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Macrophages activate the cytoprotective factor Nrf2 upon phagocytic ROS production via PI3K-calcium-Nox signaling during immune surveillance. This protective response is crucial to sustain vital immune functions and limit macrophage acquisition of senescence-like features. Macrophage Nrf2 also acts non-autonomously to limit bystander damage to adjacent healthy tissues.


Udi et al. present a new method for quantitative subcellular fractionation of a wide range of mammalian cells while maintaining nuclear integrity. This method provides a fast and reliable means to perform mass spectrometry and DeDuvian enrichment analyses for the different cellular compartments.

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