Article
Reduced voltage-activated Ca2+ release flux in muscle fibers from a rat model of Duchenne dystrophy
Defective Ca2+ signaling in muscle cells is thought to play a role in Duchenne muscular dystrophy. Schreiber et al. report that voltage-activated SR Ca2+ release is moderately depressed in muscle fibers isolated from a rat model that reproduces the human disease well.
Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
Tao and Corry investigate how the binding of sodium channel inhibitors to the Nav1.5 pore using simulations reveal promiscuous, polyspecific binding at the fenestrations and central cavity. These findings shed light on diverse ways drugs inhibit the channel, offering insights for improving therapeutic development for conditions like chronic pain, epilepsy, and cardiac arrhythmias.
Methods and Approaches
ALLIN: A tool for annotation of a protein alignment combined with structural visualization
Picollo and Pusch present ALLIN (Annotation of sequence aLignment and structuraL ProteIn visualizatioN), a web interface to generate an interactive HTML page for the simultaneous visualization of annotated protein sequences alignment and 3-D structures or homology models of the related proteins.
Commentary
How could simulations elucidate Nav1.5 channel blockers mechanism?
Tao and Corry (2025) used metadynamics, an enhanced sampling method to identify and classify Nav channel blockers.
