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The impact of fusion pores on synaptic release is difficult to discern. Through analysis of miniature excitatory synaptic currents, Jackson et al. revealed a correlation between amplitude and rise-time. Modeling indicated this correlation results from the interplay between vesicle size and fusion pore flux.

ON and OFF signals in the retina are processed via parallel pathways. Gangi et al. reveal that regulation of starburst amacrine cells, which are crucial for motion detection, is different between the ON and OFF pathways, despite their morphological mirror symmetry.

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