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Kenneth G.C. Smith
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Journal Articles

miR-374a-5p regulates inflammatory genes and monocyte function in patients with inflammatory bowel disease

In Special Collection:
JEM Mucosal Immunology 2022
Carlos Perez-Sanchez, Ariana Barbera Betancourt, Paul A. Lyons, Zinan Zhang, Chenqu Suo, James C. Lee, Eoin F. McKinney, Louise K. Modis, Christian Ellson, Kenneth G.C. Smith
Journal: Journal of Experimental Medicine
J Exp Med (2022) 219 (5): e20211366.
https://doi.org/10.1084/jem.20211366
Published: 01 April 2022
View article titled, miR-374a-5p regulates inflammatory genes and monocyte function in patients with inflammatory bowel disease
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Includes: Supplementary data
Journal Articles

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses

In Special Collection:
2019: The Year in Experimental Medicine
Sarah Spencer, Sevgi Köstel Bal, William Egner, Hana Lango Allen, Syed I. Raza, Chi A. Ma, Meltem Gürel, Yuan Zhang, Guangping Sun, Ruth A. Sabroe, Daniel Greene, William Rae, Tala Shahin, Katarzyna Kania, Rico Chandra Ardy, Marini Thian, Emily Staples, Annika Pecchia-Bekkum, William P.M. Worrall, Jonathan Stephens, Matthew Brown, Salih Tuna, Melanie York, Fiona Shackley, Diarmuid Kerrin, Ravishankar Sargur, Alison Condliffe, Hamid Nawaz Tipu, Hye Sun Kuehn, Sergio D. Rosenzweig, Ernest Turro, Simon Tavaré, Adrian J. Thrasher, Duncan Ian Jodrell, Kenneth G.C. Smith, Kaan Boztug, Joshua D. Milner, James E.D. Thaventhiran
Journal: Journal of Experimental Medicine
J Exp Med (2019) 216 (9): 1986–1998.
https://doi.org/10.1084/jem.20190344
Published: 24 June 2019
View article titled, Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses
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Includes: Supplementary data
Journal Articles

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance

In Special Collection:
From Tolerance to Autoimmunity , JEM Immunology Collection 2020
Zinan Zhang, Florian Gothe, Perrine Pennamen, John R. James, David McDonald, Carlos P. Mata, Yorgo Modis, Anas M. Alazami, Meghan Acres, Wolfram Haller, Claire Bowen, Rainer Döffinger, Jan Sinclair, Shannon Brothers, Yu Zhang, Helen F. Matthews, Sophie Naudion, Fanny Pelluard, Huda Alajlan, Yasuhiro Yamazaki, Luigi D. Notarangelo, James E. Thaventhiran, Karin R. Engelhardt, Hamoud Al-Mousa, Sophie Hambleton, Caroline Rooryck, Kenneth G.C. Smith, Michael J. Lenardo
Journal: Journal of Experimental Medicine
J Exp Med (2019) 216 (6): 1311–1327.
https://doi.org/10.1084/jem.20182304
Published: 30 April 2019
View article titled, Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance
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Includes: Supplementary data
Journal Articles

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

David C. Thomas, Simon Clare, John M. Sowerby, Mercedes Pardo, Jatinder K. Juss, David A. Goulding, Louise van der Weyden, Daniel Storisteanu, Ananth Prakash, Marion Espéli, Shaun Flint, James C. Lee, Kim Hoenderdos, Leanne Kane, Katherine Harcourt, Subhankar Mukhopadhyay, Yagnesh Umrania, Robin Antrobus, James A. Nathan, David J. Adams, Alex Bateman, Jyoti S. Choudhary, Paul A. Lyons, Alison M. Condliffe, Edwin R. Chilvers, Gordon Dougan, Kenneth G.C. Smith
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (4): 1111–1128.
https://doi.org/10.1084/jem.20161382
Published: 28 March 2017
View article titled, Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity
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Includes: Supplementary data
Journal Articles

Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity

Marion Espéli, Menna R. Clatworthy, Susanne Bökers, Kate E. Lawlor, Antony J. Cutler, Frank Köntgen, Paul A. Lyons, Kenneth G.C. Smith
Journal: Journal of Experimental Medicine
J Exp Med (2012) 209 (12): 2307–2319.
https://doi.org/10.1084/jem.20121752
Published: 29 October 2012
View article titled, Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity
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Includes: Supplementary data
Journal Articles

Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

Lisa C. Willcocks, Paul A. Lyons, Menna R. Clatworthy, James I. Robinson, Wanling Yang, Stephen A. Newland, Vincent Plagnol, Naomi N. McGovern, Alison M. Condliffe, Edwin R. Chilvers, Dwomoa Adu, Elaine C. Jolly, Richard Watts, Yu Lung Lau, Ann W. Morgan, Gerard Nash, Kenneth G.C. Smith
Journal: Journal of Experimental Medicine
J Exp Med (2008) 205 (7): 1573–1582.
https://doi.org/10.1084/jem.20072413
Published: 16 June 2008
View article titled, Copy number of <em>FCGR3B,</em> which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake
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Includes: Multimedia, Supplementary data
Journal Articles

Distinct cell-specific control of autoimmunity and infection by FcγRIIb

Rebecca J. Brownlie, Kate E. Lawlor, Heather A. Niederer, Antony J. Cutler, Zou Xiang, Menna R. Clatworthy, R. Andres Floto, David R. Greaves, Paul A. Lyons, Kenneth G.C. Smith
Journal: Journal of Experimental Medicine
J Exp Med (2008) 205 (4): 883–895.
https://doi.org/10.1084/jem.20072565
Published: 24 March 2008
View article titled, Distinct cell-specific control of autoimmunity and infection by FcγRIIb
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Includes: Supplementary data
Journal Articles

SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice

Astrid Lanoue, Menna R. Clatworthy, Philippa Smith, Sheila Green, Michael J. Townsend, Helen E. Jolin, Kenneth G.C. Smith, Padraic G. Fallon, Andrew N.J. McKenzie
Journal: Journal of Experimental Medicine
J Exp Med (2004) 200 (11): 1383–1393.
https://doi.org/10.1084/jem.20040795
Published: 06 December 2004
View article titled, SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice
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Journal Articles

FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis

Menna R. Clatworthy, Kenneth G.C. Smith
Journal: Journal of Experimental Medicine
J Exp Med (2004) 199 (5): 717–723.
https://doi.org/10.1084/jem.20032197
Published: 23 February 2004
View article titled, FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis
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Includes: Supplementary data
Journal Articles

Interleukin 4 Reduces Expression of Inhibitory Receptors on B Cells and Abolishes CD22 and FcγRII-mediated B Cell Suppression

Elizabeth U. Rudge, Antony J. Cutler, Nicholas R. Pritchard, Kenneth G.C. Smith
Journal: Journal of Experimental Medicine
J Exp Med (2002) 195 (8): 1079–1085.
https://doi.org/10.1084/jem.20011435
Published: 15 April 2002
View article titled, Interleukin 4 Reduces Expression of Inhibitory Receptors on B Cells and Abolishes CD22 and FcγRII-mediated B Cell Suppression
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Journal Articles

bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells

Kenneth G.C. Smith, Amanda Light, Lorraine A. O'Reilly, Soon-Meng Ang, Andreas Strasser, David Tarlinton
Journal: Journal of Experimental Medicine
J Exp Med (2000) 191 (3): 475–484.
https://doi.org/10.1084/jem.191.3.475
Published: 07 February 2000
View article titled, <em>bcl</em>-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells
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Journal Articles

Inhibition of the B Cell by CD22: A Requirement for Lyn

Kenneth G.C. Smith, David M. Tarlinton, Gina M. Doody, Margaret L. Hibbs, Douglas T. Fearon
Journal: Journal of Experimental Medicine
J Exp Med (1998) 187 (5): 807–811.
https://doi.org/10.1084/jem.187.5.807
Published: 02 March 1998
View article titled, Inhibition of the B Cell by CD22: A Requirement for Lyn
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