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Journal Articles

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

In Special Collection:

JEM Immunology Collection 2024 , Immunometabolism 2024 , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , Immunology Update Winter 2025

Danira Toral-Rios, Justin M. Long, Jason D. Ulrich, Jinsheng Yu, Michael R. Strickland, Xianlin Han, David M. Holtzman, Anil G. Cashikar, Steven M. Paul

J Exp Med (2024) 221 (4): e20232000.

https://doi.org/10.1084/jem.20232000

Published: 01 March 2024

View article titled, Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

Includes: Supplementary data

Journal Articles

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

In Special Collection:

Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , 2024: The Year in Experimental Medicine

Mika P. Cadiz, Katelin A. Gibson, Kennedi T. Todd, David G. Nascari, Nashali Massa, Meredith T. Lilley, Kimberly C. Olney, Md Mamun Al-Amin, Hong Jiang, David M. Holtzman, John D. Fryer

J Exp Med (2024) 221 (2): e20231363.

https://doi.org/10.1084/jem.20231363

Published: 16 January 2024

View article titled, Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

Includes: Supplementary data

Journal Articles

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

In Special Collection:

Neuroscience Collection 2023 , Neuroimmunology and Neurodegeneration 2023

Nimansha Jain, Caroline A. Lewis, Jason D. Ulrich, David M. Holtzman

J Exp Med (2022) 220 (1): e20220654.

https://doi.org/10.1084/jem.20220654

Published: 11 October 2022

View article titled, Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

Includes: Supplementary data

Journal Articles

Activated microglia mitigate Aβ-associated tau seeding and spreading

In Special Collection:

2021: The Year in Experimental Medicine , Neuroscience Collection 2021

Maud Gratuze, Yun Chen, Samira Parhizkar, Nimansha Jain, Michael R. Strickland, Javier Remolina Serrano, Marco Colonna, Jason D. Ulrich, David M. Holtzman

J Exp Med (2021) 218 (8): e20210542.

https://doi.org/10.1084/jem.20210542

Published: 08 June 2021

View article titled, Activated microglia mitigate Aβ-associated tau seeding and spreading

Journal Articles

Immigration in science

Jean-Laurent Casanova, David M. Holtzman, Susan M. Kaech, Lewis L. Lanier, Carl F. Nathan, Alexander Y. Rudensky, David Tuveson, Jedd D. Wolchok

J Exp Med (2020) 217 (11): e20202055.

https://doi.org/10.1084/jem.20202055

Published: 15 October 2020

View article titled, Immigration in science

Journal Articles

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

Yang Shi, Melissa Manis, Justin Long, Kairuo Wang, Patrick M. Sullivan, Javier Remolina Serrano, Rosa Hoyle, David M. Holtzman

J Exp Med (2019) 216 (11): 2546–2561.

https://doi.org/10.1084/jem.20190980

Published: 10 October 2019

View article titled, Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

Includes: Supplementary data

Journal Articles

Dual therapy for Aβ amyloidosis in AD: A successful one-two combo

Tirth K. Patel, David M. Holtzman

J Exp Med (2018) 215 (5): 1267–1268.

https://doi.org/10.1084/jem.20180494

Published: 23 April 2018

View article titled, Dual therapy for Aβ amyloidosis in AD: A successful one-two combo

Journal Articles

ApoE facilitates the microglial response to amyloid plaque pathology

In Special Collection:

Advances in Neurodegenerative Disease Research and Therapy , Neuroscience 2018

Jason D. Ulrich, Tyler K. Ulland, Thomas E. Mahan, Sofie Nyström, K. Peter Nilsson, Wilbur M. Song, Yingyue Zhou, Mariska Reinartz, Seulah Choi, Hong Jiang, Floy R. Stewart, Elise Anderson, Yaming Wang, Marco Colonna, David M. Holtzman

J Exp Med (2018) 215 (4): 1047–1058.

https://doi.org/10.1084/jem.20171265

Published: 26 February 2018

View article titled, ApoE facilitates the microglial response to amyloid plaque pathology

Includes: Supplementary data

Journal Articles

Regulation of amyloid-β dynamics and pathology by the circadian clock

In Special Collection:

