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Volume 207, Issue 1

18 January 2010

Journal of Experimental Medicine Cover Image for Volume 207, Issue 1

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Cover Image

Cover Image

ON THE COVER
DeBusk et al. find that δ-catenin expression in vascular endothelial cells is boosted by inflammatory cytokines, and that δ-catenin deficiency impairs tumor angiogenesis in mice. The original immunofluorescence image (right) shows the endothelial marker CD31 (green) in tumor tissue sections from mice injected subcutaneously with Lewis lung carcinoma cells. Artwork (left) by Joshua Graver ([email protected]).
See page 77
Table of Contents
Editorial Board

ISSN 0022-1007

EISSN 1540-9538

In this Issue

In This Issue
People & Ideas
Brief Definitive Report
Article

In This Issue

How herpes launches lymphatics

Amy Maxmen

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Two-pronged attack on HIV

Amy Maxmen

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Dementia's inflammatory link

Amy Maxmen

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δ-Catenin aids angiogenesis

Amy Maxmen

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To dampen demyelination

Amy Maxmen

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People & Ideas

Fiona Powrie: Gut diplomacy

Amy Maxmen

Fiona Powrie seeks to regain the peace that's been disrupted in patients with inflammatory bowel disease.

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Brief Definitive Report

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1

Hongkang Xi,Kenneth J. Katschke, Jr.,Karim Y. Helmy,Paige A. Wark,Noelyn Kljavin,Hilary Clark,Jeffrey Eastham-Anderson,Theresa Shek,Merone Roose-Girma,Nico Ghilardi,Menno van Lookeren Campagne

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Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

Trung H.M. Pham,Peter Baluk,Ying Xu,Irina Grigorova,Alex J. Bankovich,Rajita Pappu,Shaun R. Coughlin,Donald M. McDonald,Susan R. Schwab,Jason G. Cyster

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Essential role of Mannose-binding lectin-associated serine protease-1 in activation of the complement factor D

Minoru Takahashi,Yumi Ishida,Daisuke Iwaki,Kazuko Kanno,Toshiyuki Suzuki,Yuichi Endo,Yoshimi Homma,Teizo Fujita

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The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells

Nicoletta Casartelli,Florence Guivel-Benhassine,Romain Bouziat,Samantha Brandler,Olivier Schwartz,Arnaud Moris

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CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription

Anju Bansal,Jonathan Carlson,Jiyu Yan,Olusimidele T. Akinsiku,Malinda Schaefer,Steffanie Sabbaj,Anne Bet,David N. Levy,Sonya Heath,Jianming Tang,Richard A. Kaslow,Bruce D. Walker,Thumbi Ndung’u,Philip J. Goulder,David Heckerman,Eric Hunter,Paul A. Goepfert

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Article

Viral adaptation to immune selection pressure by HLA class I–restricted CTL responses targeting epitopes in HIV frameshift sequences

Christoph T. Berger,Jonathan M. Carlson,Chanson J. Brumme,Kari L. Hartman,Zabrina L. Brumme,Leah M. Henry,Pamela C. Rosato,Alicja Piechocka-Trocha,Mark A. Brockman,P. Richard Harrigan,David Heckerman,Daniel E. Kaufmann,Christian Brander

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Heterozygous deficiency of δ-catenin impairs pathological angiogenesis

Laura M. DeBusk,Kimberly Boelte,Yongfen Min,P. Charles Lin

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Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

Sara I. Cunha,Evangelia Pardali,Midory Thorikay,Charlotte Anderberg,Lukas Hawinkels,Marie-José Goumans,Jasbir Seehra,Carl-Henrik Heldin,Peter ten Dijke,Kristian Pietras

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VEGF-A expression by HSV-1–infected cells drives corneal lymphangiogenesis

Todd R. Wuest,Daniel J.J. Carr

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Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

Fangfang Yin,Rebecca Banerjee,Bobby Thomas,Ping Zhou,Liping Qian,Ting Jia,Xiaojing Ma,Yao Ma,Costantino Iadecola,M. Flint Beal,Carl Nathan,Aihao Ding

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VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

Antoun El Chemaly,Yoshifumi Okochi,Mari Sasaki,Serge Arnaudeau,Yasushi Okamura,Nicolas Demaurex

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Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

Meng Wang,Cristina Rada,Michael S. Neuberger

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B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Danielle T. Avery,Elissa K. Deenick,Cindy S. Ma,Santi Suryani,Nicholas Simpson,Gary Y. Chew,Tyani D. Chan,Umamainthan Palendira,Jacinta Bustamante,Stéphanie Boisson-Dupuis,Sharon Choo,Karl E. Bleasel,Jane Peake,Cecile King,Martyn A. French,Dan Engelhard,Sami Al-Hajjar,Saleh Al-Muhsen,Klaus Magdorf,Joachim Roesler,Peter D. Arkwright,Pravin Hissaria,D. Sean Riminton,Melanie Wong,Robert Brink,David A. Fulcher,Jean-Laurent Casanova,Matthew C. Cook,Stuart G. Tangye

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Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

Bao Hoa Duong,Hua Tian,Takayuki Ota,Gladys Completo,Shoufa Han,José Luis Vela,Miyo Ota,Michael Kubitz,Nicolai Bovin,James C. Paulson,David Nemazee

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CD207⁺ CD103⁺ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

Sandrine Henri,Lionel Franz Poulin,Samira Tamoutounour,Laurence Ardouin,Martin Guilliams,Béatrice de Bovis,Elisabeth Devilard,Christophe Viret,Hiroaki Azukizawa,Adrien Kissenpfennig,Bernard Malissen

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The nonpolymorphic MHC Qa-1^b mediates CD8⁺ T cell surveillance of antigen-processing defects

Cláudia C. Oliveira,Peter A. van Veelen,Bianca Querido,Arnoud de Ru,Marjolein Sluijter,Sandra Laban,Jan W. Drijfhout,Sjoerd H. van der Burg,Rienk Offringa,Thorbald van Hall

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CD8⁺ T cell concentration determines their efficiency in killing cognate antigen–expressing syngeneic mammalian cells in vitro and in mouse tissues

Sadna Budhu,John D. Loike,Ashley Pandolfi,Soo Han,Geoffrey Catalano,Andrei Constantinescu,Raphael Clynes,Samuel C. Silverstein

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Generation of PLZF⁺ CD4⁺ T cells via MHC class II–dependent thymocyte–thymocyte interaction is a physiological process in humans

You Jeong Lee,Yoon Kyung Jeon,Byung Hyun Kang,Doo Hyun Chung,Chung-Gyu Park,Hee Young Shin,Kyeong Cheon Jung,Seong Hoe Park

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Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

Michelle L. Janas,Gabriele Varano,Kristjan Gudmundsson,Mamiko Noda,Takashi Nagasawa,Martin Turner

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