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Volume 206, Issue 13

21 December 2009

Journal of Experimental Medicine Cover Image for Volume 206, Issue 13

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Cover Image

Cover Image

ON THE COVER
Dendritic cells (red) enter lymphatic vessels (blue) through pores and doors. Related article by Holger Pflicke and Michael Sixt.
See page 2925
Table of Contents
Editorial Board

ISSN 0022-1007

EISSN 1540-9538

In this Issue

In This Issue
People & Ideas
Commentary
Brief Definitive Report
Article
Correction

In This Issue

Crippled clock hinders healing

Amy Maxmen

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XP mutant power!

Amy Maxmen

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Regulating the regulators

Amy Maxmen

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Poking through lymphatic portals

Amy Maxmen

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Inflammation stops at Bop

Amy Maxmen

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People & Ideas

Gesundheit! Patrick Holt smothers allergies and asthma

Amy Maxmen

Drop the mop and play with Fido is Patrick Holt's recommendation for raising an allergy-free child. Although a tangled web of factors underlies allergies and asthma, Holt believes that preventing lifelong affliction could be simple.

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Commentary

Soothing signals: transplacental transmission of resistance to asthma and allergy

Patrick G. Holt,Deborah H. Strickland

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Mincle is a long sought receptor for mycobacterial cord factor

Isamu Matsunaga,D. Branch Moody

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Brief Definitive Report

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78

Melanie L. Conrad,Ruth Ferstl,René Teich,Stephanie Brand,Nicole Blümer,Ali Ö. Yildirim,Cecilia C. Patrascan,Anna Hanuszkiewicz,Shizuo Akira,Hermann Wagner,Otto Holst,Erika von Mutius,Petra I. Pfefferle,Carsten J. Kirschning,Holger Garn,Harald Renz

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Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

Eri Ishikawa,Tetsuaki Ishikawa,Yasu S. Morita,Kenji Toyonaga,Hisakata Yamada,Osamu Takeuchi,Taroh Kinoshita,Shizuo Akira,Yasunobu Yoshikai,Sho Yamasaki

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Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

Annemarieke E. Loot,Judith G. Schreiber,Beate Fisslthaler,Ingrid Fleming

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Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock

Julia V. Busik,Maria Tikhonenko,Ashay Bhatwadekar,Madalina Opreanu,Nafissa Yakubova,Sergio Caballero,Danny Player,Takahiko Nakagawa,Aqeela Afzal,Jennifer Kielczewski,Andrew Sochacki,Stephanie Hasty,Sergio Li Calzi,Sungjin Kim,Shane K. Duclas,Mark S. Segal,Dennis L. Guberski,Walter J. Esselman,Michael E. Boulton,Maria B. Grant

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Germinal center reutilization by newly activated B cells

Tanja A. Schwickert,Boris Alabyev,Tim Manser,Michel C. Nussenzweig

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Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase–dependent manner

Anje Cauwels,Emmanuel S. Buys,Robrecht Thoonen,Lisa Geary,Joris Delanghe,Sruti Shiva,Peter Brouckaert

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Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels

Holger Pflicke,Michael Sixt

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External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

Akiharu Kubo,Keisuke Nagao,Mariko Yokouchi,Hiroyuki Sasaki,Masayuki Amagai

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Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection

De'Broski R. Herbert,Jun-Qi Yang,Simon P. Hogan,Kathryn Groschwitz,Marat Khodoun,Ariel Munitz,Tatyana Orekov,Charles Perkins,Quan Wang,Frank Brombacher,Joseph F. Urban, Jr.,Marc E. Rothenberg,Fred D. Finkelman

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HLA-B*35-Px–mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses

Jinghe Huang,James J. Goedert,Eric J. Sundberg,Thai Duong Hong Cung,Patrick S. Burke,Maureen P. Martin,Liliana Preiss,Jeffrey Lifson,Mathias Lichterfeld,Mary Carrington,Xu G. Yu

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Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells

Stephen McCartney,William Vermi,Susan Gilfillan,Marina Cella,Theresa L. Murphy,Robert D. Schreiber,Kenneth M. Murphy,Marco Colonna

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Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Shintaro Kamizono,Gordon S. Duncan,Markus G. Seidel,Akira Morimoto,Koichi Hamada,Gerard Grosveld,Koichi Akashi,Evan F. Lind,Jillian P. Haight,Pamela S. Ohashi,A. Thomas Look,Tak W. Mak

