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Mariko Enshoji, Yoshiko Miyano, Nao Yoshida, Makoto Nagano, Minami Watanabe, Mayumi Kunihiro, Daria E. Siekhaus, Junko Y. Toshima, Jiro Toshima
Endocytosis is composed of early and late phases. This study demonstrates that the yeast Eps15/Pan1p is a key regulator for the late phase, and ectopic targeting of Pan1p to the peroxisome triggers most of the events occurring during the late phase at the peroxisome.
Article
Hyun Gwan Park, Yeongjin David Kim, Eunsang Cho, Ting-Yi Lu, Chi-Kuang Yao, Jihye Lee, Seungbok Lee
Park, Kim, Cho, et al. show that actin-regulatory Vav-Rac1-SCAR signaling independently regulates structural and functional presynaptic plasticity by driving BMP macropinocytosis and degradation of BMP receptors and mobilization of the reserve synaptic-vesicle pool, respectively. This work suggests that Vav differentially regulates distinct presynaptic actin pools with highly specialized tasks.
Article
Valentin Guyard, Vera Filipa Monteiro-Cardoso, Mohyeddine Omrane, Cécile Sauvanet, Audrey Houcine, Claire Boulogne, Kalthoum Ben Mbarek, Nicolas Vitale, Orestis Faklaris, Naima El Khallouki, Abdou Rachid Thiam, Francesca Giordano
We reveal that the lipid droplets can emerge from ER subdomains in contact with mitochondria. The lipid transfer proteins ORP5 and ORP8 localize at these sites where they regulate the recruitment of seipin and ensure proper LD biogenesis.
Article
Qinqin Jiang, Martina Foglizzo, Yaroslav I. Morozov, Xuejiao Yang, Arindam Datta, Lei Tian, Vaughn Thada, Weihua Li, Elton Zeqiraj, Roger A. Greenberg
Jiang et al. uncover that ubiquitylated RAP80 and BRCC36 are substrates of deubiquitylation within the BRCA1-A complex. Deubiquitylation prevents auto-inhibition of the complex, allowing RAP80 to bind ubiquitin at DNA damage sites. Autologous deubiquitylation explains the matching ubiquitin-binding and hydrolysis activities within the BRCA1-A complex.
Article
Mike F. Renne, Robin A. Corey, Joana Veríssimo Ferreira, Phillip J. Stansfeld, Pedro Carvalho
Renne et al. show that Seipin promotes the formation of lipid droplets containing either triacylglycerol or steryl esters. It is proposed that interactions between hydroxyl-residues within the Seipin complex and neutral lipid carboxyl esters provide a general mechanism for Seipin-mediated LD formation.
Article
Matthew R. Hannaford, Rong Liu, Neil Billington, Zachary T. Swider, Brian J. Galletta, Carey J. Fagerstrom, Christian Combs, James R. Sellers, Nasser M. Rusan
Hannaford et al., identify that the interaction between Kinesin-1 and Pericentrin is essential for the direct transport of centrioles on the interphase microtubule network. This transport is important for the correct segregation of centrioles during asymmetric cell division.
Tools
Liqing Liu, Shuxin Yang, Yang Liu, Xixia Li, Junjie Hu, Li Xiao, Tao Xu
Efficient and effective quantification protocol of membrane contact sites is an urgent demand in precise surveillance of various cellular processes. Liu et al. developed a deep learning–based high-throughput tool for profiling the contact with EM images.

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Current Issue
Volume 221,
Issue 8,
1 August 2022
Reviews & Opinions
People & Ideas
Lucia Morgado-Palacin
Dorothy Schafer investigates the role of microglia in neural circuit development and plasticity with a special focus on neurological disorders.
Spotlight
Mitchell S. Wang, Morgan Huse
Actin remodeling promotes B cell activation by enabling B cell antigen receptor clustering in the immune synapse. In the current issue of JCB, Droubi et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112018) find that this process is initiated by the lipid phosphatase INPP5B, which shapes synaptic actin ...
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Julian Stopp, Michael Sixt
Stopp and Sixt preview work from the Sarris lab showing that neutophrils follow a two-step search-and-run strategy to approach alarm gradients within complex tissue environments in living organisms.

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