Advances in Neurodegenerative Disease Research and Therapy , Neuroscience 2018

Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A. FitzGerald, David M. Holtzman, Erik S. Musiek

J Exp Med (2018) 215 (4): 1059–1068.

https://doi.org/10.1084/jem.20172347

Published: 30 January 2018

View article titled, Regulation of amyloid-β dynamics and pathology by the circadian clock

Includes: Supplementary data

Journal Articles

Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

Christina Ising, Gilbert Gallardo, Cheryl E.G. Leyns, Connie H. Wong, Hong Jiang, Floy Stewart, Lauren J. Koscal, Joseph Roh, Grace O. Robinson, Javier Remolina Serrano, David M. Holtzman

J Exp Med (2017) 214 (7): 2163.

https://doi.org/10.1084/jem.2016212505192017c

Published: 23 May 2017

View article titled, Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

Journal Articles

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

Christina Ising, Gilbert Gallardo, Cheryl E.G. Leyns, Connie H. Wong, Hong Jiang, Floy Stewart, Lauren J. Koscal, Joseph Roh, Grace O. Robinson, Javier Remolina Serrano, David M. Holtzman

J Exp Med (2017) 214 (5): 1227–1238.

https://doi.org/10.1084/jem.20162125

Published: 17 April 2017

View article titled, AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

Includes: Supplementary data

Journal Articles

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

In Special Collection:

Bioenergetics and Metabolic Diseases

Molly Stanley, Shannon L. Macauley, David M. Holtzman

J Exp Med (2016) 213 (8): 1375–1385.

https://doi.org/10.1084/jem.20160493

Published: 18 July 2016

View article titled, Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

Journal Articles

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Yaming Wang, Tyler K. Ulland, Jason D. Ulrich, Wilbur Song, John A. Tzaferis, Justin T. Hole, Peng Yuan, Thomas E. Mahan, Yang Shi, Susan Gilfillan, Marina Cella, Jaime Grutzendler, Ronald B. DeMattos, John R. Cirrito, David M. Holtzman, Marco Colonna

J Exp Med (2016) 213 (5): 667–675.

https://doi.org/10.1084/jem.20151948

Published: 18 April 2016

View article titled, TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Journal Articles

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis de Lecea, David M. Holtzman

J Exp Med (2014) 212 (1): 121.

https://doi.org/10.1084/jem.2014178812122014c

Published: 22 December 2014

View article titled, Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Journal Articles

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis de Lecea, David M. Holtzman

J Exp Med (2014) 211 (13): 2487–2496.

https://doi.org/10.1084/jem.20141788

Published: 24 November 2014

View article titled, Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Journal Articles

B-RAF unlocks axon regeneration

Valeria Cavalli, David M. Holtzman

J Exp Med (2014) 211 (5): 746.

https://doi.org/10.1084/jem.2115insight3

Published: 05 May 2014

View article titled, B-RAF unlocks axon regeneration

Journal Articles

Neuronal activity regulates extracellular tau in vivo

Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva-Maria Mandelkow, David M. Holtzman

J Exp Med (2014) 211 (3): 387–393.

https://doi.org/10.1084/jem.20131685

Published: 17 February 2014

View article titled, Neuronal activity regulates extracellular tau in vivo

Journal Articles

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

Jungsu Kim, Adam E.M. Eltorai, Hong Jiang, Fan Liao, Philip B. Verghese, Jaekwang Kim, Floy R. Stewart, Jacob M. Basak, David M. Holtzman

J Exp Med (2012) 209 (12): 2149–2156.

https://doi.org/10.1084/jem.20121274

Published: 05 November 2012

View article titled, Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

NARROW

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading

Activated microglia mitigate Aβ-associated tau seeding and spreading

Immigration in science

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

Dual therapy for Aβ amyloidosis in AD: A successful one-two combo

ApoE facilitates the microglial response to amyloid plaque pathology

Regulation of amyloid-β dynamics and pathology by the circadian clock

Correction: AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

B-RAF unlocks axon regeneration

Neuronal activity regulates extracellular tau in vivo

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

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