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Journal Articles

GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans

In Special Collection:
JEM Clinical Immunology Collection 2022
Yikun Yao, Ping Du Jiang, Brittany N. Chao, Deniz Cagdas, Satoshi Kubo, Arasu Balasubramaniyam, Yu Zhang, Bella Shadur, Adeeb NaserEddin, Les R. Folio, Benjamin Schwarz, Eric Bohrnsen, Lixin Zheng, Matthew Lynberg, Simone Gottlieb, Michael A. Leney-Greene, Ann Y. Park, Ilhan Tezcan, Ali Akdogan, Rahsan Gocmen, Sevgen Onder, Avi Rosenberg, Elizabeth J. Soilleux, Errin Johnson, Peter K. Jackson, Janos Demeter, Samuel D. Chauvin, Florian Paul, Matthias Selbach, Haydar Bulut, Menna R. Clatworthy, Zewen K. Tuong, Hanlin Zhang, Benjamin J. Stewart, Catharine M. Bosio, Polina Stepensky, Simon Clare, Sundar Ganesan, John C. Pascall, Oliver Daumke, Geoffrey W. Butcher, Andrew J. McMichael, Anna Katharina Simon, Michael J. Lenardo
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (6): e20201405.
https://doi.org/10.1084/jem.20201405
Published: 13 May 2022
View article titled, GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans
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Includes: Supplementary data
Journal Articles

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency

Juan Li, Wei-Te Lei, Peng Zhang, Franck Rapaport, Yoann Seeleuthner, Bingnan Lyu, Takaki Asano, Jérémie Rosain, Boualem Hammadi, Yu Zhang, Simon J. Pelham, András N. Spaan, Mélanie Migaud, David Hum, Benedetta Bigio, Maya Chrabieh, Vivien Béziat, Jacinta Bustamante, Shen-Ying Zhang, Emmanuelle Jouanguy, Stephanie Boisson-Dupuis, Jamila El Baghdadi, Vishukumar Aimanianda, Katharina Thoma, Manfred Fliegauf, Bodo Grimbacher, Anne-Sophie Korganow, Carol Saunders, V. Koneti Rao, Gulbu Uzel, Alexandra F. Freeman, Steven M. Holland, Helen C. Su, Charlotte Cunningham-Rundles, Claire Fieschi, Laurent Abel, Anne Puel, Aurélie Cobat, Jean-Laurent Casanova, Qian Zhang, Bertrand Boisson
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (11): e20210566.
https://doi.org/10.1084/jem.20210566
Published: 02 September 2021
View article titled, Biochemically deleterious human <em>NFKB1</em> variants underlie an autosomal dominant form of common variable immunodeficiency
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Includes: Supplementary data
Journal Articles

Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer

Yu Zhang, Vidhi Chandra, Erick Riquelme Sanchez, Prasanta Dutta, Pompeyo R. Quesada, Amanda Rakoski, Michelle Zoltan, Nivedita Arora, Seyda Baydogan, William Horne, Jared Burks, Hanwen Xu, Perwez Hussain, Huamin Wang, Sonal Gupta, Anirban Maitra, Jennifer M. Bailey, Seyed J. Moghaddam, Sulagna Banerjee, Ismet Sahin, Pratip Bhattacharya, Florencia McAllister
Journal: Journal of Experimental Medicine
J Exp Med (2020) 217 (12): e20190354.
https://doi.org/10.1084/jem.20190354
Published: 28 August 2020
View article titled, Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer
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Includes: Supplementary data
Journal Articles

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance

In Special Collection:
From Tolerance to Autoimmunity , JEM Immunology Collection 2020
Zinan Zhang, Florian Gothe, Perrine Pennamen, John R. James, David McDonald, Carlos P. Mata, Yorgo Modis, Anas M. Alazami, Meghan Acres, Wolfram Haller, Claire Bowen, Rainer Döffinger, Jan Sinclair, Shannon Brothers, Yu Zhang, Helen F. Matthews, Sophie Naudion, Fanny Pelluard, Huda Alajlan, Yasuhiro Yamazaki, Luigi D. Notarangelo, James E. Thaventhiran, Karin R. Engelhardt, Hamoud Al-Mousa, Sophie Hambleton, Caroline Rooryck, Kenneth G.C. Smith, Michael J. Lenardo
Journal: Journal of Experimental Medicine
J Exp Med (2019) 216 (6): 1311–1327.
https://doi.org/10.1084/jem.20182304
Published: 30 April 2019
View article titled, Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance
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Includes: Supplementary data
Journal Articles

Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10

In Special Collection:
Inflammation: From Mechanism to Disease
Peng Xiao, Huilun Zhang, Yu Zhang, Mingzhu Zheng, Rongbei Liu, Yuan Zhao, Xue Zhang, Hongqiang Cheng, Qian Cao, Yuehai Ke
Journal: Journal of Experimental Medicine
J Exp Med (2019) 216 (2): 337–349.
https://doi.org/10.1084/jem.20181198
Published: 04 January 2019
View article titled, Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10
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Includes: Supplementary data
Journal Articles

CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis

In Special Collection:
Skin Health and Disease
Tao Huang, Zhengjun Gao, Yu Zhang, Keqi Fan, Fei Wang, Yiyuan Li, Jiangyan Zhong, Heng Y. Fan, Qian Cao, Jiyong Zhou, Yichuan Xiao, Hongbo Hu, Jin Jin
Journal: Journal of Experimental Medicine
J Exp Med (2018) 215 (8): 1999–2017.
https://doi.org/10.1084/jem.20180210
Published: 17 July 2018
View article titled, CRL4<sup>DCAF2</sup> negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis
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Includes: Supplementary data
Journal Articles

Recurrent rhinovirus infections in a child with inherited MDA5 deficiency

In Special Collection:
2017: The Year in Experimental Medicine , Monogenic Auto-Inflammation and Auto-Immunity in Humans 2018
Ian T. Lamborn, Huie Jing, Yu Zhang, Scott B. Drutman, Jordan K. Abbott, Shirin Munir, Sangeeta Bade, Heardley M. Murdock, Celia P. Santos, Linda G. Brock, Evan Masutani, Emmanuel Y. Fordjour, Joshua J. McElwee, Jason D. Hughes, Dave P. Nichols, Aziz Belkadi, Andrew J. Oler, Corinne S. Happel, Helen F. Matthews, Laurent Abel, Peter L. Collins, Kanta Subbarao, Erwin W. Gelfand, Michael J. Ciancanelli, Jean-Laurent Casanova, Helen C. Su
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (7): 1949–1972.
https://doi.org/10.1084/jem.20161759
Published: 12 June 2017
View article titled, Recurrent rhinovirus infections in a child with inherited MDA5 deficiency
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Includes: Supplementary data
Journal Articles

Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency

In Special Collection:
Monogenic Auto-Inflammation and Auto-Immunity in Humans 2018
Hassan Abolhassani, Emily S.J. Edwards, Aydan Ikinciogullari, Huie Jing, Stephan Borte, Marcus Buggert, Likun Du, Mami Matsuda-Lennikov, Rosa Romano, Rozina Caridha, Sangeeta Bade, Yu Zhang, Juliet Frederiksen, Mingyan Fang, Sevgi Kostel Bal, Sule Haskologlu, Figen Dogu, Nurdan Tacyildiz, Helen F. Matthews, Joshua J. McElwee, Emma Gostick, David A. Price, Umaimainthan Palendira, Asghar Aghamohammadi, Bertrand Boisson, Nima Rezaei, Annika C. Karlsson, Michael J. Lenardo, Jean-Laurent Casanova, Lennart Hammarström, Stuart G. Tangye, Helen C. Su, Qiang Pan-Hammarström
Journal: Journal of Experimental Medicine
J Exp Med (2016) 214 (1): 91–106.
https://doi.org/10.1084/jem.20160849
Published: 23 December 2016
View article titled, Combined immunodeficiency and Epstein-Barr virus–induced B cell malignancy in humans with inherited CD70 deficiency
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Includes: Supplementary data
Journal Articles

Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K

Carrie L. Lucas, Yu Zhang, Anthony Venida, Ying Wang, Jason Hughes, Joshua McElwee, Morgan Butrick, Helen Matthews, Susan Price, Matthew Biancalana, Xiaochuan Wang, Michael Richards, Tamara Pozos, Isil Barlan, Ahmet Ozen, V. Koneti Rao, Helen C. Su, Michael J. Lenardo
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (13): 2537–2547.
https://doi.org/10.1084/jem.20141759
Published: 08 December 2014
View article titled, Heterozygous splice mutation in <em>PIK3R1</em> causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K
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Journal Articles

A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation

Tirtha Chakraborty, Thomas Perlot, Ramesh Subrahmanyam, Anant Jani, Peter H. Goff, Yu Zhang, Irina Ivanova, Frederick W. Alt, Ranjan Sen
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (5): 1019–1027.
https://doi.org/10.1084/jem.20081621
Published: 04 May 2009
View article titled, A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation
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Includes: Supplementary data