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Rebecca A. Jones, Brandon Trejo, Parijat Sil, Katherine A. Little, H. Amalia Pasolli, Bradley Joyce, Eszter Posfai, Danelle Devenport
Jones et al. describe a new mouse model for live visualization of the basement membrane (BM) in which endogenous type IV collagen is fluorescently labeled. Live imaging BM dynamics during skin development reveals that epidermal progenitors remain attached to and deform the BM during division, rather than lose adhesion as generally thought.
Article
Jumpei Omi, Taiga Kato, Yohei Yoshihama, Koki Sawada, Nozomu Kono, Junken Aoki
Omi et al. identify phosphatidylserine (PS) synthesis as a key metabolic vulnerability in B cell receptor (BCR)-positive B cell lymphomas. Inhibition of PS synthesis causes an imbalanced phospholipid metabolism via membrane contact-based lipid transfer machinery, leading to aberrant BCR hyperactivation and ultimately cell death.
Article
Bekir Altas, Hong-Jun Rhee, Anes Ju, Hugo Cruces Solís, Samir Karaca, Jan Winchenbach, Oykum Kaplan-Arabaci, Manuela Schwark, Mateusz C. Ambrozkiewicz, ChungKu Lee, Lena Spieth, Georg L. Wieser, Viduth K. Chaugule, Irina Majoul, Mohamed A. Hassan, Rashi Goel, Sonja M. Wojcik, Noriko Koganezawa, Kenji Hanamura, Daniela Rotin, Andrea Pichler, Miso Mitkovski, Livia de Hoz, Alexandros Poulopoulos, Henning Urlaub, Olaf Jahn, Gesine Saher, Nils Brose, JeongSeop Rhee, Hiroshi Kawabe
Altas et al. demonstrate that astrocytic ion channel proteostasis coordinated by an E3 ubiquitin ligase Nedd4-2 is of particular importance for the maintenance of neuronal network activity.
Article
Xinxin Li, Bowen Liu, Yue Wen, Jiabin Wang, Yusong R. Guo, Anbing Shi, Long Lin
Some integral membrane proteins can reach the plasma membrane in a Golgi-bypassing manner, a process also known as type IV UcPS. Here, Li et al. report that RAB-8– and RAB-11–positive endosomes are utilized as intermediate carriers in the unconventional apical protein transport.
Article
Christopher R. Mahone, Isaac P. Payne, Zhixin Lyu, Joshua W. McCausland, Jordan M. Barrows, Jie Xiao, Xinxing Yang, Erin D. Goley
Mahone et al. use genetic, biochemical, and single-molecule imaging approaches to define a signaling pathway that coordinates chromosome segregation with progression of constriction during cell division in the bacterium Caulobacter crescentus. This pathway ensures genome integrity during the division process.
Article
Ruoxi Wang, Jiaxiang Li, Yuqi Tian, Yating Sun, Yu Zhang, Mengfei Liu, Ruirui Zhang, Li Zhao, Qian Li, Xiaoqian Meng, Jun Zhou, Jinmin Gao
Wang et al. explore the dynamic behaviors of two chromosome axis–associated proteins, LAB-1 and LAB-2, during meiotic prophase in Caenorhabditis elegans, revealing that their recruitment senses axis differentiation. Both proteins have phase separation capacities, which may promote the establishment of distinct chromosome subdomains required for accurate chromosome segregation.
Article
Dávid Kovács, Anne-Sophie Gay, Delphine Debayle, Sophie Abélanet, Amanda Patel, Bruno Mesmin, Frédéric Luton, Bruno Antonny
Kovács et al. report that the lipid transporter OSBP regulates apicobasal cargo sorting. By regulating PI(4)P and cholesterol concentrations in the TGN, OSBP controls sorting and subsequent cargo trafficking. Thus, lipid exchange by OSBP is indispensable for the polarized epithelial phenotype.
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Current Issue
Volume 222,
Issue 12,
4 December 2023
Reviews & Opinions
Review
Qian Lyu, Qingchao Li, Jun Zhou, Huijie Zhao
Lyu et al. summarize the current knowledge of multiciliogenesis by which the respiratory tract, brain ventricles, and reproductive tracts of vertebrates form multiple motile cilia for tissue homeostasis.
Spotlight
Paulina Podszywalow-Bartnicka, Karla M. Neugebauer
Podszywalow-Bartnicka and Neugebauer preview a study from the Stoecklin lab, which shows that nuclear speckles are reorganized under stress in order to facilitate efficient splicing of immediate early genes (IEGs).
Review
Tanya N. Soliman, Daniel Keifenheim, Peter J. Parker, Duncan J. Clarke
Soliman et al. integrate recent molecular discoveries to bring insights and offer future directions to further our understanding of Topoisomerase IIA checkpoints.

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