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Lymphatic Vessels in Health and Disease 2026

This collection highlights the latest discoveries in lymphatic biology, including studies on lymphatic vessels in the skin, skull, intestine, and lung, novel imaging techniques, and the role of lymphatic vessels in various pathologies.

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Review

The cribriform plate: CNS–immune hub

Collin J. Laaker; Sophia M. Vrba; Jenna M. Port; Martin Hsu; Cameron M. Baenen; Melinda Herbath; Thanthrige Thiunuwan Priyathilaka; Matyas Sandor; Zsuzsanna Fabry

https://doi.org/10.1084/jem.20251871

Brief Definitive Report

Amyloidosis of ACE points in AD

Leon C.D. Smyth; Daan Verhaege; Elio Standen-Bloom; Yue Wu; Yiming Gan; Steffen E. Storck; Pavle Boskovic; Benjamin A. Plog; Tornike Mamuladze; Jose A. Mazzitelli; Zhuoying Wang; Daniel D. Lee; Gwendalyn J. Randolph; Antoine Drieu; Katherine E. Schwetye; Song Hu; Daniel S. Reich; Douglas H. Kelley; Rupal I. Mehta; Jonathan Kipnis

https://doi.org/10.1084/jem.20251860

Article

scRNA-seq and 3D imaging of human dermal lymphatics

Aline Bauer; Lito Zambounis; Ioannis Kritikos; Almut Lütge; Amélie Sabine; Coraline Heron; Milena Petkova; Costanza Giampietro; Katharina Blatter; Salvatore Daniele Bianco; Daniel Gschwend; Gaetana Restivo; Steven T. Proulx; Mitchell P. Levesque; Nicole Lindenblatt; Edoardo Mazza; Michael Detmar; Epameinondas Gousopoulos; Mark D. Robinson; Tatiana V. Petrova; Cornelia Halin

https://doi.org/10.1084/jem.20242353

Brief Definitive Report

Identification of lymphatic vessels in skull periosteum but not bone marrow

Qing Chang; Li Ma; Ziying Lin; Yang Shu; Pao-Fen Ko; Matthew Blumberg; Jian-Fu Chen

https://doi.org/10.1084/jem.20241971

Brief Definitive Report

A high-throughput zebrafish screen for kaposiform lymphangiomatosis (KLA)

Ivan Bassi; Amani Jabali; Lotan Levin; Giuseppina Lambiase; Noga Moshe; Naama Farag; Yaara Tevet; Gal Perlmoter; Shany Egozi; Gil S. Leichner; Polina Geva; Aviv Barzilai; Camila Avivi; Jonathan Long; Jason J. Otterstrom; Yael Paran; Haim Barr; Karina Yaniv; Shoshana Greenberger

https://doi.org/10.1084/jem.20240513

Article

S1PR1 regulates lymphatic valves and TLOs

Xin Geng; Lijuan Chen; Zoheb Ahmed; Guilherme Pedron Formigari; Yen-Chun Ho; Ilaria Del Gaudio; Marcella Neves Datilo; Zheila J. Azartash-Namin; Coraline Heron; Xindi Shan; Ravi Shankar Keshari; Soumiya Pal; Hong Chen; Florea Lupu; Lijun Xia; Gwendalyn J. Randolph; Scott D. Zawieja; Eric Camerer; Michael J. Davis; R. Sathish Srinivasan

https://doi.org/10.1084/jem.20241799

Article

Lymphatics along the gut and after helminths

Jorden I. Lane; Elida Nieves-Ortiz; Ornella Ndatabaye; Aliia R. Fatkhullina; Sebastian Lopez; Terence S. Dermody; Daria Esterházy

https://doi.org/10.1084/jem.20241181

Technical Advances and Resources

Imaging lung lymphatics in action

Simon J. Cleary; Longhui Qiu; Yurim Seo; Peter Baluk; Dan Liu; Nina K. Serwas; Catherine A. Taylor; Dongliang Zhang; Jason G. Cyster; Donald M. McDonald; Matthew F. Krummel; Mark R. Looney

https://doi.org/10.1084/jem.20241359

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