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Journal Articles

Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle

Esmeralda Villavicencio Gonzalez, Huda Y. Zoghbi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 223 (1): e20241336.
https://doi.org/10.1084/jem.20241336
Published: 23 October 2025
View article titled, Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle
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Journal Articles

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

In Special Collection:
Neuroscience Collection 2025
Matthew Paul Lennol, Chiara Bordier, Léana Kamelher, Jason D. Ulrich, David M. Holtzman, Maud Gratuze
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20250965.
https://doi.org/10.1084/jem.20250965
Published: 26 August 2025
View article titled, ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease
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Journal Articles

Taking the STING out of neurodegenerative disease

Aman Mangalmurti, John R. Lukens
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20250951.
https://doi.org/10.1084/jem.20250951
Published: 11 July 2025
View article titled, Taking the STING out of neurodegenerative disease
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Journal Articles

The STING pathway drives noninflammatory neurodegeneration in NGLY1 deficiency

In Special Collection:
Cytokines Collection 2025 , Neuroscience Collection 2025 , Pattern Recognition Receptors and Beyond
Kun Yang, Gustavo Torres-Ramirez, Nicole Dobbs, Jie Han, Makoto Asahina, Reiko Fujinawa, Kun Song, Yun Liu, Weichun Lin, Angelica Oviedo, Chuo Chen, Lei Zhu, William F. Mueller, Kevin Lee, Tadashi Suzuki, Nan Yan
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (10): e20242296.
https://doi.org/10.1084/jem.20242296
Published: 11 July 2025
View article titled, The STING pathway drives noninflammatory neurodegeneration in NGLY1 deficiency
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Includes: Supplementary data
Journal Articles

A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain

In Special Collection:
Neuroscience Collection 2025
Flavia T.T. Antunes, Maria A. Gandini, Agustin Garcia-Caballero, Sun Huang, Md Yousof Ali, Eder Gambeta, Ivana A. Souza, Erika K. Harding, Laurent Ferron, Asbjorg Stray-Pedersen, Vinicius M. Gadotti, Gerald W. Zamponi
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (8): e20241877.
https://doi.org/10.1084/jem.20241877
Published: 16 May 2025
View article titled, A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain
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Includes: Supplementary data
Journal Articles

Sympathetic axonogenesis promotes adenoid cystic carcinoma progression

In Special Collection:
Neuroimmunology and Neurodegeneration 2025
Chun-Hao Chen, Boris Reva, Nora Katabi, Avishai Wizel, Hongbo Xu, Alan L. Ho, Luc G.T. Morris, Richard L. Bakst, Anuraag S. Parikh, Yotam Drier, Sylvie Deborde, Richard J. Wong
Journal: Journal of Experimental Medicine
J Exp Med (2025) 222 (7): e20242250.
https://doi.org/10.1084/jem.20242250
Published: 24 April 2025
View article titled, Sympathetic axonogenesis promotes adenoid cystic carcinoma progression
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Includes: Supplementary data
Journal Articles

Dual role of vascular endothelial growth factor-C in post-stroke recovery

In Special Collection:
Neuroimmunology and Neurodegeneration 2025
Yun Hwa Choi, Martin Hsu, Collin Laaker, Jenna Port, Kristóf G. Kovács, Melinda Herbath, Heeyoon Yang, Peter Cismaru, Alexis M. Johnson, Bailey Spellman, Kelsey Wigand, Matyas Sandor, Zsuzsanna Fabry
Journal: Journal of Experimental Medicine
J Exp Med (2024) 222 (2): e20231816.
https://doi.org/10.1084/jem.20231816
Published: 12 December 2024
View article titled, Dual role of vascular endothelial growth factor-C in post-stroke recovery
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Includes: Supplementary data
Journal Articles

Bridging the gap between tumor and disease: Innovating cancer and glioma models

In Special Collection:
JEM Cancer Collection 2025
Stefano M. Cirigliano, Howard A. Fine
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 222 (1): e20220808.
https://doi.org/10.1084/jem.20220808
Published: 03 December 2024
View article titled, Bridging the gap between tumor and disease: Innovating cancer and glioma models
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Journal Articles

The brain–eye connection: More than just action potentials

James Walsh
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20241519.
https://doi.org/10.1084/jem.20241519
Published: 10 October 2024
View article titled, The brain–eye connection: More than just action potentials
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Journal Articles

Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer’s disease

In Special Collection:
Neuroscience Collection 2024 , Neuroimmunology and Neurodegeneration 2025
Qiuchen Cao, Shige Yang, Xiaowei Wang, Huaiqing Sun, Weijie Chen, Yuliang Wang, Junying Gao, Yanchi Wu, Qiuhua Yang, Xue Chen, Songtao Yuan, Ming Xiao, Maiken Nedergaard, Yuqing Huo, Qinghuai Liu
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (11): e20240386.
https://doi.org/10.1084/jem.20240386
Published: 24 September 2024
View article titled, Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer’s disease
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Includes: Supplementary data
Journal Articles

Immune drivers of physiological and pathological pain

In Special Collection:
JEM Clinical Immunology Collection 2024 , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024
Aakanksha Jain, Sara Hakim, Clifford J. Woolf
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (5): e20221687.
https://doi.org/10.1084/jem.20221687
Published: 12 April 2024
View article titled, Immune drivers of physiological and pathological pain
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Journal Articles

