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Brief Definitive Report

The nuclear receptor liver X receptor β (LXRβ) is a critical regulator of cholesterol homeostasis in mammalian cells. Here, we report that pan-T cell– and T reg cell–specific LXRβ ablation leads to a survival defect of LXRβ-deficient effector T cells and impaired T reg cell functionality.

Article

The Trithorax Cxxc1 molecule specifically regulates the chromatin accessibility of the genes that are downregulated during priming and reactivated in the later phase in differentiating CD4 T cells. The authors show Cxxc1 deletion induces CD4 T cell hyperactivation and enhanced allergic airway inflammation.

Cyclin D3 drives a unique form of “inertial” cell cycling responsible for clonal expansion of B cells in the germinal center dark zone.

Technical Advances and Resources

Zhuang et al. identify SARS-CoV-2–specific T cell epitopes recognized by CD4+ and CD8+ T cells in BALB/c and C57BL/6 mice. SARS-CoV-2–specific T cells are protective and cross-reactive in vivo, and are shaped by type I IFN signaling.

Insights

The activity of individual nuclear receptors is not only determined by specific actions in specific target cells, but also by their regulation in the tissue environment, as exemplified by the role of liver X receptors in regulating T cell development and effector functions.

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