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Journal Articles

Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

J Exp Med (2024) 221 (12): e20240942.

https://doi.org/10.1084/jem.20240942

Published: 01 November 2024

View article titled, Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

Journal Articles

STAT3 gain of function: Too much of a good thing in the skin!

Cindy S. Ma, Stuart G. Tangye

J Exp Med (2024) 221 (8): e20240849.

https://doi.org/10.1084/jem.20240849

Published: 01 July 2024

View article titled, STAT3 gain of function: Too much of a good thing in the skin!

Journal Articles

Helper T cell immunity in humans with inherited CD4 deficiency

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Thymus, T Cell Development, and Inborn Errors

Antoine Guérin, Marcela Moncada-Vélez, Katherine Jackson, Masato Ogishi, Jérémie Rosain, Mathieu Mancini, David Langlais, Andrea Nunez, Samantha Webster, Jesse Goyette, Taushif Khan, Nico Marr, Danielle T. Avery, Geetha Rao, Tim Waterboer, Birgitta Michels, Esmeralda Neves, Cátia Iracema Morais, Jonathan London, Stéphanie Mestrallet, Pierre Quartier dit Maire, Bénédicte Neven, Franck Rapaport, Yoann Seeleuthner, Atar Lev, Amos J. Simon, Jorge Montoya, Ortal Barel, Julio Gómez-Rodríguez, Julio C. Orrego, Anne-Sophie L’Honneur, Camille Soudée, Jessica Rojas, Alejandra C. Velez, Irini Sereti, Benjamin Terrier, Nancy Marin, Luis F. García, Laurent Abel, Stéphanie Boisson-Dupuis, Joel Reis, Antonio Marinho, Andrea Lisco, Emilia Faria, Christopher C. Goodnow, Julia Vasconcelos, Vivien Béziat, Cindy S. Ma, Raz Somech, Jean-Laurent Casanova, Jacinta Bustamante, Jose Luis Franco, Stuart G. Tangye

J Exp Med (2024) 221 (5): e20231044.

https://doi.org/10.1084/jem.20231044

Published: 01 April 2024

View article titled, Helper T cell immunity in humans with inherited CD4 deficiency

Includes: Supplementary data

Journal Articles

For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity

Stuart G. Tangye

J Exp Med (2023) 220 (12): e20231397.

https://doi.org/10.1084/jem.20231397

Published: 29 September 2023

View article titled, For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity

Journal Articles

Inborn errors of human B cell development, differentiation, and function

Stuart G. Tangye, Tina Nguyen, Elissa K. Deenick, Vanessa L. Bryant, Cindy S. Ma

J Exp Med (2023) 220 (7): e20221105.

https://doi.org/10.1084/jem.20221105

Published: 05 June 2023

View article titled, Inborn errors of human B cell development, differentiation, and function

Journal Articles

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

J Exp Med (2023) 220 (6): e20221020.

https://doi.org/10.1084/jem.20221020

Published: 21 March 2023

View article titled, Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

Includes: Supplementary data

Journal Articles

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

In Special Collection:

B Cell Biology in Health and Diseases

Aurélien Sokal, Paul Bastard, Pascal Chappert, Giovanna Barba-Spaeth, Slim Fourati, Alexis Vanderberghe, Pauline Lagouge-Roussey, Isabelle Meyts, Adrian Gervais, Magali Bouvier-Alias, Imane Azzaoui, Ignacio Fernández, Andréa de la Selle, Qian Zhang, Lucy Bizien, Isabelle Pellier, Agnès Linglart, Anya Rothenbuhler, Estelle Marcoux, Raphael Anxionnat, Nathalie Cheikh, Juliane Léger, Blanca Amador-Borrero, Fanny Fouyssac, Vanessa Menut, Jean-Christophe Goffard, Caroline Storey, Caroline Demily, Coralie Mallebranche, Jesus Troya, Aurora Pujol, Marie Zins, Pierre Tiberghien, Paul E. Gray, Peter McNaughton, Anna Sullivan, Jane Peake, Romain Levy, Laetitia Languille, Carlos Rodiguez-Gallego, Bertrand Boisson, Sébastien Gallien, Bénédicte Neven, Marc Michel, Bertrand Godeau, Laurent Abel, Felix A. Rey, Jean-Claude Weill, Claude-Agnès Reynaud, Stuart G. Tangye, Jean-Laurent Casanova, Matthieu Mahévas

