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David A. Fulcher
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Journal Articles

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

In Special Collection:
Autoimmunity 2024 , JEM Immunology Collection 2024
Yaoyuan Zhang, Rhiannon Morris, Grant J. Brown, Ayla May D. Lorenzo, Xiangpeng Meng, Nadia J. Kershaw, Pamudika Kiridena, Gaétan Burgio, Simon Gross, Jean Y. Cappello, Qian Shen, Hao Wang, Cynthia Turnbull, Tom Lea-Henry, Maurice Stanley, Zhijia Yu, Fiona D. Ballard, Aaron Chuah, James C. Lee, Ann-Maree Hatch, Anselm Enders, Seth L. Masters, Alexander P. Headley, Peter Trnka, Dominic Mallon, Jeffery T. Fletcher, Giles D. Walters, Mario Šestan, Marija Jelušić, Matthew C. Cook, Vicki Athanasopoulos, David A. Fulcher, Jeffrey J. Babon, Carola G. Vinuesa, Julia I. Ellyard
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20221080.
https://doi.org/10.1084/jem.20221080
Published: 28 February 2024
View article titled, Rare <em>SH2B3</em> coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity
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Includes: Supplementary data
Journal Articles

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets

Cindy S. Ma, Natalie Wong, Geetha Rao, Akira Nguyen, Danielle T. Avery, Kathryn Payne, James Torpy, Patrick O’Young, Elissa Deenick, Jacinta Bustamante, Anne Puel, Satoshi Okada, Masao Kobayashi, Ruben Martinez-Barricarte, Michael Elliott, Sara Sebnem Kilic, Jamila El Baghdadi, Yoshiyuki Minegishi, Aziz Bousfiha, Nic Robertson, Sophie Hambleton, Peter D. Arkwright, Martyn French, Annaliesse K. Blincoe, Peter Hsu, Dianne E. Campbell, Michael O. Stormon, Melanie Wong, Stephen Adelstein, David A. Fulcher, Matthew C. Cook, Polina Stepensky, Kaan Boztug, Rita Beier, Aydan Ikincioğullari, John B. Ziegler, Paul Gray, Capucine Picard, Stéphanie Boisson-Dupuis, Tri Giang Phan, Bodo Grimbacher, Klaus Warnatz, Steven M. Holland, Gulbu Uzel, Jean-Laurent Casanova, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (8): 1589–1608.
https://doi.org/10.1084/jem.20151467
Published: 11 July 2016
View article titled, Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4<sup>+</sup> T cells into distinct effector subsets
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Includes: Supplementary data
Journal Articles

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

Robert P. Wilson, Megan L. Ives, Geetha Rao, Anthony Lau, Kathryn Payne, Masao Kobayashi, Peter D. Arkwright, Jane Peake, Melanie Wong, Stephen Adelstein, Joanne M. Smart, Martyn A. French, David A. Fulcher, Capucine Picard, Jacinta Bustamante, Stephanie Boisson-Dupuis, Paul Gray, Polina Stepensky, Klaus Warnatz, Alexandra F. Freeman, Jamie Rossjohn, James McCluskey, Steven M. Holland, Jean-Laurent Casanova, Gulbu Uzel, Cindy S. Ma, Stuart G. Tangye, Elissa K. Deenick
Journal: Journal of Experimental Medicine
J Exp Med (2015) 212 (6): 855–864.
https://doi.org/10.1084/jem.20141992
Published: 04 May 2015
View article titled, STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function
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Journal Articles

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Elissa K. Deenick, Danielle T. Avery, Anna Chan, Lucinda J. Berglund, Megan L. Ives, Leen Moens, Jennifer L. Stoddard, Jacinta Bustamante, Stephanie Boisson-Dupuis, Miyuki Tsumura, Masao Kobayashi, Peter D. Arkwright, Diana Averbuch, Dan Engelhard, Joachim Roesler, Jane Peake, Melanie Wong, Stephen Adelstein, Sharon Choo, Joanne M. Smart, Martyn A. French, David A. Fulcher, Matthew C. Cook, Capucine Picard, Anne Durandy, Christoph Klein, Steven M. Holland, Gulbu Uzel, Jean-Laurent Casanova, Cindy S. Ma, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (12): 2739–2753.
https://doi.org/10.1084/jem.20130323
Published: 11 November 2013
View article titled, Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells
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Includes: Supplementary data
Journal Articles

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Marcel Batten, Nandhini Ramamoorthi, Noelyn M. Kljavin, Cindy S. Ma, Jennifer H. Cox, Hart S. Dengler, Dimitry M. Danilenko, Patrick Caplazi, Melanie Wong, David A. Fulcher, Matthew C. Cook, Cecile King, Stuart G. Tangye, Frederic J. de Sauvage, Nico Ghilardi
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (13): 2895–2906.
https://doi.org/10.1084/jem.20100064
Published: 22 November 2010
View article titled, IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
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Includes: Supplementary data
Journal Articles

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Danielle T. Avery, Elissa K. Deenick, Cindy S. Ma, Santi Suryani, Nicholas Simpson, Gary Y. Chew, Tyani D. Chan, Umamainthan Palendira, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Sharon Choo, Karl E. Bleasel, Jane Peake, Cecile King, Martyn A. French, Dan Engelhard, Sami Al-Hajjar, Saleh Al-Muhsen, Klaus Magdorf, Joachim Roesler, Peter D. Arkwright, Pravin Hissaria, D. Sean Riminton, Melanie Wong, Robert Brink, David A. Fulcher, Jean-Laurent Casanova, Matthew C. Cook, Stuart G. Tangye
Journal: Journal of Experimental Medicine
J Exp Med (2010) 207 (1): 155–171.
https://doi.org/10.1084/jem.20091706
Published: 04 January 2010
View article titled, B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
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Includes: Supplementary data
Journal Articles

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

Cindy S. Ma, Gary Y.J. Chew, Nicholas Simpson, Archana Priyadarshi, Melanie Wong, Bodo Grimbacher, David A. Fulcher, Stuart G. Tangye, Matthew C. Cook
Journal: Journal of Experimental Medicine
J Exp Med (2008) 205 (7): 1551–1557.
https://doi.org/10.1084/jem.20080218
Published: 30 June 2008
View article titled, Deficiency of Th17 cells in hyper IgE syndrome due to mutations in <em>STAT3 </em>
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