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Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Diana Olguín Calderón, Laura E. Kilpatrick, Clément Conil, Quentin Philippot, Masato Ogishi, Joseph Vellutini, Ji Eun Han, Narelle Keating, Hailun Li, Geetha Rao, Jonathan Bohlen, Charles S. Lay, Simon Platt, Gaspard Kerner, Elsa Feredj, Jessica N. Peel, Mana Momenilandi, Yoann Seeleuthner, Candice Lainé, Camille Soudée, Claire Leloup, Cecile Debuisson, Fanny Lanternier, Samuel Bitoun, Stephan Pavy, Xavier Mariette, Aniss Rafik, Hanaa Skhoun, Hanane El Ouazzani, Ismael Abderahmani-Ghorfi, Jamila El-Baghdadi, Andrés Baena, Manuela Tejada-Giraldo, Luis Fernando Barrera, Andrés Augusto Arias, Giovanna Fabio, Maria Carrabba, Melike Emiroglu, Liliana Bezrodnik, Loubna El Zein, Hassan Hammoud, Peter K. Gregersen, Benjamin Terrier, Rafael Leon Lopez, Marion Touzet, Vincent Pestre, Marlène Pasquet, Lars Rogge, Michael Fayon, François Galode, Eric Jeziorski, Darragh Duffy, Lluis Quintana-Murci, Etienne Patin, Charlotte Cunningham-Rundles, Isabelle Meyts, Shen-Ying Zhang, Qian Zhang, Emmanuelle Jouanguy, Bertrand Boisson, Jérémie Rosain, Vivien Béziat, Mohammad Shahrooei, Seyed Alireza Mahdaviani, Nima Rezaei, Nima Parvaneh, Zahra Chavoshzadeh, Niloufar Yazdanpanah, Nathalie Aladjidi, Antoni Noguera-Julian, Ana Esteve-Solé, Laia Alsina, Davood Mansouri, Sevgi Keles, Mediha Gonenc Ortakoylu, Deniz Aygun, Esra Yucel, Ayca Kiykim, Yildiz Camcioglu, Cindy S. Ma, Stuart G. Tangye, Peng Zhang, Laurent Abel, Peter D. Craggs, Jean-Laurent Casanova, Aurélie Cobat, Anne Puel, Jacinta Bustamante, Stephen J. Hill, Stéphanie Boisson-Dupuis

J Exp Med (2026) 223 (8): e20252236.

https://doi.org/10.1084/jem.20252236

Published: 09 July 2026

View article titled, Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Includes: Supplementary data

Journal Articles

Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

J Exp Med (2022) 219 (12): e2022020210282022c.

https://doi.org/10.1084/jem.2022020210282022c

Published: 07 November 2022

View article titled, Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

Journal Articles

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

In Special Collection:

Thymus, T Cell Development, and Inborn Errors

J Exp Med (2022) 220 (1): e20220484.

https://doi.org/10.1084/jem.20220484

Published: 03 November 2022

View article titled, Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

Includes: Supplementary data

Journal Articles

Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

In Special Collection:

JEM Mucosal Immunology 2022

J Exp Med (2022) 219 (7): e20220202.

https://doi.org/10.1084/jem.20220202

Published: 07 June 2022

View article titled, Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

Includes: Supplementary data

Journal Articles

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Alexandra Y. Kreins, Michael J. Ciancanelli, Satoshi Okada, Xiao-Fei Kong, Noé Ramírez-Alejo, Sara Sebnem Kilic, Jamila El Baghdadi, Shigeaki Nonoyama, Seyed Alireza Mahdaviani, Fatima Ailal, Aziz Bousfiha, Davood Mansouri, Elma Nievas, Cindy S. Ma, Geetha Rao, Andrea Bernasconi, Hye Sun Kuehn, Julie Niemela, Jennifer Stoddard, Paul Deveau, Aurelie Cobat, Safa El Azbaoui, Ayoub Sabri, Che Kang Lim, Mikael Sundin, Danielle T. Avery, Rabih Halwani, Audrey V. Grant, Bertrand Boisson, Dusan Bogunovic, Yuval Itan, Marcela Moncada-Velez, Ruben Martinez-Barricarte, Melanie Migaud, Caroline Deswarte, Laia Alsina, Daniel Kotlarz, Christoph Klein, Ingrid Muller-Fleckenstein, Bernhard Fleckenstein, Valerie Cormier-Daire, Stefan Rose-John, Capucine Picard, Lennart Hammarstrom, Anne Puel, Saleh Al-Muhsen, Laurent Abel, Damien Chaussabel, Sergio D. Rosenzweig, Yoshiyuki Minegishi, Stuart G. Tangye, Jacinta Bustamante, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis

J Exp Med (2015) 212 (10): 1641–1662.

https://doi.org/10.1084/jem.20140280

Published: 24 August 2015

View article titled, Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Includes: Supplementary data

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Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

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Update search

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Correction: Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis

Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

Email alerts

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