JEM Clinical Immunology Collection 2026

This special collection, timed to coincide with the Federation of Clinical Immunology Societies annual meeting, FOCIS 2026, features recent and exciting advances in translational immunology, including inborn errors of immunity, autoimmunity, tumor immunology, immunotherapy, and infectious disease.

We hope you enjoy reading this collection, and we invite you to follow JEM on Bluesky at @jem.org. We are also on X at @JExpMed. To learn more about JEM or to submit your research, please visit our Instructions for Authors or reach out to our team of editors. Sign up to receive future special collections here.

If you are attending FOCIS 2026 in person, we invite you to join JEM Executive Editor Dr. Natalie Cain for a “Meet the Editor” session on Wednesday, June 10th at 11:45 AM – 1 PM. Dr. Cain will also be co-chairing the Late-Breaking Abstracts session 4-6 PM on Wednesday, June 10th.

Image © 2026 Tachó-Piñot et al.

Special Collection Image
Review | Genes and Immunity Focus
TCR signaling and LCK-IEI
Ahmet Eken; Sara A. Johnson; Serife Erdem; Elena W.Y. Hsieh
https://doi.org/10.1084/jem.20241046
Article
Rab5 restores CAR T cell endocytosis and function
Meidi Gu; Kaitlin A. Read; Vipin Bhardwaj; Edmund J. Carvalho; David Nardo; Justin C. Shayne; Divanshu Shukla; Wei Liu; Donald L. Siegel; Neil C. Sheppard; Michael C. Milone; Adam D. Cohen; Alfred L. Garfall; James L. Riley
https://doi.org/10.1084/jem.20252564
Article
A memory–plasma cell axis governs the IgD response
Roser Tachó-Piñot; Habib Bashour; Martyna Filipska; Celia Corral-Vazquez; Mauricio Guzman; Xavi Marcos-Fa; Donata Martinuzzi; Hannah Honner; Pablo Canales Herrerias; Sonia Tejedor Vaquero; Alba Sáez Gordón; Julia Perera-Bel; Jorge Domínguez Barragán; Berta Arcos-Ribas; Leire de Campos-Mata; Andrei Slabodkin; Maria Chernigovskaya; Maria Luisa Rodríguez de la Concepción; Jose Gutierrez-Marcos; Ana García-García; Andres Nascimento Osorio; Mariona Pascal; Jordi Yagüe; Manel Juan; Juan Ignacio Aróstegui; Rafael Hijano Esqué; Albert Sánchez Font; Stephan Ehl; Bodo Grimbacher; Marta Rizzi; Laura Dotta; Kang Chen; Raffaele Badolato; Laia Alsina; Saurabh Mehandru; Charlotte Cunningham-Rundles; Jorge Carrillo; Giuliana Magri; Victor Greiff; Andrea Cerutti
https://doi.org/10.1084/jem.20251752
Article
Nasal tissue CD4 TRM protect against influenza
Nimitha R. Mathew; Romain Gailleton; Lydia Scharf; Karin Schön; Josue Enriquez; Hannes Axelsson; Anneli Strömberg; Nils Lycke; Mats Bemark; Ka-Wei Tang; Davide Angeletti
https://doi.org/10.1084/jem.20251793
Brief Definitive Report
STING HAQ and variable penetrance in COPA syndrome
Clémence David; Tifenn Wauquier; Alix de Becdelièvre; Camille Louvrier; Maud Tusseau; Cécile Masson; Luis Seabra; Caroline Kannengiesser; Hayssam Al Arab; Ibrahima Ba; Mary Brennan; Alexandre Belot; Nadia Nathan; Hélène Maillard; Héloïse Reumaux; Jérémie Sellam; Jacques Cadranel; Yves Hatchuel; Laurence Weiss; Sébastien de Almeida; Cinthia Rames; Marie Wislez; Clémentine Vigier; Géraldine Labouret; Claire Kastner; François Provot; Julien Tarabeux; Elise Schaefer; Darragh Duffy; Vincent Bondet; Paul Bastard; Anne Puel; Jean-Laurent Casanova; Gillian I. Rice; Brigitte Bader-Meunier; Yanick J. Crow; Alice Lepelley; Marie-Louise Frémond
https://doi.org/10.1084/jem.20251470
Technical Advances and Resources
Proliferative stress drives aged HSC dysfunctions
Emanuele Lettera; Luca Basso-Ricci; Edoardo Carsana; Kety Giannetti; Teresa Tavella; Luca Seffin; Giacomo Farina; Nicolò Gualandi; Pamela Quaranta; Elena Lo Furno; Guido Pacini; Lucrezia della Volpe; Kerstin B. Kaufmann; Laura Garcia-Prat; Raisa Jofra Hernandez; Alex Murison; Alicia G. Aguilar-Navarro; Stefano Beretta; Anastasia Conti; Eugenia Flores-Figueroa; Marco Ometti; Ivan Merelli; Alessandro Aiuti; Stephanie Z. Xie; Serena Scala; Raffaella Di Micco
https://doi.org/10.1084/jem.20251805
Article
Transcription in HIV-1 authentic latent clones
Cintia Bittar; Ana Rafaela Teixeira; Thiago Y. Oliveira; Gabriela S. Silva Santos; Klara Lenart; Marcilio Jorge Fumagalli; Georg H.J. Weymar; Anna Kaczynska; Noemi L. Linden; Isabella A.T.M. Ferreira; Marina Caskey; R. Brad Jones; Mila Jankovic; Michel C. Nussenzweig
https://doi.org/10.1084/jem.20251584
Review
NK cells beyond cancer
Marjorie Cayatte; Valentin Picant; Marie Vétizou; Eric Vivier
https://doi.org/10.1084/jem.20250612
Article
Neutralizing IFN-I autoantibodies in HSV hepatitis
Adrian Gervais; Astrid Marchal; Soraya Boucherit; Anthony Abi Haidar; Lucy Bizien; Ahmet Yalcinkaya; Ella Sandström; Xiao-Fei Kong; Emmanuel Jacquemin; Olivier Bernard; Dominique Debray; Florence Lacaille; Philippe Ichai; Cigdem Arikan; Etienne Javouhey; Bertrand Roquelaure; Frédéric Gottrand; Francesca Trespidi; Veronica Codullo; Lorenzo Cavagna; Nicolas Schleinitz; Mohamed Bousfiha; Naima Amenzoui; Ahmed Aziz Bousfiha; Sofie E. Jørgensen; Nanna Mørk; Trine H. Mogensen; Paul Bastard; Anne Puel; Alessandro Borghesi; Jody A. Rule; William M. Lee; Nils Landegren; Aurélie Cobat; Jean-Laurent Casanova; Emmanuelle Jouanguy
https://doi.org/10.1084/jem.20251760
Article
YTHDF2 in dendritic cells impairs radiotherapy
Dapeng Chen; Liangliang Wang; Chuangyu Wen; Andras Piffko; Jason Bugno; Xianbin Yu; Pingluan Wang; Fei Ji; Emile Z. Naccasha; Jiaai Wang; Xiaona Huang; Steven J. Chmura; Sean P. Pitroda; Chuan He; Hua Laura Liang; Ralph R. Weichselbaum
https://doi.org/10.1084/jem.20250641

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