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Ksenia Trofimov, Regina Gratz, Rumen Ivanov, Yvonne Stahl, Petra Bauer, Tzvetina Brumbarova
The bHLH transcription factor FIT controls iron acquisition and growth in plants. FIT undergoes light-induced, reversible condensation and localizes to nuclear bodies (NBs), likely via liquid–liquid phase separation. FIT engages in protein complex, preferentially in NBs. FIT NBs are related to splicing and light signaling.
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Yamini Ravichandran, Jan Hänisch, Kerren Murray, Vanessa Roca, Florent Dingli, Damarys Loew, Valentin Sabatet, Batiste Boëda, Theresia E. Stradal, Sandrine Etienne-Manneville
Using primary astrocytes and neural precursors, which naturally express both CDC42 isoforms, the authors show that the short carboxy-terminal sequence, which distinguishes the two isoforms, dictates different cell functions by influencing the protein intracellular localization.
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Andrea Scelfo, Viviana Barra, Nezar Abdennur, George Spracklin, Florence Busato, Catalina Salinas-Luypaert, Elena Bonaiti, Guillaume Velasco, Frédéric Bonhomme, Anna Chipont, Andréa E. Tijhuis, Diana C.J. Spierings, Coralie Guérin, Paola Arimondo, Claire Francastel, Floris Foijer, Jӧrg Tost, Leonid Mirny, Daniele Fachinetti
Scelfo et al. present an inducible, rapid, and reversible DNMT1 depletion cell system allowing DNA methylation modulation. They unveil a cooperative DNMT1 and DNMT3B activity in maintaining methylation, heterochromatin, chromatin compartmentalization, and cell fitness. Overall, this system offers temporal resolution for exploring the role of DNAme dysfunction in human disease.
Article
Leonie F. Schrӧder, Wesley Peng, Ge Gao, Yvette C. Wong, Michael Schwake, Dimitri Krainc
Using live-cell microscopy, we find that loss of VPS13C in human neurons disrupts lysosomal morphology and dynamics with increased inter-lysosomal tethers, leading to impaired lysosomal motility and defective lysosomal function as well as a decreased phospho-Rab10-mediated lysosomal stress response.
Article
Hideyuki Shimizu, Samira Hosseini-Alghaderi, Simon A. Woodcock, Martin Baron
Sorting of signaling receptors between membrane environments can regulate their activity. Shimizu et al. show that localization of Notch to alternative microdomains on the endosome switches between different mechanisms of activation, and lateral movement of Notch on the endosome membrane between these microdomains is regulated by Deltex and limited by differential roles of ESCRT-I and III complexes.
Article
Melissa A. Quintanilla, Hiral Patel, Huini Wu, Kem A. Sochacki, Shreya Chandrasekar, Matthew Akamatsu, Jeremy D. Rotty, Farida Korobova, James E. Bear, Justin W. Taraska, Patrick W. Oakes, Jordan R. Beach
Quintanilla et al. demonstrate that, in addition to known biochemical signaling pathways, myosin filament assembly is controlled by the local biophysical environment to enable contractile network assembly.
Article
Hiroki Inoue, Taku Kanda, Gakuto Hayashi, Ryota Munenaga, Masayuki Yoshida, Kana Hasegawa, Takuya Miyagawa, Yukiya Kurumada, Jumpei Hasegawa, Tomoyuki Wada, Motoi Horiuchi, Yasuhiro Yoshimatsu, Fumiko Itoh, Yuki Maemoto, Kohei Arasaki, Yuichi Wakana, Tetsuro Watabe, Hiromichi Matsushita, Hironori Harada, Mitsuo Tagaya
Inoue et al. demonstrate that the microtubule- and actin-binding protein MAP1B promotes invadopodia stabilization, invasion, and tumorigenesis in triple-negative breast cancer cells by preventing autophagic degradation of the pro-invasive protein Tks5 and propose the MAP1B–Tks5–cortactin axis as a potential therapeutic target for TNBC.
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Current Issue
Volume 223,
Issue 2,
5 February 2024
Reviews & Opinions
In Memoriam
Mark Peifer, Alexander R. Dunn
In October 2023, cell biology lost one of its brightest stars, Bill Weis, gone too soon at the age of 64. Bill was a masterful biochemist and structural biologist who made landmark contributions to a remarkable number of fields, most notably cell–cell adhesion, Wnt signaling, and signaling by G-protein coupled receptors.
Spotlight
Anne Fassl, Piotr Sicinski
Fassl and Sicinski highlight work from Pang and colleagues that shows that the RNA-binding protein PC4 modulates cyclin D1 levels in cancer cells by regulating mRNA stability.
Spotlight
Jinyi Chen, Mingxi Liu
Chen and Liu preview work from the Takemaru lab that describes how a Cby3/ciBAR1 complex controls positioning of the annulus in the sperm flagellum.

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