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Journal Articles

STAT3 gain of function: Too much of a good thing in the skin!

Cindy S. Ma, Stuart G. Tangye

J Exp Med (2024) 221 (8): e20240849.

https://doi.org/10.1084/jem.20240849

Published: 01 July 2024

View article titled, STAT3 gain of function: Too much of a good thing in the skin!

Journal Articles

Helper T cell immunity in humans with inherited CD4 deficiency

In Special Collection:

Journal-Based CME Activities with Journal of Experimental Medicine (JEM) , Thymus, T Cell Development, and Inborn Errors

Antoine Guérin, Marcela Moncada-Vélez, Katherine Jackson, Masato Ogishi, Jérémie Rosain, Mathieu Mancini, David Langlais, Andrea Nunez, Samantha Webster, Jesse Goyette, Taushif Khan, Nico Marr, Danielle T. Avery, Geetha Rao, Tim Waterboer, Birgitta Michels, Esmeralda Neves, Cátia Iracema Morais, Jonathan London, Stéphanie Mestrallet, Pierre Quartier dit Maire, Bénédicte Neven, Franck Rapaport, Yoann Seeleuthner, Atar Lev, Amos J. Simon, Jorge Montoya, Ortal Barel, Julio Gómez-Rodríguez, Julio C. Orrego, Anne-Sophie L’Honneur, Camille Soudée, Jessica Rojas, Alejandra C. Velez, Irini Sereti, Benjamin Terrier, Nancy Marin, Luis F. García, Laurent Abel, Stéphanie Boisson-Dupuis, Joel Reis, Antonio Marinho, Andrea Lisco, Emilia Faria, Christopher C. Goodnow, Julia Vasconcelos, Vivien Béziat, Cindy S. Ma, Raz Somech, Jean-Laurent Casanova, Jacinta Bustamante, Jose Luis Franco, Stuart G. Tangye

J Exp Med (2024) 221 (5): e20231044.

https://doi.org/10.1084/jem.20231044

Published: 01 April 2024

View article titled, Helper T cell immunity in humans with inherited CD4 deficiency

Includes: Supplementary data

Journal Articles

Inborn errors of human B cell development, differentiation, and function

Stuart G. Tangye, Tina Nguyen, Elissa K. Deenick, Vanessa L. Bryant, Cindy S. Ma

J Exp Med (2023) 220 (7): e20221105.

https://doi.org/10.1084/jem.20221105

Published: 05 June 2023

View article titled, Inborn errors of human B cell development, differentiation, and function

Journal Articles

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

J Exp Med (2023) 220 (6): e20221020.

https://doi.org/10.1084/jem.20221020

Published: 21 March 2023

View article titled, Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

Includes: Supplementary data

Journal Articles

High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

In Special Collection:

Cytokines Collection 2021 , Innate Immunity: From Basic Biology to Human Disease

J Exp Med (2021) 218 (8): e20202726.

https://doi.org/10.1084/jem.20202726

Published: 23 June 2021

View article titled, High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

Journal Articles

Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Vivien Béziat, Simon J. Tavernier, Yin-Huai Chen, Cindy S. Ma, Marie Materna, Arian Laurence, Jens Staal, Dominik Aschenbrenner, Lisa Roels, Lisa Worley, Kathleen Claes, Lisa Gartner, Lisa A. Kohn, Marieke De Bruyne, Klaus Schmitz-Abe, Louis-Marie Charbonnier, Sevgi Keles, Justine Nammour, Natasha Vladikine, Majistor Raj Luxman Maglorius Renkilaraj, Yoann Seeleuthner, Mélanie Migaud, Jérémie Rosain, Mohamed Jeljeli, Bertrand Boisson, Eva Van Braeckel, Jill A. Rosenfeld, Hongzheng Dai, Lindsay C. Burrage, David R. Murdock, Bart N. Lambrecht, Véronique Avettand-Fenoel, Tiphanie P. Vogel, Undiagnosed Diseases Network, Charles R. Esther, Jr., Sule Haskologlu, Figen Dogu, Peter Ciznar, David Boutboul, Marie Ouachée-Chardin, Jean Amourette, Marie-Noëlle Lebras, Clément Gauvain, Colas Tcherakian, Aydan Ikinciogullari, Rudi Beyaert, Laurent Abel, Joshua D. Milner, Bodo Grimbacher, Louis-Jean Couderc, Manish J. Butte, Alexandra F. Freeman, Émilie Catherinot, Claire Fieschi, Talal A. Chatila, Stuart G. Tangye, Holm H. Uhlig, Filomeen Haerynck, Jean-Laurent Casanova, Anne Puel

J Exp Med (2020) 217 (7): e2019180405272020c.

https://doi.org/10.1084/jem.2019180405272020c

Published: 09 June 2020

View article titled, Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Journal Articles

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

In Special Collection:

Cytokines Collection 2020

J Exp Med (2020) 217 (6): e20191804.

https://doi.org/10.1084/jem.20191804

Published: 24 March 2020

View article titled, Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Includes: Supplementary data

Journal Articles

Regulation of the germinal center and humoral immunity by interleukin-21

In Special Collection:

JEM Immunology Collection 2020

Stuart G. Tangye, Cindy S. Ma

J Exp Med (2019) 217 (1): e20191638.

https://doi.org/10.1084/jem.20191638

Published: 05 December 2019

View article titled, Regulation of the germinal center and humoral immunity by interleukin-21

Journal Articles

Germline-activating mutations in PIK3CD compromise B cell development and function

In Special Collection:

