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Article
Yeongho Kim, Grace Mavodza, Can E. Senkal, Christopher G. Burd
Homeostatic mechanisms maintain the lipid compositions of organelle membranes. Acute depletion of cholesterol elicited increased synthesis of very long chain sphingolipids, which facilitate lysosome-to–plasma membrane cholesterol trafficking, plasma membrane cholesterol content, and lipid order homeostasis.
Article
Guanhua Bai, Hao Li, Pengwei Qin, Yiqing Guo, Wanfa Yang, Yinmiao Lian, Fei Ye, Jianxin Chen, Meiling Wu, Ruifeng Huang, Jinsong Li, Youming Lu, Mingjie Zhang
Bai et al. discover that the X-linked neurodevelopmental disorder gene product IQSEC2 adopts an autoinhibited conformation that can be released by Ca2+ binding, revealing how synaptic activity is directly linked to the ISQEC2 enzymatic activity and why Iqsec2 mutations can have deleterious effect on brain functions. Their results also explain why different mutations of Iqsec2 identified in patients have different and even opposite impacts on the enzyme activity of IQSEC2.
Article
Phillip Scott, Ana Curinha, Colin Gliech, Andrew J. Holland
Scott et al. show with ultrastructure expansion microscopy that self-phosphorylation is a major driver of the spatial patterning of PLK4 at the centriole and plays a critical role in selecting a single centriole duplication site.
Article
Anna-Katharina Pfitzner, Henry Zivkovic, César Bernat-Silvestre, Matt West, Tanner Peltier, Frédéric Humbert, Greg Odorizzi, Aurélien Roux
Pfitzner, Zivkovic, et al. characterize a novel membrane-bound ESCRT-III copolymer initiated by Vps60. They show that Vps60-based copolymers are in vitro spatially and biochemically distinct from classical Snf7-based ESCRT-III filaments. Different behavior of both ESCRT-III filaments in cells furthermore suggests potential diverse functions in vivo.
Article
Thibault Legal, Mireya Parra, Maxwell Tong, Corbin S. Black, Ewa Joachimiak, Melissa Valente-Paterno, Karl Lechtreck, Jacek Gaertig, Khanh Huy Bui
Legal et al. use cryo-electron tomography to study the tips of motile cilia. They reveal novel structural features of the central pair, expand on the functional role of CEP104/FAP256, and identify potential new proteins that are important for the stability of the ciliary tip.
Article
Alba Yurani Torres, Maddalena Nano, Joseph P. Campanale, Sierra Deak, Denise J. Montell
Drosophila border cells are an excellent model to study fundamental cell behaviors. Torres et al show that elevated and localized Src activity in border cells induces cannibalism of neighboring cells by aberrantly activating phagocytosis with implications for the role of Src in cancer progression.
Article
Nisha R. Pawar, Marguerite S. Buzza, Nadire Duru, Amando A. Strong, Toni M. Antalis
Metastatic spread of ovarian cancer is associated with multicellular spheroids shed from the primary tumor into the peritoneal cavity. Pawar et al. show that overactive matriptase activates a PAR-2/PI3K/Akt/MMP9 signaling axis to enhance spheroid dissemination and metastasis.
Issue Cover
Current Issue
Volume 222,
Issue 10,
2 October 2023
Reviews & Opinions
Review
Muhammad U. Anwar, F. Gisou van der Goot
S-acylation is one of the most frequent posttranslational modifications that regulates diverse cellular processes. Anwar and van der Goot discuss the complexity and disease implications of this highly regulated reversible lipidation.
Spotlight
Monica Sharma, Andrey S. Shaw
Activated T cells boost ribosome production to meet their enormous protein synthesis demands. Sharma and Shaw discuss work from Zhou et al. showing the protein DCAF13 mediates nucleolar expansion in this setting.
Spotlight
Arisa Ikeda, Miho Iijima, Hiromi Sesaki
Ikeda et al. highlight work from Su and colleagues that describes the mechanism by which NME3 and phosphatidic acid promote mitochondrial tethering prior to fusion.

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