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Neurodegenerative Diseases: Biology & Therapeutics

Neurodegeneration is the progressive loss of neuronal function which leads to disorders like Alzheimer's disease and Parkinson's disease. Neurodegenerative diseases are characterized by aberrant protein misfolding and aggregate formation, but a better understanding of the mechanisms that initiate or promote protein aggregation is required for the development of therapeutics that can reverse neurodegeneration.

We are pleased to present this special collection of articles recently published in JEM highlighting the latest discoveries related to neurodegeneration and neuroinflammation. Articles featured in the collection were published within the past 12 months and include work on target identification in neurodegenerative disease, technological advances to study neurodegeneration, as well as the glial biology of neurodegeneration. We hope you enjoy reading this collection, and we encourage your feedback on Twitter @JExpMed.

Image © 2020 Bączyk et al.

Special Collection Image
Fares Bassil; Emily S. Meymand; Hannah J. Brown; Hong Xu; Timothy O. Cox; Shankar Pattabhiraman; Chantal M. Maghames; Qihui Wu; Bin Zhang; John Q. Trojanowski; Virginia M.-Y. Lee
DOI: 10.1084/jem.20192193
Jiangong Ren; Congxin Dai; Xin Zhou; Joseph A. Barnes; Xi Chen; Yunfei Wang; Liang Yuan; Takashi Shingu; Amy B. Heimberger; Yiwen Chen; Jian Hu
DOI: 10.1084/jem.20190348
Tongfei Liu; Bing Zhu; Yan Liu; Xiaoming Zhang; Jun Yin; Xiaoguang Li; LuLin Jiang; Andrew P. Hodges; Sara Brin Rosenthal; Lisa Zhou; Joel Yancey; Amanda McQuade; Mathew Blurton-Jones; Rudolph E. Tanzi; Timothy Y. Huang; Huaxi Xu
DOI: 10.1084/jem.20200474
Yulong Xu; Changning Wang; Hsiao-Ying Wey; Yingxia Liang; Zude Chen; Se Hoon Choi; Chongzhao Ran; Kevin D. Rynearson; Daniela R. Bernales; Robert E. Koegel; Stephanie A. Fiedler; Robin Striar; Steven L. Wagner; Rudolph E. Tanzi; Can Zhang
DOI: 10.1084/jem.20182266
Nicolas R. Barthélemy; Kanta Horie; Chihiro Sato; Randall J. Bateman
DOI: 10.1084/jem.20200861
Shoutang Wang; Meer Mustafa; Carla M. Yuede; Santiago Viveros Salazar; Philip Kong; Hua Long; Michael Ward; Omer Siddiqui; Robert Paul; Susan Gilfillan; Adiljan Ibrahim; Hervé Rhinn; Ilaria Tassi; Arnon Rosenthal; Tina Schwabe; Marco Colonna
DOI: 10.1084/jem.20200785
Marcin Bączyk; Najwa Ouali Alami; Nicolas Delestrée; Clémence Martinot; Linyun Tang; Barbara Commisso; David Bayer; Nicolas Doisne; Wayne Frankel; Marin Manuel; Francesco Roselli; Daniel Zytnicki
DOI: 10.1084/jem.20191734
Maria Inês Cunha; Minhui Su; Ludovico Cantuti-Castelvetri; Stephan A. Müller; Martina Schifferer; Minou Djannatian; Ioannis Alexopoulos; Franziska van der Meer; Anne Winkler; Tjakko J. van Ham; Bettina Schmid; Stefan F. Lichtenthaler; Christine Stadelmann; Mikael Simons
DOI: 10.1084/jem.20191390
Erin G. Reed-Geaghan; Andrew L. Croxford; Burkhard Becher; Gary E. Landreth
DOI: 10.1084/jem.20191374
Wei Liu; Yonju Ha; Fan Xia; Shuang Zhu; Yi Li; Shuizhen Shi; Fang C. Mei; Kevin Merkley; Gianmarco Vizzeri; Massoud Motamedi; Xiaodong Cheng; Hua Liu; Wenbo Zhang
DOI: 10.1084/jem.20190930
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