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Robert Brink
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Journal Articles

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

Tina Nguyen, Anthony Lau, Julia Bier, Kristen C. Cooke, Helen Lenthall, Stephanie Ruiz-Diaz, Danielle T. Avery, Henry Brigden, David Zahra, William A Sewell, Luke Droney, Satoshi Okada, Takaki Asano, Hassan Abolhassani, Zahra Chavoshzadeh, Roshini S. Abraham, Nipunie Rajapakse, Eric W. Klee, Joseph A. Church, Andrew Williams, Melanie Wong, Christoph Burkhart, Gulbu Uzel, David R. Croucher, David E. James, Cindy S. Ma, Robert Brink, Stuart G. Tangye, Elissa K. Deenick
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (6): e20221020.
https://doi.org/10.1084/jem.20221020
Published: 21 March 2023
View articletitled, Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2
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Includes: Supplementary data
Journal Articles

BAFFR controls early memory B cell responses but is dispensable for germinal center function

Angelica W.Y. Lau, Vivian M. Turner, Katherine Bourne, Jana R. Hermes, Tyani D. Chan, Robert Brink
Journal: Journal of Experimental Medicine
J Exp Med (2020) 218 (2): e20191167.
https://doi.org/10.1084/jem.20191167
Published: 29 October 2020
View articletitled, BAFFR controls early memory B cell responses but is dispensable for germinal center function
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Journal Articles

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage

In Special Collection:
2020 Germinal Centers and Immune Niches
Amparo Toboso-Navasa, Arief Gunawan, Giulia Morlino, Rinako Nakagawa, Andrea Taddei, Djamil Damry, Yash Patel, Probir Chakravarty, Martin Janz, George Kassiotis, Robert Brink, Martin Eilers, Dinis Pedro Calado
Journal: Journal of Experimental Medicine
J Exp Med (2020) 217 (7): e20191933.
https://doi.org/10.1084/jem.20191933
Published: 14 May 2020
View articletitled, Restriction of memory B cell differentiation at the germinal center B cell positive selection stage
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Journal Articles

Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

Anthony Lau, Danielle T. Avery, Katherine Jackson, Helen Lenthall, Stefano Volpi, Henry Brigden, Amanda J. Russell, Julia Bier, Joanne H. Reed, Joanne M. Smart, Theresa Cole, Sharon Choo, Paul E. Gray, Lucinda J. Berglund, Peter Hsu, Melanie Wong, Michael O’Sullivan, Kaan Boztug, Isabelle Meyts, Gulbu Uzel, Luigi D. Notarangelo, Robert Brink, Christopher C. Goodnow, Stuart G. Tangye, Elissa K. Deenick
Journal: Journal of Experimental Medicine
J Exp Med (2019) 217 (2): e20191336.
https://doi.org/10.1084/jem.20191336
Published: 16 December 2019
View articletitled, Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production
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Includes: Supplementary data
Journal Articles

Germline-activating mutations in PIK3CD compromise B cell development and function

In Special Collection:
Inborn Errors of Immunity 2019
Danielle T. Avery, Alisa Kane, Tina Nguyen, Anthony Lau, Akira Nguyen, Helen Lenthall, Kathryn Payne, Wei Shi, Henry Brigden, Elise French, Julia Bier, Jana R. Hermes, David Zahra, William A. Sewell, Danyal Butt, Michael Elliott, Kaan Boztug, Isabelle Meyts, Sharon Choo, Peter Hsu, Melanie Wong, Lucinda J. Berglund, Paul Gray, Michael O’Sullivan, Theresa Cole, Steven M. Holland, Cindy S. Ma, Christoph Burkhart, Lynn M. Corcoran, Tri Giang Phan, Robert Brink, Gulbu Uzel, Elissa K. Deenick, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2018) 215 (8): 2073–2095.
https://doi.org/10.1084/jem.20180010
Published: 17 July 2018
View articletitled, Germline-activating mutations in PIK3CD compromise B cell development and function
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Includes: Supplementary data
Journal Articles

Atypical chemokine receptor 4 shapes activated B cell fate

Ervin E. Kara, Cameron R. Bastow, Duncan R. McKenzie, Carly E. Gregor, Kevin A. Fenix, Rachelle Babb, Todd S. Norton, Dimitra Zotos, Lauren B. Rodda, Jana R. Hermes, Katherine Bourne, Derek S. Gilchrist, Robert J. Nibbs, Mohammed Alsharifi, Carola G. Vinuesa, David M. Tarlinton, Robert Brink, Geoffrey R. Hill, Jason G. Cyster, Iain Comerford, Shaun R. McColl
Journal: Journal of Experimental Medicine
J Exp Med (2018) 215 (3): 801–813.
https://doi.org/10.1084/jem.20171067
Published: 31 January 2018
View articletitled, Atypical chemokine receptor 4 shapes activated B cell fate
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Includes: Supplementary data
Journal Articles

Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

In Special Collection:
B Cells, T Cells, Vaccines 2019
Nike J. Kräutler, Dan Suan, Danyal Butt, Katherine Bourne, Jana R. Hermes, Tyani D. Chan, Christopher Sundling, Warren Kaplan, Peter Schofield, Jennifer Jackson, Antony Basten, Daniel Christ, Robert Brink
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (5): 1259–1267.
https://doi.org/10.1084/jem.20161533
Published: 31 March 2017
View articletitled, Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells
Open the PDF for Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells in another window
Includes: Supplementary data
Journal Articles

Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity

Elisabeth K. Malle, Nathan W. Zammit, Stacey N. Walters, Yen Chin Koay, Jianmin Wu, Bernice M. Tan, Jeanette E. Villanueva, Robert Brink, Tom Loudovaris, James Cantley, Shelli R. McAlpine, Daniel Hesselson, Shane T. Grey
Journal: Journal of Experimental Medicine
J Exp Med (2015) 212 (8): 1239–1254.
https://doi.org/10.1084/jem.20150218
Published: 29 June 2015
View articletitled, Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity
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Includes: Supplementary data
Journal Articles

TRAF3 regulates the effector function of regulatory T cells and humoral immune responses

Jae-Hoon Chang, Hongbo Hu, Jin Jin, Nahum Puebla-Osorio, Yichuan Xiao, Brian E. Gilbert, Robert Brink, Stephen E. Ullrich, Shao-Cong Sun
Journal: Journal of Experimental Medicine
J Exp Med (2013) 211 (1): 137–151.
https://doi.org/10.1084/jem.20131019
Published: 30 December 2013
View articletitled, TRAF3 regulates the effector function of regulatory T cells and humoral immune responses
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Includes: Supplementary data
Journal Articles

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

Sau K. Lee, Robert J. Rigby, Dimitra Zotos, Louis M. Tsai, Shimpei Kawamoto, Jennifer L. Marshall, Roybel R. Ramiscal, Tyani D. Chan, Dominique Gatto, Robert Brink, Di Yu, Sidonia Fagarasan, David M. Tarlinton, Adam F. Cunningham, Carola G. Vinuesa
Journal: Journal of Experimental Medicine
J Exp Med (2011) 208 (7): 1377–1388.
https://doi.org/10.1084/jem.20102065
Published: 27 June 2011
View articletitled, B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells
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Includes: Supplementary data
Journal Articles

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Danielle T. Avery, Elissa K. Deenick, Cindy S. Ma, Santi Suryani, Nicholas Simpson, Gary Y. Chew, Tyani D. Chan, Umamainthan Palendira, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Sharon Choo, Karl E. Bleasel, Jane Peake, Cecile King, Martyn A. French, Dan Engelhard, Sami Al-Hajjar, Saleh Al-Muhsen, Klaus Magdorf, Joachim Roesler, Peter D. Arkwright, Pravin Hissaria, D. Sean Riminton, Melanie Wong, Robert Brink, David A. Fulcher, Jean-Laurent Casanova, Matthew C. Cook, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (1): 155–171.
https://doi.org/10.1084/jem.20091706
Published: 04 January 2010
View articletitled, B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
Open the PDF for B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans in another window
Includes: Supplementary data
Journal Articles

Follicular helper T cells are required for systemic autoimmunity

Michelle A. Linterman, Robert J. Rigby, Raphael. K. Wong, Di Yu, Robert Brink, Jennifer L. Cannons, Pamela L. Schwartzberg, Matthew C. Cook, Giles D. Walters, Carola G. Vinuesa
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (3): 561–576.
https://doi.org/10.1084/jem.20081886
Published: 16 February 2009
View articletitled, Follicular helper T cells are required for systemic autoimmunity
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Includes: Supplementary data
Journal Articles

High affinity germinal center B cells are actively selected into the plasma cell compartment

Tri Giang Phan, Didrik Paus, Tyani D. Chan, Marian L. Turner, Stephen L. Nutt, Antony Basten, Robert Brink
Journal: Journal of Experimental Medicine
J Exp Med (2006) 203 (11): 2419–2424.
https://doi.org/10.1084/jem.20061254
Published: 09 October 2006
View articletitled, High affinity germinal center B cells are actively selected into the plasma cell compartment
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Includes: Supplementary data
Journal Articles

Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

Didrik Paus, Tri Giang Phan, Tyani D. Chan, Sandra Gardam, Antony Basten, Robert Brink
Journal: Journal of Experimental Medicine
J Exp Med (2006) 203 (4): 1081–1091.
https://doi.org/10.1084/jem.20060087
Published: 10 April 2006
View articletitled, Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
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Includes: Supplementary data
Journal Articles

B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells

Tri Giang Phan, Michelle Amesbury, Sandra Gardam, Jeffrey Crosbie, Jhagvaral Hasbold, Philip D. Hodgkin, Antony Basten, Robert Brink
Journal: Journal of Experimental Medicine
J Exp Med (2003) 197 (7): 845–860.
https://doi.org/10.1084/jem.20022144
Published: 31 March 2003
View articletitled, B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells
Open the PDF for B Cell Receptor–independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells in another window