2020 Germinal Centers and Immune Niches
A collection of latest discoveries related to germinal center biology, from immune cell interaction and dynamics, to generation of germinal center immune cell subsets, gene expression regulation and chromatin remodeling and development of malignancies.
Adaptive immune responses against pathogenic microbes are based on the generation of effector cells and high affinity and specific antibodies that give rise to long lasting immunity and guide appropriate pathogen clearance. The presentation of antigens, with subsequent generation of antibody producing cells primarily takes place in specialized microanatomical sites within lymphoid organs such lymph nodes and spleen, known as germinal centers. These are highly dynamic structures that encompass a milieu of cells such as B and T lymphocytes, dendritic cells that interact with each other in an affinity-based selection process.
We hope you appreciate this collection. If you are interested in submitting work in this field, contact JEM Senior Scientific Editor Montserrat Cols at firstname.lastname@example.org. We also encourage your comments on Twitter at @JExpMed.