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Article

GATA-3 is required for early T lineage progenitor development

Tomonori Hosoya,Takashi Kuroha,Takashi Moriguchi,Dustin Cummings,Ivan Maillard,Kim-Chew Lim,James Douglas Engel

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c-Rel is required for the development of thymic Foxp3⁺ CD4 regulatory T cells

Iwao Isomura,Stephanie Palmer,Raelene J. Grumont,Karen Bunting,Gerard Hoyne,Nancy Wilkinson,Ashish Banerjee,Anna Proietto,Raffi Gugasyan,Li Wu,Alice McNally,Raymond J. Steptoe,Ranjeny Thomas,M. Frances Shannon,Steve Gerondakis

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Loise M. Francisco,Victor H. Salinas,Keturah E. Brown,Vijay K. Vanguri,Gordon J. Freeman,Vijay K. Kuchroo,Arlene H. Sharpe

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Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients

Takahiro Ueda,Emmanuel Compe,Philippe Catez,Kenneth H. Kraemer,Jean-Marc Egly

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Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

Melba Muñoz,Markus M. Heimesaat,Kerstin Danker,Daniela Struck,Uwe Lohmann,Rita Plickert,Stefan Bereswill,André Fischer,Ildikò Rita Dunay,Kerstin Wolk,Christoph Loddenkemper,Hans-Willi Krell,Claude Libert,Leif R. Lund,Oliver Frey,Christoph Hölscher,Yoichiro Iwakura,Nico Ghilardi,Wenjun Ouyang,Thomas Kamradt,Robert Sabat,Oliver Liesenfeld

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Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Le^b-transgenic mice

Mary Ann Pohl,Judith Romero-Gallo,Janaki L. Guruge,Doris B. Tse,Jeffrey I. Gordon,Martin J. Blaser

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Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN

Kanna Nagamatsu,Asaomi Kuwae,Tadashi Konaka,Shigenori Nagai,Sei Yoshida,Masahiro Eguchi,Mineo Watanabe,Hitomi Mimuro,Shigeo Koyasu,Akio Abe

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Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

Laurent Chorro,Aurélien Sarde,Mei Li,Kevin J. Woollard,Pierre Chambon,Bernard Malissen,Adrien Kissenpfennig,Jean-Baptiste Barbaroux,Richard Groves,Frédéric Geissmann

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Intestinal CD103⁺, but not CX3CR1⁺, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

Olga Schulz,Elin Jaensson,Emma K. Persson,Xiaosun Liu,Tim Worbs,William W. Agace,Oliver Pabst

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The origin and development of nonlymphoid tissue CD103⁺ DCs

Florent Ginhoux,Kang Liu,Julie Helft,Milena Bogunovic,Melanie Greter,Daigo Hashimoto,Jeremy Price,Na Yin,Jonathan Bromberg,Sergio A. Lira,E. Richard Stanley,Michel Nussenzweig,Miriam Merad

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Bone marrow mesenchymal stem cells from infants with MLL-AF4⁺ acute leukemia harbor and express the MLL-AF4 fusion gene

Pablo Menendez,Purificación Catalina,René Rodríguez,Gustavo J. Melen,Clara Bueno,Mar Arriero,Félix García-Sánchez,Alvaro Lassaletta,Ramón García-Sanz,Javier García-Castro

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MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4^hi monocytes in obesity

Daniel J. Westcott,Jennifer B. DelProposto,Lynn M. Geletka,Tianyi Wang,Kanakadurga Singer,Alan R. Saltiel,Carey N. Lumeng

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Correction

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

Jyoti Das,Guangwen Ren,Liying Zhang,Arthur I. Roberts,Xin Zhao,Alfred L.M. Bothwell,Luc Van Kaer,Yufang Shi,Gobardhan Das

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The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

Luisa Klotz,Sven Burgdorf,Indra Dani,Kaoru Saijo,Juliane Flossdorf,Stephanie Hucke,Judith Alferink,Nina Novak,Marc Beyer,Gunter Mayer,Birgit Langhans,Thomas Klockgether,Ari Waisman,Gerard Eberl,Joachim Schultze,Michael Famulok,Waldemar Kolanus,Christopher Glass,Christian Kurts,Percy A. Knolle

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