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Issues

Volume 206, Issue 13
21 December 2009
Issue Cover
All Issues
ISSN 0022-1007
EISSN 1540-9538

In This Issue

Crippled clock hinders healing
Amy Maxmen
View Articletitled, Crippled clock hinders healing
XP mutant power!
Amy Maxmen
View Articletitled, XP mutant power!
Regulating the regulators
Amy Maxmen
View Articletitled, Regulating the regulators
Poking through lymphatic portals
Amy Maxmen
View Articletitled, Poking through lymphatic portals
Inflammation stops at Bop
Amy Maxmen
View Articletitled, Inflammation stops at Bop

People & Ideas

Gesundheit! Patrick Holt smothers allergies and asthma
Amy Maxmen

Drop the mop and play with Fido is Patrick Holt's recommendation for raising an allergy-free child. Although a tangled web of factors underlies allergies and asthma, Holt believes that preventing lifelong affliction could be simple.

View Articletitled, Gesundheit! Patrick Holt smothers allergies and asthma

Commentary

Soothing signals: transplacental transmission of resistance to asthma and allergy
Patrick G. Holt,Deborah H. Strickland
View Articletitled, Soothing signals: transplacental transmission of resistance to asthma and allergy
Mincle is a long sought receptor for mycobacterial cord factor
Isamu Matsunaga,D. Branch Moody
View Articletitled, Mincle is a long sought receptor for mycobacterial cord factor

Brief Definitive Report

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78
Melanie L. Conrad,Ruth Ferstl,René Teich,Stephanie Brand,Nicole Blümer,Ali Ö. Yildirim,Cecilia C. Patrascan,Anna Hanuszkiewicz,Shizuo Akira,Hermann Wagner,Otto Holst,Erika von Mutius,Petra I. Pfefferle,Carsten J. Kirschning,Holger Garn,Harald Renz
View Articletitled, Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe <em>Acinetobacter lwoffii</em> F78
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
Eri Ishikawa,Tetsuaki Ishikawa,Yasu S. Morita,Kenji Toyonaga,Hisakata Yamada,Osamu Takeuchi,Taroh Kinoshita,Shizuo Akira,Yasunobu Yoshikai,Sho Yamasaki
View Articletitled, Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase
Annemarieke E. Loot,Judith G. Schreiber,Beate Fisslthaler,Ingrid Fleming
View Articletitled, Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock
Julia V. Busik,Maria Tikhonenko,Ashay Bhatwadekar,Madalina Opreanu,Nafissa Yakubova,Sergio Caballero,Danny Player,Takahiko Nakagawa,Aqeela Afzal,Jennifer Kielczewski,Andrew Sochacki,Stephanie Hasty,Sergio Li Calzi,Sungjin Kim,Shane K. Duclas,Mark S. Segal,Dennis L. Guberski,Walter J. Esselman,Michael E. Boulton,Maria B. Grant
View Articletitled, Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock
Germinal center reutilization by newly activated B cells
Tanja A. Schwickert,Boris Alabyev,Tim Manser,Michel C. Nussenzweig
View Articletitled, Germinal center reutilization by newly activated B cells
Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase–dependent manner
Anje Cauwels,Emmanuel S. Buys,Robrecht Thoonen,Lisa Geary,Joris Delanghe,Sruti Shiva,Peter Brouckaert
View Articletitled, Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase–dependent manner
Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
Holger Pflicke,Michael Sixt
View Articletitled, Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
Akiharu Kubo,Keisuke Nagao,Mariko Yokouchi,Hiroyuki Sasaki,Masayuki Amagai
View Articletitled, External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection
De'Broski R. Herbert,Jun-Qi Yang,Simon P. Hogan,Kathryn Groschwitz,Marat Khodoun,Ariel Munitz,Tatyana Orekov,Charles Perkins,Quan Wang,Frank Brombacher,Joseph F. Urban, Jr.,Marc E. Rothenberg,Fred D. Finkelman
View Articletitled, Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection
HLA-B*35-Px–mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses
Jinghe Huang,James J. Goedert,Eric J. Sundberg,Thai Duong Hong Cung,Patrick S. Burke,Maureen P. Martin,Liliana Preiss,Jeffrey Lifson,Mathias Lichterfeld,Mary Carrington,Xu G. Yu
View Articletitled, HLA-B*35-Px–mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses
Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells
Stephen McCartney,William Vermi,Susan Gilfillan,Marina Cella,Theresa L. Murphy,Robert D. Schreiber,Kenneth M. Murphy,Marco Colonna
View Articletitled, Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells
Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo
Shintaro Kamizono,Gordon S. Duncan,Markus G. Seidel,Akira Morimoto,Koichi Hamada,Gerard Grosveld,Koichi Akashi,Evan F. Lind,Jillian P. Haight,Pamela S. Ohashi,A. Thomas Look,Tak W. Mak
View Articletitled, Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Article

