Brief Definitive Report
The naive polyclonal CD4 T cell repertoire can differentiate into multiple lineages during acute viral infection, with some clones exhibiting a preferred lineage choice, as revealed by scRNA-seq and scTCR-seq. TCR motifs can partially skew clone-intrinsic lineage preferences toward the TFH fate.
The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function
The m6A reader YTHDF2 is a novel regulator of inflammatory pathways in HSCs. YTHDF2 loss upregulates m6A-modified proinflammatory transcripts, resulting in chronic HSC inflammatory activation, myeloid bias, and functional exhaustion.
The cells that support hematopoietic stem cells in the developing liver in vivo are unknown. Systematic genetic dissection in vivo identifies endothelial and hepatic stellate cells as the major functional source of a key hematopoietic stem cell maintenance factor, stem cell factor (SCF).
Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo
Human monoclonal antibody potency in vitro does not uniformly correlate with its in vivo neutralization of SARS-CoV-2. Antibody Fc-effector function is important for in vivo neutralization, and antibody combinations show superior efficacy compared with single antibodies.