2020 Germinal Centers and Immune Niches
Adaptive immune responses against pathogenic microbes are based on the generation of effector cells and high affinity and specific antibodies that give rise to long lasting immunity and guide appropriate pathogen clearance. The presentation of antigens, with subsequent generation of antibody producing cells primarily takes place in specialized microanatomical sites within lymphoid organs such lymph nodes and spleen, known as germinal centers. These are highly dynamic structures that encompass a milieu of cells such as B and T lymphocytes, dendritic cells that interact with each other in an affinity-based selection process.
We are pleased to present a special collection of articles recently published in JEM highlighting the latest discoveries related to germinal center biology. From immune cell interaction and dynamics, to generation of germinal center immune cell subsets, gene expression regulation and chromatin remodeling and development of malignancies, we hope you will appreciate this collection. If you are interested in submitting work in this field, contact JEM Scientific Editor Montserrat Cols at email@example.com. We also encourage your comments on Twitter at @JExpMed.