciliogenesis.
Cell signaling

Burks…Green: Keratinocyte Dsg1 shapes the melanoma tumor niche.

New Articles

Article

| November 30 2023

Ubiquitination of astrocytic channels by Nedd4-2

Bekir Altas, Hong-Jun Rhee, Anes Ju, Hugo Cruces Solís, Samir Karaca, Jan Winchenbach, Oykum Kaplan-Arabaci, Manuela Schwark, Mateusz C. Ambrozkiewicz, ChungKu Lee, Lena Spieth, Georg L. Wieser, Viduth K. Chaugule, Irina Majoul, Mohamed A. Hassan, Rashi Goel, Sonja M. Wojcik, Noriko Koganezawa, Kenji Hanamura, Daniela Rotin, Andrea Pichler, Miso Mitkovski, Livia de Hoz, Alexandros Poulopoulos, Henning Urlaub, Olaf Jahn, Gesine Saher, Nils Brose, JeongSeop Rhee, Hiroshi Kawabe

Altas et al. demonstrate that astrocytic ion channel proteostasis coordinated by an E3 ubiquitin ligase Nedd4-2 is of particular importance for the maintenance of neuronal network activity.

Article

| November 29 2023

Rab11 regulates unconventional protein secretion

Xinxin Li, Bowen Liu, Yue Wen, Jiabin Wang, Yusong R. Guo, Anbing Shi, Long Lin

Some integral membrane proteins can reach the plasma membrane in a Golgi-bypassing manner, a process also known as type IV UcPS. Here, Li et al. report that RAB-8– and RAB-11–positive endosomes are utilized as intermediate carriers in the unconventional apical protein transport.

Article

| November 28 2023

Coordinated activation of bacterial division

Christopher R. Mahone, Isaac P. Payne, Zhixin Lyu, Joshua W. McCausland, Jordan M. Barrows, Jie Xiao, Xinxing Yang, Erin D. Goley

Mahone et al. use genetic, biochemical, and single-molecule imaging approaches to define a signaling pathway that coordinates chromosome segregation with progression of constriction during cell division in the bacterium Caulobacter crescentus. This pathway ensures genome integrity during the division process.

Article

| November 27 2023

LAB recruitment senses axis differentiation

Ruoxi Wang, Jiaxiang Li, Yuqi Tian, Yating Sun, Yu Zhang, Mengfei Liu, Ruirui Zhang, Li Zhao, Qian Li, Xiaoqian Meng, Jun Zhou, Jinmin Gao

Wang et al. explore the dynamic behaviors of two chromosome axis–associated proteins, LAB-1 and LAB-2, during meiotic prophase in Caenorhabditis elegans, revealing that their recruitment senses axis differentiation. Both proteins have phase separation capacities, which may promote the establishment of distinct chromosome subdomains required for accurate chromosome segregation.

Article

| November 22 2023

OSBP governs polarized cargo sorting

Dávid Kovács, Anne-Sophie Gay, Delphine Debayle, Sophie Abélanet, Amanda Patel, Bruno Mesmin, Frédéric Luton, Bruno Antonny

Kovács et al. report that the lipid transporter OSBP regulates apicobasal cargo sorting. By regulating PI(4)P and cholesterol concentrations in the TGN, OSBP controls sorting and subsequent cargo trafficking. Thus, lipid exchange by OSBP is indispensable for the polarized epithelial phenotype.

Report

| November 21 2023

Sirtuin 3 mediates synaptic metabolic plasticity

Anupama Tiwari, Arsalan Hashemiaghdam, Marissa A. Laramie, Dario Maschi, Tristaan Haddad, Marion I. Stunault, Carmen Bergom, Ali Javaheri, Vitaly Klyachko, Ghazaleh Ashrafi

Neurons in the brain frequently experience glucose shortage and utilize oxidative fuels instead. Here, the authors demonstrate that glucose deprivation drives neuronal expression of the mitochondrial deacetylase sirtuin 3, which stimulates oxidative ATP synthesis in hippocampal nerve terminals to sustain neurotransmission.

Article

| November 17 2023

Bridging condensins compacts mitotic chromosomes

Giada Forte, Lora Boteva, Filippo Conforto, Nick Gilbert, Peter R. Cook, Davide Marenduzzo

Forte et al. report simulations revealing that bridging condensins are important to condense chromosomes into mitotic cylinders. This work underscores the importance of the bridging, as well as looping, activity of condensins, and points to a mechanistic model for chromatin structure at chromosome fragile sites.

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Current Issue

Volume 222,

Issue 11,

6 November 2023

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Reviews & Opinions

Review

| November 30 2023

Mechanisms of multiple motile cilia formation

Qian Lyu, Qingchao Li, Jun Zhou, Huijie Zhao

Lyu et al. summarize the current knowledge of multiciliogenesis by which the respiratory tract, brain ventricles, and reproductive tracts of vertebrates form multiple motile cilia for tissue homeostasis.

Spotlight

| November 21 2023

Splicing under stress: A matter of time and place

Paulina Podszywalow-Bartnicka, Karla M. Neugebauer

Podszywalow-Bartnicka and Neugebauer preview a study from the Stoecklin lab, which shows that nuclear speckles are reorganized under stress in order to facilitate efficient splicing of immediate early genes (IEGs).

Review

| November 13 2023

Topoisomerase II checkpoint controls

Tanya N. Soliman, Daniel Keifenheim, Peter J. Parker, Duncan J. Clarke

Soliman et al. integrate recent molecular discoveries to bring insights and offer future directions to further our understanding of Topoisomerase IIA checkpoints.

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