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Matthew C. Cook
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Journal Articles

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

In Special Collection:
Autoimmunity 2024 , JEM Immunology Collection 2024
Yaoyuan Zhang, Rhiannon Morris, Grant J. Brown, Ayla May D. Lorenzo, Xiangpeng Meng, Nadia J. Kershaw, Pamudika Kiridena, Gaétan Burgio, Simon Gross, Jean Y. Cappello, Qian Shen, Hao Wang, Cynthia Turnbull, Tom Lea-Henry, Maurice Stanley, Zhijia Yu, Fiona D. Ballard, Aaron Chuah, James C. Lee, Ann-Maree Hatch, Anselm Enders, Seth L. Masters, Alexander P. Headley, Peter Trnka, Dominic Mallon, Jeffery T. Fletcher, Giles D. Walters, Mario Šestan, Marija Jelušić, Matthew C. Cook, Vicki Athanasopoulos, David A. Fulcher, Jeffrey J. Babon, Carola G. Vinuesa, Julia I. Ellyard
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20221080.
https://doi.org/10.1084/jem.20221080
Published: 28 February 2024
View article titled, Rare <em>SH2B3</em> coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity
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Includes: Supplementary data
Journal Articles

P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance

Yuke He, Antonia E. Gallman, Chengmei Xie, Qian Shen, Jianyang Ma, Finn D. Wolfreys, Moriah Sandy, Todor Arsov, Xiaoqian Wu, Yuting Qin, Pingjing Zhang, Simon Jiang, Maurice Stanley, Philip Wu, Jingjing Tan, Huihua Ding, Haiyan Xue, Wei Chen, Jinping Xu, Lindsey A. Criswell, Joanne Nititham, Marcin Adamski, A. Richard Kitching, Matthew C. Cook, Lanfang Cao, Nan Shen, Jason G. Cyster, Carola G. Vinuesa
Journal: Journal of Experimental Medicine
J Exp Med (2021) 219 (1): e20211004.
https://doi.org/10.1084/jem.20211004
Published: 10 December 2021
View article titled, P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance
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Includes: Supplementary data
Journal Articles

Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility

Rushika C. Wirasinha, Ainsley R. Davies, Monika Srivastava, Julie M. Sheridan, Xavier Y.X. Sng, Ottavia M. Delmonte, Kerry Dobbs, Khai L. Loh, Lisa A. Miosge, Cindy Eunhee Lee, Rochna Chand, Anna Chan, Jin Yan Yap, Michael D. Keller, Karin Chen, Jamie Rossjohn, Nicole L. La Gruta, Carola G. Vinuesa, Hugh H. Reid, Michail S. Lionakis, Luigi D. Notarangelo, Daniel H.D. Gray, Christopher C. Goodnow, Matthew C. Cook, Stephen R. Daley
Journal: Journal of Experimental Medicine
J Exp Med (2020) 218 (2): e20200476.
https://doi.org/10.1084/jem.20200476
Published: 27 October 2020
View article titled, <em>Nfkb2</em> variants reveal a p100-degradation threshold that defines autoimmune susceptibility
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Includes: Supplementary data
Journal Articles

Regulatory roles of IL-10–producing human follicular T cells

In Special Collection:
2019: The Year in Experimental Medicine , 2020 Germinal Centers and Immune Niches , Antibodies at the Forefront of Disease Treatment , Autoimmunity: Mechanisms and Novel Treatments
Pablo F. Cañete, Rebecca A. Sweet, Paula Gonzalez-Figueroa, Ilenia Papa, Naganari Ohkura, Holly Bolton, Jonathan A. Roco, Marta Cuenca, Katharine J. Bassett, Ismail Sayin, Emma Barry, Angel Lopez, David H. Canaday, Michael Meyer-Hermann, Claudio Doglioni, Barbara Fazekas de St Groth, Shimon Sakaguchi, Matthew C. Cook, Carola G. Vinuesa
Journal: Journal of Experimental Medicine
J Exp Med (2019) 216 (8): 1843–1856.
https://doi.org/10.1084/jem.20190493
Published: 17 June 2019
View article titled, Regulatory roles of IL-10–producing human follicular T cells
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Includes: Supplementary data
Journal Articles

