Uncovering the dosage-dependent roles of Arid1a in gastric tumorigenesis for combinatorial drug therapy
Loe et al. demonstrate dosage-dependent roles of Arid1a, whereby the loss of its single copy promotes tumor progression, but tumor cells lacking both copies exhibit a survival disadvantage. This finding leads to a novel combined targeting approach for the effective inhibition of Arid1a heterozygous tumor cell growth.
Squamous cell carcinoma subverts adjacent histologically normal epithelium to promote lateral invasion
Tumor recurrence is frequent in oral squamous cell carcinomas and leads to poor survival. This study is the first demonstration of the pivotal role of adjacent histologically normal epithelium in lateral invasion, with vital implications for understanding tumor recurrence and field cancerization.
Abdominal aortic aneurysms (AAAs) are a life-threatening disease characterized by macrophage infiltration contributing to pathological vascular remodeling. Herein, we demonstrate that the histone demethylase JMJD3 is a critical regulator of inflammation during AAA development and cell-specific inhibition reduces AAA progression.
Blood leukocytes recapitulate diabetogenic peptide–MHC-II complexes displayed in the pancreatic islets
Assessing the self-antigens causing type 1 diabetes remains challenging. This study shows that blood leukocytes contain immunogenic peptides with compatible sequences to those presented in the pancreatic islets, representing a feasible strategy for probing a target autoimmune tissue.
An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo
The study demonstrates that the S198P mutation in APP promotes accelerated folding and egress to late compartments leading to enhanced Aβ production and deposition in vivo.
Brief Definitive Report
Vijay et al. identify that phosphatidylserine exposed on dead or dying red blood cell membranes signals via Axl on B cells to promote polyclonal B cell activation and plasmablast differentiation during infections that are associated with hemolysis.