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Christoph Klein
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Journal Articles

Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis

In Special Collection:
JEM Clinical Immunology Collection 2025
Sina Ghasempour, Neil Warner, Rei Guan, Marco M. Rodari, Danton Ivanochko, Ryder Whittaker Hawkins, Ashish Marwaha, Jan K. Nowak, Yijing Liang, Daniel J. Mulder, Lorraine Stallard, Michael Li, Daniel D. Yu, Fred G. Pluthero, Vritika Batura, Mo Zhao, Iram Siddiqui, Julia E.M. Upton, Jessie M. Hulst, Walter H.A. Kahr, Roberto Mendoza-Londono, Fabienne Charbit-Henrion, Lies H. Hoefsloot, Anis Khiat, Diana Moreira, Eunice Trindade, Maria do Céu Espinheira, Isabel Pinto Pais, Marjolein J.A. Weerts, Hannie Douben, Daniel Kotlarz, Scott B. Snapper, Christoph Klein, James J. Dowling, Jean-Philippe Julien, Marieke Joosten, Nadine Cerf-Bensussan, Spencer A. Freeman, Marianna Parlato, Tjakko J. van Ham, Aleixo M. Muise
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (12): e20240546.
https://doi.org/10.1084/jem.20240546
Published: 11 November 2024
View articletitled, Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis
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Includes: Supplementary data
Journal Articles

Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency

Romain Lévy, Florian Gothe, Mana Momenilandi, Thomas Magg, Marie Materna, Philipp Peters, Johannes Raedler, Quentin Philippot, Anita Lena Rack-Hoch, David Langlais, Mathieu Bourgey, Anna-Lisa Lanz, Masato Ogishi, Jérémie Rosain, Emmanuel Martin, Sylvain Latour, Natasha Vladikine, Marco Distefano, Taushif Khan, Franck Rapaport, Marian S. Schulz, Ursula Holzer, Anders Fasth, Georgios Sogkas, Carsten Speckmann, Arianna Troilo, Venetia Bigley, Anna Roppelt, Yael Dinur-Schejter, Ori Toker, Karen Helene Bronken Martinsen, Roya Sherkat, Ido Somekh, Raz Somech, Dror S. Shouval, Jörn-Sven Kühl, Winnie Ip, Elizabeth M. McDermott, Lucy Cliffe, Ahmet Ozen, Safa Baris, Hemalatha G. Rangarajan, Emmanuelle Jouanguy, Anne Puel, Jacinta Bustamante, Marie-Alexandra Alyanakian, Mathieu Fusaro, Yi Wang, Xiao-Fei Kong, Aurélie Cobat, David Boutboul, Martin Castelle, Claire Aguilar, Olivier Hermine, Morgane Cheminant, Felipe Suarez, Alisan Yildiran, Aziz Bousfiha, Hamoud Al-Mousa, Fahad Alsohime, Deniz Cagdas, Roshini S. Abraham, Alan P. Knutsen, Borre Fevang, Sagar Bhattad, Ayca Kiykim, Baran Erman, Tugba Arikoglu, Ekrem Unal, Ashish Kumar, Christoph B. Geier, Ulrich Baumann, Bénédicte Neven, CARMIL2 Consortium, Meino Rohlfs, Christoph Walz, Laurent Abel, Bernard Malissen, Nico Marr, Christoph Klein, Jean-Laurent Casanova, Fabian Hauck, Vivien Béziat
Journal: Journal of Experimental Medicine
J Exp Med (2022) 220 (2): e20220275.
https://doi.org/10.1084/jem.20220275
Published: 14 December 2022
View articletitled, Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency
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Includes: Supplementary data
Journal Articles

A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans

Astrid Hagelkruys, Gerald Wirnsberger, Johannes Stadlmann, Miriam Wöhner, Marion Horrer, Bojan Vilagos, Gustav Jonsson, Melanie Kogler, Luigi Tortola, Maria Novatchkova, Peter Bönelt, David Hoffmann, Rubina Koglgruber, Ulrike Steffen, Georg Schett, Meinrad Busslinger, Andreas Bergthaler, Christoph Klein, Josef M. Penninger
Journal: Journal of Experimental Medicine
J Exp Med (2020) 218 (1): e20200559.
https://doi.org/10.1084/jem.20200559
Published: 15 September 2020
View articletitled, A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans
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Includes: Supplementary data
Journal Articles