Gain-of-function IKBKB mutation causes human combined immune deficiency

In Special Collection:
Inborn Errors of Immunity 2019
Chelisa Cardinez, Bahar Miraghazadeh, Kay Tanita, Elizabeth da Silva, Akihiro Hoshino, Satoshi Okada, Rochna Chand, Takaki Asano, Miyuki Tsumura, Kenichi Yoshida, Hidenori Ohnishi, Zenichiro Kato, Masahide Yamazaki, Yusuke Okuno, Satoru Miyano, Seiji Kojima, Seishi Ogawa, T. Daniel Andrews, Matthew A. Field, Gaetan Burgio, Tomohiro Morio, Carola G. Vinuesa, Hirokazu Kanegane, Matthew C. Cook
Journal: Journal of Experimental Medicine
J Exp Med (2018) 215 (11): 2715–2724.
https://doi.org/10.1084/jem.20180639
Published: 18 October 2018
View article titled, Gain-of-function <em>IKBKB</em> mutation causes human combined immune deficiency
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Includes: Supplementary data
Journal Articles

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets

Cindy S. Ma, Natalie Wong, Geetha Rao, Akira Nguyen, Danielle T. Avery, Kathryn Payne, James Torpy, Patrick O’Young, Elissa Deenick, Jacinta Bustamante, Anne Puel, Satoshi Okada, Masao Kobayashi, Ruben Martinez-Barricarte, Michael Elliott, Sara Sebnem Kilic, Jamila El Baghdadi, Yoshiyuki Minegishi, Aziz Bousfiha, Nic Robertson, Sophie Hambleton, Peter D. Arkwright, Martyn French, Annaliesse K. Blincoe, Peter Hsu, Dianne E. Campbell, Michael O. Stormon, Melanie Wong, Stephen Adelstein, David A. Fulcher, Matthew C. Cook, Polina Stepensky, Kaan Boztug, Rita Beier, Aydan Ikincioğullari, John B. Ziegler, Paul Gray, Capucine Picard, Stéphanie Boisson-Dupuis, Tri Giang Phan, Bodo Grimbacher, Klaus Warnatz, Steven M. Holland, Gulbu Uzel, Jean-Laurent Casanova, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (8): 1589–1608.
https://doi.org/10.1084/jem.20151467
Published: 11 July 2016
View article titled, Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4<sup>+</sup> T cells into distinct effector subsets
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Includes: Supplementary data
Journal Articles

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Elissa K. Deenick, Danielle T. Avery, Anna Chan, Lucinda J. Berglund, Megan L. Ives, Leen Moens, Jennifer L. Stoddard, Jacinta Bustamante, Stephanie Boisson-Dupuis, Miyuki Tsumura, Masao Kobayashi, Peter D. Arkwright, Diana Averbuch, Dan Engelhard, Joachim Roesler, Jane Peake, Melanie Wong, Stephen Adelstein, Sharon Choo, Joanne M. Smart, Martyn A. French, David A. Fulcher, Matthew C. Cook, Capucine Picard, Anne Durandy, Christoph Klein, Steven M. Holland, Gulbu Uzel, Jean-Laurent Casanova, Cindy S. Ma, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (12): 2739–2753.
https://doi.org/10.1084/jem.20130323
Published: 11 November 2013
View article titled, Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells
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Includes: Supplementary data
Journal Articles

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Marcel Batten, Nandhini Ramamoorthi, Noelyn M. Kljavin, Cindy S. Ma, Jennifer H. Cox, Hart S. Dengler, Dimitry M. Danilenko, Patrick Caplazi, Melanie Wong, David A. Fulcher, Matthew C. Cook, Cecile King, Stuart G. Tangye, Frederic J. de Sauvage, Nico Ghilardi
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (13): 2895–2906.
https://doi.org/10.1084/jem.20100064
Published: 22 November 2010
View article titled, IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
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Includes: Supplementary data
Journal Articles

