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2022: The Year in Experimental Medicine

Many aspects of our life and research have changed drastically over the last three years. Nevertheless, the goal of publishing groundbreaking studies at the Journal of Experimental Medicine (JEM) to broaden human knowledge in disease pathogenesis and treatment remains rock solid.

Here, we present our annual Best of JEM series to highlight cutting-edge research in immunology, host-pathogen interactions, cancer biology, tumor immunology, cardiovascular biology, neuroscience and other areas published in 2022 at JEM. The top 10 papers are selected by the editorial team based, in part, on the number of requests for PDF and full-text HTML versions of an article in the first three months after publication. These studies represent the breadth of JEM’s scope and our longstanding interest in original findings in disease pathogenesis and therapy.

We would also like use this opportunity to thank our authors, reviewers and readers for your interest and continued support for JEM.

We hope you will enjoy this collection and invite you to explore our other special collections. We also encourage your comments on Twitter at @JExpMed. Interested in learning how we are making the publishing process easier for authors or making use of our external transfer policy? Visit our Instructions for Authors or contact the Editorial office.

Image by Neil Smith, neil@neilsmithillustration.co.uk

Special Collection Image
Cameron S. McAlpine; Máté G. Kiss; Faris M. Zuraikat; David Cheek; Giulia Schiroli; Hajera Amatullah; Pacific Huynh; Mehreen Z. Bhatti; Lai-Ping Wong; Abi G. Yates; Wolfram C. Poller; John E. Mindur; Christopher T. Chan; Henrike Janssen; Jeffrey Downey; Sumnima Singh; Ruslan I. Sadreyev; Matthias Nahrendorf; Kate L. Jeffrey; David T. Scadden; Kamila Naxerova; Marie-Pierre St-Onge; Filip K. Swirski
DOI: 10.1084/jem.20220081
Rhea Nadkarni; Wern Cui Chu; Cheryl Q.E. Lee; Yasir Mohamud; Lynn Yap; Gee Ann Toh; Sheryl Beh; Radiance Lim; Yiyun Michelle Fan; Yizhuo Lyanne Zhang; Kim Robinson; Karl Tryggvason; Honglin Luo; Franklin Zhong; Lena Ho
DOI: 10.1084/jem.20212117
Jaechul Lim; Erica V. Lin; Jun Young Hong; Bharat Vaidyanathan; Steven A. Erickson; Charles Annicelli; Ruslan Medzhitov
DOI: 10.1084/jem.20220903
Zhipeng Li; Manoj Gurung; Richard R. Rodrigues; Jyothi Padiadpu; Nolan K. Newman; Nathan P. Manes; Jacob W. Pederson; Renee L. Greer; Stephany Vasquez-Perez; Hyekyoung You; Kaito A. Hioki; Zoe Moulton; Anna Fel; Dominic De Nardo; Amiran K. Dzutsev; Aleksandra Nita-Lazar; Giorgio Trinchieri; Natalia Shulzhenko; Andrey Morgun
DOI: 10.1084/jem.20220017
Rie Hasebe; Kaoru Murakami; Masaya Harada; Nada Halaka; Hiroshi Nakagawa; Fuminori Kawano; Yoshinobu Ohira; Tadafumi Kawamoto; Fiona E. Yull; Timothy S. Blackwell; Junko Nio-Kobayashi; Toshihiko Iwanaga; Masahiko Watanabe; Nobuhiro Watanabe; Harumi Hotta; Toshihide Yamashita; Daisuke Kamimura; Yuki Tanaka; Masaaki Murakami
DOI: 10.1084/jem.20212019
Nicola Laura Diny; Barbora Schonfeldova; Michael Shapiro; Matthew L. Winder; Sunita Varsani-Brown; Brigitta Stockinger
DOI: 10.1084/jem.20210970
Kazuhisa Ishida; Kaoru Yamada; Risa Nishiyama; Tadafumi Hashimoto; Itaru Nishida; Yoichiro Abe; Masato Yasui; Takeshi Iwatsubo
DOI: 10.1084/jem.20211275
Dimitra Kerdidani; Emmanouil Aerakis; Kleio-Maria Verrou; Ilias Angelidis; Katerina Douka; Maria-Anna Maniou; Petros Stamoulis; Katerina Goudevenou; Alejandro Prados; Christos Tzaferis; Vasileios Ntafis; Ioannis Vamvakaris; Evangelos Kaniaris; Konstantinos Vachlas; Evangelos Sepsas; Anastasios Koutsopoulos; Konstantinos Potaris; Maria Tsoumakidou
DOI: 10.1084/jem.20210815
Mojdeh Shakiba; Paul Zumbo; Gabriel Espinosa-Carrasco; Laura Menocal; Friederike Dündar; Sandra E. Carson; Emmanuel M. Bruno; Francisco J. Sanchez-Rivera; Scott W. Lowe; Steven Camara; Richard P. Koche; Vincent P. Reuter; Nicholas D. Socci; Benjamin Whitlock; Fella Tamzalit; Morgan Huse; Matthew D. Hellmann; Daniel K. Wells; Nadine A. Defranoux; Doron Betel; Mary Philip; Andrea Schietinger
DOI: 10.1084/jem.20201966
Bassem D. Khalil; Roberto Sanchez; Tasrina Rahman; Carolina Rodriguez-Tirado; Stefan Moritsch; Alba Rodriguez Martinez; Brett Miles; Eduardo Farias; Mihaly Mezei; Ana Rita Nobre; Deepak Singh; Nupura Kale; Karl Christoph Sproll; Maria Soledad Sosa; Julio A. Aguirre-Ghiso
DOI: 10.1084/jem.20210836
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