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Maxime Boutry, Laura F. DiGiovanni, Nicholas Demers, Aaron Fountain, Sami Mamand, Roberto J. Botelho, Peter K. Kim
Boutry et al. show that Arf1-PI4KIIIβ positive vesicles participate in the fission of lysosomal tubules through lysosomal PI(3)P regulation. This work identifies new components involved in the scission of lysosomal tubules and demonstrates that this process requires an exquisite regulation of phosphoinositides on lysosomes.
Article
Takahiro K. Fujiwara, Taka A. Tsunoyama, Shinji Takeuchi, Ziya Kalay, Yosuke Nagai, Thomas Kalkbrenner, Yuri L. Nemoto, Limin H. Chen, Akihiro C.E. Shibata, Kokoro Iwasawa, Ken P. Ritchie, Kenichi G.N. Suzuki, Akihiro Kusumi
The ultrafast camera with single fluorescent-molecule sensitivities developed by Fujiwara et al. has greatly improved the time resolution of single-molecule localization microscopy, revealing the focal adhesion’s dynamic nano-architecture and leading to the model of compartmentalized archipelago of focal-adhesion protein islands.
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Takahiro K. Fujiwara, Shinji Takeuchi, Ziya Kalay, Yosuke Nagai, Taka A. Tsunoyama, Thomas Kalkbrenner, Kokoro Iwasawa, Ken P. Ritchie, Kenichi G.N. Suzuki, Akihiro Kusumi
An ultrafast camera developed by Fujiwara et al. allows single fluorescent-molecule imaging every 33 µs with a localization precision of 34 nm (every 100 µs; 20 nm) and enables ultrafast PALM imaging of whole live cells.
Article
Rukshala Illukkumbura, Nisha Hirani, Joana Borrego-Pinto, Tom Bland, KangBo Ng, Lars Hubatsch, Jessica McQuade, Robert G. Endres, Nathan W. Goehring
Illukkumbura et al. reveal that cluster-dependent tuning of membrane binding rather than size-dependent coupling to the actomyosin cortex enables differential transport of PAR proteins by cortical flows in the C. elegans zygote.
Article
Amit Rahi, Manas Chakraborty, Shivangi Agarwal, Kristen M. Vosberg, Shivani Agarwal, Annie Y. Wang, Richard J. McKenney, Dileep Varma
The mechanism of how mitotic kinetochores accomplish robust, long-distance coupling with spindle microtubule plus-ends during metaphase and anaphase is unknown. This work demonstrates that the replication licensing protein Cdt1 synergizes with kinetochore Ndc80 and the Ska1 complexes to form a tripartite Ndc80-Cdt1-Ska1 complex that processively tracks the plus-ends of dynamic microtubules.
Article
Laura Hakanpää, Amr Abouelezz, An-Sofie Lenaerts, Seyda Culfa, Michael Algie, Jenny Bärlund, Pekka Katajisto, Harvey McMahon, Leonardo Almeida-Souza
Hakanpää et al. show that reticular adhesions are assembled at flat clathrin lattices, a process inhibited by fibronectin and its receptor, integrin α5β1. This novel adhesion assembly mechanism is coupled to cell migration and reveals a unique crosstalk between cell-matrix adhesions.
Article
Imre Gáspár, Ly Jane Phea, Mark A. McClintock, Simone Heber, Simon L. Bullock, Anne Ephrussi
Gáspár et al. reveal that sequential activity of dynein and kinesin-1 motors during transport of oskar mRNA to the posterior of the Drosophila oocyte is orchestrated by competition between two double-stranded RNA-binding proteins, Egl and Staufen, and that this process is spatio-temporally controlled by dynein-mediated localization of the staufen mRNA.
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Current Issue
Volume 222,
Issue 6,
5 June 2023
Reviews & Opinions
Spotlight
Annan S.I. Cook, James H. Hurley
Cook and Hurley preview two related studies examining the role of ATG9A in autophagosome biogenesis in mammalian cells.
Spotlight
Zolt Arany
Zolt Arany discusses work by Saygili Demir et al. showing that mTORC1 activation by shear stress promotes proliferation and migration of lymphatic endothelial cells which is necessary for repair of lymphatic valves.
People & Ideas
Lucia Morgado-Palacin
Gina DeNicola investigates the metabolism of cancer cells in vivo with a focus on NRF2 and the tumor microenvironment.

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