JEM Mucosal Immunology 2026

This collection explores the interface between the immune system and the environment at mucosal surfaces. Selected articles cover a range of topics including aleveolar macrophage differentiation and function, fibroblast diversity in GALT, MAIT (dys)function after neonate antibiotic use, ILC3 homeostasis, gut immune tolerance by RORγt+ regulatory T cells, macrophage containment of melanoma, nasal and tonsillar humoral responses, and enteric nervous system rewiring during inflammation.

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Image © 2025 Mörbe et al.

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Article
RXRs control alveolar macrophage identity
Jorge Mínguez-Martínez; Jesús Porcuna; Laura Casablanca; Manuel J. Gómez; Hooman Aghelpasand; Pontus Höjer; Belén García-Fojeda; Vanessa Núñez; Carlos Torroja; Severin Mühleder; Charlotte Gustafsson; Thierry Fischer; Rui Benedito; Cristina Casals; Robert Månsson; Fátima Sánchez-Cabo; Mercedes Ricote
https://doi.org/10.1084/jem.20242085
Brief Definitive Report
Skin CD169+ macrophages constrain melanoma growth
Yuki Honda Keith; Emily Duchini; Xufeng Lin; Wunna Kyaw; Felix G.P. Weninger; Rama Dhenni; Aiden Josiah Telfser; Abigail K. Grootveld; Deborah Barkauskas; Angela Fontaine-Titley; Shweta Tikoo; Rohit Jain; Wolfgang Weninger; John W. Frew; Elissa K. Deenick; Robert Brink; Linda K. Martin; Tatyana Chtanova; Leonard D. Goldstein; Richard A. Scolyer; Georgina V. Long; Umaimainthan Palendira; Tri Giang Phan
https://doi.org/10.1084/jem.20252239
Article
LINGO4 regulates intrinsic and microbiota-dependent ILC3 function
José L. Fachi; Tihana Trsan; Cristiane Sécca; Sarah de Oliveira; Vinícius R. Rodovalho; Patrick Fernandes Rodrigues; Wandy L. Beatty; Raki Sudan; Shitong Wu; Bishan Bhattarai; Santosh K. Panda; Marina Cella; Susan Gilfillan; Marco Colonna
https://doi.org/10.1084/jem.20252632
Brief Definitive Report
B7 blockade drives RORγt+ Tregs with RORγt+ APCs
Mengze Lyu; Gregory F. Sonnenberg
https://doi.org/10.1084/jem.20251094
Article
A memory–plasma cell axis governs the IgD response
Roser Tachó-Piñot; Habib Bashour; Martyna Filipska; Celia Corral-Vazquez; Mauricio Guzman; Xavi Marcos-Fa; Donata Martinuzzi; Hannah Honner; Pablo Canales Herrerias; Sonia Tejedor Vaquero; Alba Sáez Gordón; Julia Perera-Bel; Jorge Domínguez Barragán; Berta Arcos-Ribas; Leire de Campos-Mata; Andrei Slabodkin; Maria Chernigovskaya; Maria Luisa Rodríguez de la Concepción; Jose Gutierrez-Marcos; Ana García-García; Andres Nascimento Osorio; Mariona Pascal; Jordi Yagüe; Manel Juan; Juan Ignacio Aróstegui; Rafael Hijano Esqué; Albert Sánchez Font; Stephan Ehl; Bodo Grimbacher; Marta Rizzi; Laura Dotta; Kang Chen; Raffaele Badolato; Laia Alsina; Saurabh Mehandru; Charlotte Cunningham-Rundles; Jorge Carrillo; Giuliana Magri; Victor Greiff; Andrea Cerutti
https://doi.org/10.1084/jem.20251752
Article
CD163 and Tim-4 intestinal macrophage populations
Vignesh Jayaraman; Ian E. Prise; Verena Kästele; Sabrina Tamburrano; Kelly Wemyss; Hayley M. Bridgeman; Rufus H. Daw; Patrick Strangward; Alfie Sanderson; Sheena M. Cruickshank; Joanne E. Konkel; Christine Chew; Chengcan Yao; C.J. Anderson; Josef Priller; Barry McColl; David A.D. Munro; Liesbet Martens; Charlotte L. Scott; Martin Guilliams; Antony D. Adamson; John R. Grainger; Tovah N. Shaw
https://doi.org/10.1084/jem.20240801
Article
Monocytes remodel the enteric nervous system
Sravya Kurapati; Changsik Shin; Krisztina Szabo; Yu Liu; Azree Z. Ashraf; Balazs Koscso; Chinmayee Dash; Katherine L. Kruckow; Leonardo E. Navarro; Amanda M. Clark; Monalee Saha; Sushma Nagaraj; Wenhui Wang; Jun Zhu; Kevin Brown; Travis Thomson; Natalia Shulzhenko; Andrey Morgun; Christina E. Baer; Shanthi Srinivasan; Subhash Kulkarni; Pankaj J. Pasricha; Lauren A. Peters; Milena Bogunovic
https://doi.org/10.1084/jem.20251761
Article
CCR6 and BCR affinity regulate nasal IgA responses
Jingjing Liu; Liat Stoler-Barak; Ziv Shulman
https://doi.org/10.1084/jem.20251901
Article
Early-life antibiotics impair adult immunity
Gabrielle R. LeBlanc; Adam L. Sobel; Jonathan Melamed; Dominic Haas; Eduard Ansaldo; Aiko M. Cirone; Elizabeth Murguia; Michael G. Constantinides
https://doi.org/10.1084/jem.20241287
Technical Advances and Resources
Fibroblast diversity within human GALT
Urs M. Mörbe; Fredrik V. Junghus; Grigorii Nos; Peter B. Jørgensen; Melissa J. Ensmenger; Venla A. Väänänen; Mads D. Wewer; Gorm R. Madsen; Lene B. Riis; Henrik L. Jakobsen; Lars R. Olsen; Søren Brunak; Ole H. Nielsen; William W. Agace
https://doi.org/10.1084/jem.20250471

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