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Article
Sydney Holme, Jennifer Sapia, Michael Davey, Stefano Vanni, Elizabeth Conibear
ABHD17 enzymes remove fatty acids from membrane proteins like NRas. This study shows that their activity depends on two mobile regions: an S-acylated N-terminal helix and a loop. When these regions anchor to membranes, it correctly positions the enzyme, enabling efficient fatty acid removal from proteins.
Article
Miho Matsuda, Sergei Y. Sokol
Accurate spatial and temporal assembly and disassembly of cell–cell junctions are essential for epithelial morphogenesis. This work suggests that the core planar cell polarity protein Prickle2 cooperates with environmental cues to promote anisotropic remodeling of apical junctions, leading to neural tube closure in Xenopus embryos.
Article
Victoria L. Holmes, Morgan M.C. Ricci, Claire C. Weckerly, Michael Worcester, Gerald R.V. Hammond
Holmes and colleagues show that AKT activation is blocked by commonly used PIP3 biosensors, but that this can be overcome by expressing biosensors at single-molecule levels—which also improves kinetic fidelity and sensitivity.
Article
Sabina Colombo, Christel Michel, Silvia Speroni, Felix Ruhnow, Maria Gili, Cláudia Brito, Thomas Surrey
Using microscopy-based in vitro reconstitutions, Colombo et al. show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, explaining how dynein, NuMA, dynactin, and Lis1 focus microtubule minus ends at mitotic spindle poles.
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Dmitry Shatskiy, Athul Sivan, Roland Wedlich-Söldner, Alexander Belyy
This study reveals the structure of F-tractin, a widely used peptide for visualizing the actin cytoskeleton, and introduces an optimized version that minimizes disruptions to actin organization. By comparing F-tractin to Lifeact, the authors highlight their similar binding modes, providing guidance for selecting actin-binding probes.
Article
Brian J. North, Amelia E. Ohnstad, Michael J. Ragusa, Christopher J. Shoemaker
North et al. define the LC3-interacting region (LIR) of NBR1 as a multifunctional binding site that recruits ATG8 proteins, FIP200, and TAX1BP1 to drive autophagic flux. Subsequent analysis of >100 LIRs highlights these motifs as key protein interaction hotspots, shedding new light on autophagy regulation.
Article
Paolo Sanzà, Jan van der Beek, Derk Draper, Cecilia de Heus, Tineke Veenendaal, Corlinda ten Brink, Ginny G. Farías, Nalan Liv, Judith Klumperman
This study reveals a novel role of VPS41 in cellular trafficking, showing that it recruits biosynthetic LAMP carriers in a process dependent on the small GTPase Arl8b. These findings enhance our understanding of the function of VPS41 and Arl8b beyond their role in endosome–lysosome fusion.
Issue Cover
Current Issue
Volume 224,
Issue 2,
3 February 2025
Reviews & Opinions
Spotlight
Priya Sivaramakrishnan
Priya Sivaramakrishnan previews work from Lessenger et al., which shows that regulated polyploidy in the C. elegans intestine is important for modulation of transcript levels, cell size, and tissue function.
Spotlight
Stacey D. Gilk
Gilk highlights work from Acevedo-Sánchez and colleagues revealing that the cytosolic bacterial pathogen Rickettsia parkerii hijacks host machinery to form stable membrane contact sites with the ER.
Editorial
Journal of Cell Biology is pleased to introduce the newest members of our editorial board. We are grateful to these and all of our board members for their contributions to JCB and service to the cell biology community.

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