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Neuroimmunology and Neurodegeneration 2023

A collection covering a broad range of topics including meningeal lymphatics and meningeal immunity, the role of microglia in mediating tau pathology and synaptic pruning, transcriptomic analysis of the blood brain barrier in Alzheimer's Disease mice and a novel methodology to replace tissue-resident microglia.

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Brief Definitive Report

Neurons receive material from Sox10-lineage cells

Florian Mayrhofer; Angela M. Hanson; Manuel F. Navedo; Yang K. Xiang; Athena M. Soulika; Wenbin Deng; Olga V. Chechneva

https://doi.org/10.1084/jem.20221632

Brief Definitive Report

Aged meningeal immunity drives lymphatic impairments

Justin Rustenhoven; Georgios Pavlou; Steffen E. Storck; Taitea Dykstra; Siling Du; Zhengpeng Wan; Daniel Quintero; Joshua P. Scallan; Igor Smirnov; Roger D. Kamm; Jonathan Kipnis

https://doi.org/10.1084/jem.20221929

Perspective

EAE at age 90

Lawrence Steinman; Roberto Patarca; William Haseltine

https://doi.org/10.1084/jem.20221322

Brief Definitive Report

CSF1R engineering for microglia replacement

Jean Paul Chadarevian; Sonia I. Lombroso; Graham C. Peet; Jonathan Hasselmann; Christina Tu; Dave E. Marzan; Joia Capocchi; Freddy S. Purnell; Kelsey M. Nemec; Alina Lahian; Adrian Escobar; Whitney England; Sai Chaluvadi; Carleigh A. O’Brien; Fazeela Yaqoob; William H. Aisenberg; Matias Porras-Paniagua; Mariko L. Bennett; Hayk Davtyan; Robert C. Spitale; Mathew Blurton-Jones; F. Chris Bennett

https://doi.org/10.1084/jem.20220857

Viewpoint

Neuroinflammation, pain, and opioid use

Daniela Salvemini; Timothy M. Doyle

https://doi.org/10.1084/jem.20221244

Article

IL-33–MARCO axis regulates synapse refinement

Rafael T. Han; Ilia D. Vainchtein; Johannes C.M. Schlachetzki; Frances S. Cho; Leah C. Dorman; Eunji Ahn; Dong Kyu Kim; Jerika J. Barron; Hiromi Nakao-Inoue; Ari B. Molofsky; Christopher K. Glass; Jeanne T. Paz; Anna V. Molofsky

https://doi.org/10.1084/jem.20220605

Review | Sex Differences Series

X factor in neurodegeneration

Rhonda Voskuhl; Yuichiro Itoh

https://doi.org/10.1084/jem.20211488

Brief Definitive Report

TREM2 activation and Aβ-associated tau seeding

Nimansha Jain; Caroline A. Lewis; Jason D. Ulrich; David M. Holtzman

https://doi.org/10.1084/jem.20220654

Article

Elevating microglia TREM2 reduces amyloid seeding

Na Zhao; Wenhui Qiao; Fuyao Li; Yingxue Ren; Jiaying Zheng; Yuka A. Martens; Xusheng Wang; Ling Li; Chia-Chen Liu; Kai Chen; Yiyang Zhu; Tadafumi C. Ikezu; Zonghua Li; Axel D. Meneses; Yunjung Jin; Joshua A. Knight; Yixing Chen; Ligia Bastea; Cynthia Linares; Berkiye Sonustun; Lucy Job; Madeleine L. Smith; Manling Xie; Yong U. Liu; Anthony D. Umpierre; Koichiro Haruwaka; Zachary S. Quicksall; Peter Storz; Yan W. Asmann; Long-Jun Wu; Guojun Bu

https://doi.org/10.1084/jem.20212479

Technical Advances and Resources

APOE4 BBB and synaptic molecular signatures

Giuseppe Barisano; Kassandra Kisler; Brent Wilkinson; Angeliki Maria Nikolakopoulou; Abhay P. Sagare; Yaoming Wang; William Gilliam; Mikko T. Huuskonen; Shu-Ting Hung; Justin K. Ichida; Fan Gao; Marcelo P. Coba; Berislav V. Zlokovic

https://doi.org/10.1084/jem.20221137

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Neuroimmunology and Neurodegeneration 2023

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