GATA-3 is required for early T lineage progenitor development
Tomonori Hosoya,Takashi Kuroha,Takashi Moriguchi,Dustin Cummings,Ivan Maillard,Kim-Chew Lim,James Douglas Engel
View Articletitled, GATA-3 is required for early T lineage progenitor development
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
Iwao Isomura,Stephanie Palmer,Raelene J. Grumont,Karen Bunting,Gerard Hoyne,Nancy Wilkinson,Ashish Banerjee,Anna Proietto,Raffi Gugasyan,Li Wu,Alice McNally,Raymond J. Steptoe,Ranjeny Thomas,M. Frances Shannon,Steve Gerondakis
View Articletitled, c-Rel is required for the development of thymic Foxp3<sup>+</sup> CD4 regulatory T cells
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
Loise M. Francisco,Victor H. Salinas,Keturah E. Brown,Vijay K. Vanguri,Gordon J. Freeman,Vijay K. Kuchroo,Arlene H. Sharpe
View Articletitled, PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients
Takahiro Ueda,Emmanuel Compe,Philippe Catez,Kenneth H. Kraemer,Jean-Marc Egly
View Articletitled, Both <em>XPD</em> alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients
Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
Melba Muñoz,Markus M. Heimesaat,Kerstin Danker,Daniela Struck,Uwe Lohmann,Rita Plickert,Stefan Bereswill,André Fischer,Ildikò Rita Dunay,Kerstin Wolk,Christoph Loddenkemper,Hans-Willi Krell,Claude Libert,Leif R. Lund,Oliver Frey,Christoph Hölscher,Yoichiro Iwakura,Nico Ghilardi,Wenjun Ouyang,Thomas Kamradt,Robert Sabat,Oliver Liesenfeld
View Articletitled, Interleukin (IL)-23 mediates <em>Toxoplasma gondii</em>–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice
Mary Ann Pohl,Judith Romero-Gallo,Janaki L. Guruge,Doris B. Tse,Jeffrey I. Gordon,Martin J. Blaser
View Articletitled, Host-dependent Lewis (Le) antigen expression in <em>Helicobacter pylori</em> cells recovered from Le<sup>b</sup>-transgenic mice
Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN
Kanna Nagamatsu,Asaomi Kuwae,Tadashi Konaka,Shigenori Nagai,Sei Yoshida,Masahiro Eguchi,Mineo Watanabe,Hitomi Mimuro,Shigeo Koyasu,Akio Abe
View Articletitled, <em>Bordetella</em> evades the host immune system by inducing IL-10 through a type III effector, BopN
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
Laurent Chorro,Aurélien Sarde,Mei Li,Kevin J. Woollard,Pierre Chambon,Bernard Malissen,Adrien Kissenpfennig,Jean-Baptiste Barbaroux,Richard Groves,Frédéric Geissmann
View Articletitled, Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
Olga Schulz,Elin Jaensson,Emma K. Persson,Xiaosun Liu,Tim Worbs,William W. Agace,Oliver Pabst
View Articletitled, Intestinal CD103<sup>+</sup>, but not CX3CR1<sup>+</sup>, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
The origin and development of nonlymphoid tissue CD103+ DCs
Florent Ginhoux,Kang Liu,Julie Helft,Milena Bogunovic,Melanie Greter,Daigo Hashimoto,Jeremy Price,Na Yin,Jonathan Bromberg,Sergio A. Lira,E. Richard Stanley,Michel Nussenzweig,Miriam Merad
View Articletitled, The origin and development of nonlymphoid tissue CD103<sup>+</sup> DCs
Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene
Pablo Menendez,Purificación Catalina,René Rodríguez,Gustavo J. Melen,Clara Bueno,Mar Arriero,Félix García-Sánchez,Alvaro Lassaletta,Ramón García-Sanz,Javier García-Castro
View Articletitled, Bone marrow mesenchymal stem cells from infants with MLL-AF4<sup>+</sup> acute leukemia harbor and express the MLL-AF4 fusion gene
MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity
Daniel J. Westcott,Jennifer B. DelProposto,Lynn M. Geletka,Tianyi Wang,Kanakadurga Singer,Alan R. Saltiel,Carey N. Lumeng
View Articletitled, MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4<sup>hi</sup> monocytes in obesity

Correction

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
Jyoti Das,Guangwen Ren,Liying Zhang,Arthur I. Roberts,Xin Zhao,Alfred L.M. Bothwell,Luc Van Kaer,Yufang Shi,Gobardhan Das
View Articletitled, Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation
The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity
Luisa Klotz,Sven Burgdorf,Indra Dani,Kaoru Saijo,Juliane Flossdorf,Stephanie Hucke,Judith Alferink,Nina Novak,Marc Beyer,Gunter Mayer,Birgit Langhans,Thomas Klockgether,Ari Waisman,Gerard Eberl,Joachim Schultze,Michael Famulok,Waldemar Kolanus,Christopher Glass,Christian Kurts,Percy A. Knolle
View Articletitled, The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

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