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Neuroimmunology and Neurodegeneration 2025

This collection of neuroimmunology and neurodegeneration articles covers a broad range of topics including macular degeneration, the role of microglia, β-amyloid transport, CNS autoimmunity, and the sympathetic control of cancer progression.

We hope you enjoy reading this collection, and we invite you to follow JEM on Bluesky (@jem.org) or X/Twitter (@JExpMed). To learn more about JEM or to submit your research, please visit our Instructions for Authors or reach out to our team of editors. Sign up to receive future special collections here.

Image © Cao et al. 2024

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Article
Sympathetic axonogenesis in adenoid cystic cancer
Chun-Hao Chen; Boris Reva; Nora Katabi; Avishai Wizel; Hongbo Xu; Alan L. Ho; Luc G.T. Morris; Richard L. Bakst; Anuraag S. Parikh; Yotam Drier; Sylvie Deborde; Richard J. Wong
https://doi.org/10.1084/jem.20242250
Brief Definitive Report
Increased DAM and CD8+ T cells in Spg15-deficiency
Aleksej Frolov; Hao Huang; Dagmar Schütz; Maren Köhne; Nelli Blank-Stein; Collins Osei-Sarpong; Maren Büttner; Tarek Elmzzahi; Mukhran Khundadze; Marina Zahid; Michael Reuter; Matthias Becker; Elena De Domenico; Lorenzo Bonaguro; Axel Kallies; Helen Morrison; Christian A. Hübner; Kristian Händler; Ralf Stumm; Elvira Mass; Marc D. Beyer
https://doi.org/10.1084/jem.20232357
Article
Resident macrophages are defective in AMD choroid
Seth D. Fortmann; Blake F. Frey; Robert F. Rosencrans; Yvonne Adu-Rutledge; Edgar Ready V; Kameron V. Kilchrist; Robert S. Welner; Michael E. Boulton; Daniel R. Saban; Maria B. Grant
https://doi.org/10.1084/jem.20242007
Brief Definitive Report
IL-33 fuels CD8+ T cells in CNS inflammation
Nicolas Fonta; Nicolas Page; Bogna Klimek; Margot Piccinno; Giovanni Di Liberto; Sylvain Lemeille; Mario Kreutzfeldt; Anna Lena Kastner; Yusuf I. Ertuna; Ilena Vincenti; Ingrid Wagner; Daniel D. Pinschewer; Doron Merkler
https://doi.org/10.1084/jem.20241188
Article
ATG7 deficiency in microglia induces ferroptosis
Zhangying Cai; Shoutang Wang; Siyan Cao; Yun Chen; Silvia Penati; Vincent Peng; Carla M. Yuede; Wandy L. Beatty; Kent Lin; Yiyang Zhu; Yingyue Zhou; Marco Colonna
https://doi.org/10.1084/jem.20230173
Article
VEGF-C/VEGFR-3 in stroke-induced lymphangiogenesis
Yun Hwa Choi; Martin Hsu; Collin Laaker; Jenna Port; Kristóf G. Kovács; Melinda Herbath; Heeyoon Yang; Peter Cismaru; Alexis M. Johnson; Bailey Spellman; Kelsey Wigand; Matyas Sandor; Zsuzsanna Fabry
https://doi.org/10.1084/jem.20231816
Article
Brain eye transport causes AD retinopathy
Qiuchen Cao; Shige Yang; Xiaowei Wang; Huaiqing Sun; Weijie Chen; Yuliang Wang; Junying Gao; Yanchi Wu; Qiuhua Yang; Xue Chen; Songtao Yuan; Ming Xiao; Maiken Nedergaard; Yuqing Huo; Qinghuai Liu
https://doi.org/10.1084/jem.20240386

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  • © 2025 Rockefeller University Press
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  • Online ISSN 1540-9538
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