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Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

In Special Collection:

Cytokines Collection 2026

Diana Olguín Calderón, Laura E. Kilpatrick, Clément Conil, Quentin Philippot, Masato Ogishi, Joseph Vellutini, Ji Eun Han, Narelle Keating, Hailun Li, Geetha Rao, Jonathan Bohlen, Charles S. Lay, Simon Platt, Gaspard Kerner, Elsa Feredj, Jessica N. Peel, Mana Momenilandi, Yoann Seeleuthner, Candice Lainé, Camille Soudée, Claire Leloup, Cecile Debuisson, Fanny Lanternier, Samuel Bitoun, Stephan Pavy, Xavier Mariette, Aniss Rafik, Hanaa Skhoun, Hanane El Ouazzani, Ismael Abderahmani-Ghorfi, Jamila El-Baghdadi, Andrés Baena, Manuela Tejada-Giraldo, Luis Fernando Barrera, Andrés Augusto Arias, Giovanna Fabio, Maria Carrabba, Melike Emiroglu, Liliana Bezrodnik, Loubna El Zein, Hassan Hammoud, Peter K. Gregersen, Benjamin Terrier, Rafael Leon Lopez, Marion Touzet, Vincent Pestre, Marlène Pasquet, Lars Rogge, Michael Fayon, François Galode, Eric Jeziorski, Darragh Duffy, Lluis Quintana-Murci, Etienne Patin, Charlotte Cunningham-Rundles, Isabelle Meyts, Shen-Ying Zhang, Qian Zhang, Emmanuelle Jouanguy, Bertrand Boisson, Jérémie Rosain, Vivien Béziat, Mohammad Shahrooei, Seyed Alireza Mahdaviani, Nima Rezaei, Nima Parvaneh, Zahra Chavoshzadeh, Niloufar Yazdanpanah, Nathalie Aladjidi, Antoni Noguera-Julian, Ana Esteve-Solé, Laia Alsina, Davood Mansouri, Sevgi Keles, Mediha Gonenc Ortakoylu, Deniz Aygun, Esra Yucel, Ayca Kiykim, Yildiz Camcioglu, Cindy S. Ma, Stuart G. Tangye, Peng Zhang, Laurent Abel, Peter D. Craggs, Jean-Laurent Casanova, Aurélie Cobat, Anne Puel, Jacinta Bustamante, Stephen J. Hill, Stéphanie Boisson-Dupuis

J Exp Med (2026) 223 (8): e20252236.

https://doi.org/10.1084/jem.20252236

Published: 09 July 2026

View article titled, Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Includes: Supplementary data

Journal Articles

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

In Special Collection:

Monogenic Auto-Inflammation and Auto-Immunity in Humans 2018

J Exp Med (2016) 213 (11): 2413–2435.

https://doi.org/10.1084/jem.20160576

Published: 19 September 2016

View article titled, Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

Includes: Supplementary data

Journal Articles

Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis

J Exp Med (2015) 212 (5): 619–631.

https://doi.org/10.1084/jem.20141065

Published: 27 April 2015

View article titled, Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis

Journal Articles

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

J Exp Med (2008) 205 (7): 1543–1550.

https://doi.org/10.1084/jem.20080321

Published: 30 June 2008

View article titled, Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

Includes: Supplementary data

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Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

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Update search

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations

Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis

Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

Email alerts

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