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JEM Cancer Immunotherapy 2022

A collection of recent JEM preclinical and clinical studies that develop novel immunotherapies for cancer. Read and learn how we could harness innate immune cells, adaptive immune cells, immunometabolism and engineered cytokines to treat solid and hematologic tumors.

We hope you enjoy reading the collection and encourage your feedback on Twitter at @JExpMed. To learn more about JEM and to submit your research, please visit our Instructions for Authors or contact the editorial office. Sign up to receive future special collections here.

Image © 2022 Schad et al.

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Karmele Valencia; Mirari Echepare; Álvaro Teijeira; Andrea Pasquier; Cristina Bértolo; Cristina Sainz; Ibon Tamayo; Beñat Picabea; Graziella Bosco; Roman Thomas; Jackeline Agorreta; José María López-Picazo; Joan Frigola; Ramon Amat; Alfonso Calvo; Enriqueta Felip; Ignacio Melero; Luis M. Montuenga
DOI: 10.1084/jem.20220726
Jiao Shen; Zhuangzhi Zou; Jingya Guo; Yueqi Cai; Diyuan Xue; Yong Liang; Wenyan Wang; Hua Peng; Yang-Xin Fu
DOI: 10.1084/jem.20220745
Alessandro Camponeschi; Kathrin Kläsener; Timothy Sundell; Christina Lundqvist; Paul T. Manna; Negar Ayoubzadeh; Martina Sundqvist; Katrin Thorarinsdottir; Mariele Gatto; Marcella Visentini; Karin Önnheim; Alaitz Aranburu; Huamei Forsman; Olov Ekwall; Linda Fogelstrand; Inger Gjertsson; Michael Reth; Inga-Lill Mårtensson
DOI: 10.1084/jem.20220201
Margherita Boieri; Anna Malishkevich; Ranya Guennoun; Emanuela Marchese; Sanne Kroon; Kathryn E. Trerice; Mary Awad; Jong Ho Park; Sowmya Iyer; Johannes Kreuzer; Wilhelm Haas; Miguel N. Rivera; Shadmehr Demehri
DOI: 10.1084/jem.20201963
Sara E. Schad; Andrew Chow; Levi Mangarin; Heng Pan; Jiajia Zhang; Nicholas Ceglia; Justina X. Caushi; Nicole Malandro; Roberta Zappasodi; Mathieu Gigoux; Daniel Hirschhorn; Sadna Budhu; Masataka Amisaki; Monica Arniella; David Redmond; Jamie Chaft; Patrick M. Forde; Justin F. Gainor; Matthew D. Hellmann; Vinod Balachandran; Sohrab Shah; Kellie N. Smith; Drew Pardoll; Olivier Elemento; Jedd D. Wolchok; Taha Merghoub
DOI: 10.1084/jem.20212169
Daniela F. Quail; Borko Amulic; Monowar Aziz; Betsy J. Barnes; Evgeniy Eruslanov; Zvi G. Fridlender; Helen S. Goodridge; Zvi Granot; Andrés Hidalgo; Anna Huttenlocher; Mariana J. Kaplan; Ilaria Malanchi; Taha Merghoub; Etienne Meylan; Vivek Mittal; Mikael J. Pittet; Andrea Rubio-Ponce; Irina A. Udalova; Timo K. van den Berg; Denisa D. Wagner; Ping Wang; Arturo Zychlinsky; Karin E. de Visser; Mikala Egeblad; Paul Kubes
DOI: 10.1084/jem.20220011
Jianxin Wang; May Tun Saung; Keyu Li; Juan Fu; Kenji Fujiwara; Nan Niu; Stephen Muth; Junke Wang; Yao Xu; Noah Rozich; Haley Zlomke; Sophia Chen; Birginia Espinoza; MacKenzie Henderson; Vanessa Funes; Brian Herbst; Ding Ding; Christina Twyman-Saint Victor; Qihong Zhao; Amol Narang; Jin He; Lei Zheng
DOI: 10.1084/jem.20211631
Xing Chen; Junjie Zhao; Tomasz Herjan; Lingzi Hong; Yun Liao; Caini Liu; Kommireddy Vasu; Han Wang; Austin Thompson; Paul L. Fox; Brian R. Gastman; Xiao Li; Xiaoxia Li
DOI: 10.1084/jem.20210693
Lydia Dyck; Hannah Prendeville; Mathilde Raverdeau; Mieszko M. Wilk; Roisin M. Loftus; Aaron Douglas; Janet McCormack; Bruce Moran; Michael Wilkinson; Evanna L. Mills; Michael Doughty; Aurelie Fabre; Helen Heneghan; Carel LeRoux; Andrew Hogan; Edward T. Chouchani; Donal O’Shea; Donal Brennan; Lydia Lynch
DOI: 10.1084/jem.20210042
Mojdeh Shakiba; Paul Zumbo; Gabriel Espinosa-Carrasco; Laura Menocal; Friederike Dündar; Sandra E. Carson; Emmanuel M. Bruno; Francisco J. Sanchez-Rivera; Scott W. Lowe; Steven Camara; Richard P. Koche; Vincent P. Reuter; Nicholas D. Socci; Benjamin Whitlock; Fella Tamzalit; Morgan Huse; Matthew D. Hellmann; Daniel K. Wells; Nadine A. Defranoux; Doron Betel; Mary Philip; Andrea Schietinger
DOI: 10.1084/jem.20201966
Michela Masetti; Roberta Carriero; Federica Portale; Giulia Marelli; Nicolò Morina; Marta Pandini; Marta Iovino; Bianca Partini; Marco Erreni; Andrea Ponzetta; Elena Magrini; Piergiuseppe Colombo; Grazia Elefante; Federico Simone Colombo; Joke M.M. den Haan; Clelia Peano; Javier Cibella; Alberto Termanini; Paolo Kunderfranco; Jolanda Brummelman; Matthew Wai Heng Chung; Massimo Lazzeri; Rodolfo Hurle; Paolo Casale; Enrico Lugli; Ronald A. DePinho; Subhankar Mukhopadhyay; Siamon Gordon; Diletta Di Mitri
DOI: 10.1084/jem.20210564
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