Inborn Errors of Immunity 2019

J Exp Med (2018) 215 (8): 2073–2095.

https://doi.org/10.1084/jem.20180010

Published: 17 July 2018

View article titled, Germline-activating mutations in PIK3CD compromise B cell development and function

Includes: Supplementary data

Journal Articles

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

In Special Collection:

Monogenic Auto-Inflammation and Auto-Immunity in Humans 2018

J Exp Med (2016) 213 (11): 2413–2435.

https://doi.org/10.1084/jem.20160576

Published: 19 September 2016

View article titled, Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

Includes: Supplementary data

Journal Articles

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4⁺ T cells into distinct effector subsets

J Exp Med (2016) 213 (8): 1589–1608.

https://doi.org/10.1084/jem.20151467

Published: 11 July 2016

View article titled, Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets

Includes: Supplementary data

Journal Articles

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Alexandra Y. Kreins, Michael J. Ciancanelli, Satoshi Okada, Xiao-Fei Kong, Noé Ramírez-Alejo, Sara Sebnem Kilic, Jamila El Baghdadi, Shigeaki Nonoyama, Seyed Alireza Mahdaviani, Fatima Ailal, Aziz Bousfiha, Davood Mansouri, Elma Nievas, Cindy S. Ma, Geetha Rao, Andrea Bernasconi, Hye Sun Kuehn, Julie Niemela, Jennifer Stoddard, Paul Deveau, Aurelie Cobat, Safa El Azbaoui, Ayoub Sabri, Che Kang Lim, Mikael Sundin, Danielle T. Avery, Rabih Halwani, Audrey V. Grant, Bertrand Boisson, Dusan Bogunovic, Yuval Itan, Marcela Moncada-Velez, Ruben Martinez-Barricarte, Melanie Migaud, Caroline Deswarte, Laia Alsina, Daniel Kotlarz, Christoph Klein, Ingrid Muller-Fleckenstein, Bernhard Fleckenstein, Valerie Cormier-Daire, Stefan Rose-John, Capucine Picard, Lennart Hammarstrom, Anne Puel, Saleh Al-Muhsen, Laurent Abel, Damien Chaussabel, Sergio D. Rosenzweig, Yoshiyuki Minegishi, Stuart G. Tangye, Jacinta Bustamante, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis

J Exp Med (2015) 212 (10): 1641–1662.

https://doi.org/10.1084/jem.20140280

Published: 24 August 2015

View article titled, Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Includes: Supplementary data

Journal Articles

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

J Exp Med (2015) 212 (6): 855–864.

https://doi.org/10.1084/jem.20141992

Published: 04 May 2015

View article titled, STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

Journal Articles

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

J Exp Med (2013) 210 (12): 2739–2753.

https://doi.org/10.1084/jem.20130323

Published: 11 November 2013

View article titled, Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Includes: Supplementary data

Journal Articles

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood

J Exp Med (2013) 210 (9): 1743–1759.

https://doi.org/10.1084/jem.20130592

Published: 29 July 2013

View article titled, Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood

Includes: Supplementary data

Journal Articles

The origins, function, and regulation of T follicular helper cells

Cindy S. Ma, Elissa K. Deenick, Marcel Batten, Stuart G. Tangye

J Exp Med (2012) 209 (7): 1241–1253.

https://doi.org/10.1084/jem.20120994

Published: 02 July 2012

View article titled, The origins, function, and regulation of T follicular helper cells

Journal Articles

Expansion of somatically reverted memory CD8⁺ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

Umaimainthan Palendira, Carol Low, Andrew I. Bell, Cindy S. Ma, Rachel J.M. Abbott, Tri Giang Phan, D. Sean Riminton, Sharon Choo, Joanne M. Smart, Vassilios Lougaris, Silvia Giliani, Rebecca H. Buckley, Bodo Grimbacher, Frank Alvaro, Amy D. Klion, Kim E. Nichols, Stephen Adelstein, Alan B. Rickinson, Stuart G. Tangye

J Exp Med (2012) 209 (5): 913–924.

https://doi.org/10.1084/jem.20112391

Published: 09 April 2012

View article titled, Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

Journal Articles

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

J Exp Med (2011) 208 (11): 2305–2320.

https://doi.org/10.1084/jem.20110345

Published: 17 October 2011

View article titled, DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

Includes: Supplementary data

Journal Articles

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Marcel Batten, Nandhini Ramamoorthi, Noelyn M. Kljavin, Cindy S. Ma, Jennifer H. Cox, Hart S. Dengler, Dimitry M. Danilenko, Patrick Caplazi, Melanie Wong, David A. Fulcher, Matthew C. Cook, Cecile King, Stuart G. Tangye, Frederic J. de Sauvage, Nico Ghilardi

J Exp Med (2010) 207 (13): 2895–2906.

https://doi.org/10.1084/jem.20100064

Published: 22 November 2010

View article titled, IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Includes: Supplementary data

Journal Articles

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

J Exp Med (2010) 207 (1): 155–171.

https://doi.org/10.1084/jem.20091706

Published: 04 January 2010

View article titled, B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Includes: Supplementary data

NARROW

STAT3 gain of function: Too much of a good thing in the skin!

Helper T cell immunity in humans with inherited CD4 deficiency

Inborn errors of human B cell development, differentiation, and function

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency

Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Regulation of the germinal center and humoral immunity by interleukin-21

Germline-activating mutations in PIK3CD compromise B cell development and function

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4⁺ T cells into distinct effector subsets

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood

The origins, function, and regulation of T follicular helper cells

Expansion of somatically reverted memory CD8⁺ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

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