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Lu Song, Xinran Tian, Randy Schekman
Extracellular vesicles (EVs) may mediate intercellular communication through the transfer of cargo molecules. Song et al. report that cyclin D1 is sorted into EVs during neuronal differentiation and that these EVs help to promote the neural induction of embryonic stem cells.
Article
Gordon L. Frazer, Christian M. Gawden-Bone, Nele M.G. Dieckmann, Yukako Asano, Gillian M. Griffiths
Frazer et al. use 4D imaging to reveal that while the intracellular pathways orchestrating killing within CTL are conserved, the rate of initiation along these pathways varies with TCR signal strength.
Article
Rosanne Wouters, Christine Michiels, Ragna Sannerud, Bertrand Kleizen, Katleen Dillen, Wendy Vermeire, Abril Escamilla Ayala, David Demedts, Randy Schekman, Wim Annaert
The assembly of the γ-secretase complex is coordinated by prior formation in the ER of dimeric subcomplexes, which next independently exit the ER. This mechanism could both prevent premature assembly and help the maintenance of stoichiometric levels of γ-secretase subunits during the assembly process.
Article
Jessica J.A. Hummel, Casper C. Hoogenraad
This work dissects the role of different KIF1A tail domains in motor activity and cargo binding. Based on the results, the authors propose a mechanism for the regulation of KIF1A cargo transport in hippocampal neurons.
Article
Kilian Trillet, Kathryn A. Jacobs, Gwennan André-Grégoire, An Thys, Clément Maghe, Jonathan Cruard, Stéphane Minvielle, Sara Gonzalez Diest, Guillaume Montagnac, Nicolas Bidère, Julie Gavard
Trillet et al. report that the glycoprotein GP130 orchestrates the availability of the G protein–coupled receptor for apelin APLNR at the plasma membrane of glioblastoma stem-like cells, thereby modulating APLN signaling toward self-renewal. By modulating ELMOD1 expression, GP130 ultimately tunes ARF-mediated endovesicular internalization and recycling.
Article
Gabrielle Larocque, Daniel J. Moore, Méghane Sittewelle, Cansu Kuey, Joseph H.R. Hetmanski, Penelope J. La-Borde, Beverley J. Wilson, Nicholas I. Clarke, Patrick T. Caswell, Stephen J. Royle
Larocque et al. describe how tumor protein D52-like proteins associate with intracellular nanovesicles. These small transport vesicles are shown to be involved in recycling α5β1 integrins during cell migration and invasion.
Report
Javier Encinar del Dedo, Isabel María Fernández-Golbano, Laura Pastor, Paula Meler, Cristina Ferrer-Orta, Elena Rebollo, Maria Isabel Geli
This work identifies endoplasmic reticulum subdomains, where the sterol synthesis and export machineries are coupled to sustain endocytosis in yeast mother cells, but not in daughters, where endocytosis and plasma membrane loading with accessible sterols are linked to secretion.

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Issue Cover
Current Issue
Volume 220,
Issue 7,
July 5, 2021
Reviews & Opinions
Viewpoint
Nicolas Tavernier, Frank Sicheri, Lionel Pintard
Tavernier et al. review the different activation mechanisms of the Aurora A kinase during mitotic entry and progression.
Spotlight
W. Mike Henne
In this JCB issue, work from Yang et al. highlights how the ESCRT pathway localizes to the vacuole surface to execute protein sorting of its resident proteins.
Review
Ákos Farkas, Katherine E. Bohnsack
Farkas and Bohnsack describe advances in understanding targeting of tail-anchored (TA) proteins, including their insertion into the ER, how nascent TA proteins are selectively captured at the ribosome, and recently discovered quality control pathways.

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