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James P. Zewe, April M. Miller, Sahana Sangappa, Rachel C. Wills, Brady D. Goulden, Gerald R.V. Hammond
Zewe et al. develop approaches to map the subcellular distribution of the major phospholipid, phosphatidylinositol (PI), revealing that the lipid is present in most membranes except for plasma membrane, where it is found mainly as PI4P and PI(4,5)P2.
Article
Eisuke Itakura, Momoka Chiba, Takeshi Murata, Akira Matsuura
Itakura et al. identify a protein quality control system for aberrant extracellular proteins, including misfolded proteins and amyloid β. This extracellular proteostasis pathway involves the cell-surface heparan sulfate receptor, which mediates internalization of aberrant extracellular proteins in complex with an extracellular chaperone.
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Joshua G. Pemberton, Yeun Ju Kim, Jana Humpolickova, Andrea Eisenreichova, Nivedita Sengupta, Daniel J. Toth, Evzen Boura, Tamas Balla
Pemberton et al. characterize a molecular toolbox for the visualization and manipulation of phosphatidylinositol (PI) within intact cells. Results using these approaches define the steady-state distribution of PI across subcellular membrane compartments and provide new insights into the relationship between PI availability and polyphosphoinositide turnover.
Article
Linda Viol, Shoji Hata, Ana Pastor-Peidro, Annett Neuner, Florian Murke, Patrick Wuchter, Anthony D. Ho, Bernd Giebel, Gislene Pereira
Viol et al. show that the conserved Never-in-mitosis-A–related kinase-2 (Nek2) removes distal appendage components from the mother centriole prior to mitosis in every cell cycle. These findings suggest that Nek2 prevents cilia maintenance during mitosis via distal appendage regulation.
Article
Gisela Cairo, Anne M. MacKenzie, Soni Lacefield
Cairo et al. show that in S. cerevisiae meiosis, spindle checkpoint proteins Bub1 and Bub3 have a critical role in preventing chromosome missegregation and setting the normal duration of anaphase I and II onset by regulating the kinetochore-localization of Ipl1 and PP1.
Article
Jorge Larios, Vincent Mercier, Aurélien Roux, Aurélien Roux, Jean Gruenberg, Jean Gruenberg
ALIX recruits ESCRT-III onto endosomes in a process that does not depend on other ESCRTs but requires the late endosome–specific lipid LBPA in vivo and in vitro. This novel pathway of ILV formation promotes tetraspanin sorting and delivery to exosomes.
Article
Matthäus Mittasch, Vanna M. Tran, Manolo U. Rios, Anatol W. Fritsch, Stephen J. Enos, Beatriz Ferreira Gomes, Alec Bond, Moritz Kreysing, Jeffrey B. Woodruff
Centrosomes withstand microtubule-mediated forces during spindle assembly, yet they are disassembled by similar forces during mitotic exit. Mittasch et al. use nanorheology to probe the material properties of centrosomes and how they change during the cell cycle. In anaphase, the centrosome scaffold becomes weak and brittle, thus allowing force-induced disassembly.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 2,
February 3, 2020
Reviews & Opinions
Review
Daniel Blumenthal, Janis K. Burkhardt
T cell activation requires force production at the immunological synapse. Blumenthal and Burkhardt describe how distinct actin structures contribute to this process, addressing canonical immunological models from a mechanobiology perspective.
Spotlight
Neel S. Singhal, Evan M. Lee, Dengke K. Ma
Singhal et al. highlight new findings from Schulz et al. regarding the survival-promoting effects of GDPGP1 in neural cells.
Spotlight
Linda Ma, Daniel A. Starr
Ma and Starr highlight new work from Rahman et al. that reveals new insight into the mechanisms controlling embryonic pronuclei fusion.

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