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Alexandra Y. Kreins, Michael J. Ciancanelli, Satoshi Okada, Xiao-Fei Kong, Noé Ramírez-Alejo, Sara Sebnem Kilic, Jamila El Baghdadi, Shigeaki Nonoyama, Seyed Alireza Mahdaviani, Fatima Ailal, Aziz Bousfiha, Davood Mansouri, Elma Nievas, Cindy S. Ma, Geetha Rao, Andrea Bernasconi, Hye Sun Kuehn, Julie Niemela, Jennifer Stoddard, Paul Deveau, Aurelie Cobat, Safa El Azbaoui, Ayoub Sabri, Che Kang Lim, Mikael Sundin, Danielle T. Avery, Rabih Halwani, Audrey V. Grant, Bertrand Boisson, Dusan Bogunovic, Yuval Itan, Marcela Moncada-Velez, Ruben Martinez-Barricarte, Melanie Migaud, Caroline Deswarte, Laia Alsina, Daniel Kotlarz, Christoph Klein, Ingrid Muller-Fleckenstein, Bernhard Fleckenstein, Valerie Cormier-Daire, Stefan Rose-John, Capucine Picard, Lennart Hammarstrom, Anne Puel, Saleh Al-Muhsen, Laurent Abel, Damien Chaussabel, Sergio D. Rosenzweig, Yoshiyuki Minegishi, Stuart G. Tangye, Jacinta Bustamante, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis
Journal: Journal of Experimental Medicine
J Exp Med (2015) 212 (10): 1641–1662.
https://doi.org/10.1084/jem.20140280
Published: 24 August 2015
View articletitled, Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
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Includes: Supplementary data
Journal Articles

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Elissa K. Deenick, Danielle T. Avery, Anna Chan, Lucinda J. Berglund, Megan L. Ives, Leen Moens, Jennifer L. Stoddard, Jacinta Bustamante, Stephanie Boisson-Dupuis, Miyuki Tsumura, Masao Kobayashi, Peter D. Arkwright, Diana Averbuch, Dan Engelhard, Joachim Roesler, Jane Peake, Melanie Wong, Stephen Adelstein, Sharon Choo, Joanne M. Smart, Martyn A. French, David A. Fulcher, Matthew C. Cook, Capucine Picard, Anne Durandy, Christoph Klein, Steven M. Holland, Gulbu Uzel, Jean-Laurent Casanova, Cindy S. Ma, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (12): 2739–2753.
https://doi.org/10.1084/jem.20130323
Published: 11 November 2013
View articletitled, Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells
Open the PDF for Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells in another window
Includes: Supplementary data
Journal Articles

Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome

Daniel Kotlarz, Natalia Ziętara, Gulbu Uzel, Thomas Weidemann, Christian J. Braun, Jana Diestelhorst, Peter M. Krawitz, Peter N. Robinson, Jochen Hecht, Jacek Puchałka, E. Michael Gertz, Alejandro A. Schäffer, Monica G. Lawrence, Lela Kardava, Dietmar Pfeifer, Ulrich Baumann, Eva-Doreen Pfister, Eric P. Hanson, Axel Schambach, Roland Jacobs, Hans Kreipe, Susan Moir, Joshua D. Milner, Petra Schwille, Stefan Mundlos, Christoph Klein
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (3): 433–443.
https://doi.org/10.1084/jem.20111229
Published: 25 February 2013
View articletitled, Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome
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Includes: Supplementary data
Journal Articles

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes

Lisa S. Westerberg, Parool Meelu, Marisa Baptista, Michelle A. Eston, David A. Adamovich, Vinicius Cotta-de-Almeida, Brian Seed, Michael K. Rosen, Peter Vandenberghe, Adrian J. Thrasher, Christoph Klein, Frederick W. Alt, Scott B. Snapper
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (6): 1145–1152.
https://doi.org/10.1084/jem.20091245
Published: 31 May 2010
View articletitled, Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes
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Includes: Supplementary data
Journal Articles

Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes

A. Maria Dahl, Christoph Klein, Pietro G. Andres, Cheryl A. London, Michael P. Lodge, Richard C. Mulligan, Abul K. Abbas
Journal: Journal of Experimental Medicine
J Exp Med (2000) 191 (12): 2031–2038.
https://doi.org/10.1084/jem.191.12.2031
Published: 12 June 2000
View articletitled, Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes
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Journal Articles

Comparative Analysis of Genetically Modified Dendritic Cells and Tumor Cells as Therapeutic Cancer Vaccines

Christoph Klein, Hansruedi Bueler, Richard C. Mulligan
Journal: Journal of Experimental Medicine
J Exp Med (2000) 191 (10): 1699–1708.
https://doi.org/10.1084/jem.191.10.1699
Published: 15 May 2000
View articletitled, Comparative Analysis of Genetically Modified Dendritic Cells and Tumor Cells as Therapeutic Cancer Vaccines
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