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Danielle T. Avery, Elissa K. Deenick, Cindy S. Ma, Santi Suryani, Nicholas Simpson, Gary Y. Chew, Tyani D. Chan, Umamainthan Palendira, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Sharon Choo, Karl E. Bleasel, Jane Peake, Cecile King, Martyn A. French, Dan Engelhard, Sami Al-Hajjar, Saleh Al-Muhsen, Klaus Magdorf, Joachim Roesler, Peter D. Arkwright, Pravin Hissaria, D. Sean Riminton, Melanie Wong, Robert Brink, David A. Fulcher, Jean-Laurent Casanova, Matthew C. Cook, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (1): 155–171.
https://doi.org/10.1084/jem.20091706
Published: 04 January 2010
View article titled, B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
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Includes: Supplementary data
Journal Articles

Follicular helper T cells are required for systemic autoimmunity

Michelle A. Linterman, Robert J. Rigby, Raphael. K. Wong, Di Yu, Robert Brink, Jennifer L. Cannons, Pamela L. Schwartzberg, Matthew C. Cook, Giles D. Walters, Carola G. Vinuesa
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (3): 561–576.
https://doi.org/10.1084/jem.20081886
Published: 16 February 2009
View article titled, Follicular helper T cells are required for systemic autoimmunity
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Includes: Supplementary data
Journal Articles

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

Cindy S. Ma, Gary Y.J. Chew, Nicholas Simpson, Archana Priyadarshi, Melanie Wong, Bodo Grimbacher, David A. Fulcher, Stuart G. Tangye, Matthew C. Cook
Journal: Journal of Experimental Medicine
J Exp Med (2008) 205 (7): 1551–1557.
https://doi.org/10.1084/jem.20080218
Published: 30 June 2008
View article titled, Deficiency of Th17 cells in hyper IgE syndrome due to mutations in <em>STAT3 </em>
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Journal Articles

Germinal Centers without T Cells

Carola García de Vinuesa, Matthew C. Cook, Jennifer Ball, Marion Drew, Yvonne Sunners, Marilia Cascalho, Matthias Wabl, Gerry G.B. Klaus, Ian C.M. MacLennan
Journal: Journal of Experimental Medicine
J Exp Med (2000) 191 (3): 485–494.
https://doi.org/10.1084/jem.191.3.485
Published: 07 February 2000
View article titled, Germinal Centers without T Cells
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Journal Articles

Generation of Splenic Follicular Structure and B Cell Movement in Tumor Necrosis Factor–deficient Mice

Matthew C. Cook, Heinrich Körner, D. Sean Riminton, Frances A. Lemckert, Jhagvaral Hasbold, Michelle Amesbury, Philip D. Hodgkin, Jason G. Cyster, Jonathon D. Sedgwick, Antony Basten
Journal: Journal of Experimental Medicine
J Exp Med (1998) 188 (8): 1503–1510.
https://doi.org/10.1084/jem.188.8.1503
Published: 19 October 1998
View article titled, Generation of Splenic Follicular Structure and B Cell Movement in Tumor Necrosis Factor–deficient Mice
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Journal Articles

Outer Periarteriolar Lymphoid Sheath Arrest and Subsequent Differentiation of Both Naive and Tolerant Immunoglobulin Transgenic B Cells Is Determined by B Cell Receptor Occupancy

Matthew C. Cook, Antony Basten, Barbara Fazekas de St. Groth
Journal: Journal of Experimental Medicine
J Exp Med (1997) 186 (5): 631–643.
https://doi.org/10.1084/jem.186.5.631
Published: 29 August 1997
View article titled, Outer Periarteriolar Lymphoid Sheath Arrest and Subsequent Differentiation of Both Naive and Tolerant Immunoglobulin Transgenic B Cells Is Determined by B Cell Receptor Occupancy
Open the PDF for Outer Periarteriolar Lymphoid Sheath Arrest and Subsequent Differentiation of Both Naive and Tolerant Immunoglobulin Transgenic B Cells Is Determined by B Cell Receptor Occupancy in another window