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Journal Articles

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

J Exp Med (2021) 218 (11): e20210566.

https://doi.org/10.1084/jem.20210566

Published: 02 September 2021

View article titled, Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

Includes: Supplementary data

Journal Articles

Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

In Special Collection:

Cytokines Collection 2021 , Innate Immunity: From Basic Biology to Human Disease , JEM Clinical Immunology Collection 2021

Paul Bastard, Elizaveta Orlova, Leila Sozaeva, Romain Lévy, Alyssa James, Monica M. Schmitt, Sebastian Ochoa, Maria Kareva, Yulia Rodina, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Anna-Lena Neehus, Elana Shaw, Mélanie Migaud, Lucy Bizien, Olov Ekwall, Stefan Berg, Guglielmo Beccuti, Lucia Ghizzoni, Gérard Thiriez, Arthur Pavot, Cécile Goujard, Marie-Louise Frémond, Edwin Carter, Anya Rothenbuhler, Agnès Linglart, Brigite Mignot, Aurélie Comte, Nathalie Cheikh, Olivier Hermine, Lars Breivik, Eystein S. Husebye, Sébastien Humbert, Pierre Rohrlich, Alain Coaquette, Fanny Vuoto, Karine Faure, Nizar Mahlaoui, Primož Kotnik, Tadej Battelino, Katarina Trebušak Podkrajšek, Kai Kisand, Elise M.N. Ferré, Thomas DiMaggio, Lindsey B. Rosen, Peter D. Burbelo, Martin McIntyre, Nelli Y. Kann, Anna Shcherbina, Maria Pavlova, Anna Kolodkina, Steven M. Holland, Shen-Ying Zhang, Yanick J. Crow, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Mark S. Anderson, Emmanuelle Jouanguy, Bénédicte Neven, Anne Puel, Jean-Laurent Casanova, Michail S. Lionakis

J Exp Med (2021) 218 (7): e20210554.

https://doi.org/10.1084/jem.20210554

Published: 23 April 2021

View article titled, Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

Includes: Supplementary data

Journal Articles

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

In Special Collection:

Antibodies at the Forefront of Disease Treatment , JEM Clinical Immunology Collection 2021

J Exp Med (2021) 218 (4): e20202486.

https://doi.org/10.1084/jem.20202486

Published: 05 February 2021

View article titled, Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

Includes: Supplementary data

Journal Articles

Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories

Kirby D. Johnson, Daniel J. Conn, Evgenia Shishkova, Koichi R. Katsumura, Peng Liu, Siqi Shen, Erik A. Ranheim, Sean G. Kraus, Weixin Wang, Katherine R. Calvo, Amy P. Hsu, Steven M. Holland, Joshua J. Coon, Sunduz Keles, Emery H. Bresnick

J Exp Med (2020) 217 (11): e20191526.

https://doi.org/10.1084/jem.20191526

Published: 31 July 2020

View article titled, Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories

Includes: Supplementary data

Journal Articles

Germline-activating mutations in PIK3CD compromise B cell development and function

In Special Collection:

Inborn Errors of Immunity 2019

J Exp Med (2018) 215 (8): 2073–2095.

https://doi.org/10.1084/jem.20180010

Published: 17 July 2018

View article titled, Germline-activating mutations in PIK3CD compromise B cell development and function

Includes: Supplementary data

Journal Articles

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

J Exp Med (2017) 214 (9): 2547–2562.

https://doi.org/10.1084/jem.20161810

Published: 26 July 2017

View article titled, A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

Includes: Supplementary data

Journal Articles

PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients

In Special Collection:

Inborn Errors of Immunity 2019

Yuan Zhang, Chi A. Ma, Monica G. Lawrence, Timothy J. Break, Michael P. O’Connell, Jonathan J. Lyons, Diego B. López, John S. Barber, Yongge Zhao, Daniel L. Barber, Alexandra F. Freeman, Steven M. Holland, Michail S. Lionakis, Joshua D. Milner

J Exp Med (2017) 214 (9): 2523–2533.

https://doi.org/10.1084/jem.20161427

Published: 14 July 2017

View article titled, PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients

Includes: Supplementary data

Journal Articles

Correction: Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

Jean-Nicolas Schickel, Salomé Glauzy, Yen-Shing Ng, Nicolas Chamberlain, Christopher Massad, Isabelle Isnardi, Nathan Katz, Gulbu Uzel, Steven M. Holland, Capucine Picard, Anne Puel, Jean-Laurent Casanova, Eric Meffre

J Exp Med (2017) 214 (7): 2161.

https://doi.org/10.1084/jem.2016020105152017c

Published: 18 May 2017

View article titled, Correction: Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

Journal Articles

Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

J Exp Med (2017) 214 (7): 1991–2003.

https://doi.org/10.1084/jem.20160201

Published: 12 May 2017

View article titled, Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

Includes: Supplementary data

Journal Articles

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4⁺ T cells into distinct effector subsets

J Exp Med (2016) 213 (8): 1589–1608.

https://doi.org/10.1084/jem.20151467

Published: 11 July 2016

View article titled, Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets

Includes: Supplementary data

Journal Articles

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

J Exp Med (2015) 212 (6): 855–864.

https://doi.org/10.1084/jem.20141992

Published: 04 May 2015

View article titled, STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

Journal Articles

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

J Exp Med (2013) 210 (12): 2739–2753.

https://doi.org/10.1084/jem.20130323

Published: 11 November 2013

View article titled, Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Includes: Supplementary data

Journal Articles

Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

J Exp Med (2007) 204 (10): 2407–2422.

https://doi.org/10.1084/jem.20070628

Published: 24 September 2007

View article titled, Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

Includes: Supplementary data

Journal Articles

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

J Exp Med (2006) 203 (7): 1745–1759.

https://doi.org/10.1084/jem.20060085

Published: 03 July 2006

View article titled, X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

Journal Articles

Neutrophil-specific Granule Deficiency Results from a Novel Mutation with Loss of Function of the Transcription Factor CCAAT/Enhancer Binding Protein ε

Julie A. Lekstrom-Himes, Susan E. Dorman, Piroska Kopar, Steven M. Holland, John I. Gallin

J Exp Med (1999) 189 (11): 1847–1852.

https://doi.org/10.1084/jem.189.11.1847

Published: 07 June 1999

View article titled, Neutrophil-specific Granule Deficiency Results from a Novel Mutation with Loss of Function of the Transcription Factor CCAAT/Enhancer Binding Protein ε

NARROW

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories

Germline-activating mutations in PIK3CD compromise B cell development and function

A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis

PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients

Correction: Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4⁺ T cells into distinct effector subsets

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production

Neutrophil-specific Granule Deficiency Results from a Novel Mutation with Loss of Function of the Transcription Factor CCAAT/Enhancer Binding Protein ε

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