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Klaus Ley
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Journal Articles

Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain

In Special Collection:
Neuroscience Collection 2021
Juliana M. Navia-Pelaez, Soo-Ho Choi, Luciano dos Santos Aggum Capettini, Yining Xia, Ayelet Gonen, Colin Agatisa-Boyle, Lauriane Delay, Gilson Gonçalves dos Santos, Glaucilene F. Catroli, Jungsu Kim, Jenny W. Lu, Benjamin Saylor, Holger Winkels, Christopher P. Durant, Yanal Ghosheh, Graham Beaton, Klaus Ley, Irina Kufareva, Maripat Corr, Tony L. Yaksh, Yury I. Miller
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (7): e20202059.
https://doi.org/10.1084/jem.20202059
Published: 10 May 2021
View article titled, Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain
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Includes: Supplementary data
Journal Articles

Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis

Alex Marki, Konrad Buscher, Cristina Lorenzini, Matthew Meyer, Ryosuke Saigusa, Zhichao Fan, Yi-Ting Yeh, Nadine Hartmann, Jennifer M. Dan, William B. Kiosses, Gregory J. Golden, Rajee Ganesan, Holger Winkels, Marco Orecchioni, Sara McArdle, Zbigniew Mikulski, Yoav Altman, Jack Bui, Mitchell Kronenberg, Shu Chien, Jeffrey D. Esko, Victor Nizet, David Smalley, Johannes Roth, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2020) 218 (3): e20200551.
https://doi.org/10.1084/jem.20200551
Published: 04 December 2020
View article titled, Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
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Includes: Supplementary data
Journal Articles

Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis

Sara McArdle, Zbigniew Mikulski, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (7): 1117–1131.
https://doi.org/10.1084/jem.20151885
Published: 06 June 2016
View article titled, Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis
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Journal Articles

Monocyte phenotypes: When local education counts

Amado A. Quintar, Catherine C. Hedrick, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2015) 212 (4): 432.
https://doi.org/10.1084/jem.2124insight1
Published: 06 April 2015
View article titled, Monocyte phenotypes: When local education counts
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Journal Articles

Fueling the fire: Src family kinases drive inflammation

Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (10): 1922.
https://doi.org/10.1084/jem.21110insight1
Published: 22 September 2014
View article titled, Fueling the fire: Src family kinases drive inflammation
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Journal Articles

The PSGL-1–L-selectin signaling complex regulates neutrophil adhesion under flow

Anika Stadtmann, Giulia Germena, Helena Block, Mark Boras, Jan Rossaint, Prithu Sundd, Craig Lefort, Charles I. Fisher, Konrad Buscher, Bernadette Gelschefarth, Ana Urzainqui, Volker Gerke, Klaus Ley, Alexander Zarbock
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (11): 2171–2180.
https://doi.org/10.1084/jem.20130664
Published: 14 October 2013
View article titled, The PSGL-1–L-selectin signaling complex regulates neutrophil adhesion under flow
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Journal Articles

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

Alexander Zarbock, Clare L. Abram, Matthias Hundt, Amnon Altman, Clifford A. Lowell, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2008) 205 (10): 2339–2347.
https://doi.org/10.1084/jem.20072660
Published: 15 September 2008
View article titled, PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling
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Includes: Supplementary data
Journal Articles

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation

David Frommhold, Andreas Ludwig, M. Gabriele Bixel, Alexander Zarbock, Inna Babushkina, Melitta Weissinger, Sandra Cauwenberghs, Lesley G. Ellies, Jamey D. Marth, Annette G. Beck-Sickinger, Michael Sixt, Bärbel Lange-Sperandio, Alma Zernecke, Ernst Brandt, Christian Weber, Dietmar Vestweber, Klaus Ley, Markus Sperandio
Journal: Journal of Experimental Medicine
J Exp Med (2008) 205 (6): 1435–1446.
https://doi.org/10.1084/jem.20070846
Published: 02 June 2008
View article titled, Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation
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Includes: Supplementary data
Journal Articles