Hormonal basis of brain fog in cancer treatment

In Special Collection:
Neuroscience Collection 2024
Yuan Pan, Jian Hu
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (5): e20231942.
https://doi.org/10.1084/jem.20231942
Published: 10 April 2024
View article titled, Hormonal basis of brain fog in cancer treatment
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Journal Articles

A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice

In Special Collection:
JEM Clinical Immunology Collection 2024 , Innate Immune Signaling: From Host Defense to Disease Pathogenesis , Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024
David Brenner, Kirsten Sieverding, Jahnavi Srinidhi, Susanne Zellner, Christopher Secker, Rüstem Yilmaz, Julia Dyckow, Shady Amr, Anna Ponomarenko, Esra Tunaboylu, Yasmin Douahem, Joana S. Schlag, Lucía Rodríguez Martínez, Georg Kislinger, Cornelia Niemann, Karsten Nalbach, Wolfgang P. Ruf, Jonathan Uhl, Johanna Hollenbeck, Lucas Schirmer, Alberto Catanese, Christian S. Lobsiger, Karin M. Danzer, Deniz Yilmazer-Hanke, Christian Münch, Philipp Koch, Axel Freischmidt, Martina Fetting, Christian Behrends, Rosanna Parlato, Jochen H. Weishaupt
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (5): e20221190.
https://doi.org/10.1084/jem.20221190
Published: 22 March 2024
View article titled, A TBK1 variant causes autophagolysosomal and motoneuron pathology without neuroinflammation in mice
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Includes: Supplementary data
Journal Articles

The anatomic basis of leptomeningeal metastasis

In Special Collection:
JEM Cancer Collection 2024 , Neuroscience Collection 2024
Morgan E. Freret, Adrienne Boire
Journal: Journal of Experimental Medicine
Series: Cancer Focus
J Exp Med (2024) 221 (4): e20212121.
https://doi.org/10.1084/jem.20212121
Published: 07 March 2024
View article titled, The anatomic basis of leptomeningeal metastasis
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Journal Articles

VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , 2024: The Year in Experimental Medicine
Ligia Simoes Braga Boisserand, Luiz Henrique Geraldo, Jean Bouchart, Marie-Renee El Kamouh, Seyoung Lee, Basavaraju G. Sanganahalli, Myriam Spajer, Shenqi Zhang, Sungwoon Lee, Maxime Parent, Yuechuan Xue, Mario Skarica, Xiangyun Yin, Justine Guegan, Kevin Boyé, Felipe Saceanu Leser, Laurent Jacob, Mathilde Poulet, Mingfeng Li, Xiaodan Liu, Sofia E. Velazquez, Ruchith Singhabahu, Mark E. Robinson, Michael H. Askenase, Artem Osherov, Nenad Sestan, Jiangbing Zhou, Kari Alitalo, Eric Song, Anne Eichmann, Lauren H. Sansing, Helene Benveniste, Fahmeed Hyder, Jean-Leon Thomas
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (4): e20221983.
https://doi.org/10.1084/jem.20221983
Published: 05 March 2024
View article titled, VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
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Includes: Supplementary data
Journal Articles

Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Immunology Update Winter 2025
Chen Yu, Eleonora M. Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jinchao Hou, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D. Proia, Marco Colonna, Christian Haass, Daniel R. Saban
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (3): e20231011.
https://doi.org/10.1084/jem.20231011
Published: 30 January 2024
View article titled, Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2
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Includes: Supplementary data
Journal Articles

Dural mural cells paint an anti-inflammatory picture

Nicole C. Lummis, Benjamin D. Gastfriend, Richard Daneman
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20232263.
https://doi.org/10.1084/jem.20232263
Published: 25 January 2024
View article titled, Dural mural cells paint an anti-inflammatory picture
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Journal Articles

Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024 , 2024: The Year in Experimental Medicine
Mika P. Cadiz, Katelin A. Gibson, Kennedi T. Todd, David G. Nascari, Nashali Massa, Meredith T. Lilley, Kimberly C. Olney, Md Mamun Al-Amin, Hong Jiang, David M. Holtzman, John D. Fryer
Journal: Journal of Experimental Medicine
J Exp Med (2024) 221 (2): e20231363.
https://doi.org/10.1084/jem.20231363
Published: 16 January 2024
View article titled, Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations
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Includes: Supplementary data
Journal Articles

ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model

In Special Collection:
Neuroimmunology and Neurodegeneration 2024 , Neuroscience Collection 2024
Jung Hwa Lim, Hyun Mi Kang, Dae Hun Kim, Bohyeon Jeong, Da Yong Lee, Jae-Ran Lee, Jeong Yeob Baek, Hyun-Soo Cho, Mi-Young Son, Dae Soo Kim, Nam-Soon Kim, Cho-Rok Jung
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (1): e20230367.
https://doi.org/10.1084/jem.20230367
Published: 07 November 2023
View article titled, ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model
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Includes: Supplementary data
Journal Articles

Maternal diet during early gestation influences postnatal taste activity–dependent pruning by microglia

Chengsan Sun, Shuqiu Zheng, Justin S.A. Perry, Geoffrey T. Norris, Mei Cheng, Fanzhen Kong, Rolf Skyberg, Jianhua Cang, Alev Erisir, Jonathan Kipnis, David L. Hill
Journal: Journal of Experimental Medicine
J Exp Med (2023) 220 (12): e20212476.
https://doi.org/10.1084/jem.20212476
Published: 21 September 2023
View article titled, Maternal diet during early gestation influences postnatal taste activity–dependent pruning by microglia
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Includes: Supplementary data