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Emil R. Unanue
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Journal Articles

Blood leukocytes recapitulate diabetogenic peptide–MHC-II complexes displayed in the pancreatic islets

Anthony N. Vomund, Cheryl F. Lichti, Orion J. Peterson, Ana Maria Arbelaez, Xiaoxiao Wan, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2021) 218 (6): e20202530.
https://doi.org/10.1084/jem.20202530
Published: 06 April 2021
View article titled, Blood leukocytes recapitulate diabetogenic peptide–MHC-II complexes displayed in the pancreatic islets
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Includes: Supplementary data
Journal Articles

Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes

Pavel N. Zakharov, Hao Hu, Xiaoxiao Wan, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2020) 217 (6): e20192362.
https://doi.org/10.1084/jem.20192362
Published: 06 April 2020
View article titled, Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes
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Includes: Supplementary data
Journal Articles

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

Stephen T. Ferris, Pavel N. Zakharov, Xiaoxiao Wan, Boris Calderon, Maxim N. Artyomov, Emil R. Unanue, Javier A. Carrero
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (8): 2369–2385.
https://doi.org/10.1084/jem.20170074
Published: 19 June 2017
View article titled, The islet-resident macrophage is in an inflammatory state and senses microbial products in blood
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Includes: Supplementary data
Journal Articles

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites

Xiaoxiao Wan, James W. Thomas, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (6): 967–978.
https://doi.org/10.1084/jem.20151869
Published: 02 May 2016
View article titled, Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites
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Journal Articles

The pancreas anatomy conditions the origin and properties of resident macrophages

Boris Calderon, Javier A. Carrero, Stephen T. Ferris, Dorothy K. Sojka, Lindsay Moore, Slava Epelman, Kenneth M. Murphy, Wayne M. Yokoyama, Gwendalyn J. Randolph, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2015) 212 (10): 1497–1512.
https://doi.org/10.1084/jem.20150496
Published: 07 September 2015
View article titled, The pancreas anatomy conditions the origin and properties of resident macrophages
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Includes: Supplementary data
Journal Articles

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

Sarah L. Rowland, Jeffrey M. Riggs, Susan Gilfillan, Mattia Bugatti, William Vermi, Roland Kolbeck, Emil R. Unanue, Miguel A. Sanjuan, Marco Colonna
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (10): 1977–1991.
https://doi.org/10.1084/jem.20132620
Published: 01 September 2014
View article titled, Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model
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Journal Articles

Pathogenic CD4+ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

James F. Mohan, Boris Calderon, Mark S. Anderson, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (11): 2403–2414.
https://doi.org/10.1084/jem.20130582
Published: 14 October 2013
View article titled, Pathogenic CD4<sup>+</sup> T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes
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Journal Articles

Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process

Chiao-Wen Yang, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (2): 375–387.
https://doi.org/10.1084/jem.20122183
Published: 21 January 2013
View article titled, Neutrophils control the magnitude and spread of the immune response in a thromboxane A<sub>2</sub>-mediated process
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Journal Articles

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

Jamie M. Ireland, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2011) 208 (13): 2625–2632.
https://doi.org/10.1084/jem.20110640
Published: 12 December 2011
View article titled, Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells
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Includes: Supplementary data
Journal Articles

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

James F. Mohan, Shirley J. Petzold, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2011) 208 (12): 2375–2383.
https://doi.org/10.1084/jem.20111502
Published: 07 November 2011
View article titled, Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion
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Includes: Supplementary data
Journal Articles

Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes

Javier A. Carrero, Boris Calderon, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2006) 203 (4): 933–940.
https://doi.org/10.1084/jem.20060045
Published: 20 March 2006
View article titled, Lymphocytes are detrimental during the early innate immune response against <em>Listeria monocytogenes </em>
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Journal Articles

Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to Listeria Infection

Javier A. Carrero, Boris Calderon, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2004) 200 (4): 535–540.
https://doi.org/10.1084/jem.20040769
Published: 09 August 2004
View article titled, Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to <em>Listeria</em> Infection
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Journal Articles

Interferon-producing Cells Fail to Induce Proliferation of Naive T Cells but Can Promote Expansion and T Helper 1 Differentiation of Antigen-experienced Unpolarized T Cells

Anne Krug, Ravi Veeraswamy, Andrew Pekosz, Osami Kanagawa, Emil R. Unanue, Marco Colonna, Marina Cella
Journal: Journal of Experimental Medicine
J Exp Med (2003) 197 (7): 899–906.
https://doi.org/10.1084/jem.20021091
Published: 31 March 2003
View article titled, Interferon-producing Cells Fail to Induce Proliferation of Naive T Cells but Can Promote Expansion and T Helper 1 Differentiation of Antigen-experienced Unpolarized T Cells
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Journal Articles

Deamidation of Asparagine in a Major Histocompatibility Complex–Bound Peptide Affects T Cell Recognition but Does Not Explain Type B Reactivity

Thomas P. Cirrito, Zheng Pu, M. Brian Deck, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (2001) 194 (8): 1165–1170.
https://doi.org/10.1084/jem.194.8.1165
Published: 15 October 2001
View article titled, Deamidation of Asparagine in a Major Histocompatibility Complex–Bound Peptide Affects T Cell Recognition but Does Not Explain Type B Reactivity
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Journal Articles

LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : V. Capping, Cell Movement, and Microtubular Function in Normal and Lectin-Treated Lymphocytes

