Skip Nav Destination

JEM Cancer Collection 2022

This collection reflects the advent of new lines of cancer research, including studies on the tumor microenvironment, tumor metabolism, anti-tumor immunity, and innovative anti-cancer therapies.

In addition, we are pleased to present a special magazine that contains brief summaries of some of the research articles from this collection, including insights from the authors, and cancer research published in our fellow Rockefeller University Press journal, the Journal of Cell Biology. Download the special collection PDF here.

We hope you appreciate this collection and encourage your comments on Twitter at @JExpMed. Interested in learning how we are making the publishing process easier for authors? Visit our Instructions for Authors or email the Editorial office. Sign up to receive future special collections here.

Article

Obesity suppresses CD8 T cells in cancer

Lydia Dyck; Hannah Prendeville; Mathilde Raverdeau; Mieszko M. Wilk; Roisin M. Loftus; Aaron Douglas; Janet McCormack; Bruce Moran; Michael Wilkinson; Evanna L. Mills; Michael Doughty; Aurelie Fabre; Helen Heneghan; Carel LeRoux; Andrew Hogan; Edward T. Chouchani; Donal O’Shea; Donal Brennan; Lydia Lynch

DOI: 10.1084/jem.20210042

Article

TCR signal strength and cancer evasion

Mojdeh Shakiba; Paul Zumbo; Gabriel Espinosa-Carrasco; Laura Menocal; Friederike Dündar; Sandra E. Carson; Emmanuel M. Bruno; Francisco J. Sanchez-Rivera; Scott W. Lowe; Steven Camara; Richard P. Koche; Vincent P. Reuter; Nicholas D. Socci; Benjamin Whitlock; Fella Tamzalit; Morgan Huse; Matthew D. Hellmann; Daniel K. Wells; Nadine A. Defranoux; Doron Betel; Mary Philip; Andrea Schietinger

DOI: 10.1084/jem.20201966

Article

NR2F1 agonist induces cancer cell dormancy

Bassem D. Khalil; Roberto Sanchez; Tasrina Rahman; Carolina Rodriguez-Tirado; Stefan Moritsch; Alba Rodriguez Martinez; Brett Miles; Eduardo Farias; Mihaly Mezei; Ana Rita Nobre; Deepak Singh; Nupura Kale; Karl Christoph Sproll; Maria Soledad Sosa; Julio A. Aguirre-Ghiso

DOI: 10.1084/jem.20210836

Article

Targeting EYA2 kills glioblastoma stem cells

Guoxin Zhang; Zhen Dong; Ryan C. Gimple; Arthur Wolin; Qiulian Wu; Zhixin Qiu; Lisa M. Wood; Jia Z. Shen; Li Jiang; Linjie Zhao; Deguan Lv; Briana C. Prager; Leo J.Y. Kim; Xiuxing Wang; Lingdi Zhang; Ryan L. Anderson; Jeffrey K. Moore; Shideng Bao; Thomas H. Keller; Grace Lin; Congbao Kang; Petra Hamerlik; Rui Zhao; Heide L. Ford; Jeremy N. Rich

DOI: 10.1084/jem.20202669

Article

TIMP1-dependent sex disparity in pancreatic cancer

Chris D. Hermann; Benjamin Schoeps; Celina Eckfeld; Enkhtsetseg Munkhbaatar; Lukas Kniep; Olga Prokopchuk; Nils Wirges; Katja Steiger; Daniel Häußler; Percy Knolle; Emily Poulton; Rama Khokha; Barbara T. Grünwald; Ihsan Ekin Demir; Achim Krüger

DOI: 10.1084/jem.20210911

Article

Targeting mitochondrial translation in melanoma

Roberto Vendramin; Vicky Katopodi; Sonia Cinque; Angelina Konnova; Zorica Knezevic; Sara Adnane; Yvessa Verheyden; Panagiotis Karras; Ewout Demesmaeker; Francesca M. Bosisio; Lukas Kucera; Jan Rozman; Ivan Gladwyn-Ng; Lara Rizzotto; Erik Dassi; Stefania Millevoi; Oliver Bechter; Jean-Christophe Marine; Eleonora Leucci

DOI: 10.1084/jem.20210571

Article

Tumor–adipose–muscle crosstalk via IL-6 in cachexia

Joseph E. Rupert; Ashok Narasimhan; Daenique H.A. Jengelley; Yanlin Jiang; Jianguo Liu; Ernie Au; Libbie M. Silverman; George Sandusky; Andrea Bonetto; Sha Cao; Xiaoyu Lu; Thomas M. O’Connell; Yunlong Liu; Leonidas G. Koniaris; Teresa A. Zimmers

DOI: 10.1084/jem.20190450

Article

Adjacent histologically normal epithelium promotes tumor progression

Priyanka Singh; Rajat Banerjee; Songlin Piao; Marcell Costa de Medeiros; Emily Bellile; Min Liu; Dilna Damodaran Puthiya Veettil; Ligia B. Schmitd; Nickole Russo; Erika Danella; Ronald C. Inglehart; Kyriel M. Pineault; Deneen M. Wellik; Greg Wolf; Nisha J. D’Silva

DOI: 10.1084/jem.20200944

Article

Stiffness regulates cancer therapy resistance

Allison P. Drain; Nastaran Zahir; Jason J. Northey; Hui Zhang; Po-Jui Huang; Ori Maller; Johnathon N. Lakins; Xinmiao Yu; Jennifer L. Leight; Brenda P. Alston-Mills; E. Shelley Hwang; Yunn-Yi Chen; Catherine C. Park; Valerie M. Weaver

DOI: 10.1084/jem.20191360

Article

A novel treatment strategy for TNBC

Malvika Sharma; Ravi Chakra Turaga; Yi Yuan; Ganesh Satyanarayana; Falguni Mishra; Zhen Bian; Wei Liu; Li Sun; Jenny Yang; Zhi-Ren Liu

DOI: 10.1084/jem.20200712

JEM Cancer Collection 2022

This Feature Is Available To Subscribers Only