J Exp Med (2022) 220 (1): e20220258.

https://doi.org/10.1084/jem.20220258

Published: 07 November 2022

View article titled, Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Includes: Supplementary data

Journal Articles

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

In Special Collection:

JEM Clinical Immunology Collection 2022

Paul Bastard, Kuang-Chih Hsiao, Qian Zhang, Jeremy Choin, Emma Best, Jie Chen, Adrian Gervais, Lucy Bizien, Marie Materna, Christine Harmant, Maguelonne Roux, Nicola L. Hawley, Daniel E. Weeks, Stephen T. McGarvey, Karla Sandoval, Carmina Barberena-Jonas, Consuelo D. Quinto-Cortés, Erika Hagelberg, Alexander J. Mentzer, Kathryn Robson, Boubacar Coulibaly, Yoann Seeleuthner, Benedetta Bigio, Zhi Li, Gilles Uzé, Sandra Pellegrini, Lazaro Lorenzo, Zineb Sbihi, Sylvain Latour, Marianne Besnard, Tiphaine Adam de Beaumais, Evelyne Jacqz Aigrain, Vivien Béziat, Ranjan Deka, Litara Esera Tulifau, Satupa‘itea Viali, Muagututi‘a Sefuiva Reupena, Take Naseri, Peter McNaughton, Vanessa Sarkozy, Jane Peake, Annaliesse Blincoe, Sarah Primhak, Simon Stables, Kate Gibson, See-Tarn Woon, Kylie Marie Drake, Adrian V.S. Hill, Cheng-Yee Chan, Richard King, Rohan Ameratunga, Iotefa Teiti, Maite Aubry, Van-Mai Cao-Lormeau, Stuart G. Tangye, Shen-Ying Zhang, Emmanuelle Jouanguy, Paul Gray, Laurent Abel, Andrés Moreno-Estrada, Ryan L. Minster, Lluis Quintana-Murci, Andrew C. Wood, Jean-Laurent Casanova

J Exp Med (2022) 219 (6): e20220028.

https://doi.org/10.1084/jem.20220028

Published: 20 April 2022

View article titled, A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

Includes: Supplementary data

Journal Articles

High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

In Special Collection:

Cytokines Collection 2021 , Innate Immunity: From Basic Biology to Human Disease

J Exp Med (2021) 218 (8): e20202726.

https://doi.org/10.1084/jem.20202726

Published: 23 June 2021

View article titled, High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

Journal Articles

Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance

J Exp Med (2021) 218 (8): e20202592.

https://doi.org/10.1084/jem.20202592

Published: 17 June 2021

View article titled, Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance

Includes: Supplementary data

Journal Articles

SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

Vanessa Sancho-Shimizu, Petter Brodin, Aurélie Cobat, Catherine M. Biggs, Julie Toubiana, Carrie L. Lucas, Sarah E. Henrickson, Alexandre Belot, MIS-C@CHGE, Stuart G. Tangye, Joshua D. Milner, Michael Levin, Laurent Abel, Dusan Bogunovic, Jean-Laurent Casanova, Shen-Ying Zhang

J Exp Med (2021) 218 (6): e20210446.

https://doi.org/10.1084/jem.20210446

Published: 27 April 2021

View article titled, SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

Includes: Supplementary data

Journal Articles

JEM career launchpad

Anna Bigas, Ivan Zanoni, Matthew R. Hepworth, Stephanie C. Eisenbarth, Seth Lucian Masters, Jonathan Kipnis, Carola G. Vinuesa, Kim L. Good-Jacobson, Stuart G. Tangye, Sayuri Yamazaki, Claire Hivroz, Elia Tait Wojno, Ziv Shulman, Marco Colonna

J Exp Med (2021) 218 (2): e20202509.