Emil R. Unanue, Morris J. Karnovsky
Journal: Journal of Experimental Medicine
J Exp Med (1974) 140 (5): 1207–1220.
https://doi.org/10.1084/jem.140.5.1207
Published: 01 November 1974
View article titled, LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : <subtitle>V. Capping, Cell Movement, and Microtubular Function in Normal and Lectin-Treated Lymphocytes </subtitle>
Open the PDF for LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : <subtitle>V. Capping, Cell Movement, and Microtubular Function in Normal and Lectin-Treated Lymphocytes </subtitle> in another window
Journal Articles

EVENTS AFTER THE BINDING OF ANTIGEN TO LYMPHOCYTES : REMOVAL AND REGENERATION OF THE ANTIGEN RECEPTOR

Kenneth A. Ault, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (1974) 139 (5): 1110–1124.
https://doi.org/10.1084/jem.139.5.1110
Published: 01 May 1974
View article titled, EVENTS AFTER THE BINDING OF ANTIGEN TO LYMPHOCYTES : <subtitle>R<sc>EMOVAL AND</sc> R<sc>EGENERATION OF THE</sc> A<sc>NTIGEN</sc> R<sc>ECEPTOR </sc></subtitle>
Open the PDF for EVENTS AFTER THE BINDING OF ANTIGEN TO LYMPHOCYTES : <subtitle>R<sc>EMOVAL AND</sc> R<sc>EGENERATION OF THE</sc> A<sc>NTIGEN</sc> R<sc>ECEPTOR </sc></subtitle> in another window
Journal Articles

LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE SURFACE MACROMOLECULES : IV. STIMULATION OF CELL MOTILITY BY ANTI-IG AND LACK OF RELATIONSHIP TO CAPPING

Emil R. Unanue, Kenneth A. Ault, Morris J. Karnovsky
Journal: Journal of Experimental Medicine
J Exp Med (1974) 139 (2): 295–312.
https://doi.org/10.1084/jem.139.2.295
Published: 01 February 1974
View article titled, LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE SURFACE MACROMOLECULES : <subtitle>IV. S<sc>TIMULATION OF</sc> C<sc>ELL</sc> M<sc>OTILITY BY</sc> A<sc>NTI</sc>-I<sc>G AND</sc> L<sc>ACK OF</sc> R<sc>ELATIONSHIP TO</sc> C<sc>APPING </sc></subtitle>
Open the PDF for LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE SURFACE MACROMOLECULES : <subtitle>IV. S<sc>TIMULATION OF</sc> C<sc>ELL</sc> M<sc>OTILITY BY</sc> A<sc>NTI</sc>-I<sc>G AND</sc> L<sc>ACK OF</sc> R<sc>ELATIONSHIP TO</sc> C<sc>APPING </sc></subtitle> in another window
Journal Articles

CRITICAL ROLE OF DETERMINANT PRESENTATION IN THE INDUCTION OF SPECIFIC RESPONSES IN IMMUNO-COMPETENT LYMPHOCYTES

David H. Katz, Emil R. Unanue
Journal: Journal of Experimental Medicine
J Exp Med (1973) 137 (4): 967–990.
https://doi.org/10.1084/jem.137.4.967
Published: 01 April 1973
View article titled, CRITICAL ROLE OF DETERMINANT PRESENTATION IN THE INDUCTION OF SPECIFIC RESPONSES IN IMMUNO-COMPETENT LYMPHOCYTES
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Journal Articles

LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : III. RELATIONSHIP BETWEEN THE FORMATION AND FATE OF ANTI-IG-SURFACE IG COMPLEXES AND CELL METABOLISM

Emil R. Unanue, Morris J. Karnovsky, Howard D. Engers
Journal: Journal of Experimental Medicine
J Exp Med (1973) 137 (3): 675–689.
https://doi.org/10.1084/jem.137.3.675
Published: 01 March 1973
View article titled, LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : <subtitle>III. R<sc>ELATIONSHIP</sc> B<sc>ETWEEN THE</sc> F<sc>ORMATION AND</sc> F<sc>ATE OF</sc> A<sc>NTI</sc>-I<sc>G</sc>-S<sc>URFACE</sc> I<sc>G</sc> C<sc>OMPLEXES AND</sc> C<sc>ELL</sc> M<sc>ETABOLISM </sc></subtitle>
Open the PDF for LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : <subtitle>III. R<sc>ELATIONSHIP</sc> B<sc>ETWEEN THE</sc> F<sc>ORMATION AND</sc> F<sc>ATE OF</sc> A<sc>NTI</sc>-I<sc>G</sc>-S<sc>URFACE</sc> I<sc>G</sc> C<sc>OMPLEXES AND</sc> C<sc>ELL</sc> M<sc>ETABOLISM </sc></subtitle> in another window
Journal Articles

LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : I. ANALYSIS BY IMMUNOFLUORESCENCE AND ULTRASTRUCTURAL RADIOAUTOGRAPHY

Emil R. Unanue, William D. Perkins, Morris J. Karnovsky
Journal: Journal of Experimental Medicine
J Exp Med (1972) 136 (4): 885–906.
https://doi.org/10.1084/jem.136.4.885
Published: 01 October 1972
View article titled, LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : <subtitle>I. A<sc>NALYSIS BY</sc> I<sc>MMUNOFLUORESCENCE AND</sc> U<sc>LTRASTRUCTURAL</sc> R<sc>ADIOAUTOGRAPHY </sc></subtitle>
Open the PDF for LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES : <subtitle>I. A<sc>NALYSIS BY</sc> I<sc>MMUNOFLUORESCENCE AND</sc> U<sc>LTRASTRUCTURAL</sc> R<sc>ADIOAUTOGRAPHY </sc></subtitle> in another window