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John R. Cirrito
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Journal Articles

Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice

In Special Collection:
Advances in Neurodegenerative Disease Research and Therapy , Neuroscience 2018
Angie C.A. Chiang, Stephanie W. Fowler, Ricky R. Savjani, Susan G. Hilsenbeck, Clare E. Wallace, John R. Cirrito, Pritam Das, Joanna L. Jankowsky
Journal: Journal of Experimental Medicine
J Exp Med (2018) 215 (5): 1349–1364.
https://doi.org/10.1084/jem.20171484
Published: 06 April 2018
View article titled, Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice
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Includes: Supplementary data
Journal Articles

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

Eva Czirr, Nicholas A. Castello, Kira I. Mosher, Joseph M. Castellano, Izumi V. Hinkson, Kurt M. Lucin, Bernat Baeza-Raja, Jae Kyu Ryu, Lulin Li, Sasha N. Farina, Nadia P. Belichenko, Frank M. Longo, Katerina Akassoglou, Markus Britschgi, John R. Cirrito, Tony Wyss-Coray
Journal: Journal of Experimental Medicine
J Exp Med (2017) 214 (4): 1081–1092.
https://doi.org/10.1084/jem.20162011
Published: 15 March 2017
View article titled, Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity
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Includes: Supplementary data
Journal Articles

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Yaming Wang, Tyler K. Ulland, Jason D. Ulrich, Wilbur Song, John A. Tzaferis, Justin T. Hole, Peng Yuan, Thomas E. Mahan, Yang Shi, Susan Gilfillan, Marina Cella, Jaime Grutzendler, Ronald B. DeMattos, John R. Cirrito, David M. Holtzman, Marco Colonna
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (5): 667–675.
https://doi.org/10.1084/jem.20151948
Published: 18 April 2016
View article titled, TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
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Journal Articles

Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model

Carla M. Yuede, Hyo Lee, Jessica L. Restivo, Todd A. Davis, Jane C. Hettinger, Clare E. Wallace, Katherine L. Young, Margaret R. Hayne, Guojun Bu, Chen-zhong Li, John R. Cirrito
Journal: Journal of Experimental Medicine
J Exp Med (2016) 213 (5): 677–685.
https://doi.org/10.1084/jem.20151428
Published: 11 April 2016
View article titled, Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model
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Journal Articles

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis de Lecea, David M. Holtzman
Journal: Journal of Experimental Medicine
J Exp Med (2014) 212 (1): 121.
https://doi.org/10.1084/jem.2014178812122014c
Published: 22 December 2014
View article titled, Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease
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Journal Articles

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis de Lecea, David M. Holtzman
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (13): 2487–2496.
https://doi.org/10.1084/jem.20141788
Published: 24 November 2014
View article titled, Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease
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Journal Articles

Neuronal activity regulates extracellular tau in vivo

Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva-Maria Mandelkow, David M. Holtzman
Journal: Journal of Experimental Medicine
J Exp Med (2014) 211 (3): 387–393.
https://doi.org/10.1084/jem.20131685
Published: 17 February 2014
View article titled, Neuronal activity regulates extracellular tau in vivo
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