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent

Elena Galkina, Alexandra Kadl, John Sanders, Danielle Varughese, Ian J. Sarembock, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2006) 203 (5): 1273–1282.
https://doi.org/10.1084/jem.20052205
Published: 08 May 2006
View article titled, Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
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Includes: Supplementary data
Journal Articles

Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis

Jesús Rivera-Nieves, Tracy L. Burcin, Timothy S. Olson, Margaret A. Morris, Marcia McDuffie, Fabio Cominelli, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2006) 203 (4): 907–917.
https://doi.org/10.1084/jem.20052530
Published: 27 March 2006
View article titled, Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis
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Journal Articles

The primary defect in experimental ileitis originates from a nonhematopoietic source

Timothy S. Olson, Brian K. Reuter, Kevin G-E. Scott, Margaret A. Morris, Xiao-Ming Wang, Leslie N. Hancock, Tracy L. Burcin, Steven M. Cohn, Peter B. Ernst, Fabio Cominelli, Jonathan B. Meddings, Klaus Ley, Theresa T. Pizarro
Journal: Journal of Experimental Medicine
J Exp Med (2006) 203 (3): 541–552.
https://doi.org/10.1084/jem.20050407
Published: 27 February 2006
View article titled, The primary defect in experimental ileitis originates from a nonhematopoietic source
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Journal Articles

CXCR2- and E-Selectin–induced Neutrophil Arrest during Inflammation In Vivo

Michael L. Smith, Timothy S. Olson, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2004) 200 (7): 935–939.
https://doi.org/10.1084/jem.20040424
Published: 04 October 2004
View article titled, CXCR2- and E-Selectin–induced Neutrophil Arrest during Inflammation In Vivo
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Journal Articles

Sulfated Sugars for Rolling Lymphocytes

Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2003) 198 (9): 1285–1288.
https://doi.org/10.1084/jem.20031664
Published: 03 November 2003
View article titled, Sulfated Sugars for Rolling Lymphocytes
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Journal Articles

P-selectin Glycoprotein Ligand-1 Mediates L-Selectin–dependent Leukocyte Rolling in Venules

Markus Sperandio, Michael L. Smith, S. Bradley Forlow, Timothy S. Olson, Lijun Xia, Rodger P. McEver, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2003) 197 (10): 1355–1363.
https://doi.org/10.1084/jem.20021854
Published: 19 May 2003
View article titled, P-selectin Glycoprotein Ligand-1 Mediates L-Selectin–dependent Leukocyte Rolling in Venules
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Journal Articles

L-Selectin Shedding Regulates Leukocyte Recruitment

Ali Hafezi-Moghadam, Kennard L. Thomas, Alyson J. Prorock, Yuqing Huo, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (2001) 193 (7): 863–872.
https://doi.org/10.1084/jem.193.7.863
Published: 02 April 2001
View article titled, L-Selectin Shedding Regulates Leukocyte Recruitment
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Journal Articles

Relevance of L-selectin Shedding for Leukocyte Rolling In Vivo

Ali Hafezi-Moghadam, Klaus Ley
Journal: Journal of Experimental Medicine
J Exp Med (1999) 189 (6): 939–948.
https://doi.org/10.1084/jem.189.6.939
Published: 15 March 1999
View article titled, Relevance of L-selectin Shedding for Leukocyte Rolling In Vivo
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Journal Articles

Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice

Karin Scharffetter-Kochanek, Huifang Lu, Keith Norman, Nicole van Nood, Flor Munoz, Stephan Grabbe, Mark McArthur, Isabel Lorenzo, Sheldon Kaplan, Klaus Ley, C. Wayne Smith, Charles A. Montgomery, Susan Rich, Arthur L. Beaudet
Journal: Journal of Experimental Medicine
J Exp Med (1998) 188 (1): 119–131.
https://doi.org/10.1084/jem.188.1.119
Published: 01 July 1998
View article titled, Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice
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