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Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Diana Olguín Calderón, Laura E. Kilpatrick, Clément Conil, Quentin Philippot, Masato Ogishi, Joseph Vellutini, Ji Eun Han, Narelle Keating, Hailun Li, Geetha Rao, Jonathan Bohlen, Charles S. Lay, Simon Platt, Gaspard Kerner, Elsa Feredj, Jessica N. Peel, Mana Momenilandi, Yoann Seeleuthner, Candice Lainé, Camille Soudée, Claire Leloup, Cecile Debuisson, Fanny Lanternier, Samuel Bitoun, Stephan Pavy, Xavier Mariette, Aniss Rafik, Hanaa Skhoun, Hanane El Ouazzani, Ismael Abderahmani-Ghorfi, Jamila El-Baghdadi, Andrés Baena, Manuela Tejada-Giraldo, Luis Fernando Barrera, Andrés Augusto Arias, Giovanna Fabio, Maria Carrabba, Melike Emiroglu, Liliana Bezrodnik, Loubna El Zein, Hassan Hammoud, Peter K. Gregersen, Benjamin Terrier, Rafael Leon Lopez, Marion Touzet, Vincent Pestre, Marlène Pasquet, Lars Rogge, Michael Fayon, François Galode, Eric Jeziorski, Darragh Duffy, Lluis Quintana-Murci, Etienne Patin, Charlotte Cunningham-Rundles, Isabelle Meyts, Shen-Ying Zhang, Qian Zhang, Emmanuelle Jouanguy, Bertrand Boisson, Jérémie Rosain, Vivien Béziat, Mohammad Shahrooei, Seyed Alireza Mahdaviani, Nima Rezaei, Nima Parvaneh, Zahra Chavoshzadeh, Niloufar Yazdanpanah, Nathalie Aladjidi, Antoni Noguera-Julian, Ana Esteve-Solé, Laia Alsina, Davood Mansouri, Sevgi Keles, Mediha Gonenc Ortakoylu, Deniz Aygun, Esra Yucel, Ayca Kiykim, Yildiz Camcioglu, Cindy S. Ma, Stuart G. Tangye, Peng Zhang, Laurent Abel, Peter D. Craggs, Jean-Laurent Casanova, Aurélie Cobat, Anne Puel, Jacinta Bustamante, Stephen J. Hill, Stéphanie Boisson-Dupuis

J Exp Med (2026) 223 (8): e20252236.

https://doi.org/10.1084/jem.20252236

Published: 09 July 2026

View article titled, Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Includes: Supplementary data

Journal Articles

IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens

In Special Collection:

JEM Clinical Immunology Collection 2026 , JEM Mucosal Immunology 2026

J Exp Med (2026) 223 (5): e20251752.

https://doi.org/10.1084/jem.20251752

Published: 24 April 2026

View article titled, IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens

Includes: Supplementary data

Journal Articles

TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance

In Special Collection:

2023: The Year in Experimental Medicine , Immunology Update Winter 2024 , Innate Immune Signaling: From Host Defense to Disease Pathogenesis

J Exp Med (2023) 220 (12): e20230944.

https://doi.org/10.1084/jem.20230944

Published: 29 September 2023

View article titled, TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance

Includes: Supplementary data

Journal Articles

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

J Exp Med (2021) 218 (11): e20210566.

https://doi.org/10.1084/jem.20210566

Published: 02 September 2021

View article titled, Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

Includes: Supplementary data

Journal Articles

Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

Darren Ruane, Alejo Chorny, Haekyung Lee, Jeremiah Faith, Gaurav Pandey, Meimei Shan, Noa Simchoni, Adeeb Rahman, Aakash Garg, Erica G. Weinstein, Michael Oropallo, Michelle Gaylord, Ryan Ungaro, Charlotte Cunningham-Rundles, Konstantina Alexandropoulos, Daniel Mucida, Miriam Merad, Andrea Cerutti, Saurabh Mehandru

J Exp Med (2015) 213 (1): 53–73.

https://doi.org/10.1084/jem.20150567

Published: 28 December 2015

View article titled, Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

Includes: Supplementary data

Journal Articles

CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

Maxime Hervé, Isabelle Isnardi, Yen-shing Ng, James B. Bussel, Hans D. Ochs, Charlotte Cunningham-Rundles, Eric Meffre

J Exp Med (2007) 204 (7): 1583–1593.

https://doi.org/10.1084/jem.20062287

Published: 11 June 2007

View article titled, CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

Includes: Supplementary data

Journal Articles

Bruton's Tyrosine Kinase Is Essential for Human B Cell Tolerance

Yen-Shing Ng, Hedda Wardemann, James Chelnis, Charlotte Cunningham-Rundles, Eric Meffre

J Exp Med (2004) 200 (7): 927–934.

https://doi.org/10.1084/jem.20040920

Published: 04 October 2004

View article titled, Bruton's Tyrosine Kinase Is Essential for Human B Cell Tolerance

Includes: Supplementary data

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Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens

TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

Bruton's Tyrosine Kinase Is Essential for Human B Cell Tolerance

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Update search

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

IgD from atypical-like memory B cells and plasma cells targets commensal and environmental antigens

TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses

CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

Bruton's Tyrosine Kinase Is Essential for Human B Cell Tolerance

Email alerts

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