https://doi.org/10.1084/jem.20202509

Published: 19 January 2021

View article titled, JEM career launchpad

Journal Articles

Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Vivien Béziat, Simon J. Tavernier, Yin-Huai Chen, Cindy S. Ma, Marie Materna, Arian Laurence, Jens Staal, Dominik Aschenbrenner, Lisa Roels, Lisa Worley, Kathleen Claes, Lisa Gartner, Lisa A. Kohn, Marieke De Bruyne, Klaus Schmitz-Abe, Louis-Marie Charbonnier, Sevgi Keles, Justine Nammour, Natasha Vladikine, Majistor Raj Luxman Maglorius Renkilaraj, Yoann Seeleuthner, Mélanie Migaud, Jérémie Rosain, Mohamed Jeljeli, Bertrand Boisson, Eva Van Braeckel, Jill A. Rosenfeld, Hongzheng Dai, Lindsay C. Burrage, David R. Murdock, Bart N. Lambrecht, Véronique Avettand-Fenoel, Tiphanie P. Vogel, Undiagnosed Diseases Network, Charles R. Esther, Jr., Sule Haskologlu, Figen Dogu, Peter Ciznar, David Boutboul, Marie Ouachée-Chardin, Jean Amourette, Marie-Noëlle Lebras, Clément Gauvain, Colas Tcherakian, Aydan Ikinciogullari, Rudi Beyaert, Laurent Abel, Joshua D. Milner, Bodo Grimbacher, Louis-Jean Couderc, Manish J. Butte, Alexandra F. Freeman, Émilie Catherinot, Claire Fieschi, Talal A. Chatila, Stuart G. Tangye, Holm H. Uhlig, Filomeen Haerynck, Jean-Laurent Casanova, Anne Puel

J Exp Med (2020) 217 (7): e2019180405272020c.

https://doi.org/10.1084/jem.2019180405272020c

Published: 09 June 2020

View article titled, Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Journal Articles

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

In Special Collection:

Cytokines Collection 2020

J Exp Med (2020) 217 (6): e20191804.

https://doi.org/10.1084/jem.20191804

Published: 24 March 2020

View article titled, Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Includes: Supplementary data

Journal Articles

Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

J Exp Med (2019) 217 (2): e20191336.

https://doi.org/10.1084/jem.20191336

Published: 16 December 2019

View article titled, Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

Includes: Supplementary data

Journal Articles

Regulation of the germinal center and humoral immunity by interleukin-21

In Special Collection:

JEM Immunology Collection 2020

Stuart G. Tangye, Cindy S. Ma

J Exp Med (2019) 217 (1): e20191638.

https://doi.org/10.1084/jem.20191638

Published: 05 December 2019

View article titled, Regulation of the germinal center and humoral immunity by interleukin-21

Journal Articles

Germline-activating mutations in PIK3CD compromise B cell development and function

In Special Collection:

Inborn Errors of Immunity 2019

J Exp Med (2018) 215 (8): 2073–2095.

https://doi.org/10.1084/jem.20180010

Published: 17 July 2018

View article titled, Germline-activating mutations in PIK3CD compromise B cell development and function

Includes: Supplementary data

Journal Articles

Human immunity against EBV—lessons from the clinic

In Special Collection:

JEM Reviews Collection

Stuart G. Tangye, Umaimainthan Palendira, Emily S.J. Edwards

J Exp Med (2017) 214 (2): 269–283.

https://doi.org/10.1084/jem.20161846

Published: 20 January 2017

View article titled, Human immunity against EBV—lessons from the clinic

Journal Articles

Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

In Special Collection:

Monogenic Auto-Inflammation and Auto-Immunity in Humans 2018

J Exp Med (2016) 214 (1): 91–106.

https://doi.org/10.1084/jem.20160849

Published: 23 December 2016

View article titled, Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

Includes: Supplementary data

Journal Articles

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

In Special Collection:

Monogenic Auto-Inflammation and Auto-Immunity in Humans 2018

J Exp Med (2016) 213 (11): 2413–2435.

https://doi.org/10.1084/jem.20160576

Published: 19 September 2016

View article titled, Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

Includes: Supplementary data

NARROW

Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease

STAT3 gain of function: Too much of a good thing in the skin!

Helper T cell immunity in humans with inherited CD4 deficiency

For whom the B(c)ell tolls: CXCL4 AIDs human autoimmunity

Inborn errors of human B cell development, differentiation, and function

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance

SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

JEM career launchpad

Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

Regulation of the germinal center and humoral immunity by interleukin-21

Germline-activating mutations in PIK3CD compromise B cell development and function

Human immunity against EBV—lessons from the clinic

Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

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