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Valentin Guyard, Vera Filipa Monteiro-Cardoso, Mohyeddine Omrane, Cécile Sauvanet, Audrey Houcine, Claire Boulogne, Kalthoum Ben Mbarek, Nicolas Vitale, Orestis Faklaris, Naima El Khallouki, Abdou Rachid Thiam, Francesca Giordano
We reveal that the lipid droplets can emerge from ER subdomains in contact with mitochondria. The lipid transfer proteins ORP5 and ORP8 localize at these sites where they regulate the recruitment of seipin and ensure proper LD biogenesis.
Article
Qinqin Jiang, Martina Foglizzo, Yaroslav I. Morozov, Xuejiao Yang, Arindam Datta, Lei Tian, Vaughn Thada, Weihua Li, Elton Zeqiraj, Roger A. Greenberg
Jiang et al. uncover that ubiquitylated RAP80 and BRCC36 are substrates of deubiquitylation within the BRCA1-A complex. Deubiquitylation prevents auto-inhibition of the complex, allowing RAP80 to bind ubiquitin at DNA damage sites. Autologous deubiquitylation explains the matching ubiquitin-binding and hydrolysis activities within the BRCA1-A complex.
Article
Mike F. Renne, Robin A. Corey, Joana Veríssimo Ferreira, Phillip J. Stansfeld, Pedro Carvalho
Renne et al. show that Seipin promotes the formation of lipid droplets containing either triacylglycerol or steryl esters. It is proposed that interactions between hydroxyl-residues within the Seipin complex and neutral lipid carboxyl esters provide a general mechanism for Seipin-mediated LD formation.
Article
Matthew R. Hannaford, Rong Liu, Neil Billington, Zachary T. Swider, Brian J. Galletta, Carey J. Fagerstrom, Christian Combs, James R. Sellers, Nasser M. Rusan
Hannaford et al., identify that the interaction between Kinesin-1 and Pericentrin is essential for the direct transport of centrioles on the interphase microtubule network. This transport is important for the correct segregation of centrioles during asymmetric cell division.
Tools
Liqing Liu, Shuxin Yang, Yang Liu, Xixia Li, Junjie Hu, Li Xiao, Tao Xu
Efficient and effective quantification protocol of membrane contact sites is an urgent demand in precise surveillance of various cellular processes. Liu et al. developed a deep learning–based high-throughput tool for profiling the contact with EM images.
Article
Thomas J. Kucharski, Rufus Hards, Sarah E. Vandal, Maria Alba Abad, A. Arockia Jeyaprakash, Edward Kaye, Aymen al-Rawi, Tony Ly, Kristina M. Godek, Scott A. Gerber, Duane A. Compton
Kucharski et al. show that small changes to phosphorylation of Hec1 and partial phospho-occupancy are sufficient to support mitotic fidelity. They also show that Cdk1–Cyclin B1 localizes to improperly attached kinetochores during mitosis and directly participates in kinetochore–microtubule attachment error correction by phosphorylating Hec1.
Article
Davina Camargo Madeira Simoes, Nikolaos Paschalidis, Evangelia Kourepini, Vily Panoutsakopoulou
Simoes et al. demonstrate that the SLAYGLR/osteopontin motif induces the production of IFN-β in murine pDCs through α4-integrin receptor in the absence of Toll-like receptor activation. This axis not only enhances pDCs’ suppressive function against melanoma tumor growth, but also boosts pDC generation from bone marrow progenitors.

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Current Issue
Volume 221,
Issue 8,
1 August 2022
Reviews & Opinions
Spotlight
Mitchell S. Wang, Morgan Huse
Actin remodeling promotes B cell activation by enabling B cell antigen receptor clustering in the immune synapse. In the current issue of JCB, Droubi et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112018) find that this process is initiated by the lipid phosphatase INPP5B, which shapes synaptic actin ...
Spotlight
Julian Stopp, Michael Sixt
Stopp and Sixt preview work from the Sarris lab showing that neutophrils follow a two-step search-and-run strategy to approach alarm gradients within complex tissue environments in living organisms.
People & Ideas
Lucia Morgado-Palacin
Sara Cuylen-Haering studies the molecular mechanisms driving phase separation of chromosomes and other cellular organelles, with a special focus on biological surfactants.

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