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5 June 2023
A PI3K-calcium-Nox axis primes leukocyte Nrf2 to boost immune resilience and limit collateral damage
Macrophages activate the cytoprotective factor Nrf2 upon phagocytic ROS production via PI3K-calcium-Nox signaling during immune surveillance. This protective response is crucial to sustain vital immune functions and limit macrophage acquisition of senescence-like features. Macrophage Nrf2 also acts non-autonomously to limit bystander damage to adjacent healthy tissues.
A general method for quantitative fractionation of mammalian cells
Yael Udi,Wenzhu Zhang,Milana E. Stein,Inna Ricardo-Lax,Hilda A. Pasolli,Brian T. Chait,Michael P. Rout
Udi et al. present a new method for quantitative subcellular fractionation of a wide range of mammalian cells while maintaining nuclear integrity. This method provides a fast and reliable means to perform mass spectrometry and DeDuvian enrichment analyses for the different cellular compartments.
EvolutionThe evolution of the cytoskeleton