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2021: The Year in Experimental Medicine

This year marked the 125th anniversary of the Journal of Experimental Medicine (JEM). Since its inception in 1896, JEM has been a leader in publishing outstanding and enduring studies in medical biology and has greatly contributed to the fields of immunology, cancer biology, neuroscience, cardiovascular biology, host-pathogen interaction, and stem cell biology. Throughout the year, we have been thrilled to celebrate this incredible milestone with a variety of special articles and features which are collected together in the anniversary center.

To highlight our continuing interest in original findings in disease pathogenesis and therapeutic opportunities, we are proud to present our annual Year in Experimental Medicine collection. Ten research articles published in 2021 that were of greatest interest to our readers are highlighted. The papers were selected by the editorial team based, in part, on the number of requests for PDF and full-text HTML versions of an article in the first three months after publication.

We thank our authors for contributing to JEM, our reviewers for contributing their time and expertise to ensure the publication of quality science, and our readers for their interest and continued support of JEM. We hope you enjoy this collection and invite you to explore additional special collections. We also invite your feedback on Twitter @JExpMed. Sign up to receive announcements via email. Visit our Instructions for Authors or contact the Editorial office.

Special Collection Image
Peter Geon Kim; Abhishek Niroula; Veronica Shkolnik; Marie McConkey; Amy E. Lin; Mikołaj Słabicki; John P. Kemp; Alexander Bick; Christopher J. Gibson; Gabriel Griffin; Aswin Sekar; Daniel J. Brooks; Waihay J. Wong; Drew N. Cohen; Md Mesbah Uddin; Wesley J. Shin; James Pirruccello; Jonathan M. Tsai; Mridul Agrawal; Douglas P. Kiel; Mary L. Bouxsein; J. Brent Richards; David M. Evans; Marc N. Wein; Julia F. Charles; Siddhartha Jaiswal; Pradeep Natarajan; Benjamin L. Ebert
DOI: 10.1084/jem.20211872
Wendy Fonseca; Carrie-Anne Malinczak; Kei Fujimura; Danny Li; Kathryn McCauley; Jia Li; Shannon K.K. Best; Diana Zhu; Andrew J. Rasky; Christine C. Johnson; Jennifer Bermick; Edward M. Zoratti; Dennis Ownby; Susan V. Lynch; Nicholas W. Lukacs; Catherine Ptaschinski
DOI: 10.1084/jem.20210235
Sarah A. Greaves; Avinash Ravindran; Radleigh G. Santos; Lan Chen; Michael T. Falta; Yang Wang; Angela M. Mitchell; Shaikh M. Atif; Douglas G. Mack; Alex N. Tinega; Lisa A. Maier; Shaodong Dai; Clemencia Pinilla; Johan Grunewald; Andrew P. Fontenot
DOI: 10.1084/jem.20210785
Satoshi Nakamizo; Charles-Antoine Dutertre; Ahad Khalilnezhad; Xiao Meng Zhang; Shawn Lim; Josephine Lum; Geraldine Koh; Charlene Foong; Pearly Jean Ai Yong; Kahbing Jasmine Tan; Reiko Sato; Kaori Tomari; Laurent Yvan-Charvet; Helen He; Emma Guttman-Yassky; Benoit Malleret; Rintaro Shibuya; Masashi Iwata; Baptiste Janela; Tsuyoshi Goto; Tan Siyun Lucinda; Mark B.Y. Tang; Colin Theng; Valerie Julia; Feriel Hacini-Rachinel; Kenji Kabashima; Florent Ginhoux
DOI: 10.1084/jem.20202345
Nagarjuna R. Cheemarla; Timothy A. Watkins; Valia T. Mihaylova; Bao Wang; Dejian Zhao; Guilin Wang; Marie L. Landry; Ellen F. Foxman
DOI: 10.1084/jem.20210583
Maud Gratuze; Yun Chen; Samira Parhizkar; Nimansha Jain; Michael R. Strickland; Javier Remolina Serrano; Marco Colonna; Jason D. Ulrich; David M. Holtzman
DOI: 10.1084/jem.20210542
Frank M. Davis; Lam C. Tsoi; William J. Melvin; Aaron denDekker; Rachael Wasikowski; Amrita D. Joshi; Sonya Wolf; Andrea T. Obi; Allison C. Billi; Xianying Xing; Christopher Audu; Bethany B. Moore; Steven L. Kunkel; Alan Daugherty; Hong S. Lu; Johann E. Gudjonsson; Katherine A. Gallagher
DOI: 10.1084/jem.20201839
Nuo Xu; Douglas C. Palmer; Alexander C. Robeson; Peishun Shou; Hemamalini Bommiasamy; Sonia J. Laurie; Caryn Willis; Gianpietro Dotti; Benjamin G. Vincent; Nicholas P. Restifo; Jonathan S. Serody
DOI: 10.1084/jem.20200844
Tamara S. Rodrigues; Keyla S.G. de Sá; Adriene Y. Ishimoto; Amanda Becerra; Samuel Oliveira; Leticia Almeida; Augusto V. Gonçalves; Debora B. Perucello; Warrison A. Andrade; Ricardo Castro; Flavio P. Veras; Juliana E. Toller-Kawahisa; Daniele C. Nascimento; Mikhael H.F. de Lima; Camila M.S. Silva; Diego B. Caetite; Ronaldo B. Martins; Italo A. Castro; Marjorie C. Pontelli; Fabio C. de Barros; Natália B. do Amaral; Marcela C. Giannini; Letícia P. Bonjorno; Maria Isabel F. Lopes; Rodrigo C. Santana; Fernando C. Vilar; Maria Auxiliadora-Martins; Rodrigo Luppino-Assad; Sergio C.L. de Almeida; Fabiola R. de Oliveira; Sabrina S. Batah; Li Siyuan; Maira N. Benatti; Thiago M. Cunha; José C. Alves-Filho; Fernando Q. Cunha; Larissa D. Cunha; Fabiani G. Frantz; Tiana Kohlsdorf; Alexandre T. Fabro; Eurico Arruda; Renê D.R. de Oliveira; Paulo Louzada-Junior; Dario S. Zamboni
DOI: 10.1084/jem.20201707
Carmine Fedele; Shuai Li; Kai Wen Teng; Connor J.R. Foster; David Peng; Hao Ran; Paolo Mita; Mitchell J. Geer; Takamitsu Hattori; Akiko Koide; Yubao Wang; Kwan Ho Tang; Joshua Leinwand; Wei Wang; Brian Diskin; Jiehui Deng; Ting Chen; Igor Dolgalev; Ugur Ozerdem; George Miller; Shohei Koide; Kwok-Kin Wong; Benjamin G. Neel
DOI: 10.1084/jem.20201414
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