JEM Cancer Immunotherapy 2026

This collection highlights the latest discoveries in cancer immunology and immunotherapy published in JEM. It spans a broad range of topics including the therapeutic potential of targeting cDC1, a strategy to harness the immunosuppressive potential of inhibitory receptors, targeting of inhibitory receptor agonists, leveraging microbiota to improve immune checkpoint blockade therapies, and advances in CAR-T cell development.

We hope you enjoy reading this collection, and we invite you to follow JEM on Bluesky at @jem.org. We are also on X at @JExpMed. To learn more about JEM or to submit your research, please visit our Instructions for Authors or reach out to our team of editors. Sign up to receive future special collections here.

Image © 2026 Aggarwal et al.

Shows circos plot illustrating the distribution of highly expanded clones and PD1 expression in a study involving melanoma.
Article
Fate flexibility of LAG3+ progenitor TEX cells
Vaishali Aggarwal; Yangxi Sun; Chang Liu; Jian Cui; Sasikanth Manne; Yingtong Dou; Qiang Chen; Erin A. Brunazzi; Kate M. Vignali; Haiguang Wang; E. John Wherry; Creg J. Workman; Dario A.A. Vignali
https://doi.org/10.1084/jem.20241968
Brief Definitive Report
CD1d controls antitumor immunity
Lauren Evans; Maria Conde Poole; Cenk Celik; Harshita Mishra; Michael J. Pitcher; Anita Grigoriadis; Maria Secrier; Patricia Barral
https://doi.org/10.1084/jem.20260216
Article
MSLN-based CAR T cells control bladder cancer
Parwiz Abrahimi; Jonathan F. Khan; Alyssa Duren-Lubanski; Winson Cai; Yacine Marouf; Nan Chen; Daniel Hirschhorn; Renata Mammone; Ileana C. Miranda; Jacob E. Tallman; Alejandra Vela-Moreno; Mohamad Hamieh; Bishoy M. Faltas; Thomas M. Carroll; Micaela L. Everitt; Hari K.K. Subramanian; Hikmat A. Al-Ahmadie; Olivier Elemento; Benjamin D. Hopkins; Douglas S. Scherr; Renier J. Brentjens; Jedd D. Wolchok; Taha Merghoub
https://doi.org/10.1084/jem.20250699
Article
IRF8 enforces tumor-induced CD8+ T cell exhaustion
Marco Ongaro; Romane Thouenon; Isaac Crespo; Alexandre Dumez; Mélanie Charmoy; Eduardo Roman Camacho; Victoria J. Morel; Daniela Cropp; Emma Desponds; Giulio Zanette; Yi-Chuan Wang; Letizia Vergili; Laure Tillé; Inés Di Resta; Marine M. Leblond; Jésus Corria Osorio; Ping-Chih Ho; Werner Held; Grégory Verdeil
https://doi.org/10.1084/jem.20252115
Review | Cancer Focus
Leveraging cDC1s to enhance cancer immunotherapy
Ross W. Ward; Uddipan Kar; Sreekumar Balan; Nina Bhardwaj
https://doi.org/10.1084/jem.20241199
Article
Cell interactions reveal disease-relevant TCRs
Shibo Liu; Guanghao Liang; Yayun Yang; Yanyang Shi; Lihui Dong; Yue Zhao; Boyuan Mei; Jun Wang; Feng Lin; Yilin Li; Wenxin Dong; Chengyang Liu; Yuhui Cao; Dali Han; Peng R. Chen; Meng Michelle Xu
https://doi.org/10.1084/jem.20251779
Article
Targeting Mettl8–Tcf1 to reprogram TPEX
Jiaxi Song; Dan Cui; Jiabao Wang; Xuewei Qi; Jiaxin Ma; Qing Liu; Jing Yang; Haoyu Yu; Lilin Ye; Qizhao Huang; Jia Li; Fengyin Li
https://doi.org/10.1084/jem.20250424
Article
LXR activation promotes T cell activation
Benjamin N. Ostendorf; Jonathan G. Goldstein; Shuang Liu; Foster C. Gonsalves; Jana Bilanovic; Mathias Yuan; Ji-Young Kim; Christopher Rouya; Masoud Tavazoie; Sohail F. Tavazoie
https://doi.org/10.1084/jem.20252290
Review | Cancer Focus
TCEs are a compelling therapeutic modality
P.A. Baeuerle; K. Sauer; R. Grieshaber-Bouyer; J.S. Michaelson
https://doi.org/10.1084/jem.20251652
Review | Cancer Focus
Antitumor immunity in cancer patient
Spencer E. Mirabile-Brightman; Lisa H. Butterfield
https://doi.org/10.1084/jem.20241234
Review | Cancer Focus
Microbiota-centered interventions in oncology
Andrew A. Almonte; Simon Thomas; Laurence Zitvogel
https://doi.org/10.1084/jem.20250378

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