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2018 Nobel Prize Collection

Immunotherapy has changed the direction of cancer treatment. James P. Allison at the University of Texas MD Anderson Cancer Center and Tasuku Honjo at Kyoto University have been pioneers of this field. Their studies on the identification of tumor checkpoints and their discoveries on the immunoregulatory role of these molecules in cancer have greatly increased the survival of cancer patients. We celebrate their winning the 2018 Nobel Prize in Physiology or Medicine with a collection of JEM studies that have made the difference in the history of cancer immunotherapy.

Illustration: Niklas Elmehed. © Nobel Media AB 2018

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Article
Xiaozhou Fan; Sergio A. Quezada; Manuel A. Sepulveda; Padmanee Sharma; James P. Allison
DOI: 10.1084/jem.20130590
Article
Rikke B. Holmgaard; Dmitriy Zamarin; David H. Munn; Jedd D. Wolchok; James P. Allison
DOI: 10.1084/jem.20130066
Article
Taku Okazaki; Il-mi Okazaki; Jian Wang; Daisuke Sugiura; Fumio Nakaki; Taku Yoshida; Yu Kato; Sidonia Fagarasan; Masamichi Muramatsu; Tomoo Eto; Kyoji Hioki; Tasuku Honjo
DOI: 10.1084/jem.20100466
Article
Sergio A. Quezada; Tyler R. Simpson; Karl S. Peggs; Taha Merghoub; Jelena Vider; Xiaozhou Fan; Ronald Blasberg; Hideo Yagita; Pawel Muranski; Paul A. Antony; Nicholas P. Restifo; James P. Allison
DOI: 10.1084/jem.20091918
Brief Definitive Report
Karl S. Peggs; Sergio A. Quezada; Cynthia A. Chambers; Alan J. Korman; James P. Allison
DOI: 10.1084/jem.20082492
Article
Shengdian Wang; Jürgen Bajorath; Dallas B. Flies; Haidong Dong; Tasuku Honjo; Lieping Chen
DOI: 10.1084/jem.20021752
Article
Andrea van Elsas; Roger P.M. Sutmuller; Arthur A. Hurwitz; Jennifer Ziskin; Jennifer Villasenor; Jan-Paul Medema; Willem W. Overwijk; Nicholas P. Restifo; Cornelis J.M. Melief; Rienk Offringa; James P. Allison
DOI: 10.1084/jem.194.4.481
Article
Gordon J. Freeman; Andrew J. Long; Yoshiko Iwai; Karen Bourque; Tatyana Chernova; Hiroyuki Nishimura; Lori J. Fitz; Nelly Malenkovich; Taku Okazaki; Michael C. Byrne; Heidi F. Horton; Lynette Fouser; Laura Carter; Vincent Ling; Michael R. Bowman; Beatriz M. Carreno; Mary Collins; Clive R. Wood; Tasuku Honjo
DOI: 10.1084/jem.192.7.1027
Article
Andrea van Elsas; Arthur A. Hurwitz; James P. Allison
DOI: 10.1084/jem.190.3.355
Article
M F Krummel; J P Allison
DOI: 10.1084/jem.183.6.2533
Article
M F Krummel; J P Allison
DOI: 10.1084/jem.182.2.459
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