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Gender-biased vessel growth

Amy Maxmen
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Accelerated aging

Amy Maxmen
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Antibodies attack IL-17

Amy Maxmen
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Interferon crossfire

Amy Maxmen
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Cancers converge at 2-HG

Amy Maxmen
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People & Ideas

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Ron Germain: Towards a grand unified theory

Amy Maxmen

As data floods in, Germain works overtime to decipher which immunological information matters and how it can be applied to saving lives.

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Commentary

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Natural killer receptors: the burden of a name

Henrique Veiga-Fernandes,Dimitris Kioussis,Mark Coles
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Brief Definitive Report

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IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+ cell subsets from Id2-dependent precursors

Naoko Satoh-Takayama,Sarah Lesjean-Pottier,Paulo Vieira,Shinichiro Sawa,Gerard Eberl,Christian A.J. Vosshenrich,James P. Di Santo
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Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells

Natasha K. Crellin,Sara Trifari,Charles D. Kaplan,Tom Cupedo,Hergen Spits
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Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

Anne Puel,Rainer Döffinger,Angels Natividad,Maya Chrabieh,Gabriela Barcenas-Morales,Capucine Picard,Aurélie Cobat,Marie Ouachée-Chardin,Antoine Toulon,Jacinta Bustamante,Saleh Al-Muhsen,Mohammed Al-Owain,Peter D. Arkwright,Colm Costigan,Vivienne McConnell,Andrew J. Cant,Mario Abinun,Michel Polak,Pierre-François Bougnères,Dinakantha Kumararatne,László Marodi,Amit Nahum,Chaim Roifman,Stéphane Blanche,Alain Fischer,Christine Bodemer,Laurent Abel,Desa Lilic,Jean-Laurent Casanova
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Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

Kai Kisand,Anette S. Bøe Wolff,Katarina Trebušak Podkrajšek,Liina Tserel,Maire Link,Kalle V. Kisand,Elisabeth Ersvaer,Jaakko Perheentupa,Martina Moter Erichsen,Nina Bratanic,Antonella Meloni,Filomena Cetani,Roberto Perniola,Berrin Ergun-Longmire,Noel Maclaren,Kai J. E. Krohn,Mikuláš Pura,Berthold Schalke,Philipp Ströbel,Maria Isabel Leite,Tadej Battelino,Eystein S. Husebye,Pärt Peterson,Nick Willcox,Anthony Meager
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Phospholipase Cγ1 is essential for T cell development, activation, and tolerance

Guoping Fu,Yuhong Chen,Mei Yu,Andy Podd,James Schuman,Yinghong He,Lie Di,Maryam Yassai,Dipica Haribhai,Paula E. North,Jack Gorski,Calvin B. Williams,Demin Wang,Renren Wen
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Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10

Kindra M. Kelly-Scumpia,Philip O. Scumpia,Matthew J. Delano,Jason S. Weinstein,Alex G. Cuenca,James L. Wynn,Lyle L. Moldawer
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Induction of IFN-αβ enables Listeria monocytogenes to suppress macrophage activation by IFN-γ

Manira Rayamajhi,Jessica Humann,Kristi Penheiter,Karl Andreasen,Laurel L. Lenz
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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

Stefan Gross,Rob A. Cairns,Mark D. Minden,Edward M. Driggers,Mark A. Bittinger,Hyun Gyung Jang,Masato Sasaki,Shengfang Jin,David P. Schenkein,Shinsan M. Su,Lenny Dang,Valeria R. Fantin,Tak W. Mak
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A sex-specific role for androgens in angiogenesis

Daniel P. Sieveking,Patrick Lim,Renée W.Y. Chow,Louise L. Dunn,Shisan Bao,Kristine C.Y. McGrath,Alison K. Heather,David J. Handelsman,David S. Celermajer,Martin K.C. Ng
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IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

Michelle A. Linterman,Laura Beaton,Di Yu,Roybel R. Ramiscal,Monika Srivastava,Jennifer J. Hogan,Naresh K. Verma,Mark J. Smyth,Robert J. Rigby,Carola G. Vinuesa
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Article

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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

Dimitra Zotos,Jonathan M. Coquet,Yang Zhang,Amanda Light,Kathy D'Costa,Axel Kallies,Lynn M. Corcoran,Dale I. Godfrey,Kai-Michael Toellner,Mark J. Smyth,Stephen L. Nutt,David M. Tarlinton
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Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

York Kamenisch,Maria Fousteri,Jennifer Knoch,Anna-Katharina von Thaler,Birgit Fehrenbacher,Hiroki Kato,Thomas Becker,Martijn E.T. Dollé,Raoul Kuiper,Marc Majora,Martin Schaller,Gijsbertus T.J. van der Horst,Harry van Steeg,Martin Röcken,Doron Rapaport,Jean Krutmann,Leon H. Mullenders,Mark Berneburg
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Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

Esther Lutgens,Dirk Lievens,Linda Beckers,Erwin Wijnands,Oliver Soehnlein,Alma Zernecke,Tom Seijkens,David Engel,Jack Cleutjens,Anna M. Keller,Shalin H. Naik,Louis Boon,Hafid Ait Oufella,Ziad Mallat,Cory L. Ahonen,Randolph J. Noelle,Menno P. de Winther,Mat J. Daemen,Erik A. Biessen,Christian Weber
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Attracting AID to targets of somatic hypermutation

Atsushi Tanaka,Hong Ming Shen,Sarayu Ratnam,Prashant Kodgire,Ursula Storb
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Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Cristian Boboila,Catherine Yan,Duane R. Wesemann,Mila Jankovic,Jing H. Wang,John Manis,Andre Nussenzweig,Michel Nussenzweig,Frederick W. Alt
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Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

Clémentine Schilte,Thérèse Couderc,Fabrice Chretien,Marion Sourisseau,Nicolas Gangneux,Florence Guivel-Benhassine,Anton Kraxner,Jürg Tschopp,Stephen Higgs,Alain Michault,Fernando Arenzana-Seisdedos,Marco Colonna,Lucie Peduto,Olivier Schwartz,Marc Lecuit,Matthew L. Albert
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Correction

Heterozygous deficiency of δ-catenin impairs pathological angiogenesis

Laura M. DeBusk,Kimberly Boelte,Yongfen Min,P. Charles Lin
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Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

Bao Hoa Duong,Hua Tian,Takayuki Ota,Gladys Completo,Shoufa Han,José Luis Vela,Miyo Ota,Michael Kubitz,Nicolai Bovin,James C. Paulson,David Nemazee
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CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

Sandrine Henri,Lionel Franz Poulin,Samira Tamoutounour,Laurence Ardouin,Martin Guilliams,Béatrice de Bovis,Elisabeth Devilard,Christophe Viret,Hiroaki Azukizawa,Adrien Kissenpfennig,Bernard Malissen
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